PubMed:26044798
Annnotations
GlyCosmos6-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 294-299 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
T3 | 304-307 | Body_part | denotes | eye | http://purl.obolibrary.org/obo/UBERON_0000019|http://purl.obolibrary.org/obo/UBERON_0000970|http://purl.obolibrary.org/obo/UBERON_0010230 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-145 | Sentence | denotes | Investigation of the protective properties of glycosylphosphatidylinositol-based vaccine candidates in a Toxoplasma gondii mouse challenge model. |
TextSentencer_T2 | 146-327 | Sentence | denotes | Vaccination against the ubiquitous parasite Toxoplasma gondii would provide the most efficient prevention against toxoplasmosis-related congenital, brain and eye diseases in humans. |
TextSentencer_T3 | 328-500 | Sentence | denotes | We investigated the immune response elicited by pathogen-specific glycosylphosphatidylinositol (GPI) glycoconjugates using carbohydrate microarrays in a BALB/c mouse model. |
TextSentencer_T4 | 501-637 | Sentence | denotes | We further examined the protective properties of the glycoconjugates in a lethal challenge model using the virulent T. gondii RH strain. |
TextSentencer_T5 | 638-822 | Sentence | denotes | Upon immunization, mice raised antibodies that bind to the respective GPIs on carbohydrate microarrays, but were mainly directed against an unspecific GPI epitope including the linker. |
TextSentencer_T6 | 823-966 | Sentence | denotes | The observed immune response, though robust, was unable to provide protection in mice when challenged with a lethal dose of viable tachyzoites. |
TextSentencer_T7 | 967-1139 | Sentence | denotes | We demonstrate that anti-GPI antibodies raised against the here described semi-synthetic glycoconjugates do not confer protective immunity against T. gondii in BALB/c mice. |
T1 | 0-145 | Sentence | denotes | Investigation of the protective properties of glycosylphosphatidylinositol-based vaccine candidates in a Toxoplasma gondii mouse challenge model. |
T2 | 146-327 | Sentence | denotes | Vaccination against the ubiquitous parasite Toxoplasma gondii would provide the most efficient prevention against toxoplasmosis-related congenital, brain and eye diseases in humans. |
T3 | 328-500 | Sentence | denotes | We investigated the immune response elicited by pathogen-specific glycosylphosphatidylinositol (GPI) glycoconjugates using carbohydrate microarrays in a BALB/c mouse model. |
T4 | 501-637 | Sentence | denotes | We further examined the protective properties of the glycoconjugates in a lethal challenge model using the virulent T. gondii RH strain. |
T5 | 638-822 | Sentence | denotes | Upon immunization, mice raised antibodies that bind to the respective GPIs on carbohydrate microarrays, but were mainly directed against an unspecific GPI epitope including the linker. |
T6 | 823-966 | Sentence | denotes | The observed immune response, though robust, was unable to provide protection in mice when challenged with a lethal dose of viable tachyzoites. |
T7 | 967-1139 | Sentence | denotes | We demonstrate that anti-GPI antibodies raised against the here described semi-synthetic glycoconjugates do not confer protective immunity against T. gondii in BALB/c mice. |
T1 | 0-145 | Sentence | denotes | Investigation of the protective properties of glycosylphosphatidylinositol-based vaccine candidates in a Toxoplasma gondii mouse challenge model. |
T2 | 146-327 | Sentence | denotes | Vaccination against the ubiquitous parasite Toxoplasma gondii would provide the most efficient prevention against toxoplasmosis-related congenital, brain and eye diseases in humans. |
T3 | 328-500 | Sentence | denotes | We investigated the immune response elicited by pathogen-specific glycosylphosphatidylinositol (GPI) glycoconjugates using carbohydrate microarrays in a BALB/c mouse model. |
T4 | 501-637 | Sentence | denotes | We further examined the protective properties of the glycoconjugates in a lethal challenge model using the virulent T. gondii RH strain. |
T5 | 638-822 | Sentence | denotes | Upon immunization, mice raised antibodies that bind to the respective GPIs on carbohydrate microarrays, but were mainly directed against an unspecific GPI epitope including the linker. |
T6 | 823-966 | Sentence | denotes | The observed immune response, though robust, was unable to provide protection in mice when challenged with a lethal dose of viable tachyzoites. |
T7 | 967-1139 | Sentence | denotes | We demonstrate that anti-GPI antibodies raised against the here described semi-synthetic glycoconjugates do not confer protective immunity against T. gondii in BALB/c mice. |
Glycosmos6-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 294-299 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
T2 | 304-307 | http://purl.obolibrary.org/obo/MAT_0000140 | denotes | eye |
GlyCosmos6-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 123-128 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T2 | 488-493 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 260-273 | Disease | denotes | toxoplasmosis | http://purl.obolibrary.org/obo/MONDO_0005989 |
T2 | 304-316 | Disease | denotes | eye diseases | http://purl.obolibrary.org/obo/MONDO_0005328 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 105-122 | OrganismTaxon | denotes | Toxoplasma gondii | NCBItxid:5811 |
T2 | 123-128 | OrganismTaxon | denotes | mouse | NCBItxid:10088|NCBItxid:10090 |
T4 | 190-207 | OrganismTaxon | denotes | Toxoplasma gondii | NCBItxid:5811 |
T5 | 320-326 | OrganismTaxon | denotes | humans | NCBItxid:9605 |
T6 | 488-493 | OrganismTaxon | denotes | mouse | NCBItxid:10088|NCBItxid:10090 |
T8 | 657-661 | OrganismTaxon | denotes | mice | NCBItxid:10088|NCBItxid:10095 |
T10 | 904-908 | OrganismTaxon | denotes | mice | NCBItxid:10088|NCBItxid:10095 |
T12 | 1134-1138 | OrganismTaxon | denotes | mice | NCBItxid:10088|NCBItxid:10095 |
ICD10
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 260-273 | http://purl.bioontology.org/ontology/ICD10/B58.9 | denotes | toxoplasmosis |
T2 | 260-273 | http://purl.bioontology.org/ontology/ICD10/B58 | denotes | toxoplasmosis |
GlycoBiology-FMA
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
_T1 | 46-74 | FMAID:196801 | denotes | glycosylphosphatidylinositol |
_T2 | 46-74 | FMAID:82806 | denotes | glycosylphosphatidylinositol |
_T3 | 46-74 | FMAID:199790 | denotes | glycosylphosphatidylinositol |
_T4 | 46-74 | FMAID:85436 | denotes | glycosylphosphatidylinositol |
_T5 | 294-299 | FMAID:50801 | denotes | brain |
_T6 | 294-299 | FMAID:146514 | denotes | brain |
_T7 | 394-422 | FMAID:199790 | denotes | glycosylphosphatidylinositol |
_T8 | 394-422 | FMAID:196801 | denotes | glycosylphosphatidylinositol |
_T9 | 394-422 | FMAID:82806 | denotes | glycosylphosphatidylinositol |
_T10 | 394-422 | FMAID:85436 | denotes | glycosylphosphatidylinositol |
_T11 | 429-444 | FMAID:196776 | denotes | glycoconjugates |
_T12 | 429-444 | FMAID:82782 | denotes | glycoconjugates |
_T13 | 451-463 | FMAID:197276 | denotes | carbohydrate |
_T14 | 451-463 | FMAID:82737 | denotes | carbohydrate |
_T15 | 554-569 | FMAID:196776 | denotes | glycoconjugates |
_T16 | 554-569 | FMAID:82782 | denotes | glycoconjugates |
_T17 | 669-679 | FMAID:167180 | denotes | antibodies |
_T18 | 716-728 | FMAID:82737 | denotes | carbohydrate |
_T19 | 716-728 | FMAID:197276 | denotes | carbohydrate |
_T20 | 996-1006 | FMAID:167180 | denotes | antibodies |
_T21 | 1056-1071 | FMAID:196776 | denotes | glycoconjugates |
_T22 | 1056-1071 | FMAID:82782 | denotes | glycoconjugates |
uniprot-human
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 424-427 | http://www.uniprot.org/uniprot/P06744 | denotes | GPI |
T2 | 789-792 | http://www.uniprot.org/uniprot/P06744 | denotes | GPI |
T3 | 992-995 | http://www.uniprot.org/uniprot/P06744 | denotes | GPI |
uniprot-mouse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 424-427 | http://www.uniprot.org/uniprot/Q8C675 | denotes | GPI |
T2 | 789-792 | http://www.uniprot.org/uniprot/Q8C675 | denotes | GPI |
T3 | 992-995 | http://www.uniprot.org/uniprot/Q8C675 | denotes | GPI |
GlycoBiology-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 105-115 | http://purl.bioontology.org/ontology/NCBITAXON/241603 | denotes | Toxoplasma |
T2 | 105-115 | http://purl.bioontology.org/ontology/NCBITAXON/152250 | denotes | Toxoplasma |
T3 | 105-115 | http://purl.bioontology.org/ontology/NCBITAXON/5810 | denotes | Toxoplasma |
T4 | 105-122 | http://purl.bioontology.org/ontology/NCBITAXON/5811 | denotes | Toxoplasma gondii |
T5 | 181-189 | http://purl.bioontology.org/ontology/NCBITAXON/600794 | denotes | parasite |
T6 | 190-200 | http://purl.bioontology.org/ontology/NCBITAXON/241603 | denotes | Toxoplasma |
T7 | 190-200 | http://purl.bioontology.org/ontology/NCBITAXON/5810 | denotes | Toxoplasma |
T8 | 190-200 | http://purl.bioontology.org/ontology/NCBITAXON/152250 | denotes | Toxoplasma |
T9 | 190-207 | http://purl.bioontology.org/ontology/NCBITAXON/5811 | denotes | Toxoplasma gondii |
T10 | 274-281 | http://purl.bioontology.org/ontology/NCBITAXON/353209 | denotes | related |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 181-189 | http://purl.obolibrary.org/obo/GO_0072519 | denotes | parasite |
T2 | 348-363 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
T3 | 836-851 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
T4 | 608-616 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | virulent |
T5 | 608-616 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | virulent |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 669-679 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibodies |
T2 | 996-1006 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibodies |
T3 | 685-689 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | bind |
T4 | 685-689 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | bind |
T5 | 685-689 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | bind |
T6 | 685-689 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | bind |
UBERON-AE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 294-299 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T2 | 304-307 | http://purl.obolibrary.org/obo/UBERON_0000970 | denotes | eye |
GlycoBiology-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 294-299 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
T2 | 304-307 | http://purl.obolibrary.org/obo/MAT_0000140 | denotes | eye |
performance-test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 294-299 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
PD-UBERON-AE-B_T2 | 304-307 | http://purl.obolibrary.org/obo/UBERON_0000970 | denotes | eye |