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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-5 PR:Q9Z1M7 denotes Large
T2 23-26 CVCL_D569 denotes CAG
T3 53-57 PR:000023326 denotes MutS
T4 53-57 PR:P23909 denotes MutS
T5 53-57 PR:Q2FYZ9 denotes MutS
T6 62-67 D006801 denotes human
T7 89-95 SO:0001068 denotes repeat
T8 117-121 PR:P69783 denotes TRED
T9 117-121 PR:000022334 denotes TRED
T10 159-172 CHEBI:74953 denotes trinucleotide
T11 198-201 CVCL_D569 denotes CAG
T12 302-309 D004194 denotes disease
T13 302-309 D004194 denotes disease
T15 374-377 CHEBI:16991 denotes DNA
T17 374-377 D004247 denotes DNA
T16 374-377 SO:0000352 denotes DNA
T14 374-377 GO:0005574 denotes DNA
T18 374-384 GO:0006281 denotes DNA repair
T19 385-393 CHEBI:36080 denotes proteins
T20 397-403 SO:0001068 denotes repeat
T21 458-464 SO:0001068 denotes repeat
T22 544-549 D006801 denotes human
T23 579-582 CVCL_D569 denotes CAG
T24 629-632 GO:0005574 denotes DNA
T26 629-632 SO:0000352 denotes DNA
T25 629-632 CHEBI:16991 denotes DNA
T27 629-632 D004247 denotes DNA
T28 629-639 GO:0006281 denotes DNA repair
T29 640-648 CHEBI:36080 denotes proteins
T30 655-676 D034741 denotes short interfering RNA
T33 673-676 GO:0005562 denotes RNA
T34 673-676 SO:0000356 denotes RNA
T36 691-694 CHEBI:16768 denotes MSH
T40 691-694 D009074 denotes MSH
T41 691-694 D009074 denotes MSH
T42 691-695 PR:000010666 denotes MSH2
T43 691-695 PR:P25847 denotes MSH2
T44 691-695 PR:P43246 denotes MSH2
T45 691-695 P22711 denotes MSH2
T46 691-695 PR:P22711 denotes MSH2
T47 691-695 PR:P54275 denotes MSH2
T48 691-695 PR:O74773 denotes MSH2
T49 691-695 PR:P43247 denotes MSH2
T50 691-695 PR:Q553L4 denotes MSH2
T51 691-695 PR:O24617 denotes MSH2
T53 700-703 CHEBI:16768 denotes MSH
T57 700-703 D009074 denotes MSH
T58 700-703 D009074 denotes MSH
T59 700-704 PR:O65607 denotes MSH3
T60 700-704 PR:000010667 denotes MSH3
T61 700-704 PR:Q59Y41 denotes MSH3
T62 700-704 PR:P25336 denotes MSH3
T63 700-704 PR:P20585 denotes MSH3
T64 700-704 PR:P26359 denotes MSH3
T65 700-704 PR:P13705 denotes MSH3
T66 700-704 PR:Q1ZXH0 denotes MSH3
T67 721-725 PR:000023326 denotes MutS
T68 721-725 PR:P23909 denotes MutS
T69 721-725 PR:Q2FYZ9 denotes MutS
T70 755-770 GO:0006298 denotes mismatch repair
T71 789-795 SO:0001068 denotes repeat
T73 829-832 CHEBI:16768 denotes MSH
T77 829-832 D009074 denotes MSH
T78 829-832 D009074 denotes MSH
T79 829-833 PR:P52701 denotes MSH6
T80 829-833 PR:P54276 denotes MSH6
T81 829-833 PR:Q9VUM0 denotes MSH6
T82 829-833 PR:Q55GU9 denotes MSH6
T83 829-833 PR:O04716 denotes MSH6
T84 829-833 PR:Q03834 denotes MSH6
T85 829-833 PR:O74502 denotes MSH6
T86 829-833 PR:000010670 denotes MSH6
T87 851-855 PR:000023326 denotes MutS
T88 851-855 PR:P23909 denotes MutS
T89 851-855 PR:Q2FYZ9 denotes MutS
T91 874-877 CHEBI:16768 denotes MSH
T95 874-877 D009074 denotes MSH
T96 874-877 D009074 denotes MSH
T97 874-878 PR:000010666 denotes MSH2
T98 874-878 PR:P25847 denotes MSH2
T99 874-878 PR:P43246 denotes MSH2
T100 874-878 P22711 denotes MSH2
T101 874-878 PR:P22711 denotes MSH2
T102 874-878 PR:P54275 denotes MSH2
T103 874-878 PR:O74773 denotes MSH2
T104 874-878 PR:P43247 denotes MSH2
T105 874-878 PR:Q553L4 denotes MSH2
T106 874-878 PR:O24617 denotes MSH2
T108 957-960 CHEBI:16768 denotes MSH
T112 957-960 D009074 denotes MSH
T113 957-960 D009074 denotes MSH
T114 957-961 PR:O65607 denotes MSH3
T115 957-961 PR:000010667 denotes MSH3
T116 957-961 PR:Q59Y41 denotes MSH3
T117 957-961 PR:P25336 denotes MSH3
T118 957-961 PR:P20585 denotes MSH3
T119 957-961 PR:P26359 denotes MSH3
T120 957-961 PR:P13705 denotes MSH3
T121 957-961 PR:Q1ZXH0 denotes MSH3
T122 970-974 PR:000023326 denotes MutS
T123 970-974 PR:P23909 denotes MutS
T124 970-974 PR:Q2FYZ9 denotes MutS
T125 998-1011 GO:0003917 denotes topoisomerase
T126 998-1011 GO:0003918 denotes topoisomerase
T127 1015-1019 PR:P11387 denotes TOP1
T128 1015-1019 PR:Q94AM1 denotes TOP1
T129 1015-1019 PR:P30181 denotes TOP1
T130 1015-1019 PR:000016542 denotes TOP1
T131 1015-1019 PR:P30189 denotes TOP1
T132 1015-1019 PR:Q9FJ79 denotes TOP1
T133 1015-1019 PR:Q54RC3 denotes TOP1
T134 1015-1019 PR:P07799 denotes TOP1
T135 1015-1019 PR:Q04750 denotes TOP1
T136 1015-1019 PR:Q9WUL0 denotes TOP1
T137 1015-1019 PR:P04786 denotes TOP1
T138 1015-1019 PR:O17966 denotes TOP1
T139 1025-1028 CHEBI:61377 denotes TDP
T140 1025-1028 CHEBI:61417 denotes TDP
T141 1025-1029 PR:Q4G056 denotes TDP1
T142 1025-1029 PR:000016215 denotes TDP1
T143 1025-1029 PR:Q8BJ37 denotes TDP1
T144 1025-1029 PR:Q9VQM4 denotes TDP1
T145 1025-1029 PR:Q8H1D9 denotes TDP1
T146 1025-1029 PR:P38319 denotes TDP1
T147 1025-1029 PR:Q9NUW8 denotes TDP1
T148 1025-1029 PR:D0VWM8 denotes TDP1
T149 1053-1079 GO:0000012 denotes single-strand break repair
T150 1060-1066 SO:0001111 denotes strand
T151 1096-1102 SO:0001068 denotes repeat
T152 1143-1152 Q7Z333 denotes senataxin
T156 1157-1160 SO:0000356 denotes RNA
T153 1157-1160 CHEBI:33697 denotes RNA
T154 1157-1160 D012313 denotes RNA
T155 1157-1160 GO:0005562 denotes RNA
T159 1161-1164 SO:0000352 denotes DNA
T158 1161-1164 CHEBI:16991 denotes DNA
T160 1161-1164 D004247 denotes DNA
T157 1161-1164 GO:0005574 denotes DNA
T161 1161-1173 B5X582 denotes DNA helicase
T164 1188-1191 SO:0000352 denotes DNA
T163 1188-1191 CHEBI:16991 denotes DNA
T165 1188-1191 D004247 denotes DNA
T162 1188-1191 GO:0005574 denotes DNA
T169 1192-1195 SO:0000356 denotes RNA
T166 1192-1195 CHEBI:33697 denotes RNA
T167 1192-1195 D012313 denotes RNA
T168 1192-1195 GO:0005562 denotes RNA
T170 1196-1202 37965 denotes hybrid
T171 1196-1202 D002678 denotes hybrid
T172 1203-1212 GO:0009058 denotes formation
T174 1217-1265 GO:0006283 denotes transcription-coupled nucleotide excision repair
T175 1239-1249 CHEBI:36976 denotes nucleotide
T177 1279-1285 SO:0001068 denotes repeat
T179 1346-1349 CHEBI:16991 denotes DNA
T181 1346-1349 D004247 denotes DNA
T180 1346-1349 SO:0000352 denotes DNA
T178 1346-1349 GO:0005574 denotes DNA
T182 1346-1356 GO:0006281 denotes DNA repair
T183 1374-1378 PR:000023326 denotes MutS
T184 1374-1378 PR:P23909 denotes MutS
T185 1374-1378 PR:Q2FYZ9 denotes MutS
T186 1410-1416 SO:0001068 denotes repeat
T187 1491-1495 PR:P69783 denotes TRED
T188 1491-1495 PR:000022334 denotes TRED

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-74 DRI_Approach denotes Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.
T2 75-202 DRI_Approach denotes Trinucleotide repeat expansion disorders (TRED) are caused by genomic expansions of trinucleotide repeats, such as CTG and CAG.
T3 203-319 DRI_Approach denotes These expanded repeats are unstable in germline and somatic cells, with potential consequences for disease severity.
T4 320-503 DRI_Approach denotes Previous studies have demonstrated the involvement of DNA repair proteins in repeat instability, although the key factors affecting large repeat expansion and contraction are unclear.
T5 504-677 DRI_Approach denotes Here we investigated these factors in a human cell model harboring 800 CTG•CAG repeats by individually knocking down various DNA repair proteins using short interfering RNA.
T6 678-984 DRI_Background denotes Knockdown of MSH2 and MSH3, which form the MutSβ heterodimer and function in mismatch repair, suppressed large repeat expansions, whereas knockdown of MSH6, which forms the MutSα heterodimer with MSH2, promoted large expansions exceeding 200 repeats by compensatory increases in MSH3 and the MutSβ complex.
T7 985-1116 DRI_Approach denotes Knockdown of topoisomerase 1 (TOP1) and TDP1, which are involved in single-strand break repair, enhanced large repeat contractions.
T8 1117-1317 DRI_Approach denotes Furthermore, knockdown of senataxin, an RNA/DNA helicase which affects DNA:RNA hybrid formation and transcription-coupled nucleotide excision repair, exacerbated repeat instability in both directions.
T9 1318-1496 DRI_Outcome denotes These results indicate that DNA repair factors, such as MutSβ play important roles in large repeat expansion and contraction, and can be an excellent therapeutic target for TRED.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 62-67 OrganismTaxon denotes human 9606
T2 544-549 OrganismTaxon denotes human 9606