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PubMed:26122871 JSONTXT

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GoldHamster

Id Subject Object Predicate Lexical cue
T1 54-59 UBERON:0000062 denotes organ
T2 54-59 UBERON:0003103 denotes organ
T3 91-97 UBERON:0000479 denotes tissue
T4 267-272 UBERON:0000062 denotes organ
T5 267-272 UBERON:0003103 denotes organ
T6 383-388 UBERON:0000062 denotes organ
T7 383-388 UBERON:0003103 denotes organ
T8 429-436 GO:0005625 denotes soluble
T9 452-470 D017077 denotes conditioned medium
T10 486-492 UBERON:0000479 denotes tissue
T15 588-594 189294 denotes Triton
T16 588-600 CHEBI:9750 denotes Triton X-100
T17 588-600 D017830 denotes Triton X-100
T18 588-600 D017830 denotes Triton X-100
T19 621-629 GO:0019835 denotes necrosis
T20 621-629 GO:0008219 denotes necrosis
T23 621-629 GO:0008220 denotes necrosis
T24 621-629 GO:0001906 denotes necrosis
T25 621-629 GO:0070265 denotes necrosis
T21 621-629 D009336 denotes necrosis
T22 621-629 D009336 denotes necrosis
T26 632-644 D002166 denotes camptothecin
T27 632-644 CHEBI:27656 denotes camptothecin
T28 632-644 D002166 denotes camptothecin
T29 656-665 GO:0097194 denotes apoptosis
T30 656-665 GO:0006915 denotes apoptosis
T31 727-733 UBERON:0000479 denotes tissue
T32 755-758 GO:0033815 denotes bis
T36 755-760 PR:Q8S307 denotes bis[2
T37 755-760 PR:000028348 denotes bis[2
T38 761-768 CHEBI:44520 denotes methoxy
T39 761-768 CHEBI:32772 denotes methoxy
T40 771-776 CHEBI:29785 denotes nitro
T41 836-840 CHEBI:26710 denotes salt
T42 836-840 CHEBI:24866 denotes salt
T43 886-895 UBERON:0002418 denotes cartilage
T44 886-895 UBERON:0007844 denotes cartilage
T45 980-992 CHEBI:51686 denotes haematoxylin
T46 980-992 CHEBI:5601 denotes haematoxylin
T47 980-992 CHEBI:51684 denotes haematoxylin
T48 995-1000 1310593 denotes eosin
T49 995-1000 D004801 denotes eosin
T50 995-1000 D004801 denotes eosin
T54 1005-1015 CHEBI:33601 denotes safranin O
T55 1017-1035 D017077 denotes Conditioned medium
T58 1068-1075 4850 denotes glucose
T56 1068-1075 D005947 denotes glucose
T57 1068-1075 D005947 denotes glucose
T59 1068-1075 CHEBI:42758 denotes glucose
T60 1068-1075 CHEBI:4167 denotes glucose
T61 1068-1075 CHEBI:17234 denotes glucose
T65 1101-1108 114202 denotes lactate
T67 1101-1122 D007770 denotes lactate dehydrogenase
T68 1109-1122 A0A5C1RDA6 denotes dehydrogenase
T70 1124-1127 P29038 denotes LDH
T71 1124-1127 PR:A5I1Z6 denotes LDH
T72 1124-1127 Q99289 denotes LDH
T73 1124-1127 Q27888 denotes LDH
T74 1124-1127 P93052 denotes LDH
T75 1124-1127 Q27797 denotes LDH
T76 1124-1127 P33571 denotes LDH
T77 1130-1150 P19147 denotes alkaline phosphatase
T78 1130-1150 P83456 denotes alkaline phosphatase
T80 1130-1150 PR:000023540 denotes alkaline phosphatase
T81 1130-1150 O60109 denotes alkaline phosphatase
T82 1130-1150 P21948 denotes alkaline phosphatase
T83 1130-1150 P00634 denotes alkaline phosphatase
T84 1130-1150 P86348 denotes alkaline phosphatase
T85 1130-1150 P81800 denotes alkaline phosphatase
T86 1130-1150 Q05205 denotes alkaline phosphatase
T79 1130-1150 D000469 denotes alkaline phosphatase
T87 1139-1150 GO:0016791 denotes phosphatase
T89 1157-1175 CHEBI:18085 denotes glycosaminoglycans
T90 1157-1175 D006025 denotes glycosaminoglycans
T91 1157-1175 D006025 denotes glycosaminoglycans
T92 1188-1194 UBERON:0027368 denotes matrix
T93 1195-1220 D020778 denotes metalloproteinase (MMP)-2
T98 1214-1220 PR:P08253 denotes MMP)-2
T99 1214-1220 Q9GLE5 denotes MMP)-2
T100 1214-1220 P08253 denotes MMP)-2
T101 1214-1220 Q90611 denotes MMP)-2
T103 1214-1220 PR:Q8MPP3 denotes MMP)-2
T104 1214-1220 P33436 denotes MMP)-2
T105 1214-1220 PR:Q90611 denotes MMP)-2
T106 1214-1220 PR:P33436 denotes MMP)-2
T107 1214-1220 PR:000010479 denotes MMP)-2
T108 1214-1220 PR:P33434 denotes MMP)-2
T109 1214-1220 P33434 denotes MMP)-2
T110 1214-1220 P50757 denotes MMP)-2
T102 1214-1220 GO:0004228 denotes MMP)-2
T111 1225-1228 CHEBI:340824 denotes MMP
T114 1225-1228 CHEBI:59761 denotes MMP
T115 1225-1230 PR:P50282 denotes MMP-9
T116 1225-1230 PR:P14780 denotes MMP-9
T117 1225-1230 P14780 denotes MMP-9
T118 1225-1230 PR:P41245 denotes MMP-9
T119 1225-1230 P41246 denotes MMP-9
T120 1225-1230 P41245 denotes MMP-9
T121 1225-1230 PR:P52176 denotes MMP-9
T122 1225-1230 P50282 denotes MMP-9
T124 1225-1230 PR:000010491 denotes MMP-9
T125 1225-1230 P52176 denotes MMP-9
T126 1225-1230 O18733 denotes MMP-9
T123 1225-1230 GO:0004229 denotes MMP-9
T127 1271-1280 MOP:0000569 denotes reduction
T130 1284-1291 4850 denotes glucose
T128 1284-1291 D005947 denotes glucose
T129 1284-1291 D005947 denotes glucose
T131 1284-1291 CHEBI:42758 denotes glucose
T132 1284-1291 CHEBI:4167 denotes glucose
T133 1284-1291 CHEBI:17234 denotes glucose
T134 1334-1337 P29038 denotes LDH
T135 1334-1337 PR:A5I1Z6 denotes LDH
T136 1334-1337 Q99289 denotes LDH
T137 1334-1337 Q27888 denotes LDH
T138 1334-1337 P93052 denotes LDH
T139 1334-1337 Q27797 denotes LDH
T140 1334-1337 P33571 denotes LDH
T144 1339-1342 1498292 denotes GAG
T142 1339-1342 PR:P21330 denotes GAG
T143 1339-1342 PR:Q967S7 denotes GAG
T145 1339-1342 PR:Q8I7Q0 denotes GAG
T147 1339-1342 PR:P20828 denotes GAG
T148 1339-1342 PR:P10405 denotes GAG
T149 1339-1342 PR:P04282 denotes GAG
T141 1339-1342 103820 denotes GAG
T146 1339-1342 CHEBI:143889 denotes GAG
T150 1344-1347 CHEBI:340824 denotes MMP
T153 1344-1347 CHEBI:59761 denotes MMP
T154 1344-1349 PR:P08253 denotes MMP-2
T155 1344-1349 Q9GLE5 denotes MMP-2
T156 1344-1349 P08253 denotes MMP-2
T157 1344-1349 Q90611 denotes MMP-2
T159 1344-1349 PR:Q8MPP3 denotes MMP-2
T160 1344-1349 P33436 denotes MMP-2
T161 1344-1349 PR:Q90611 denotes MMP-2
T162 1344-1349 PR:P33436 denotes MMP-2
T163 1344-1349 PR:000010479 denotes MMP-2
T164 1344-1349 PR:P33434 denotes MMP-2
T165 1344-1349 P33434 denotes MMP-2
T166 1344-1349 P50757 denotes MMP-2
T158 1344-1349 GO:0004228 denotes MMP-2
T167 1354-1357 CHEBI:340824 denotes MMP
T170 1354-1357 CHEBI:59761 denotes MMP
T171 1354-1359 PR:P50282 denotes MMP-9
T172 1354-1359 PR:P14780 denotes MMP-9
T173 1354-1359 P14780 denotes MMP-9
T174 1354-1359 PR:P41245 denotes MMP-9
T175 1354-1359 P41246 denotes MMP-9
T176 1354-1359 P41245 denotes MMP-9
T177 1354-1359 PR:P52176 denotes MMP-9
T178 1354-1359 P50282 denotes MMP-9
T180 1354-1359 PR:000010491 denotes MMP-9
T181 1354-1359 P52176 denotes MMP-9
T182 1354-1359 O18733 denotes MMP-9
T179 1354-1359 GO:0004229 denotes MMP-9
T183 1404-1413 MOP:0000569 denotes reduction
T186 1417-1424 4850 denotes glucose
T184 1417-1424 D005947 denotes glucose
T185 1417-1424 D005947 denotes glucose
T187 1417-1424 CHEBI:42758 denotes glucose
T188 1417-1424 CHEBI:4167 denotes glucose
T189 1417-1424 CHEBI:17234 denotes glucose
T197 1461-1467 Q98SL0 denotes LDH, a
T198 1461-1467 Q9W7L3 denotes LDH, a
T199 1461-1467 P69080 denotes LDH, a
T200 1461-1467 P19858 denotes LDH, a
T201 1461-1467 O93537 denotes LDH, a
T203 1461-1467 P69082 denotes LDH, a
T204 1461-1467 O93541 denotes LDH, a
T205 1461-1467 P22988 denotes LDH, a
T206 1461-1467 Q9PW58 denotes LDH, a
T207 1461-1467 P69081 denotes LDH, a
T208 1461-1467 Q9PW61 denotes LDH, a
T209 1461-1467 A0A1F3 denotes LDH, a
T210 1461-1467 Q9XT87 denotes LDH, a
T211 1461-1467 O93542 denotes LDH, a
T212 1461-1467 Q9PVK5 denotes LDH, a
T213 1461-1467 P79912 denotes LDH, a
T214 1461-1467 P04642 denotes LDH, a
T215 1461-1467 O13277 denotes LDH, a
T216 1461-1467 P00341 denotes LDH, a
T217 1461-1467 P00338 denotes LDH, a
T218 1461-1467 P42120 denotes LDH, a
T219 1461-1467 P06151 denotes LDH, a
T220 1461-1467 Q5R1W9 denotes LDH, a
T221 1461-1467 Q9PW07 denotes LDH, a
T222 1461-1467 O93543 denotes LDH, a
T223 1461-1467 P00339 denotes LDH, a
T224 1461-1467 P69085 denotes LDH, a
T225 1461-1467 O93540 denotes LDH, a
T226 1461-1467 Q9PT43 denotes LDH, a
T227 1461-1467 O93539 denotes LDH, a
T228 1461-1467 O93538 denotes LDH, a
T229 1461-1467 Q92055 denotes LDH, a
T230 1461-1467 O13276 denotes LDH, a
T231 1461-1467 Q9W7K5 denotes LDH, a
T232 1461-1467 P69084 denotes LDH, a
T233 1461-1467 P69086 denotes LDH, a
T234 1461-1467 Q9BE24 denotes LDH, a
T235 1461-1467 P13491 denotes LDH, a
T236 1461-1467 Q5R5F0 denotes LDH, a
T237 1461-1467 O13278 denotes LDH, a
T238 1461-1467 Q9PW06 denotes LDH, a
T239 1461-1467 PR:000009739 denotes LDH, a
T240 1461-1467 P00340 denotes LDH, a
T241 1461-1467 O93401 denotes LDH, a
T242 1461-1467 O93545 denotes LDH, a
T243 1461-1467 Q9W7L5 denotes LDH, a
T244 1461-1467 Q98SL2 denotes LDH, a
T245 1461-1467 Q9W7M6 denotes LDH, a
T246 1461-1467 O93544 denotes LDH, a
T247 1461-1467 P69083 denotes LDH, a
T248 1461-1467 O93546 denotes LDH, a
T202 1461-1467 D000080864 denotes LDH, a
T249 1482-1485 CHEBI:340824 denotes MMP
T252 1482-1485 CHEBI:59761 denotes MMP
T253 1482-1487 PR:P08253 denotes MMP-2
T254 1482-1487 Q9GLE5 denotes MMP-2
T255 1482-1487 P08253 denotes MMP-2
T256 1482-1487 Q90611 denotes MMP-2
T258 1482-1487 PR:Q8MPP3 denotes MMP-2
T259 1482-1487 P33436 denotes MMP-2
T260 1482-1487 PR:Q90611 denotes MMP-2
T261 1482-1487 PR:P33436 denotes MMP-2
T262 1482-1487 PR:000010479 denotes MMP-2
T263 1482-1487 PR:P33434 denotes MMP-2
T264 1482-1487 P33434 denotes MMP-2
T265 1482-1487 P50757 denotes MMP-2
T257 1482-1487 GO:0004228 denotes MMP-2
T266 1492-1495 CHEBI:340824 denotes MMP
T269 1492-1495 CHEBI:59761 denotes MMP
T270 1492-1497 PR:P50282 denotes MMP-9
T271 1492-1497 PR:P14780 denotes MMP-9
T272 1492-1497 P14780 denotes MMP-9
T273 1492-1497 PR:P41245 denotes MMP-9
T274 1492-1497 P41246 denotes MMP-9
T275 1492-1497 P41245 denotes MMP-9
T276 1492-1497 PR:P52176 denotes MMP-9
T277 1492-1497 P50282 denotes MMP-9
T279 1492-1497 PR:000010491 denotes MMP-9
T280 1492-1497 P52176 denotes MMP-9
T281 1492-1497 O18733 denotes MMP-9
T278 1492-1497 GO:0004229 denotes MMP-9
T282 1551-1569 D017077 denotes conditioned medium
T283 1592-1598 UBERON:0000479 denotes tissue
T284 1645-1663 D017077 denotes conditioned medium
T285 1718-1724 UBERON:0000479 denotes tissue
T286 1785-1790 UBERON:0004905 denotes joint
T287 1785-1790 UBERON:0000982 denotes joint
T288 1791-1796 UBERON:0000062 denotes organ
T289 1791-1796 UBERON:0003103 denotes organ
T291 1840-1843 PR:Q8LLD0 denotes pre
T293 1840-1843 UBERON:0001782 denotes pre
T292 1840-1843 SO:0002045 denotes pre
T290 1840-1843 GO:0003904 denotes pre

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 99-255 DRI_Background denotes Organ culture is an increasingly important tool in research, with advantages over monolayer cell culture due to the inherent natural environment of tissues.
T2 256-309 DRI_Background denotes Successful organ cultures must retain cell viability.
T3 310-503 DRI_Background denotes The aim of this study was to produce viable and non-viable osteochondral organ cultures, to assess the accumulation of soluble markers in the conditioned medium for predicting tissue viability.
T4 504-689 DRI_Outcome denotes Porcine femoral osteochondral plugs were cultured for 20 days, with the addition of Triton X-100 on day 6 (to induce necrosis), camptothecin (to induce apoptosis) or no toxic additives.
T5 690-791 DRI_Background denotes Tissue viability was assessed by the tissue destructive XTT (2,3-bis[2-methoxy-4-nitro-5-sulfophenyl]
T6 836-916 DRI_Background denotes salt) assay method and LIVE/DEAD® staining of the cartilage at days 0, 6 and 20.
T7 917-1016 DRI_Background denotes Tissue structure was assessed by histological evaluation using haematoxylin & eosin and safranin O.
T8 1232-1367 DRI_Background denotes Necrotic cultures immediately showed a reduction in glucose consumption, and an immediate increase in LDH, GAG, MMP-2 and MMP-9 levels.
T9 1368-1570 DRI_Background denotes Apoptotic cultures showed a delayed reduction in glucose consumption and delayed increase in LDH, a small rise in MMP-2 and MMP-9, but no significant effect on GAGs released into the conditioned medium.
T10 1571-1744 DRI_Outcome denotes The data showed that tissue viability could be monitored by assessing the conditioned medium for the aforementioned markers, negating the need for tissue destructive assays.
T11 1745-2018 DRI_Background denotes Physiologically relevant whole- or part-joint organ culture models, necessary for research and pre-clinical assessment of therapies, could be monitored this way, reducing the need to sacrifice tissues to determine viability, and hence reducing the sample numbers necessary.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 43-45 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T2 43-45 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T3 116-118 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T4 116-118 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T5 558-560 CVCL_J923|Hybridoma|Mus musculus denotes 20
T6 913-915 CVCL_J923|Hybridoma|Mus musculus denotes 20
T7 1055-1058 CVCL_J663|Hybridoma|Mus musculus denotes 3-4
T8 1152-1154 CVCL_E457|Transformed_cell_line|Homo sapiens denotes AP
T9 1269-1270 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T10 1309-1311 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T11 1309-1311 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T12 1394-1395 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T13 1466-1467 CVCL_6479|Finite_cell_line|Mus musculus denotes a