PubMed:26216879
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 45-59 | Cell | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T3 | 94-109 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T5 | 306-320 | Cell | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T7 | 459-485 | Cell | denotes | vascular endothelial cells | http://purl.obolibrary.org/obo/CL:0002139 |
| T8 | 536-547 | Cell | denotes | immune cell | http://purl.obolibrary.org/obo/CL:0000738 |
| T9 | 647-674 | Cell | denotes | lymphatic endothelial cells | http://purl.obolibrary.org/obo/CL:0002138 |
| T10 | 779-793 | Cell | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T12 | 864-879 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T14 | 924-951 | Cell | denotes | lymphatic endothelial cells | http://purl.obolibrary.org/obo/CL:0002138 |
| T15 | 1002-1017 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T17 | 1065-1079 | Cell | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T19 | 1188-1203 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T21 | 1220-1235 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T23 | 1350-1365 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T25 | 1601-1616 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T27 | 1655-1670 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T29 | 1821-1836 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1137-1143 | Glycan_Motif | denotes | core 2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-72 | Sentence | denotes | Galectin-1 regulates tissue exit of specific dendritic cell populations. |
| T2 | 73-268 | Sentence | denotes | During inflammation, dendritic cells emigrate from inflamed tissue across the lymphatic endothelium into the lymphatic vasculature and travel to regional lymph nodes to initiate immune responses. |
| T3 | 269-403 | Sentence | denotes | However, the processes that regulate dendritic cell tissue egress and migration across the lymphatic endothelium are not well defined. |
| T4 | 404-582 | Sentence | denotes | The mammalian lectin galectin-1 is highly expressed by vascular endothelial cells in inflamed tissue and has been shown to regulate immune cell tissue entry into inflamed tissue. |
| T5 | 583-802 | Sentence | denotes | Here, we show that galectin-1 is also highly expressed by human lymphatic endothelial cells, and deposition of galectin-1 in extracellular matrix selectively regulates migration of specific human dendritic cell subsets. |
| T6 | 803-1018 | Sentence | denotes | The presence of galectin-1 inhibits migration of immunogenic dendritic cells through the extracellular matrix and across lymphatic endothelial cells, but it has no effect on migration of tolerogenic dendritic cells. |
| T7 | 1019-1312 | Sentence | denotes | The major galectin-1 counter-receptor on both dendritic cell populations is the cell surface mucin CD43; differential core 2 O-glycosylation of CD43 between immunogenic dendritic cells and tolerogenic dendritic cells appears to contribute to the differential effect of galectin-1 on migration. |
| T8 | 1313-1511 | Sentence | denotes | Binding of galectin-1 to immunogenic dendritic cells reduces phosphorylation and activity of the protein-tyrosine kinase Pyk2, an effect that may also contribute to reduced migration of this subset. |
| T9 | 1512-1701 | Sentence | denotes | In a murine lymphedema model, galectin-1(-/-) animals had increased numbers of migratory dendritic cells in draining lymph nodes, specifically dendritic cells with an immunogenic phenotype. |
| T10 | 1702-1920 | Sentence | denotes | These findings define a novel role for galectin-1 in inhibiting tissue emigration of immunogenic, but not tolerogenic, dendritic cells, providing an additional mechanism by which galectin-1 can dampen immune responses. |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 1434-1438 | GlycoEpitope | denotes | Pyk2 | http://www.glycoepitope.jp/epitopes/AN0554 |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 192-203 | http://purl.obolibrary.org/obo/MAT_0000393 | denotes | vasculature |
| T2 | 227-238 | http://purl.obolibrary.org/obo/MAT_0000197 | denotes | lymph nodes |
| T3 | 227-238 | http://purl.obolibrary.org/obo/MAT_0000442 | denotes | lymph nodes |
| T4 | 227-232 | http://purl.obolibrary.org/obo/MAT_0000055 | denotes | lymph |
| T5 | 1629-1640 | http://purl.obolibrary.org/obo/MAT_0000197 | denotes | lymph nodes |
| T6 | 1629-1640 | http://purl.obolibrary.org/obo/MAT_0000442 | denotes | lymph nodes |
| T7 | 1629-1634 | http://purl.obolibrary.org/obo/MAT_0000055 | denotes | lymph |
Inflammaging
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-72 | Sentence | denotes | Galectin-1 regulates tissue exit of specific dendritic cell populations. |
| T2 | 73-268 | Sentence | denotes | During inflammation, dendritic cells emigrate from inflamed tissue across the lymphatic endothelium into the lymphatic vasculature and travel to regional lymph nodes to initiate immune responses. |
| T3 | 269-403 | Sentence | denotes | However, the processes that regulate dendritic cell tissue egress and migration across the lymphatic endothelium are not well defined. |
| T4 | 404-582 | Sentence | denotes | The mammalian lectin galectin-1 is highly expressed by vascular endothelial cells in inflamed tissue and has been shown to regulate immune cell tissue entry into inflamed tissue. |
| T5 | 583-802 | Sentence | denotes | Here, we show that galectin-1 is also highly expressed by human lymphatic endothelial cells, and deposition of galectin-1 in extracellular matrix selectively regulates migration of specific human dendritic cell subsets. |
| T6 | 803-1018 | Sentence | denotes | The presence of galectin-1 inhibits migration of immunogenic dendritic cells through the extracellular matrix and across lymphatic endothelial cells, but it has no effect on migration of tolerogenic dendritic cells. |
| T7 | 1019-1312 | Sentence | denotes | The major galectin-1 counter-receptor on both dendritic cell populations is the cell surface mucin CD43; differential core 2 O-glycosylation of CD43 between immunogenic dendritic cells and tolerogenic dendritic cells appears to contribute to the differential effect of galectin-1 on migration. |
| T8 | 1313-1511 | Sentence | denotes | Binding of galectin-1 to immunogenic dendritic cells reduces phosphorylation and activity of the protein-tyrosine kinase Pyk2, an effect that may also contribute to reduced migration of this subset. |
| T9 | 1512-1701 | Sentence | denotes | In a murine lymphedema model, galectin-1(-/-) animals had increased numbers of migratory dendritic cells in draining lymph nodes, specifically dendritic cells with an immunogenic phenotype. |
| T10 | 1702-1920 | Sentence | denotes | These findings define a novel role for galectin-1 in inhibiting tissue emigration of immunogenic, but not tolerogenic, dendritic cells, providing an additional mechanism by which galectin-1 can dampen immune responses. |
| T1 | 0-72 | Sentence | denotes | Galectin-1 regulates tissue exit of specific dendritic cell populations. |
| T2 | 73-268 | Sentence | denotes | During inflammation, dendritic cells emigrate from inflamed tissue across the lymphatic endothelium into the lymphatic vasculature and travel to regional lymph nodes to initiate immune responses. |
| T3 | 269-403 | Sentence | denotes | However, the processes that regulate dendritic cell tissue egress and migration across the lymphatic endothelium are not well defined. |
| T4 | 404-582 | Sentence | denotes | The mammalian lectin galectin-1 is highly expressed by vascular endothelial cells in inflamed tissue and has been shown to regulate immune cell tissue entry into inflamed tissue. |
| T5 | 583-802 | Sentence | denotes | Here, we show that galectin-1 is also highly expressed by human lymphatic endothelial cells, and deposition of galectin-1 in extracellular matrix selectively regulates migration of specific human dendritic cell subsets. |
| T6 | 803-1018 | Sentence | denotes | The presence of galectin-1 inhibits migration of immunogenic dendritic cells through the extracellular matrix and across lymphatic endothelial cells, but it has no effect on migration of tolerogenic dendritic cells. |
| T7 | 1019-1312 | Sentence | denotes | The major galectin-1 counter-receptor on both dendritic cell populations is the cell surface mucin CD43; differential core 2 O-glycosylation of CD43 between immunogenic dendritic cells and tolerogenic dendritic cells appears to contribute to the differential effect of galectin-1 on migration. |
| T8 | 1313-1511 | Sentence | denotes | Binding of galectin-1 to immunogenic dendritic cells reduces phosphorylation and activity of the protein-tyrosine kinase Pyk2, an effect that may also contribute to reduced migration of this subset. |
| T9 | 1512-1701 | Sentence | denotes | In a murine lymphedema model, galectin-1(-/-) animals had increased numbers of migratory dendritic cells in draining lymph nodes, specifically dendritic cells with an immunogenic phenotype. |
| T10 | 1702-1920 | Sentence | denotes | These findings define a novel role for galectin-1 in inhibiting tissue emigration of immunogenic, but not tolerogenic, dendritic cells, providing an additional mechanism by which galectin-1 can dampen immune responses. |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 80-92 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T2 | 1524-1534 | Disease | denotes | lymphedema | http://purl.obolibrary.org/obo/MONDO_0019297 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 192-203 | Body_part | denotes | vasculature | http://purl.obolibrary.org/obo/MAT_0000393 |
| T2 | 227-238 | Body_part | denotes | lymph nodes | http://purl.obolibrary.org/obo/MAT_0000197|http://purl.obolibrary.org/obo/MAT_0000442 |
| T4 | 1629-1640 | Body_part | denotes | lymph nodes | http://purl.obolibrary.org/obo/MAT_0000197|http://purl.obolibrary.org/obo/MAT_0000442 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1524-1534 | Phenotype | denotes | lymphedema | HP:0001004 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1137-1143 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 1434-1438 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Pyk2 | http://www.glycoepitope.jp/epitopes/AN0554 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1524-1534 | Phenotype | denotes | lymphedema | HP:0001004 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 80-92 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T2 | 1524-1534 | Disease | denotes | lymphedema | http://purl.obolibrary.org/obo/MONDO_0019297 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 641-646 | OrganismTaxon | denotes | human | 9606 |
| T2 | 773-778 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 45-59 | Cell | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T3 | 94-109 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T5 | 306-320 | Cell | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T7 | 459-485 | Cell | denotes | vascular endothelial cells | http://purl.obolibrary.org/obo/CL:0002139 |
| T8 | 536-547 | Cell | denotes | immune cell | http://purl.obolibrary.org/obo/CL:0000738 |
| T9 | 647-674 | Cell | denotes | lymphatic endothelial cells | http://purl.obolibrary.org/obo/CL:0002138 |
| T10 | 779-793 | Cell | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T12 | 864-879 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T14 | 924-951 | Cell | denotes | lymphatic endothelial cells | http://purl.obolibrary.org/obo/CL:0002138 |
| T15 | 1002-1017 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T17 | 1065-1079 | Cell | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T19 | 1188-1203 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T21 | 1220-1235 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T23 | 1350-1365 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T25 | 1601-1616 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T27 | 1655-1670 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T29 | 1821-1836 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 21-27 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T2 | 45-59 | Body_part | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL_0000451 |
| T3 | 94-109 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T4 | 133-139 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T5 | 151-172 | Body_part | denotes | lymphatic endothelium | http://purl.obolibrary.org/obo/UBERON_0002042 |
| T6 | 182-203 | Body_part | denotes | lymphatic vasculature | http://purl.obolibrary.org/obo/UBERON_0004536 |
| T7 | 227-238 | Body_part | denotes | lymph nodes | http://purl.obolibrary.org/obo/UBERON_0000029 |
| T8 | 306-320 | Body_part | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL_0000451 |
| T9 | 321-327 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T10 | 360-381 | Body_part | denotes | lymphatic endothelium | http://purl.obolibrary.org/obo/UBERON_0002042 |
| T11 | 459-485 | Body_part | denotes | vascular endothelial cells | http://purl.obolibrary.org/obo/CL_0002139 |
| T12 | 498-504 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T13 | 536-547 | Body_part | denotes | immune cell | http://purl.obolibrary.org/obo/CL_0000738 |
| T14 | 548-554 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T15 | 575-581 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T16 | 647-674 | Body_part | denotes | lymphatic endothelial cells | http://purl.obolibrary.org/obo/CL_0002138 |
| T17 | 708-728 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T18 | 779-793 | Body_part | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL_0000451 |
| T19 | 864-879 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T20 | 892-912 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T21 | 924-951 | Body_part | denotes | lymphatic endothelial cells | http://purl.obolibrary.org/obo/CL_0002138 |
| T22 | 1002-1017 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T23 | 1065-1079 | Body_part | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL_0000451 |
| T24 | 1188-1203 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T25 | 1220-1235 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T26 | 1350-1365 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T27 | 1601-1616 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T28 | 1629-1640 | Body_part | denotes | lymph nodes | http://purl.obolibrary.org/obo/UBERON_0000029 |
| T29 | 1655-1670 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T30 | 1766-1772 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T31 | 1821-1836 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 192-203 | Body_part | denotes | vasculature | http://purl.obolibrary.org/obo/MAT_0000393 |
| T2 | 227-238 | Body_part | denotes | lymph nodes | http://purl.obolibrary.org/obo/MAT_0000197|http://purl.obolibrary.org/obo/MAT_0000442 |
| T4 | 1629-1640 | Body_part | denotes | lymph nodes | http://purl.obolibrary.org/obo/MAT_0000197|http://purl.obolibrary.org/obo/MAT_0000442 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-72 | Sentence | denotes | Galectin-1 regulates tissue exit of specific dendritic cell populations. |
| T2 | 73-268 | Sentence | denotes | During inflammation, dendritic cells emigrate from inflamed tissue across the lymphatic endothelium into the lymphatic vasculature and travel to regional lymph nodes to initiate immune responses. |
| T3 | 269-403 | Sentence | denotes | However, the processes that regulate dendritic cell tissue egress and migration across the lymphatic endothelium are not well defined. |
| T4 | 404-582 | Sentence | denotes | The mammalian lectin galectin-1 is highly expressed by vascular endothelial cells in inflamed tissue and has been shown to regulate immune cell tissue entry into inflamed tissue. |
| T5 | 583-802 | Sentence | denotes | Here, we show that galectin-1 is also highly expressed by human lymphatic endothelial cells, and deposition of galectin-1 in extracellular matrix selectively regulates migration of specific human dendritic cell subsets. |
| T6 | 803-1018 | Sentence | denotes | The presence of galectin-1 inhibits migration of immunogenic dendritic cells through the extracellular matrix and across lymphatic endothelial cells, but it has no effect on migration of tolerogenic dendritic cells. |
| T7 | 1019-1312 | Sentence | denotes | The major galectin-1 counter-receptor on both dendritic cell populations is the cell surface mucin CD43; differential core 2 O-glycosylation of CD43 between immunogenic dendritic cells and tolerogenic dendritic cells appears to contribute to the differential effect of galectin-1 on migration. |
| T8 | 1313-1511 | Sentence | denotes | Binding of galectin-1 to immunogenic dendritic cells reduces phosphorylation and activity of the protein-tyrosine kinase Pyk2, an effect that may also contribute to reduced migration of this subset. |
| T9 | 1512-1701 | Sentence | denotes | In a murine lymphedema model, galectin-1(-/-) animals had increased numbers of migratory dendritic cells in draining lymph nodes, specifically dendritic cells with an immunogenic phenotype. |
| T10 | 1702-1920 | Sentence | denotes | These findings define a novel role for galectin-1 in inhibiting tissue emigration of immunogenic, but not tolerogenic, dendritic cells, providing an additional mechanism by which galectin-1 can dampen immune responses. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-72 | Sentence | denotes | Galectin-1 regulates tissue exit of specific dendritic cell populations. |
| T2 | 73-268 | Sentence | denotes | During inflammation, dendritic cells emigrate from inflamed tissue across the lymphatic endothelium into the lymphatic vasculature and travel to regional lymph nodes to initiate immune responses. |
| T3 | 269-403 | Sentence | denotes | However, the processes that regulate dendritic cell tissue egress and migration across the lymphatic endothelium are not well defined. |
| T4 | 404-582 | Sentence | denotes | The mammalian lectin galectin-1 is highly expressed by vascular endothelial cells in inflamed tissue and has been shown to regulate immune cell tissue entry into inflamed tissue. |
| T5 | 583-802 | Sentence | denotes | Here, we show that galectin-1 is also highly expressed by human lymphatic endothelial cells, and deposition of galectin-1 in extracellular matrix selectively regulates migration of specific human dendritic cell subsets. |
| T6 | 803-1018 | Sentence | denotes | The presence of galectin-1 inhibits migration of immunogenic dendritic cells through the extracellular matrix and across lymphatic endothelial cells, but it has no effect on migration of tolerogenic dendritic cells. |
| T7 | 1019-1312 | Sentence | denotes | The major galectin-1 counter-receptor on both dendritic cell populations is the cell surface mucin CD43; differential core 2 O-glycosylation of CD43 between immunogenic dendritic cells and tolerogenic dendritic cells appears to contribute to the differential effect of galectin-1 on migration. |
| T8 | 1313-1511 | Sentence | denotes | Binding of galectin-1 to immunogenic dendritic cells reduces phosphorylation and activity of the protein-tyrosine kinase Pyk2, an effect that may also contribute to reduced migration of this subset. |
| T9 | 1512-1701 | Sentence | denotes | In a murine lymphedema model, galectin-1(-/-) animals had increased numbers of migratory dendritic cells in draining lymph nodes, specifically dendritic cells with an immunogenic phenotype. |
| T10 | 1702-1920 | Sentence | denotes | These findings define a novel role for galectin-1 in inhibiting tissue emigration of immunogenic, but not tolerogenic, dendritic cells, providing an additional mechanism by which galectin-1 can dampen immune responses. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1137-1143 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 1434-1438 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Pyk2 | http://www.glycoepitope.jp/epitopes/AN0554 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 641-646 | OrganismTaxon | denotes | human | 9606 |
| T2 | 773-778 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 21-27 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T2 | 45-59 | Body_part | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL_0000451 |
| T3 | 94-109 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T4 | 133-139 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T5 | 151-172 | Body_part | denotes | lymphatic endothelium | http://purl.obolibrary.org/obo/UBERON_0002042 |
| T6 | 182-203 | Body_part | denotes | lymphatic vasculature | http://purl.obolibrary.org/obo/UBERON_0004536 |
| T7 | 227-238 | Body_part | denotes | lymph nodes | http://purl.obolibrary.org/obo/UBERON_0000029 |
| T8 | 306-320 | Body_part | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL_0000451 |
| T9 | 321-327 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T10 | 360-381 | Body_part | denotes | lymphatic endothelium | http://purl.obolibrary.org/obo/UBERON_0002042 |
| T11 | 459-485 | Body_part | denotes | vascular endothelial cells | http://purl.obolibrary.org/obo/CL_0002139 |
| T12 | 498-504 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T13 | 536-547 | Body_part | denotes | immune cell | http://purl.obolibrary.org/obo/CL_0000738 |
| T14 | 548-554 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T15 | 575-581 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T16 | 647-674 | Body_part | denotes | lymphatic endothelial cells | http://purl.obolibrary.org/obo/CL_0002138 |
| T17 | 708-728 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T18 | 779-793 | Body_part | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL_0000451 |
| T19 | 864-879 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T20 | 892-912 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T21 | 924-951 | Body_part | denotes | lymphatic endothelial cells | http://purl.obolibrary.org/obo/CL_0002138 |
| T22 | 1002-1017 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T23 | 1065-1079 | Body_part | denotes | dendritic cell | http://purl.obolibrary.org/obo/CL_0000451 |
| T24 | 1188-1203 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T25 | 1220-1235 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T26 | 1350-1365 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T27 | 1601-1616 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T28 | 1629-1640 | Body_part | denotes | lymph nodes | http://purl.obolibrary.org/obo/UBERON_0000029 |
| T29 | 1655-1670 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T30 | 1766-1772 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T31 | 1821-1836 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |