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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 6-17 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 88-99 https://glytoucan.org/Structures/Glycans/G81533KY denotes Sialic acid
T3 195-206 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T4 639-650 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T5 1648-1659 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 6-17 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2 88-99 Glycan_Motif denotes Sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T3 195-206 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T4 639-650 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T5 1633-1659 Glycan_Motif denotes 9-O-acetylated sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G47325QT
T6 1648-1659 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 6-17 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 88-99 https://glytoucan.org/Structures/Glycans/G81533KY denotes Sialic acid
T3 195-206 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T4 639-650 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T5 1633-1659 https://glytoucan.org/Structures/Glycans/G47325QT denotes 9-O-acetylated sialic acid
T6 1648-1659 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-34 Sentence denotes Human sialic acid acetyl esterase:
TextSentencer_T2 35-87 Sentence denotes Towards a better understanding of a puzzling enzyme.
TextSentencer_T3 88-207 Sentence denotes Sialic acid acetyl esterase (SIAE) removes acetyl moieties from the hydroxyl groups in position 9 and 4 of sialic acid.
TextSentencer_T4 208-279 Sentence denotes Recently, a dispute has been opened on its association to autoimmunity.
TextSentencer_T5 280-516 Sentence denotes In order to get new insights on human SIAE biology and to clarify its seemingly contradictory molecular properties, we combined in silico characterization, phylogenetic analysis and homology modeling with cellular studies in COS7 cells.
TextSentencer_T6 517-673 Sentence denotes Genomic and phylogenetic analysis revealed that in most tissues only the "long" isoform, originally referred to lysosomal sialic acid esterase, is detected.
TextSentencer_T7 674-820 Sentence denotes Using the homology modeling approach, we predicted a model of SIAE 3D structure, which fulfills the topological features of SGNH-hydrolase family.
TextSentencer_T8 821-947 Sentence denotes In addition, the model and site-directed mutagenesis experiments allowed the definition of the residues involved in catalysis.
TextSentencer_T9 948-1097 Sentence denotes SIAE transient expression revealed that the protein is glycosylated and is active in vitro as an esterase with a pH optimum corresponding to 8.4-8.5.
TextSentencer_T10 1098-1232 Sentence denotes Moreover, glycosylation influences the biological activity of the enzyme and is essential for release of SIAE into the culture medium.
TextSentencer_T11 1233-1406 Sentence denotes According to these findings, co-localization experiments demonstrated the presence of SIAE in membranous structures corresponding to endoplasmic reticulum and Golgi complex.
TextSentencer_T12 1407-1585 Sentence denotes Thus, at least in COS7 cells, SIAE behaves as a typical secreted enzyme, subjected to glycosylation and located along the classical secretory route or in the extracellular space.
TextSentencer_T13 1586-1755 Sentence denotes In these environments, the enzyme could act on 9-O-acetylated sialic acid residues, contributing to the fine-tuning of the various functions played by this acidic sugar.
T1 0-34 Sentence denotes Human sialic acid acetyl esterase:
T2 35-87 Sentence denotes Towards a better understanding of a puzzling enzyme.
T3 88-207 Sentence denotes Sialic acid acetyl esterase (SIAE) removes acetyl moieties from the hydroxyl groups in position 9 and 4 of sialic acid.
T4 208-279 Sentence denotes Recently, a dispute has been opened on its association to autoimmunity.
T5 280-516 Sentence denotes In order to get new insights on human SIAE biology and to clarify its seemingly contradictory molecular properties, we combined in silico characterization, phylogenetic analysis and homology modeling with cellular studies in COS7 cells.
T6 517-673 Sentence denotes Genomic and phylogenetic analysis revealed that in most tissues only the "long" isoform, originally referred to lysosomal sialic acid esterase, is detected.
T7 674-820 Sentence denotes Using the homology modeling approach, we predicted a model of SIAE 3D structure, which fulfills the topological features of SGNH-hydrolase family.
T8 821-947 Sentence denotes In addition, the model and site-directed mutagenesis experiments allowed the definition of the residues involved in catalysis.
T9 948-1097 Sentence denotes SIAE transient expression revealed that the protein is glycosylated and is active in vitro as an esterase with a pH optimum corresponding to 8.4-8.5.
T10 1098-1232 Sentence denotes Moreover, glycosylation influences the biological activity of the enzyme and is essential for release of SIAE into the culture medium.
T11 1233-1406 Sentence denotes According to these findings, co-localization experiments demonstrated the presence of SIAE in membranous structures corresponding to endoplasmic reticulum and Golgi complex.
T12 1407-1585 Sentence denotes Thus, at least in COS7 cells, SIAE behaves as a typical secreted enzyme, subjected to glycosylation and located along the classical secretory route or in the extracellular space.
T13 1586-1755 Sentence denotes In these environments, the enzyme could act on 9-O-acetylated sialic acid residues, contributing to the fine-tuning of the various functions played by this acidic sugar.
T1 0-34 Sentence denotes Human sialic acid acetyl esterase:
T2 35-87 Sentence denotes Towards a better understanding of a puzzling enzyme.
T3 88-207 Sentence denotes Sialic acid acetyl esterase (SIAE) removes acetyl moieties from the hydroxyl groups in position 9 and 4 of sialic acid.
T4 208-279 Sentence denotes Recently, a dispute has been opened on its association to autoimmunity.
T5 280-516 Sentence denotes In order to get new insights on human SIAE biology and to clarify its seemingly contradictory molecular properties, we combined in silico characterization, phylogenetic analysis and homology modeling with cellular studies in COS7 cells.
T6 517-673 Sentence denotes Genomic and phylogenetic analysis revealed that in most tissues only the "long" isoform, originally referred to lysosomal sialic acid esterase, is detected.
T7 674-820 Sentence denotes Using the homology modeling approach, we predicted a model of SIAE 3D structure, which fulfills the topological features of SGNH-hydrolase family.
T8 821-947 Sentence denotes In addition, the model and site-directed mutagenesis experiments allowed the definition of the residues involved in catalysis.
T9 948-1097 Sentence denotes SIAE transient expression revealed that the protein is glycosylated and is active in vitro as an esterase with a pH optimum corresponding to 8.4-8.5.
T10 1098-1232 Sentence denotes Moreover, glycosylation influences the biological activity of the enzyme and is essential for release of SIAE into the culture medium.
T11 1233-1406 Sentence denotes According to these findings, co-localization experiments demonstrated the presence of SIAE in membranous structures corresponding to endoplasmic reticulum and Golgi complex.
T12 1407-1585 Sentence denotes Thus, at least in COS7 cells, SIAE behaves as a typical secreted enzyme, subjected to glycosylation and located along the classical secretory route or in the extracellular space.
T13 1586-1755 Sentence denotes In these environments, the enzyme could act on 9-O-acetylated sialic acid residues, contributing to the fine-tuning of the various functions played by this acidic sugar.

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 510-515 FMAID:68646 denotes cells
_T2 510-515 FMAID:169002 denotes cells
_T3 517-524 FMAID:84116 denotes Genomic
_T4 517-524 FMAID:198062 denotes Genomic
_T5 573-580 FMAID:256050 denotes tissues
_T6 629-638 FMAID:162299 denotes lysosomal
_T7 629-638 FMAID:63836 denotes lysosomal
_T8 992-999 FMAID:165447 denotes protein
_T9 992-999 FMAID:67257 denotes protein
_T10 1327-1337 FMAID:93573 denotes membranous
_T11 1327-1337 FMAID:7145 denotes membranous
_T12 1327-1337 FMAID:167608 denotes membranous
_T13 1327-1337 FMAID:30322 denotes membranous
_T14 1363-1387 FMAID:165146 denotes to endoplasmic reticulum
_T15 1366-1377 FMAID:66856 denotes endoplasmic
_T16 1366-1377 FMAID:165003 denotes endoplasmic
_T17 1366-1387 FMAID:210679 denotes endoplasmic reticulum
_T18 1366-1387 FMAID:67438 denotes endoplasmic reticulum
_T19 1366-1387 FMAID:165142 denotes endoplasmic reticulum
_T20 1366-1387 FMAID:67434 denotes endoplasmic reticulum
_T21 1366-1387 FMAID:80351 denotes endoplasmic reticulum
_T22 1366-1387 FMAID:165141 denotes endoplasmic reticulum
_T23 1366-1387 FMAID:165144 denotes endoplasmic reticulum
_T24 1366-1387 FMAID:66897 denotes endoplasmic reticulum
_T25 1366-1387 FMAID:66898 denotes endoplasmic reticulum
_T26 1366-1387 FMAID:165026 denotes endoplasmic reticulum
_T27 1366-1387 FMAID:210694 denotes endoplasmic reticulum
_T28 1366-1387 FMAID:211269 denotes endoplasmic reticulum
_T29 1366-1387 FMAID:199093 denotes endoplasmic reticulum
_T30 1366-1387 FMAID:165250 denotes endoplasmic reticulum
_T31 1366-1387 FMAID:67429 denotes endoplasmic reticulum
_T32 1366-1387 FMAID:212510 denotes endoplasmic reticulum
_T33 1366-1387 FMAID:63842 denotes endoplasmic reticulum
_T34 1366-1387 FMAID:162308 denotes endoplasmic reticulum
_T35 1366-1387 FMAID:165027 denotes endoplasmic reticulum
_T36 1366-1387 FMAID:188464 denotes endoplasmic reticulum
_T37 1378-1387 FMAID:7646 denotes reticulum
_T38 1378-1387 FMAID:94520 denotes reticulum
_T39 1392-1405 FMAID:162310 denotes Golgi complex
_T40 1392-1405 FMAID:63843 denotes Golgi complex
_T41 1430-1435 FMAID:169002 denotes cells
_T42 1430-1435 FMAID:68646 denotes cells
_T43 1565-1584 FMAID:170759 denotes extracellular space
_T44 1565-1584 FMAID:70022 denotes extracellular space
_T45 1749-1754 FMAID:196724 denotes sugar

uniprot-human

Id Subject Object Predicate Lexical cue
T1 117-121 http://www.uniprot.org/uniprot/Q9HAT2 denotes SIAE
T2 318-322 http://www.uniprot.org/uniprot/Q9HAT2 denotes SIAE
T3 736-740 http://www.uniprot.org/uniprot/Q9HAT2 denotes SIAE
T4 948-952 http://www.uniprot.org/uniprot/Q9HAT2 denotes SIAE
T5 1203-1207 http://www.uniprot.org/uniprot/Q9HAT2 denotes SIAE
T6 1319-1323 http://www.uniprot.org/uniprot/Q9HAT2 denotes SIAE
T7 1437-1441 http://www.uniprot.org/uniprot/Q9HAT2 denotes SIAE

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 1093-1096 http://www.uniprot.org/uniprot/P47759 denotes 8.5

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 165-171 http://purl.bioontology.org/ontology/STY/T096 denotes groups
T2 510-515 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 573-580 http://purl.bioontology.org/ontology/STY/T024 denotes tissues
T4 1252-1260 http://purl.bioontology.org/ontology/STY/T033 denotes findings
T5 1262-1264 http://purl.bioontology.org/ontology/NCBITAXON/13893 denotes co
T6 1430-1435 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 25-33 http://purl.obolibrary.org/obo/GO_0052689 denotes esterase
T2 107-115 http://purl.obolibrary.org/obo/GO_0052689 denotes esterase
T3 651-659 http://purl.obolibrary.org/obo/GO_0052689 denotes esterase
T4 1045-1053 http://purl.obolibrary.org/obo/GO_0052689 denotes esterase
T5 485-493 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T6 992-1015 http://purl.obolibrary.org/obo/GO_0006486 denotes protein is glycosylated
T7 1003-1015 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylated
T8 1108-1121 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T9 1493-1506 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T10 1148-1170 http://purl.obolibrary.org/obo/GO_0003824 denotes activity of the enzyme
T11 1265-1277 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T12 1366-1397 http://purl.obolibrary.org/obo/GO_0006888 denotes endoplasmic reticulum and Golgi
T13 1463-1471 http://purl.obolibrary.org/obo/GO_0046903 denotes secreted

GO-CC

Id Subject Object Predicate Lexical cue
T1 510-515 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 1430-1435 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 629-638 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T4 1327-1337 http://purl.obolibrary.org/obo/GO_0016020 denotes membranous
T5 1366-1387 http://purl.obolibrary.org/obo/GO_0005783 denotes endoplasmic reticulum
T6 1392-1397 http://purl.obolibrary.org/obo/GO_0005794 denotes Golgi
T7 1392-1405 http://purl.obolibrary.org/obo/GO_0005794 denotes Golgi complex
T8 1565-1578 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular
T9 1565-1584 http://purl.obolibrary.org/obo/GO_0005615 denotes extracellular space

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 573-580 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 1749-1754 "http://rdf.glycoinfo.org/glycan/G59665TO" denotes sugar
GlycanIUPAC_T2 1749-1754 "http://rdf.glycoinfo.org/glycan/G32915EI" denotes sugar
GlycanIUPAC_T3 1749-1754 "http://rdf.glycoinfo.org/glycan/G60625TS" denotes sugar

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 1633-1659 http://www.glycoepitope.jp/epitopes/EP0065 denotes 9-O-acetylated sialic acid

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 573-580 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 266-278 Phenotype denotes autoimmunity HP:0002960

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 0-5 OrganismTaxon denotes Human 9606
T2 312-317 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1378-1387 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T2 1392-1405 Body_part denotes Golgi complex http://purl.obolibrary.org/obo/GO_0005794
T3 1565-1584 Body_part denotes extracellular space http://purl.obolibrary.org/obo/GO_0005615