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PubMed:26206502 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 187-203 Cell denotes eukaryotic cells http://purl.obolibrary.org/obo/CL:0000255
T2 869-890 Cell denotes embryonic fibroblasts http://purl.obolibrary.org/obo/CL:2000042

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-134 Sentence denotes Cytosolic-free oligosaccharides are predominantly generated by the degradation of dolichol-linked oligosaccharides in mammalian cells.
TextSentencer_T2 135-281 Sentence denotes During asparagine (N)-linked protein glycosylation, eukaryotic cells generate considerable amounts of free oligosaccharides (fOSs) in the cytosol.
TextSentencer_T3 282-580 Sentence denotes It is generally assumed that such fOSs are produced by the deglycosylation of misfolded N-glycoproteins that are destined for proteasomal degradation or as the result of the degradation of dolichol-linked oligosaccharides (DLOs), which serve as glycan donor substrates in N-glycosylation reactions.
TextSentencer_T4 581-785 Sentence denotes The findings reported herein show that the majority of cytosolic fOSs are generated by a peptide:N-glycanase (PNGase) and an endo-β-N-acetylglucosaminidase (ENGase)-independent pathway in mammalian cells.
TextSentencer_T5 786-951 Sentence denotes The ablation of the cytosolic deglycosylating enzymes, PNGase and ENGase, in mouse embryonic fibroblasts had little effect on the amount of cytosolic fOSs generated.
TextSentencer_T6 952-1179 Sentence denotes Quantitative analyses of fOSs using digitonin-permeabilized cells revealed that they are generated by the degradation of fully assembled Glc3Man9GlcNAc2-pyrophosphate-dolichol (PP-Dol) in the lumen of the endoplasmic reticulum.
TextSentencer_T7 1180-1502 Sentence denotes Because the degradation of Glc3Man9GlcNAc2-PP-Dol is greatly inhibited in the presence of an N-glycosylation acceptor peptide that is recognized by the oligosaccharyltransferase (OST), the OST-mediated hydrolysis of DLO is the most likely mechanism responsible for the production of a large fraction of the cytosolic fOSs.
T1 0-134 Sentence denotes Cytosolic-free oligosaccharides are predominantly generated by the degradation of dolichol-linked oligosaccharides in mammalian cells.
T2 135-281 Sentence denotes During asparagine (N)-linked protein glycosylation, eukaryotic cells generate considerable amounts of free oligosaccharides (fOSs) in the cytosol.
T3 282-580 Sentence denotes It is generally assumed that such fOSs are produced by the deglycosylation of misfolded N-glycoproteins that are destined for proteasomal degradation or as the result of the degradation of dolichol-linked oligosaccharides (DLOs), which serve as glycan donor substrates in N-glycosylation reactions.
T4 581-785 Sentence denotes The findings reported herein show that the majority of cytosolic fOSs are generated by a peptide:N-glycanase (PNGase) and an endo-β-N-acetylglucosaminidase (ENGase)-independent pathway in mammalian cells.
T5 786-951 Sentence denotes The ablation of the cytosolic deglycosylating enzymes, PNGase and ENGase, in mouse embryonic fibroblasts had little effect on the amount of cytosolic fOSs generated.
T6 952-1179 Sentence denotes Quantitative analyses of fOSs using digitonin-permeabilized cells revealed that they are generated by the degradation of fully assembled Glc3Man9GlcNAc2-pyrophosphate-dolichol (PP-Dol) in the lumen of the endoplasmic reticulum.
T7 1180-1502 Sentence denotes Because the degradation of Glc3Man9GlcNAc2-PP-Dol is greatly inhibited in the presence of an N-glycosylation acceptor peptide that is recognized by the oligosaccharyltransferase (OST), the OST-mediated hydrolysis of DLO is the most likely mechanism responsible for the production of a large fraction of the cytosolic fOSs.
T1 0-134 Sentence denotes Cytosolic-free oligosaccharides are predominantly generated by the degradation of dolichol-linked oligosaccharides in mammalian cells.
T2 135-281 Sentence denotes During asparagine (N)-linked protein glycosylation, eukaryotic cells generate considerable amounts of free oligosaccharides (fOSs) in the cytosol.
T3 282-580 Sentence denotes It is generally assumed that such fOSs are produced by the deglycosylation of misfolded N-glycoproteins that are destined for proteasomal degradation or as the result of the degradation of dolichol-linked oligosaccharides (DLOs), which serve as glycan donor substrates in N-glycosylation reactions.
T4 581-785 Sentence denotes The findings reported herein show that the majority of cytosolic fOSs are generated by a peptide:N-glycanase (PNGase) and an endo-β-N-acetylglucosaminidase (ENGase)-independent pathway in mammalian cells.
T5 786-951 Sentence denotes The ablation of the cytosolic deglycosylating enzymes, PNGase and ENGase, in mouse embryonic fibroblasts had little effect on the amount of cytosolic fOSs generated.
T6 952-1179 Sentence denotes Quantitative analyses of fOSs using digitonin-permeabilized cells revealed that they are generated by the degradation of fully assembled Glc3Man9GlcNAc2-pyrophosphate-dolichol (PP-Dol) in the lumen of the endoplasmic reticulum.
T7 1180-1502 Sentence denotes Because the degradation of Glc3Man9GlcNAc2-PP-Dol is greatly inhibited in the presence of an N-glycosylation acceptor peptide that is recognized by the oligosaccharyltransferase (OST), the OST-mediated hydrolysis of DLO is the most likely mechanism responsible for the production of a large fraction of the cytosolic fOSs.

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 15-31 FMAID:196731 denotes oligosaccharides
_T2 15-31 FMAID:82742 denotes oligosaccharides
_T3 98-114 FMAID:196731 denotes oligosaccharides
_T4 98-114 FMAID:82742 denotes oligosaccharides
_T5 128-133 FMAID:169002 denotes cells
_T6 128-133 FMAID:68646 denotes cells
_T7 142-152 FMAID:196739 denotes asparagine
_T8 142-152 FMAID:82750 denotes asparagine
_T9 164-171 FMAID:67257 denotes protein
_T10 164-171 FMAID:165447 denotes protein
_T11 198-203 FMAID:68646 denotes cells
_T12 198-203 FMAID:169002 denotes cells
_T13 242-258 FMAID:196731 denotes oligosaccharides
_T14 242-258 FMAID:82742 denotes oligosaccharides
_T15 273-280 FMAID:256055 denotes cytosol
_T16 372-385 FMAID:167256 denotes glycoproteins
_T17 372-385 FMAID:62925 denotes glycoproteins
_T18 487-503 FMAID:196731 denotes oligosaccharides
_T19 487-503 FMAID:82742 denotes oligosaccharides
_T20 713-736 FMAID:82787 denotes N-acetylglucosaminidase
_T21 713-736 FMAID:196781 denotes N-acetylglucosaminidase
_T22 779-784 FMAID:169002 denotes cells
_T23 779-784 FMAID:68646 denotes cells
_T24 879-890 FMAID:63877 denotes fibroblasts
_T25 879-890 FMAID:162340 denotes fibroblasts
_T26 1012-1017 FMAID:169002 denotes cells
_T27 1012-1017 FMAID:68646 denotes cells
_T28 1144-1178 FMAID:199160 denotes lumen of the endoplasmic reticulum
_T29 1144-1178 FMAID:67672 denotes lumen of the endoplasmic reticulum
_T30 1144-1178 FMAID:165580 denotes lumen of the endoplasmic reticulum
_T31 1144-1178 FMAID:199094 denotes lumen of the endoplasmic reticulum
_T32 1144-1178 FMAID:165060 denotes lumen of the endoplasmic reticulum
_T33 1144-1178 FMAID:199158 denotes lumen of the endoplasmic reticulum
_T34 1157-1168 FMAID:66856 denotes endoplasmic
_T35 1157-1168 FMAID:165003 denotes endoplasmic
_T36 1157-1178 FMAID:165250 denotes endoplasmic reticulum
_T37 1157-1178 FMAID:165144 denotes endoplasmic reticulum
_T38 1157-1178 FMAID:210694 denotes endoplasmic reticulum
_T39 1157-1178 FMAID:211269 denotes endoplasmic reticulum
_T40 1157-1178 FMAID:199093 denotes endoplasmic reticulum
_T41 1157-1178 FMAID:67429 denotes endoplasmic reticulum
_T42 1157-1178 FMAID:165142 denotes endoplasmic reticulum
_T43 1157-1178 FMAID:212510 denotes endoplasmic reticulum
_T44 1157-1178 FMAID:63842 denotes endoplasmic reticulum
_T45 1157-1178 FMAID:162308 denotes endoplasmic reticulum
_T46 1157-1178 FMAID:67434 denotes endoplasmic reticulum
_T47 1157-1178 FMAID:165026 denotes endoplasmic reticulum
_T48 1157-1178 FMAID:67438 denotes endoplasmic reticulum
_T49 1157-1178 FMAID:210679 denotes endoplasmic reticulum
_T50 1157-1178 FMAID:80351 denotes endoplasmic reticulum
_T51 1157-1178 FMAID:188464 denotes endoplasmic reticulum
_T52 1157-1178 FMAID:165027 denotes endoplasmic reticulum
_T53 1157-1178 FMAID:66898 denotes endoplasmic reticulum
_T54 1157-1178 FMAID:66897 denotes endoplasmic reticulum
_T55 1157-1178 FMAID:165141 denotes endoplasmic reticulum
_T56 1169-1178 FMAID:7646 denotes reticulum
_T57 1169-1178 FMAID:94520 denotes reticulum

uniprot-human

Id Subject Object Predicate Lexical cue
T1 670-689 http://www.uniprot.org/uniprot/Q96IV0 denotes peptide:N-glycanase
T2 691-697 http://www.uniprot.org/uniprot/Q96IV0 denotes PNGase
T3 841-847 http://www.uniprot.org/uniprot/Q96IV0 denotes PNGase
T4 711-736 http://www.uniprot.org/uniprot/Q9HAR0 denotes β-N-acetylglucosaminidase
T5 738-744 http://www.uniprot.org/uniprot/Q8NFI3 denotes ENGase
T6 852-858 http://www.uniprot.org/uniprot/Q8NFI3 denotes ENGase
T7 1129-1131 http://www.uniprot.org/uniprot/Q15181 denotes PP
T8 1223-1225 http://www.uniprot.org/uniprot/Q15181 denotes PP
T9 1129-1131 http://www.uniprot.org/uniprot/P01298 denotes PP
T10 1223-1225 http://www.uniprot.org/uniprot/P01298 denotes PP

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 670-689 http://www.uniprot.org/uniprot/Q9JI78 denotes peptide:N-glycanase
T2 691-697 http://www.uniprot.org/uniprot/Q9JI78 denotes PNGase
T3 841-847 http://www.uniprot.org/uniprot/Q9JI78 denotes PNGase
T4 738-744 http://www.uniprot.org/uniprot/Q8BX80 denotes ENGase
T5 852-858 http://www.uniprot.org/uniprot/Q8BX80 denotes ENGase
T6 1129-1131 http://www.uniprot.org/uniprot/P10601 denotes PP
T7 1223-1225 http://www.uniprot.org/uniprot/P10601 denotes PP

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 128-133 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T2 187-197 http://purl.bioontology.org/ontology/NCBITAXON/2759 denotes eukaryotic
T3 198-203 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T4 585-593 http://purl.bioontology.org/ontology/STY/T033 denotes findings
T5 779-784 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T6 1012-1017 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T7 1419-1428 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism

GO-BP

Id Subject Object Predicate Lexical cue
T1 67-78 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T2 420-431 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T3 456-467 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T4 1058-1069 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T5 1192-1203 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T6 164-185 http://purl.obolibrary.org/obo/GO_0006486 denotes protein glycosylation
T7 172-185 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T8 556-569 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T9 1275-1288 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T10 408-431 http://purl.obolibrary.org/obo/GO_1903009 denotes proteasomal degradation
T11 670-689 http://purl.obolibrary.org/obo/GO_0000224 denotes peptide:N-glycanase
T12 691-697 http://purl.obolibrary.org/obo/GO_0000224 denotes PNGase
T13 841-847 http://purl.obolibrary.org/obo/GO_0000224 denotes PNGase

GO-CC

Id Subject Object Predicate Lexical cue
T1 0-9 http://purl.obolibrary.org/obo/GO_0005829 denotes Cytosolic
T2 273-280 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosol
T3 636-645 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosolic
T4 806-815 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosolic
T5 926-935 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosolic
T6 1487-1496 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosolic
T7 128-133 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8 198-203 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9 779-784 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10 1012-1017 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11 408-419 http://purl.obolibrary.org/obo/GO_0000502 denotes proteasomal
T12 1144-1178 http://purl.obolibrary.org/obo/GO_0048238 denotes lumen of the endoplasmic reticulum
T13 1144-1178 http://purl.obolibrary.org/obo/GO_0044166 denotes lumen of the endoplasmic reticulum
T14 1144-1178 http://purl.obolibrary.org/obo/GO_0005788 denotes lumen of the endoplasmic reticulum
T15 1144-1178 http://purl.obolibrary.org/obo/GO_0048237 denotes lumen of the endoplasmic reticulum
T16 1157-1178 http://purl.obolibrary.org/obo/GO_0005783 denotes endoplasmic reticulum

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 691-697 hgnc:17646 denotes PNGase
PD-NGLY1-deficiency-B_T2 841-847 hgnc:17646 denotes PNGase
PD-NGLY1-deficiency-B_T3 738-744 hgnc:24622 denotes ENGase
PD-NGLY1-deficiency-B_T4 852-858 hgnc:24622 denotes ENGase

GlycoGenes

Id Subject Object Predicate Lexical cue
PD-GlycoGenes-B_T1 1465-1470 GGDB:LARGE denotes large

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 863-868 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 187-203 Body_part denotes eukaryotic cells http://purl.obolibrary.org/obo/CL_0000255
T2 273-280 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829
T3 869-890 Body_part denotes embryonic fibroblasts http://purl.obolibrary.org/obo/CL_2000042
T4 1144-1149 Body_part denotes lumen http://purl.obolibrary.org/obo/UBERON_0000464
T5 1169-1178 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361