PubMed:26253172 JSON TXT

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silkwormbase

Id	Subject	Object	Predicate	Lexical cue
T1	55-61	Gene:693025	denotes	POU-M2
T10	1073-1079	Gene:693025	denotes	POU-M2
T11	1113-1121	Species:7091	denotes	silkworm
T12	1349-1355	Gene:693025	denotes	POU-M2
T13	1430-1438	Species:7091	denotes	silkworm
T14	1517-1521	Chemical:-	denotes	Antp
T15	1540-1546	Gene:693025	denotes	POU-M2
T16	1618-1624	Gene:693025	denotes	POU-M2
T17	1632-1640	Species:7091	denotes	silkworm
T18	1674-1682	Chemical:MESH:D004440	denotes	ecdysone
T19	1781-1787	Gene:693025	denotes	POU-M2
T2	137-145	Species:7091	denotes	silkworm
T20	1824-1832	Species:7091	denotes	silkworm
T3	151-166	Chemical:MESH:D013256	denotes	steroid hormone
T4	167-175	Chemical:MESH:D004440	denotes	ecdysone
T6	485-493	Species:7091	denotes	silkworm
T7	666-672	Gene:693025	denotes	POU-M2
T8	739-745	Gene:693025	denotes	POU-M2
T9	837-845	Species:7091	denotes	silkworm

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-146	Sentence	denotes	The homeodomain transcription factors antennapedia and POU-M2 regulate the transcription of the steroidogenic enzyme gene Phantom in the silkworm.
T2	147-384	Sentence	denotes	The steroid hormone ecdysone, which controls insect molting and metamorphosis, is synthesized in the prothoracic gland (PG), and several steroidogenic enzymes that are expressed specifically in the PG are involved in ecdysteroidogenesis.
T3	385-521	Sentence	denotes	In this study, we identified new regulators that are involved in the transcriptional control of the silkworm steroidogenic enzyme genes.
T4	522-729	Sentence	denotes	In silico analysis predicted several potential cis-regulatory elements (CREs) for the homeodomain transcription factors Antennapedia (Antp) and POU-M2 in the proximal promoters of steroidogenic enzyme genes.
T5	730-926	Sentence	denotes	Antp and POU-M2 are expressed dynamically in the PG during larval development, and their overexpression in silkworm embryo-derived (BmE) cells induced the expression of steroidogenic enzyme genes.
T6	927-1245	Sentence	denotes	Importantly, luciferase reporter analyses, electrophoretic mobility shift assays, and chromatin immunoprecipitation assays revealed that Antp and POU-M2 promote the transcription of the silkworm steroidogenic enzyme gene Phantom (Phm) by binding directly to specific motifs within overlapping CREs in the Phm promoter.
T7	1246-1442	Sentence	denotes	Mutations of these CREs in the Phm promoter suppressed the transcriptional activities of both Antp and POU-M2 in BmE cells and decreased the activities of mutated Phm promoters in the silkworm PG.
T8	1443-1547	Sentence	denotes	In addition, pulldown and co-immunoprecipitation assays demonstrated that Antp can interact with POU-M2.
T9	1548-1734	Sentence	denotes	Moreover, RNA interference-mediated down-regulation of either Antp or POU-M2 during silkworm wandering not only decreased the ecdysone titer but also led to the failure of metamorphosis.
T10	1735-1939	Sentence	denotes	In summary, our results suggest that Antp and POU-M2 coordinate the transcription of the silkworm Phm gene directly, indicating new roles for homeodomain proteins in regulating insect ecdysteroidogenesis.

Glycosmos6-MAT

Id	Subject	Object	Predicate	Lexical cue
T1	260-265	http://purl.obolibrary.org/obo/MAT_0000021	denotes	gland
T2	680-688	http://purl.obolibrary.org/obo/MAT_0000491	denotes	proximal
T3	846-852	http://purl.obolibrary.org/obo/MAT_0000226	denotes	embryo

silkworm

Id	Subject	Object	Predicate	Lexical cue
T1	55-61	Gene:693025	denotes	POU-M2
T2	137-145	Species:7091	denotes	silkworm
T3	151-166	Chemical:MESH:D013256	denotes	steroid hormone
T4	167-175	Chemical:MESH:D004440	denotes	ecdysone
T5	267-269	Chemical:-	denotes	PG
T6	485-493	Species:7091	denotes	silkworm
T7	666-672	Gene:693025	denotes	POU-M2
T8	739-745	Gene:693025	denotes	POU-M2
T9	837-845	Species:7091	denotes	silkworm
T10	1073-1079	Gene:693025	denotes	POU-M2
T11	1113-1121	Species:7091	denotes	silkworm
T12	1349-1355	Gene:693025	denotes	POU-M2
T13	1430-1438	Species:7091	denotes	silkworm
T14	1517-1521	Chemical:-	denotes	Antp
T15	1540-1546	Gene:693025	denotes	POU-M2
T16	1618-1624	Gene:693025	denotes	POU-M2
T17	1632-1640	Species:7091	denotes	silkworm
T18	1674-1682	Chemical:MESH:D004440	denotes	ecdysone
T19	1781-1787	Gene:693025	denotes	POU-M2
T20	1824-1832	Species:7091	denotes	silkworm

silkworm_test

Subject	Object	Predicate	Lexical cue
55-61	Gene:693025	denotes	POU-M2
137-145	Species:7091	denotes	silkworm
151-166	Chemical:MESH:D013256	denotes	steroid hormone
167-175	Chemical:MESH:D004440	denotes	ecdysone
267-269	Chemical:-	denotes	PG
485-493	Species:7091	denotes	silkworm
666-672	Gene:693025	denotes	POU-M2
739-745	Gene:693025	denotes	POU-M2
837-845	Species:7091	denotes	silkworm
1073-1079	Gene:693025	denotes	POU-M2
1113-1121	Species:7091	denotes	silkworm
1349-1355	Gene:693025	denotes	POU-M2
1430-1438	Species:7091	denotes	silkworm
1517-1521	Chemical:-	denotes	Antp
1540-1546	Gene:693025	denotes	POU-M2
1618-1624	Gene:693025	denotes	POU-M2
1632-1640	Species:7091	denotes	silkworm
1674-1682	Chemical:MESH:D004440	denotes	ecdysone
1781-1787	Gene:693025	denotes	POU-M2
1824-1832	Species:7091	denotes	silkworm

NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	137-145	OrganismTaxon	denotes	silkworm	7091
T2	485-493	OrganismTaxon	denotes	silkworm	7091
T3	837-845	OrganismTaxon	denotes	silkworm	7091
T4	1113-1121	OrganismTaxon	denotes	silkworm	7091
T5	1430-1438	OrganismTaxon	denotes	silkworm	7091
T6	1632-1640	OrganismTaxon	denotes	silkworm	7091
T7	1824-1832	OrganismTaxon	denotes	silkworm	7091

Anatomy-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	260-265	Body_part	denotes	gland	http://purl.obolibrary.org/obo/UBERON_0002530
T2	846-852	Body_part	denotes	embryo	http://purl.obolibrary.org/obo/UBERON_0000922

Anatomy-MAT

Id	Subject	Object	Predicate	Lexical cue	mat_id
T1	260-265	Body_part	denotes	gland	http://purl.obolibrary.org/obo/MAT_0000021
T2	680-688	Body_part	denotes	proximal	http://purl.obolibrary.org/obo/MAT_0000491
T3	846-852	Body_part	denotes	embryo	http://purl.obolibrary.org/obo/MAT_0000226