PubMed:26149685
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 364-387 | Cell | denotes | colonic epithelial cell | http://purl.obolibrary.org/obo/CL:0011108 |
| T2 | 372-387 | Cell | denotes | epithelial cell | http://purl.obolibrary.org/obo/CL:0000066 |
| T3 | 1098-1122 | Cell | denotes | colonic epithelial cells | http://purl.obolibrary.org/obo/CL:0011108 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-102 | Sentence | denotes | Autophagy Protects against Colitis by the Maintenance of Normal Gut Microflora and Secretion of Mucus. |
| T2 | 103-231 | Sentence | denotes | Genome-wide association studies of inflammatory bowel diseases identified susceptible loci containing an autophagy-related gene. |
| T3 | 232-344 | Sentence | denotes | However, the role of autophagy in the colon, a major affected area in inflammatory bowel diseases, is not clear. |
| T4 | 345-572 | Sentence | denotes | Here, we show that colonic epithelial cell-specific autophagy-related gene 7 (Atg7) conditional knock-out (cKO) mice showed exacerbation of experimental colitis with more abundant bacterial invasion into the colonic epithelium. |
| T5 | 573-678 | Sentence | denotes | Quantitative PCR analysis revealed that cKO mice had abnormal microflora with an increase of some genera. |
| T6 | 679-892 | Sentence | denotes | Consistently, expression of antimicrobial or antiparasitic peptides such as angiogenin-4, Relmβ, intelectin-1, and intelectin-2 as well as that of their inducer cytokines was significantly reduced in the cKO mice. |
| T7 | 893-1042 | Sentence | denotes | Furthermore, secretion of colonic mucins that function as a mucosal barrier against bacterial invasion was also significantly diminished in cKO mice. |
| T8 | 1043-1215 | Sentence | denotes | Taken together, our results indicate that autophagy in colonic epithelial cells protects against colitis by the maintenance of normal gut microflora and secretion of mucus. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 64-67 | http://purl.obolibrary.org/obo/MAT_0000043 | denotes | Gut |
| T2 | 270-275 | http://purl.obolibrary.org/obo/MAT_0000526 | denotes | colon |
| T3 | 364-371 | http://purl.obolibrary.org/obo/MAT_0000526 | denotes | colonic |
| T4 | 553-560 | http://purl.obolibrary.org/obo/MAT_0000526 | denotes | colonic |
| T5 | 919-926 | http://purl.obolibrary.org/obo/MAT_0000526 | denotes | colonic |
| T6 | 1098-1105 | http://purl.obolibrary.org/obo/MAT_0000526 | denotes | colonic |
| T7 | 1177-1180 | http://purl.obolibrary.org/obo/MAT_0000043 | denotes | gut |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 64-67 | Body_part | denotes | Gut | http://purl.obolibrary.org/obo/MAT_0000043 |
| T2 | 270-275 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/MAT_0000526 |
| T3 | 364-371 | Body_part | denotes | colonic | http://purl.obolibrary.org/obo/MAT_0000526 |
| T4 | 553-560 | Body_part | denotes | colonic | http://purl.obolibrary.org/obo/MAT_0000526 |
| T5 | 919-926 | Body_part | denotes | colonic | http://purl.obolibrary.org/obo/MAT_0000526 |
| T6 | 1098-1105 | Body_part | denotes | colonic | http://purl.obolibrary.org/obo/MAT_0000526 |
| T7 | 1177-1180 | Body_part | denotes | gut | http://purl.obolibrary.org/obo/MAT_0000043 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 27-34 | Phenotype | denotes | Colitis | HP:0002583 |
| T2 | 138-165 | Phenotype | denotes | inflammatory bowel diseases | HP:0002037 |
| T3 | 302-329 | Phenotype | denotes | inflammatory bowel diseases | HP:0002037 |
| T4 | 498-505 | Phenotype | denotes | colitis | HP:0002583 |
| T5 | 1140-1147 | Phenotype | denotes | colitis | HP:0002583 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 27-34 | Disease | denotes | Colitis | http://purl.obolibrary.org/obo/MONDO_0005292 |
| T2 | 138-165 | Disease | denotes | inflammatory bowel diseases | http://purl.obolibrary.org/obo/MONDO_0005265 |
| T3 | 302-329 | Disease | denotes | inflammatory bowel diseases | http://purl.obolibrary.org/obo/MONDO_0005265 |
| T4 | 498-505 | Disease | denotes | colitis | http://purl.obolibrary.org/obo/MONDO_0005292 |
| T5 | 1140-1147 | Disease | denotes | colitis | http://purl.obolibrary.org/obo/MONDO_0005292 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 270-278 | OrganismTaxon | denotes | colon, a | 82403 |
| T2 | 457-461 | OrganismTaxon | denotes | mice | 10088 |
| T3 | 617-621 | OrganismTaxon | denotes | mice | 10088 |
| T4 | 887-891 | OrganismTaxon | denotes | mice | 10088 |
| T5 | 1037-1041 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 96-101 | Body_part | denotes | Mucus | http://purl.obolibrary.org/obo/UBERON_0000912 |
| T2 | 151-156 | Body_part | denotes | bowel | http://purl.obolibrary.org/obo/UBERON_0000160 |
| T3 | 270-275 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/UBERON_0001155 |
| T4 | 315-320 | Body_part | denotes | bowel | http://purl.obolibrary.org/obo/UBERON_0000160 |
| T5 | 364-387 | Body_part | denotes | colonic epithelial cell | http://purl.obolibrary.org/obo/CL_0011108 |
| T6 | 553-571 | Body_part | denotes | colonic epithelium | http://purl.obolibrary.org/obo/UBERON_0000397 |
| T7 | 1098-1122 | Body_part | denotes | colonic epithelial cells | http://purl.obolibrary.org/obo/CL_0011108 |
| T8 | 1177-1180 | Body_part | denotes | gut | http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0004907 |
| T11 | 1209-1214 | Body_part | denotes | mucus | http://purl.obolibrary.org/obo/UBERON_0000912 |