PubMed:26042596 JSONTXT

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"26042596-10#66#74#geners266729","span":{"begin":2040,"end":2048},"obj":"geners266729"},{"id":"26042596-10#102#107#diseaseC0400966","span":{"begin":2076,"end":2081},"obj":"diseaseC0400966"},{"id":"26042596-11#12#20#geners266729","span":{"begin":2095,"end":2103},"obj":"geners266729"},{"id":"26042596-11#40#59#diseaseC2675519","span":{"begin":2123,"end":2142},"obj":"diseaseC2675519"}],"relations":[{"id":"66#74#geners266729102#107#diseaseC0400966","pred":"associated_with","subj":"26042596-10#66#74#geners266729","obj":"26042596-10#102#107#diseaseC0400966"},{"id":"12#20#geners26672940#59#diseaseC2675519","pred":"associated_with","subj":"26042596-11#12#20#geners266729","obj":"26042596-11#40#59#diseaseC2675519"}],"text":"Association of adiponectin gene polymorphism with nonalcoholic fatty liver disease in Taiwanese patients with type 2 diabetes.\nOBJECTIVE: Patients with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) have a higher prevalence of cardiovascular diseases. In this study we investigated the frequency of single nucleotide polymorphisms (SNPs) of several candidate genes associated with NAFLD in Taiwanese patients with type 2 diabetes mellitus (DM) and NAFLD and in those with DM but without fatty liver disease.\nMETHODS: We enrolled 350 patients with type 2 DM and NAFLD and 209 patients with DM but without NAFLD. Body mass index (BMI), % body fat (% BF), glycated hemoglobin (HbA1c), high molecular weight (HMW) isoform of adiponectin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) levels were measured. Thirteen SNPs in 5 genes (adiponectin, leptin, peroxisome proliferator-activated receptor alpha, adiponutrin/patatin-like phospholipase domain-containing protein 3 and peroxisome proliferator-activated receptor γ co-activator 1α ) were measured.\nRESULTS: Only adiponectin rs266729 polymorphism was associated with susceptibility to NAFLD (p = 0.001). Subgroup analysis revealed that the proportion of subjects with homozygous genotype GG was higher in patients with NAFLD (31%) than in controls (11%) and that the proportions of heterozygous CG and homozygous CC were higher in controls (37% and 52%, respectively) than in patients with NAFLD (33% and 36%, respectively). Patients with NAFLD carrying the GG genotype of rs266729 showed significantly lower serum HMW adiponectin levels than patients carrying the GC or CC genotype (3.75±0.37 vs. 3.99±0.66 vs. 4.79±0.58 μg/ml, p\u003c 0.001). Body fat and serum HMW adiponectin levels were the strongest predictors of developing NAFLD (p \u003c 0.001 and 0.004, respectively).\nCONCLUSIONS: In patients with type 2 diabetes gene polymorphism of adiponectin rs266729 is associated with risk of NAFLD. G allele of rs266729 is associated with hypoadiponectinemia. Low serum adiponectin level may precipitate liver steatosis in patients with type 2 diabetes."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"26042596-0#15#26#gene9370","span":{"begin":15,"end":26},"obj":"gene9370"},{"id":"26042596-0#50#82#diseaseC0400966","span":{"begin":50,"end":82},"obj":"diseaseC0400966"},{"id":"26042596-0#110#125#diseaseC0011860","span":{"begin":110,"end":125},"obj":"diseaseC0011860"}],"relations":[{"id":"15#26#gene937050#82#diseaseC0400966","pred":"associated_with","subj":"26042596-0#15#26#gene9370","obj":"26042596-0#50#82#diseaseC0400966"},{"id":"15#26#gene9370110#125#diseaseC0011860","pred":"associated_with","subj":"26042596-0#15#26#gene9370","obj":"26042596-0#110#125#diseaseC0011860"}],"text":"Association of adiponectin gene polymorphism with nonalcoholic fatty liver disease in Taiwanese patients with type 2 diabetes.\nOBJECTIVE: Patients with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) have a higher prevalence of cardiovascular diseases. In this study we investigated the frequency of single nucleotide polymorphisms (SNPs) of several candidate genes associated with NAFLD in Taiwanese patients with type 2 diabetes mellitus (DM) and NAFLD and in those with DM but without fatty liver disease.\nMETHODS: We enrolled 350 patients with type 2 DM and NAFLD and 209 patients with DM but without NAFLD. Body mass index (BMI), % body fat (% BF), glycated hemoglobin (HbA1c), high molecular weight (HMW) isoform of adiponectin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) levels were measured. Thirteen SNPs in 5 genes (adiponectin, leptin, peroxisome proliferator-activated receptor alpha, adiponutrin/patatin-like phospholipase domain-containing protein 3 and peroxisome proliferator-activated receptor γ co-activator 1α ) were measured.\nRESULTS: Only adiponectin rs266729 polymorphism was associated with susceptibility to NAFLD (p = 0.001). Subgroup analysis revealed that the proportion of subjects with homozygous genotype GG was higher in patients with NAFLD (31%) than in controls (11%) and that the proportions of heterozygous CG and homozygous CC were higher in controls (37% and 52%, respectively) than in patients with NAFLD (33% and 36%, respectively). Patients with NAFLD carrying the GG genotype of rs266729 showed significantly lower serum HMW adiponectin levels than patients carrying the GC or CC genotype (3.75±0.37 vs. 3.99±0.66 vs. 4.79±0.58 μg/ml, p\u003c 0.001). Body fat and serum HMW adiponectin levels were the strongest predictors of developing NAFLD (p \u003c 0.001 and 0.004, respectively).\nCONCLUSIONS: In patients with type 2 diabetes gene polymorphism of adiponectin rs266729 is associated with risk of NAFLD. G allele of rs266729 is associated with hypoadiponectinemia. Low serum adiponectin level may precipitate liver steatosis in patients with type 2 diabetes."}