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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-110 Sentence denotes Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide.
T2 111-383 Sentence denotes Tumor cellular senescence induced by genotoxic treatments has recently been found to be paradoxically linked to the induction of "stemness." This observation is critical as it directly impinges upon the response of tumors to current chemo-radio-therapy treatment regimens.
T3 384-627 Sentence denotes Previously, we showed that following etoposide (ETO) treatment embryonal carcinoma PA-1 cells undergo a p53-dependent upregulation of OCT4A and p21Cip1 (governing self-renewal and regulating cell cycle inhibition and senescence, respectively).
T4 628-732 Sentence denotes Here we report further detail on the relationship between these and other critical cell-fate regulators.
T5 733-862 Sentence denotes PA-1 cells treated with ETO display highly heterogeneous increases in OCT4A and p21Cip1 indicative of dis-adaptation catastrophe.
T6 863-1050 Sentence denotes Silencing OCT4A suppresses p21Cip1, changes cell cycle regulation and subsequently suppresses terminal senescence; p21Cip1-silencing did not affect OCT4A expression or cellular phenotype.
T7 1051-1182 Sentence denotes SOX2 and NANOG expression did not change following ETO treatment suggesting a dissociation of OCT4A from its pluripotency function.
T8 1183-1465 Sentence denotes Instead, ETO-induced OCT4A was concomitant with activation of AMPK, a key component of metabolic stress and autophagy regulation. p16ink4a, the inducer of terminal senescence, underwent autophagic sequestration in the cytoplasm of ETO-treated cells, allowing alternative cell fates.
T9 1466-1598 Sentence denotes Accordingly, failure of autophagy was accompanied by an accumulation of p16ink4a, nuclear disintegration, and loss of cell recovery.
T10 1599-1841 Sentence denotes Together, these findings imply that OCT4A induction following DNA damage in PA-1 cells, performs a cell stress, rather than self-renewal, function by moderating the expression of p21Cip1, which alongside AMPK helps to then regulate autophagy.
T11 1842-1978 Sentence denotes Moreover, this data indicates that exhaustion of autophagy, through persistent DNA damage, is the cause of terminal cellular senescence.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
10704 25-30 GeneOrGeneProduct denotes OCT4A NCBIGene:5460
10705 61-80 DiseaseOrPhenotypicFeature denotes embryonal carcinoma MESH:D018236
10706 100-109 ChemicalEntity denotes etoposide MESH:D005047
10707 326-332 DiseaseOrPhenotypicFeature denotes tumors MESH:D009369
10708 421-430 ChemicalEntity denotes etoposide MESH:D005047
10709 432-435 ChemicalEntity denotes ETO MESH:D005047
10710 447-466 DiseaseOrPhenotypicFeature denotes embryonal carcinoma MESH:D018236
10711 467-471 CellLine denotes PA-1 NCBITaxon:9606
10712 488-491 GeneOrGeneProduct denotes p53 NCBIGene:7157
10713 518-523 GeneOrGeneProduct denotes OCT4A NCBIGene:5460
10714 528-535 GeneOrGeneProduct denotes p21Cip1 NCBIGene:1026
10715 733-737 CellLine denotes PA-1 NCBITaxon:9606
10716 757-760 ChemicalEntity denotes ETO MESH:D005047
10717 803-808 GeneOrGeneProduct denotes OCT4A NCBIGene:5460
10718 813-820 GeneOrGeneProduct denotes p21Cip1 NCBIGene:1026
10719 873-878 GeneOrGeneProduct denotes OCT4A NCBIGene:5460
10720 890-897 GeneOrGeneProduct denotes p21Cip1 NCBIGene:1026
10721 978-985 GeneOrGeneProduct denotes p21Cip1 NCBIGene:1026
10722 1011-1016 GeneOrGeneProduct denotes OCT4A NCBIGene:5460
10723 1051-1055 GeneOrGeneProduct denotes SOX2 NCBIGene:6657
10724 1060-1065 GeneOrGeneProduct denotes NANOG NCBIGene:79923
10725 1102-1105 ChemicalEntity denotes ETO MESH:D005047
10726 1145-1150 GeneOrGeneProduct denotes OCT4A NCBIGene:5460
10727 1192-1195 ChemicalEntity denotes ETO MESH:D005047
10728 1204-1209 GeneOrGeneProduct denotes OCT4A NCBIGene:5460
10729 1245-1249 GeneOrGeneProduct denotes AMPK NCBIGene:5562
10730 1313-1321 GeneOrGeneProduct denotes p16ink4a NCBIGene:1029
10731 1414-1417 ChemicalEntity denotes ETO MESH:D005047
10732 1538-1546 GeneOrGeneProduct denotes p16ink4a NCBIGene:1029
10733 1635-1640 GeneOrGeneProduct denotes OCT4A NCBIGene:5460
10734 1675-1679 CellLine denotes PA-1 NCBITaxon:9606
10735 1778-1785 GeneOrGeneProduct denotes p21Cip1 NCBIGene:1026
10736 1803-1807 GeneOrGeneProduct denotes AMPK NCBIGene:5562

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 61-80 DiseaseOrPhenotypicFeature denotes embryonal carcinoma 0005440
T2 71-80 DiseaseOrPhenotypicFeature denotes carcinoma 0004993
T3 447-466 DiseaseOrPhenotypicFeature denotes embryonal carcinoma 0005440
T4 457-466 DiseaseOrPhenotypicFeature denotes carcinoma 0004993

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 38-42 GeneOrGeneProduct denotes cell
T2 528-535 GeneOrGeneProduct denotes p21Cip1
T3 575-585 GeneOrGeneProduct denotes cell cycle
T4 696-701 GeneOrGeneProduct denotes other
T5 711-715 GeneOrGeneProduct denotes cell
T6 721-731 GeneOrGeneProduct denotes regulators
T7 813-820 GeneOrGeneProduct denotes p21Cip1
T8 890-897 GeneOrGeneProduct denotes p21Cip1
T9 907-917 GeneOrGeneProduct denotes cell cycle
T10 978-985 GeneOrGeneProduct denotes p21Cip1
T11 1051-1055 GeneOrGeneProduct denotes SOX2
T12 1060-1065 GeneOrGeneProduct denotes NANOG
T13 1245-1249 GeneOrGeneProduct denotes AMPK
T14 1291-1300 GeneOrGeneProduct denotes autophagy
T15 1313-1321 GeneOrGeneProduct denotes p16ink4a
T16 1454-1458 GeneOrGeneProduct denotes cell
T17 1490-1499 GeneOrGeneProduct denotes autophagy
T18 1538-1546 GeneOrGeneProduct denotes p16ink4a
T19 1584-1588 GeneOrGeneProduct denotes cell
T20 1698-1702 GeneOrGeneProduct denotes cell
T21 1778-1785 GeneOrGeneProduct denotes p21Cip1
T22 1803-1807 GeneOrGeneProduct denotes AMPK
T23 1831-1840 GeneOrGeneProduct denotes autophagy
T24 1891-1900 GeneOrGeneProduct denotes autophagy

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 15-24 GeneOrGeneProduct denotes activated
T2 38-42 GeneOrGeneProduct denotes cell
T3 43-47 GeneOrGeneProduct denotes fate
T4 81-86 GeneOrGeneProduct denotes cells
T5 111-116 GeneOrGeneProduct denotes Tumor
T6 137-144 GeneOrGeneProduct denotes induced
T7 213-219 GeneOrGeneProduct denotes linked
T8 326-332 GeneOrGeneProduct denotes tumors
T9 472-477 GeneOrGeneProduct denotes cells
T10 528-535 GeneOrGeneProduct denotes p21Cip1
T11 575-585 GeneOrGeneProduct denotes cell cycle
T12 696-701 GeneOrGeneProduct denotes other
T13 711-715 GeneOrGeneProduct denotes cell
T14 716-720 GeneOrGeneProduct denotes fate
T15 721-731 GeneOrGeneProduct denotes regulators
T16 738-743 GeneOrGeneProduct denotes cells
T17 769-775 GeneOrGeneProduct denotes highly
T18 813-820 GeneOrGeneProduct denotes p21Cip1
T19 890-897 GeneOrGeneProduct denotes p21Cip1
T20 907-917 GeneOrGeneProduct denotes cell cycle
T21 918-928 GeneOrGeneProduct denotes regulation
T22 978-985 GeneOrGeneProduct denotes p21Cip1
T23 1051-1055 GeneOrGeneProduct denotes SOX2
T24 1060-1065 GeneOrGeneProduct denotes NANOG
T25 1196-1203 GeneOrGeneProduct denotes induced
T26 1231-1241 GeneOrGeneProduct denotes activation
T27 1245-1249 GeneOrGeneProduct denotes AMPK
T28 1291-1300 GeneOrGeneProduct denotes autophagy
T29 1301-1311 GeneOrGeneProduct denotes regulation
T30 1313-1321 GeneOrGeneProduct denotes p16ink4a
T31 1327-1334 GeneOrGeneProduct denotes inducer
T32 1401-1410 GeneOrGeneProduct denotes cytoplasm
T33 1426-1431 GeneOrGeneProduct denotes cells
T34 1454-1458 GeneOrGeneProduct denotes cell
T35 1459-1464 GeneOrGeneProduct denotes fates
T36 1490-1499 GeneOrGeneProduct denotes autophagy
T37 1538-1546 GeneOrGeneProduct denotes p16ink4a
T38 1584-1588 GeneOrGeneProduct denotes cell
T39 1615-1623 GeneOrGeneProduct denotes findings
T40 1665-1671 GeneOrGeneProduct denotes damage
T41 1680-1685 GeneOrGeneProduct denotes cells
T42 1698-1702 GeneOrGeneProduct denotes cell
T43 1778-1785 GeneOrGeneProduct denotes p21Cip1
T44 1803-1807 GeneOrGeneProduct denotes AMPK
T45 1808-1813 GeneOrGeneProduct denotes helps
T46 1822-1830 GeneOrGeneProduct denotes regulate
T47 1831-1840 GeneOrGeneProduct denotes autophagy
T48 1891-1900 GeneOrGeneProduct denotes autophagy
T49 1910-1920 GeneOrGeneProduct denotes persistent
T50 1925-1931 GeneOrGeneProduct denotes damage

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 61-80 DiseaseOrPhenotypicFeature denotes embryonal carcinoma D018236
T2 111-116 DiseaseOrPhenotypicFeature denotes Tumor D009369
T3 326-332 DiseaseOrPhenotypicFeature denotes tumors D009369
T4 447-466 DiseaseOrPhenotypicFeature denotes embryonal carcinoma D018236
T5 1129-1141 DiseaseOrPhenotypicFeature denotes dissociation D004213

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 528-535 GeneOrGeneProduct denotes p21Cip1
T2 813-820 GeneOrGeneProduct denotes p21Cip1
T3 890-897 GeneOrGeneProduct denotes p21Cip1
T4 907-928 GeneOrGeneProduct denotes cell cycle regulation
T5 978-985 GeneOrGeneProduct denotes p21Cip1
T6 1051-1055 GeneOrGeneProduct denotes SOX2
T7 1060-1065 GeneOrGeneProduct denotes NANOG
T8 1245-1249 GeneOrGeneProduct denotes AMPK
T9 1313-1321 GeneOrGeneProduct denotes p16ink4a
T10 1538-1546 GeneOrGeneProduct denotes p16ink4a
T11 1778-1785 GeneOrGeneProduct denotes p21Cip1
T12 1803-1807 GeneOrGeneProduct denotes AMPK

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 61-80 DiseaseOrPhenotypicFeature denotes embryonal carcinoma 0018843|0005440|0003581
T4 447-466 DiseaseOrPhenotypicFeature denotes embryonal carcinoma 0018843|0005440|0003581
T7 835-838 DiseaseOrPhenotypicFeature denotes dis 0012621

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 61-80 DiseaseOrPhenotypicFeature denotes embryonal carcinoma D018236
T2 111-116 DiseaseOrPhenotypicFeature denotes Tumor D009369
T3 326-332 DiseaseOrPhenotypicFeature denotes tumors DISEASE|D009369
T5 447-466 DiseaseOrPhenotypicFeature denotes embryonal carcinoma D018236
T6 1129-1141 DiseaseOrPhenotypicFeature denotes dissociation D004213

LitCoin_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 467-471 CellLine denotes PA-1 CVCL_0479
T2 733-737 CellLine denotes PA-1 CVCL_0479
T3 1675-1679 CellLine denotes PA-1 CVCL_0479

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 61-80 DiseaseOrPhenotypicFeature denotes embryonal carcinoma D018236
T2 111-116 DiseaseOrPhenotypicFeature denotes Tumor D009369
T3 326-332 DiseaseOrPhenotypicFeature denotes tumors D009369
T4 447-466 DiseaseOrPhenotypicFeature denotes embryonal carcinoma D018236
T5 1129-1141 DiseaseOrPhenotypicFeature denotes dissociation D004213

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 100-109 ChemicalEntity denotes etoposide D005047|http://purl.obolibrary.org/obo/CHEBI_4911
T3 350-355 ChemicalEntity denotes radio http://purl.obolibrary.org/obo/CHEBI_33325
T4 421-430 ChemicalEntity denotes etoposide D005047|http://purl.obolibrary.org/obo/CHEBI_4911
T6 432-435 ChemicalEntity denotes ETO http://purl.obolibrary.org/obo/CHEBI_27561|D005047
T8 757-760 ChemicalEntity denotes ETO http://purl.obolibrary.org/obo/CHEBI_27561|D005047
T10 1102-1105 ChemicalEntity denotes ETO http://purl.obolibrary.org/obo/CHEBI_27561|D005047
T12 1192-1195 ChemicalEntity denotes ETO http://purl.obolibrary.org/obo/CHEBI_27561|D005047
T14 1414-1417 ChemicalEntity denotes ETO http://purl.obolibrary.org/obo/CHEBI_27561|D005047

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T3 1675-1679 CellLine denotes PA-1 CVCL_0479
T2 733-737 CellLine denotes PA-1 CVCL_0479
T1 467-471 CellLine denotes PA-1 CVCL_0479
T14 1414-1417 ChemicalEntity denotes ETO D005047|http://purl.obolibrary.org/obo/CHEBI_27561
T12 1192-1195 ChemicalEntity denotes ETO D005047|http://purl.obolibrary.org/obo/CHEBI_27561
T10 1102-1105 ChemicalEntity denotes ETO D005047|http://purl.obolibrary.org/obo/CHEBI_27561
T8 757-760 ChemicalEntity denotes ETO D005047|http://purl.obolibrary.org/obo/CHEBI_27561
T6 432-435 ChemicalEntity denotes ETO D005047|http://purl.obolibrary.org/obo/CHEBI_27561
T4 421-430 ChemicalEntity denotes etoposide http://purl.obolibrary.org/obo/CHEBI_4911|D005047
T88682 350-355 ChemicalEntity denotes radio http://purl.obolibrary.org/obo/CHEBI_33325
T17415 100-109 ChemicalEntity denotes etoposide http://purl.obolibrary.org/obo/CHEBI_4911|D005047
T37772 1803-1807 GeneOrGeneProduct denotes AMPK
T11 1778-1785 GeneOrGeneProduct denotes p21Cip1
T4797 1538-1546 GeneOrGeneProduct denotes p16ink4a
T9 1313-1321 GeneOrGeneProduct denotes p16ink4a
T98634 1245-1249 GeneOrGeneProduct denotes AMPK
T7 1060-1065 GeneOrGeneProduct denotes NANOG
T94672 1051-1055 GeneOrGeneProduct denotes SOX2
T5 978-985 GeneOrGeneProduct denotes p21Cip1
T33894 907-928 GeneOrGeneProduct denotes cell cycle regulation
T518 890-897 GeneOrGeneProduct denotes p21Cip1
T59571 813-820 GeneOrGeneProduct denotes p21Cip1
T16086 528-535 GeneOrGeneProduct denotes p21Cip1
T24414 1129-1141 DiseaseOrPhenotypicFeature denotes dissociation D004213
T62671 447-466 DiseaseOrPhenotypicFeature denotes embryonal carcinoma D018236
T25932 326-332 DiseaseOrPhenotypicFeature denotes tumors D009369
T57540 111-116 DiseaseOrPhenotypicFeature denotes Tumor D009369
T74245 61-80 DiseaseOrPhenotypicFeature denotes embryonal carcinoma D018236