PubMed:25979836
Annnotations
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-146 | Sentence | denotes | Gastrointestinal hormones/neurotransmitters and growth factors can activate P21 activated kinase 2 in pancreatic acinar cells by novel mechanisms. |
| T2 | 147-421 | Sentence | denotes | P-21-activated kinases (PAKs) are serine/threonine kinases comprising six isoforms divided in two groups, group-I (PAK1-3)/group-II (PAK4-6) which play important roles in cell cytoskeletal dynamics, survival, secretion and proliferation and are activated by diverse stimuli. |
| T3 | 422-549 | Sentence | denotes | However, little is known about PAKs ability to be activated by gastrointestinal (GI) hormones/neurotransmitters/growth-factors. |
| T4 | 550-711 | Sentence | denotes | We used rat pancreatic acini to explore the ability of GI-hormones/neurotransmitters/growth-factors to activate Group-I-PAKs and the signaling cascades involved. |
| T5 | 712-743 | Sentence | denotes | Only PAK2 was present in acini. |
| T6 | 744-1020 | Sentence | denotes | PAK2 was activated by some pancreatic growth-factors [EGF, PDGF, bFGF], by secretagogues activating phospholipase-C (PLC) [CCK, carbachol, bombesin] and by post-receptor stimulants activating PKC [TPA], but not agents only mobilizing cellular calcium or increasing cyclic AMP. |
| T7 | 1021-1112 | Sentence | denotes | CCK-activation of PAK2 required both high- and low-affinity-CCK1-receptor-state activation. |
| T8 | 1113-1233 | Sentence | denotes | It was partially reduced by PKC- or Src-inhibition, but not with PI3K-inhibitors (wortmannin, LY294002) or thapsigargin. |
| T9 | 1234-1419 | Sentence | denotes | IPA-3, which prevents PAK2 binding to small-GTPases partially inhibited PAK2-activation, as well as reduced CCK-induced ERK1/2 activation and amylase release induced by CCK or bombesin. |
| T10 | 1420-1497 | Sentence | denotes | This study demonstrates pancreatic acini, possess only one Group-I-PAK, PAK2. |
| T11 | 1498-1649 | Sentence | denotes | CCK and other GI-hormones/neurotransmitters/growth-factors activate PAK2 via small GTPases (CDC42/Rac1), PKC and SFK but not cytosolic calcium or PI3K. |
| T12 | 1650-1858 | Sentence | denotes | CCK-activation of PAK2 showed several novel features being dependent on both receptor-activation states, having PLC- and PKC-dependent/independent components and small-GTPase-dependent/independent components. |
| T13 | 1859-2155 | Sentence | denotes | These results show that PAK2 is important in signaling cascades activated by numerous pancreatic stimuli which mediate their various physiological/pathophysiological responses and thus could be a promising target for the development of therapies in some pancreatic disorders such as pancreatitis. |
LitCoin-entities-OrganismTaxon-PD
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 558-561 | OrganismTaxon | denotes | rat | NCBItxid:10116|NCBItxid:10114 |
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 10635 | 0-25 | ChemicalEntity | denotes | Gastrointestinal hormones | MESH:D005768 |
| 10636 | 26-43 | ChemicalEntity | denotes | neurotransmitters | MESH:D018377 |
| 10637 | 76-98 | GeneOrGeneProduct | denotes | P21 activated kinase 2 | NCBIGene:29432 |
| 10638 | 147-169 | GeneOrGeneProduct | denotes | P-21-activated kinases | NCBIGene:292756|NCBIGene:29431|NCBIGene:29432|NCBIGene:29433|NCBIGene:296078|NCBIGene:311450 |
| 10639 | 171-175 | GeneOrGeneProduct | denotes | PAKs | NCBIGene:292756|NCBIGene:29431|NCBIGene:29432|NCBIGene:29433|NCBIGene:296078|NCBIGene:311450 |
| 10640 | 181-205 | GeneOrGeneProduct | denotes | serine/threonine kinases | NCBIGene:292756|NCBIGene:29431|NCBIGene:29432|NCBIGene:29433|NCBIGene:296078|NCBIGene:311450 |
| 10641 | 262-268 | GeneOrGeneProduct | denotes | PAK1-3 | NCBIGene:29431|NCBIGene:29432|NCBIGene:29433 |
| 10642 | 280-286 | GeneOrGeneProduct | denotes | PAK4-6 | NCBIGene:292756|NCBIGene:296078|NCBIGene:311450 |
| 10643 | 453-457 | GeneOrGeneProduct | denotes | PAKs | NCBIGene:292756|NCBIGene:29431|NCBIGene:29432|NCBIGene:29433|NCBIGene:296078|NCBIGene:311450 |
| 10644 | 485-515 | ChemicalEntity | denotes | gastrointestinal (GI) hormones | MESH:D005768 |
| 10645 | 516-533 | ChemicalEntity | denotes | neurotransmitters | MESH:D018377 |
| 10646 | 558-561 | OrganismTaxon | denotes | rat | NCBITaxon:10116 |
| 10647 | 605-616 | ChemicalEntity | denotes | GI-hormones | MESH:D005768 |
| 10648 | 617-634 | ChemicalEntity | denotes | neurotransmitters | MESH:D018377 |
| 10649 | 662-674 | GeneOrGeneProduct | denotes | Group-I-PAKs | NCBIGene:29431|NCBIGene:29432|NCBIGene:29433 |
| 10650 | 717-721 | GeneOrGeneProduct | denotes | PAK2 | NCBIGene:29432 |
| 10651 | 744-748 | GeneOrGeneProduct | denotes | PAK2 | NCBIGene:29432 |
| 10652 | 771-796 | GeneOrGeneProduct | denotes | pancreatic growth-factors | NCBIGene:25266|NCBIGene:25313|NCBIGene:54250 |
| 10653 | 798-801 | GeneOrGeneProduct | denotes | EGF | NCBIGene:25313 |
| 10654 | 803-807 | GeneOrGeneProduct | denotes | PDGF | NCBIGene:25266 |
| 10655 | 809-813 | GeneOrGeneProduct | denotes | bFGF | NCBIGene:54250 |
| 10656 | 844-859 | GeneOrGeneProduct | denotes | phospholipase-C | NCBIGene:24655 |
| 10657 | 861-864 | GeneOrGeneProduct | denotes | PLC | NCBIGene:24655 |
| 10658 | 867-870 | GeneOrGeneProduct | denotes | CCK | NCBIGene:25298 |
| 10659 | 872-881 | ChemicalEntity | denotes | carbachol | MESH:D002217 |
| 10660 | 883-891 | ChemicalEntity | denotes | bombesin | MESH:D001839 |
| 10661 | 936-939 | GeneOrGeneProduct | denotes | PKC | NCBIGene:24681 |
| 10662 | 941-944 | ChemicalEntity | denotes | TPA | MESH:D013755 |
| 10663 | 987-994 | ChemicalEntity | denotes | calcium | MESH:D002118 |
| 10664 | 1009-1019 | ChemicalEntity | denotes | cyclic AMP | MESH:D000242 |
| 10665 | 1021-1024 | GeneOrGeneProduct | denotes | CCK | NCBIGene:25298 |
| 10666 | 1039-1043 | GeneOrGeneProduct | denotes | PAK2 | NCBIGene:29432 |
| 10667 | 1081-1094 | GeneOrGeneProduct | denotes | CCK1-receptor | NCBIGene:24889 |
| 10668 | 1141-1144 | GeneOrGeneProduct | denotes | PKC | NCBIGene:24681 |
| 10669 | 1149-1152 | GeneOrGeneProduct | denotes | Src | NCBIGene:83805 |
| 10670 | 1178-1182 | GeneOrGeneProduct | denotes | PI3K | NCBIGene:298947 |
| 10671 | 1195-1205 | ChemicalEntity | denotes | wortmannin | MESH:D000077191 |
| 10672 | 1207-1215 | ChemicalEntity | denotes | LY294002 | MESH:C085911 |
| 10673 | 1220-1232 | ChemicalEntity | denotes | thapsigargin | MESH:D019284 |
| 10674 | 1234-1239 | ChemicalEntity | denotes | IPA-3 | MESH:C541795 |
| 10675 | 1256-1260 | GeneOrGeneProduct | denotes | PAK2 | NCBIGene:29432 |
| 10676 | 1272-1285 | GeneOrGeneProduct | denotes | small-GTPases | NCBIGene:363875|NCBIGene:64465 |
| 10677 | 1306-1310 | GeneOrGeneProduct | denotes | PAK2 | NCBIGene:29432 |
| 10678 | 1342-1345 | GeneOrGeneProduct | denotes | CCK | NCBIGene:25298 |
| 10679 | 1354-1360 | GeneOrGeneProduct | denotes | ERK1/2 | NCBIGene:116590|NCBIGene:50689 |
| 10680 | 1376-1383 | GeneOrGeneProduct | denotes | amylase | NCBIGene:24203 |
| 10681 | 1403-1406 | GeneOrGeneProduct | denotes | CCK | NCBIGene:25298 |
| 10682 | 1410-1418 | ChemicalEntity | denotes | bombesin | MESH:D001839 |
| 10683 | 1479-1490 | GeneOrGeneProduct | denotes | Group-I-PAK | NCBIGene:29431|NCBIGene:29432|NCBIGene:29433 |
| 10684 | 1492-1496 | GeneOrGeneProduct | denotes | PAK2 | NCBIGene:29432 |
| 10685 | 1498-1501 | GeneOrGeneProduct | denotes | CCK | NCBIGene:25298 |
| 10686 | 1512-1523 | ChemicalEntity | denotes | GI-hormones | MESH:D005768 |
| 10687 | 1524-1541 | ChemicalEntity | denotes | neurotransmitters | MESH:D018377 |
| 10688 | 1566-1570 | GeneOrGeneProduct | denotes | PAK2 | NCBIGene:29432 |
| 10689 | 1575-1588 | GeneOrGeneProduct | denotes | small GTPases | NCBIGene:363875|NCBIGene:64465 |
| 10690 | 1590-1595 | GeneOrGeneProduct | denotes | CDC42 | NCBIGene:64465 |
| 10691 | 1596-1600 | GeneOrGeneProduct | denotes | Rac1 | NCBIGene:363875 |
| 10692 | 1603-1606 | GeneOrGeneProduct | denotes | PKC | NCBIGene:24681 |
| 10693 | 1611-1614 | GeneOrGeneProduct | denotes | SFK | NCBIGene:83805 |
| 10694 | 1633-1640 | ChemicalEntity | denotes | calcium | MESH:D002118 |
| 10695 | 1644-1648 | GeneOrGeneProduct | denotes | PI3K | NCBIGene:298947 |
| 10696 | 1650-1653 | GeneOrGeneProduct | denotes | CCK | NCBIGene:25298 |
| 10697 | 1668-1672 | GeneOrGeneProduct | denotes | PAK2 | NCBIGene:29432 |
| 10698 | 1762-1765 | GeneOrGeneProduct | denotes | PLC | NCBIGene:24655 |
| 10699 | 1771-1774 | GeneOrGeneProduct | denotes | PKC | NCBIGene:24681 |
| 10700 | 1812-1824 | GeneOrGeneProduct | denotes | small-GTPase | NCBIGene:363875|NCBIGene:64465 |
| 10701 | 1883-1887 | GeneOrGeneProduct | denotes | PAK2 | NCBIGene:29432 |
| 10702 | 2113-2133 | DiseaseOrPhenotypicFeature | denotes | pancreatic disorders | MESH:D010182 |
| 10703 | 2142-2154 | DiseaseOrPhenotypicFeature | denotes | pancreatitis | MESH:D010195 |
LitCoin_Mondo
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 102-112 | DiseaseOrPhenotypicFeature | denotes | pancreatic | 0004982 |
| T2 | 562-572 | DiseaseOrPhenotypicFeature | denotes | pancreatic | 0004982 |
| T3 | 771-781 | DiseaseOrPhenotypicFeature | denotes | pancreatic | 0004982 |
| T4 | 1444-1454 | DiseaseOrPhenotypicFeature | denotes | pancreatic | 0004982 |
| T5 | 1945-1955 | DiseaseOrPhenotypicFeature | denotes | pancreatic | 0004982 |
| T6 | 2113-2123 | DiseaseOrPhenotypicFeature | denotes | pancreatic | 0004982 |
| T7 | 2142-2154 | DiseaseOrPhenotypicFeature | denotes | pancreatitis | 0004982 |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-62 | GeneOrGeneProduct | denotes | growth factors |
| T2 | 90-98 | GeneOrGeneProduct | denotes | kinase 2 |
| T3 | 129-134 | GeneOrGeneProduct | denotes | novel |
| T4 | 147-169 | GeneOrGeneProduct | denotes | P-21-activated kinases |
| T5 | 171-175 | GeneOrGeneProduct | denotes | PAKs |
| T6 | 181-205 | GeneOrGeneProduct | denotes | serine/threonine kinases |
| T7 | 253-260 | GeneOrGeneProduct | denotes | group-I |
| T8 | 262-266 | GeneOrGeneProduct | denotes | PAK1 |
| T9 | 270-278 | GeneOrGeneProduct | denotes | group-II |
| T10 | 280-284 | GeneOrGeneProduct | denotes | PAK4 |
| T11 | 318-322 | GeneOrGeneProduct | denotes | cell |
| T12 | 431-437 | GeneOrGeneProduct | denotes | little |
| T13 | 453-457 | GeneOrGeneProduct | denotes | PAKs |
| T14 | 534-540 | GeneOrGeneProduct | denotes | growth |
| T15 | 635-641 | GeneOrGeneProduct | denotes | growth |
| T16 | 662-669 | GeneOrGeneProduct | denotes | Group-I |
| T17 | 670-674 | GeneOrGeneProduct | denotes | PAKs |
| T18 | 717-721 | GeneOrGeneProduct | denotes | PAK2 |
| T19 | 744-748 | GeneOrGeneProduct | denotes | PAK2 |
| T20 | 782-788 | GeneOrGeneProduct | denotes | growth |
| T21 | 803-807 | GeneOrGeneProduct | denotes | PDGF |
| T22 | 809-813 | GeneOrGeneProduct | denotes | bFGF |
| T23 | 844-859 | GeneOrGeneProduct | denotes | phospholipase-C |
| T24 | 861-864 | GeneOrGeneProduct | denotes | PLC |
| T25 | 883-891 | GeneOrGeneProduct | denotes | bombesin |
| T26 | 900-904 | GeneOrGeneProduct | denotes | post |
| T27 | 905-913 | GeneOrGeneProduct | denotes | receptor |
| T28 | 936-939 | GeneOrGeneProduct | denotes | PKC |
| T29 | 1039-1043 | GeneOrGeneProduct | denotes | PAK2 |
| T30 | 1058-1062 | GeneOrGeneProduct | denotes | high |
| T31 | 1081-1085 | GeneOrGeneProduct | denotes | CCK1 |
| T32 | 1086-1094 | GeneOrGeneProduct | denotes | receptor |
| T33 | 1130-1137 | GeneOrGeneProduct | denotes | reduced |
| T34 | 1141-1144 | GeneOrGeneProduct | denotes | PKC |
| T35 | 1178-1182 | GeneOrGeneProduct | denotes | PI3K |
| T36 | 1183-1193 | GeneOrGeneProduct | denotes | inhibitors |
| T37 | 1256-1260 | GeneOrGeneProduct | denotes | PAK2 |
| T38 | 1261-1268 | GeneOrGeneProduct | denotes | binding |
| T39 | 1272-1277 | GeneOrGeneProduct | denotes | small |
| T40 | 1306-1310 | GeneOrGeneProduct | denotes | PAK2 |
| T41 | 1334-1341 | GeneOrGeneProduct | denotes | reduced |
| T42 | 1354-1360 | GeneOrGeneProduct | denotes | ERK1/2 |
| T43 | 1376-1383 | GeneOrGeneProduct | denotes | amylase |
| T44 | 1410-1418 | GeneOrGeneProduct | denotes | bombesin |
| T45 | 1479-1486 | GeneOrGeneProduct | denotes | Group-I |
| T46 | 1492-1496 | GeneOrGeneProduct | denotes | PAK2 |
| T47 | 1506-1511 | GeneOrGeneProduct | denotes | other |
| T48 | 1542-1548 | GeneOrGeneProduct | denotes | growth |
| T49 | 1566-1570 | GeneOrGeneProduct | denotes | PAK2 |
| T50 | 1575-1580 | GeneOrGeneProduct | denotes | small |
| T51 | 1590-1595 | GeneOrGeneProduct | denotes | CDC42 |
| T52 | 1596-1600 | GeneOrGeneProduct | denotes | Rac1 |
| T53 | 1603-1606 | GeneOrGeneProduct | denotes | PKC |
| T54 | 1623-1632 | GeneOrGeneProduct | denotes | cytosolic |
| T55 | 1644-1648 | GeneOrGeneProduct | denotes | PI3K |
| T56 | 1668-1672 | GeneOrGeneProduct | denotes | PAK2 |
| T57 | 1688-1693 | GeneOrGeneProduct | denotes | novel |
| T58 | 1727-1735 | GeneOrGeneProduct | denotes | receptor |
| T59 | 1762-1765 | GeneOrGeneProduct | denotes | PLC |
| T60 | 1771-1774 | GeneOrGeneProduct | denotes | PKC |
| T61 | 1812-1817 | GeneOrGeneProduct | denotes | small |
| T62 | 1818-1824 | GeneOrGeneProduct | denotes | GTPase |
| T63 | 1883-1887 | GeneOrGeneProduct | denotes | PAK2 |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 17-25 | GeneOrGeneProduct | denotes | hormones |
| T2 | 48-62 | GeneOrGeneProduct | denotes | growth factors |
| T3 | 67-75 | GeneOrGeneProduct | denotes | activate |
| T4 | 90-98 | GeneOrGeneProduct | denotes | kinase 2 |
| T5 | 120-125 | GeneOrGeneProduct | denotes | cells |
| T6 | 129-134 | GeneOrGeneProduct | denotes | novel |
| T7 | 147-169 | GeneOrGeneProduct | denotes | P-21-activated kinases |
| T8 | 181-205 | GeneOrGeneProduct | denotes | serine/threonine kinases |
| T9 | 253-260 | GeneOrGeneProduct | denotes | group-I |
| T10 | 262-266 | GeneOrGeneProduct | denotes | PAK1 |
| T11 | 270-278 | GeneOrGeneProduct | denotes | group-II |
| T12 | 280-284 | GeneOrGeneProduct | denotes | PAK4 |
| T13 | 318-322 | GeneOrGeneProduct | denotes | cell |
| T14 | 356-365 | GeneOrGeneProduct | denotes | secretion |
| T15 | 392-401 | GeneOrGeneProduct | denotes | activated |
| T16 | 431-437 | GeneOrGeneProduct | denotes | little |
| T17 | 472-481 | GeneOrGeneProduct | denotes | activated |
| T18 | 503-505 | GeneOrGeneProduct | denotes | GI |
| T19 | 507-515 | GeneOrGeneProduct | denotes | hormones |
| T20 | 534-540 | GeneOrGeneProduct | denotes | growth |
| T21 | 541-548 | GeneOrGeneProduct | denotes | factors |
| T22 | 605-607 | GeneOrGeneProduct | denotes | GI |
| T23 | 608-616 | GeneOrGeneProduct | denotes | hormones |
| T24 | 635-641 | GeneOrGeneProduct | denotes | growth |
| T25 | 642-649 | GeneOrGeneProduct | denotes | factors |
| T26 | 653-661 | GeneOrGeneProduct | denotes | activate |
| T27 | 662-669 | GeneOrGeneProduct | denotes | Group-I |
| T28 | 717-721 | GeneOrGeneProduct | denotes | PAK2 |
| T29 | 744-748 | GeneOrGeneProduct | denotes | PAK2 |
| T30 | 753-762 | GeneOrGeneProduct | denotes | activated |
| T31 | 782-788 | GeneOrGeneProduct | denotes | growth |
| T32 | 789-796 | GeneOrGeneProduct | denotes | factors |
| T33 | 803-807 | GeneOrGeneProduct | denotes | PDGF |
| T34 | 809-813 | GeneOrGeneProduct | denotes | bFGF |
| T35 | 833-843 | GeneOrGeneProduct | denotes | activating |
| T36 | 844-859 | GeneOrGeneProduct | denotes | phospholipase-C |
| T37 | 861-864 | GeneOrGeneProduct | denotes | PLC |
| T38 | 883-891 | GeneOrGeneProduct | denotes | bombesin |
| T39 | 900-904 | GeneOrGeneProduct | denotes | post |
| T40 | 905-913 | GeneOrGeneProduct | denotes | receptor |
| T41 | 925-935 | GeneOrGeneProduct | denotes | activating |
| T42 | 936-939 | GeneOrGeneProduct | denotes | PKC |
| T43 | 941-944 | GeneOrGeneProduct | denotes | TPA |
| T44 | 1016-1019 | GeneOrGeneProduct | denotes | AMP |
| T45 | 1025-1035 | GeneOrGeneProduct | denotes | activation |
| T46 | 1039-1043 | GeneOrGeneProduct | denotes | PAK2 |
| T47 | 1058-1062 | GeneOrGeneProduct | denotes | high |
| T48 | 1081-1085 | GeneOrGeneProduct | denotes | CCK1 |
| T49 | 1086-1094 | GeneOrGeneProduct | denotes | receptor |
| T50 | 1101-1111 | GeneOrGeneProduct | denotes | activation |
| T51 | 1130-1137 | GeneOrGeneProduct | denotes | reduced |
| T52 | 1141-1144 | GeneOrGeneProduct | denotes | PKC |
| T53 | 1178-1182 | GeneOrGeneProduct | denotes | PI3K |
| T54 | 1183-1193 | GeneOrGeneProduct | denotes | inhibitors |
| T55 | 1234-1237 | GeneOrGeneProduct | denotes | IPA |
| T56 | 1256-1260 | GeneOrGeneProduct | denotes | PAK2 |
| T57 | 1261-1268 | GeneOrGeneProduct | denotes | binding |
| T58 | 1272-1277 | GeneOrGeneProduct | denotes | small |
| T59 | 1278-1285 | GeneOrGeneProduct | denotes | GTPases |
| T60 | 1306-1310 | GeneOrGeneProduct | denotes | PAK2 |
| T61 | 1311-1321 | GeneOrGeneProduct | denotes | activation |
| T62 | 1334-1341 | GeneOrGeneProduct | denotes | reduced |
| T63 | 1346-1353 | GeneOrGeneProduct | denotes | induced |
| T64 | 1354-1360 | GeneOrGeneProduct | denotes | ERK1/2 |
| T65 | 1361-1371 | GeneOrGeneProduct | denotes | activation |
| T66 | 1376-1383 | GeneOrGeneProduct | denotes | amylase |
| T67 | 1392-1399 | GeneOrGeneProduct | denotes | induced |
| T68 | 1410-1418 | GeneOrGeneProduct | denotes | bombesin |
| T69 | 1479-1486 | GeneOrGeneProduct | denotes | Group-I |
| T70 | 1492-1496 | GeneOrGeneProduct | denotes | PAK2 |
| T71 | 1506-1511 | GeneOrGeneProduct | denotes | other |
| T72 | 1512-1514 | GeneOrGeneProduct | denotes | GI |
| T73 | 1515-1523 | GeneOrGeneProduct | denotes | hormones |
| T74 | 1542-1548 | GeneOrGeneProduct | denotes | growth |
| T75 | 1549-1556 | GeneOrGeneProduct | denotes | factors |
| T76 | 1557-1565 | GeneOrGeneProduct | denotes | activate |
| T77 | 1566-1570 | GeneOrGeneProduct | denotes | PAK2 |
| T78 | 1575-1580 | GeneOrGeneProduct | denotes | small |
| T79 | 1581-1588 | GeneOrGeneProduct | denotes | GTPases |
| T80 | 1590-1595 | GeneOrGeneProduct | denotes | CDC42 |
| T81 | 1596-1600 | GeneOrGeneProduct | denotes | Rac1 |
| T82 | 1603-1606 | GeneOrGeneProduct | denotes | PKC |
| T83 | 1623-1632 | GeneOrGeneProduct | denotes | cytosolic |
| T84 | 1644-1648 | GeneOrGeneProduct | denotes | PI3K |
| T85 | 1654-1664 | GeneOrGeneProduct | denotes | activation |
| T86 | 1668-1672 | GeneOrGeneProduct | denotes | PAK2 |
| T87 | 1688-1693 | GeneOrGeneProduct | denotes | novel |
| T88 | 1727-1735 | GeneOrGeneProduct | denotes | receptor |
| T89 | 1736-1746 | GeneOrGeneProduct | denotes | activation |
| T90 | 1762-1765 | GeneOrGeneProduct | denotes | PLC |
| T91 | 1771-1774 | GeneOrGeneProduct | denotes | PKC |
| T92 | 1812-1817 | GeneOrGeneProduct | denotes | small |
| T93 | 1818-1824 | GeneOrGeneProduct | denotes | GTPase |
| T94 | 1883-1887 | GeneOrGeneProduct | denotes | PAK2 |
| T95 | 1923-1932 | GeneOrGeneProduct | denotes | activated |
| T96 | 1970-1977 | GeneOrGeneProduct | denotes | mediate |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 102-112 | DiseaseOrPhenotypicFeature | denotes | pancreatic | D010195 |
| T2 | 562-572 | DiseaseOrPhenotypicFeature | denotes | pancreatic | D010195 |
| T3 | 771-781 | DiseaseOrPhenotypicFeature | denotes | pancreatic | D010195 |
| T4 | 1444-1454 | DiseaseOrPhenotypicFeature | denotes | pancreatic | D010195 |
| T5 | 1945-1955 | DiseaseOrPhenotypicFeature | denotes | pancreatic | D010195 |
| T6 | 2113-2123 | DiseaseOrPhenotypicFeature | denotes | pancreatic | D010195 |
| T7 | 2142-2154 | DiseaseOrPhenotypicFeature | denotes | pancreatitis | D010195 |
LitCoin-GeneOrGeneProduct-v3
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-62 | GeneOrGeneProduct | denotes | growth factors |
| T2 | 90-98 | GeneOrGeneProduct | denotes | kinase 2 |
| T3 | 147-169 | GeneOrGeneProduct | denotes | P-21-activated kinases |
| T4 | 171-175 | GeneOrGeneProduct | denotes | PAKs |
| T5 | 181-205 | GeneOrGeneProduct | denotes | serine/threonine kinases |
| T6 | 253-260 | GeneOrGeneProduct | denotes | group-I |
| T7 | 262-266 | GeneOrGeneProduct | denotes | PAK1 |
| T8 | 270-278 | GeneOrGeneProduct | denotes | group-II |
| T9 | 280-284 | GeneOrGeneProduct | denotes | PAK4 |
| T10 | 453-457 | GeneOrGeneProduct | denotes | PAKs |
| T11 | 662-669 | GeneOrGeneProduct | denotes | Group-I |
| T12 | 670-674 | GeneOrGeneProduct | denotes | PAKs |
| T13 | 717-721 | GeneOrGeneProduct | denotes | PAK2 |
| T14 | 744-748 | GeneOrGeneProduct | denotes | PAK2 |
| T15 | 803-807 | GeneOrGeneProduct | denotes | PDGF |
| T16 | 809-813 | GeneOrGeneProduct | denotes | bFGF |
| T17 | 844-859 | GeneOrGeneProduct | denotes | phospholipase-C |
| T18 | 861-864 | GeneOrGeneProduct | denotes | PLC |
| T19 | 936-939 | GeneOrGeneProduct | denotes | PKC |
| T20 | 1039-1043 | GeneOrGeneProduct | denotes | PAK2 |
| T21 | 1081-1085 | GeneOrGeneProduct | denotes | CCK1 |
| T22 | 1141-1144 | GeneOrGeneProduct | denotes | PKC |
| T23 | 1178-1182 | GeneOrGeneProduct | denotes | PI3K |
| T24 | 1256-1260 | GeneOrGeneProduct | denotes | PAK2 |
| T25 | 1272-1285 | GeneOrGeneProduct | denotes | small-GTPases |
| T26 | 1306-1310 | GeneOrGeneProduct | denotes | PAK2 |
| T27 | 1354-1360 | GeneOrGeneProduct | denotes | ERK1/2 |
| T28 | 1376-1383 | GeneOrGeneProduct | denotes | amylase |
| T29 | 1479-1486 | GeneOrGeneProduct | denotes | Group-I |
| T30 | 1492-1496 | GeneOrGeneProduct | denotes | PAK2 |
| T31 | 1566-1570 | GeneOrGeneProduct | denotes | PAK2 |
| T32 | 1575-1588 | GeneOrGeneProduct | denotes | small GTPases |
| T33 | 1590-1595 | GeneOrGeneProduct | denotes | CDC42 |
| T34 | 1596-1600 | GeneOrGeneProduct | denotes | Rac1 |
| T35 | 1603-1606 | GeneOrGeneProduct | denotes | PKC |
| T36 | 1644-1648 | GeneOrGeneProduct | denotes | PI3K |
| T37 | 1668-1672 | GeneOrGeneProduct | denotes | PAK2 |
| T38 | 1762-1765 | GeneOrGeneProduct | denotes | PLC |
| T39 | 1771-1774 | GeneOrGeneProduct | denotes | PKC |
| T40 | 1812-1824 | GeneOrGeneProduct | denotes | small-GTPase |
| T41 | 1883-1887 | GeneOrGeneProduct | denotes | PAK2 |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 63-66 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
| T2 | 1234-1237 | DiseaseOrPhenotypicFeature | denotes | IPA | 0010302 |
| T3 | 2113-2133 | DiseaseOrPhenotypicFeature | denotes | pancreatic disorders | 0002356 |
| T4 | 2142-2154 | DiseaseOrPhenotypicFeature | denotes | pancreatitis | 0004982 |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 2142-2154 | DiseaseOrPhenotypicFeature | denotes | pancreatitis | D010195 |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 2142-2154 | DiseaseOrPhenotypicFeature | denotes | pancreatitis | D010195 |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 0-25 | ChemicalEntity | denotes | Gastrointestinal hormones | ChemicalEntity |
| T2 | 26-43 | ChemicalEntity | denotes | neurotransmitters | ChemicalEntity |
| T3 | 181-187 | ChemicalEntity | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T4 | 188-197 | ChemicalEntity | denotes | threonine | http://purl.obolibrary.org/obo/CHEBI_26986 |
| T5 | 485-515 | ChemicalEntity | denotes | gastrointestinal (GI) hormones | ChemicalEntity |
| T6 | 516-533 | ChemicalEntity | denotes | neurotransmitters | ChemicalEntity |
| T7 | 605-616 | ChemicalEntity | denotes | GI-hormones | ChemicalEntity |
| T8 | 617-634 | ChemicalEntity | denotes | neurotransmitters | ChemicalEntity |
| T9 | 798-801 | ChemicalEntity | denotes | EGF | http://purl.obolibrary.org/obo/CHEBI_140739 |
| T10 | 844-859 | ChemicalEntity | denotes | phospholipase-C | D010738 |
| T11 | 861-864 | ChemicalEntity | denotes | PLC | D010738 |
| T12 | 872-881 | ChemicalEntity | denotes | carbachol | D002217|http://purl.obolibrary.org/obo/CHEBI_3385 |
| T14 | 883-891 | ChemicalEntity | denotes | bombesin | http://purl.obolibrary.org/obo/CHEBI_80229 |
| T15 | 941-944 | ChemicalEntity | denotes | TPA | http://purl.obolibrary.org/obo/CHEBI_61432|http://purl.obolibrary.org/obo/CHEBI_53394|http://purl.obolibrary.org/obo/CHEBI_37537|http://purl.obolibrary.org/obo/CHEBI_15702 |
| T19 | 987-994 | ChemicalEntity | denotes | calcium | D002118|http://purl.obolibrary.org/obo/CHEBI_29320|http://purl.obolibrary.org/obo/CHEBI_22984 |
| T22 | 1009-1019 | ChemicalEntity | denotes | cyclic AMP | http://purl.obolibrary.org/obo/CHEBI_17489 |
| T23 | 1195-1205 | ChemicalEntity | denotes | wortmannin | D000077191|http://purl.obolibrary.org/obo/CHEBI_52289 |
| T25 | 1207-1215 | ChemicalEntity | denotes | LY294002 | C085911|http://purl.obolibrary.org/obo/CHEBI_65329 |
| T27 | 1220-1232 | ChemicalEntity | denotes | thapsigargin | D019284|http://purl.obolibrary.org/obo/CHEBI_9516 |
| T29 | 1234-1239 | ChemicalEntity | denotes | IPA-3 | http://purl.obolibrary.org/obo/CHEBI_101355 |
| T30 | 1278-1285 | ChemicalEntity | denotes | GTPases | D020558 |
| T31 | 1376-1383 | ChemicalEntity | denotes | amylase | D000681 |
| T32 | 1410-1418 | ChemicalEntity | denotes | bombesin | http://purl.obolibrary.org/obo/CHEBI_80229 |
| T33 | 1512-1523 | ChemicalEntity | denotes | GI-hormones | ChemicalEntity |
| T34 | 1524-1541 | ChemicalEntity | denotes | neurotransmitters | ChemicalEntity |
| T35 | 1581-1588 | ChemicalEntity | denotes | GTPases | D020558 |
| T36 | 1633-1640 | ChemicalEntity | denotes | calcium | D002118|http://purl.obolibrary.org/obo/CHEBI_29320|http://purl.obolibrary.org/obo/CHEBI_22984 |
| T39 | 1762-1765 | ChemicalEntity | denotes | PLC | D010738 |
| T40 | 1818-1824 | ChemicalEntity | denotes | GTPase | D020558 |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 558-561 | OrganismTaxon | denotes | rat |
| T2 | 1234-1237 | OrganismTaxon | denotes | IPA |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
|---|---|---|---|---|---|---|
| T40 | 1818-1824 | ChemicalEntity | denotes | GTPase | D020558 | |
| T39 | 1762-1765 | ChemicalEntity | denotes | PLC | D010738 | |
| T36 | 1633-1640 | ChemicalEntity | denotes | calcium | http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320|D002118 | |
| T35 | 1581-1588 | ChemicalEntity | denotes | GTPases | D020558 | |
| T34 | 1524-1541 | ChemicalEntity | denotes | neurotransmitters | ChemicalEntity | |
| T33 | 1512-1523 | ChemicalEntity | denotes | GI-hormones | ChemicalEntity | |
| T32 | 1410-1418 | ChemicalEntity | denotes | bombesin | http://purl.obolibrary.org/obo/CHEBI_80229 | |
| T31 | 1376-1383 | ChemicalEntity | denotes | amylase | D000681 | |
| T30 | 1278-1285 | ChemicalEntity | denotes | GTPases | D020558 | |
| T29 | 1234-1239 | ChemicalEntity | denotes | IPA-3 | http://purl.obolibrary.org/obo/CHEBI_101355 | |
| T27 | 1220-1232 | ChemicalEntity | denotes | thapsigargin | http://purl.obolibrary.org/obo/CHEBI_9516|D019284 | |
| T25 | 1207-1215 | ChemicalEntity | denotes | LY294002 | http://purl.obolibrary.org/obo/CHEBI_65329|C085911 | |
| T23 | 1195-1205 | ChemicalEntity | denotes | wortmannin | http://purl.obolibrary.org/obo/CHEBI_52289|D000077191 | |
| T22 | 1009-1019 | ChemicalEntity | denotes | cyclic AMP | http://purl.obolibrary.org/obo/CHEBI_17489 | |
| T19 | 987-994 | ChemicalEntity | denotes | calcium | http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320|D002118 | |
| T15 | 941-944 | ChemicalEntity | denotes | TPA | http://purl.obolibrary.org/obo/CHEBI_15702|http://purl.obolibrary.org/obo/CHEBI_37537|http://purl.obolibrary.org/obo/CHEBI_53394|http://purl.obolibrary.org/obo/CHEBI_61432 | |
| T14 | 883-891 | ChemicalEntity | denotes | bombesin | http://purl.obolibrary.org/obo/CHEBI_80229 | |
| T12 | 872-881 | ChemicalEntity | denotes | carbachol | http://purl.obolibrary.org/obo/CHEBI_3385|D002217 | |
| T11 | 861-864 | ChemicalEntity | denotes | PLC | D010738 | |
| T10 | 844-859 | ChemicalEntity | denotes | phospholipase-C | D010738 | |
| T9 | 798-801 | ChemicalEntity | denotes | EGF | http://purl.obolibrary.org/obo/CHEBI_140739 | |
| T8 | 617-634 | ChemicalEntity | denotes | neurotransmitters | ChemicalEntity | |
| T4 | 188-197 | ChemicalEntity | denotes | threonine | http://purl.obolibrary.org/obo/CHEBI_26986 | |
| T7 | 605-616 | ChemicalEntity | denotes | GI-hormones | ChemicalEntity | |
| T6 | 516-533 | ChemicalEntity | denotes | neurotransmitters | ChemicalEntity | |
| T5 | 485-515 | ChemicalEntity | denotes | gastrointestinal (GI) hormones | ChemicalEntity | |
| T3 | 181-187 | ChemicalEntity | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 | |
| T2 | 26-43 | ChemicalEntity | denotes | neurotransmitters | ChemicalEntity | |
| T1 | 0-25 | ChemicalEntity | denotes | Gastrointestinal hormones | ChemicalEntity | |
| T41 | 1883-1887 | GeneOrGeneProduct | denotes | PAK2 | ||
| T75499 | 1812-1824 | GeneOrGeneProduct | denotes | small-GTPase | ||
| T59045 | 1771-1774 | GeneOrGeneProduct | denotes | PKC | ||
| T38 | 1762-1765 | GeneOrGeneProduct | denotes | PLC | ||
| T37 | 1668-1672 | GeneOrGeneProduct | denotes | PAK2 | ||
| T4836 | 1644-1648 | GeneOrGeneProduct | denotes | PI3K | ||
| T76996 | 1603-1606 | GeneOrGeneProduct | denotes | PKC | ||
| T35415 | 1596-1600 | GeneOrGeneProduct | denotes | Rac1 | ||
| T51326 | 147-169 | GeneOrGeneProduct | denotes | P-21-activated kinases | ||
| T64313 | 90-98 | GeneOrGeneProduct | denotes | kinase 2 | ||
| T77355 | 48-62 | GeneOrGeneProduct | denotes | growth factors | ||
| T4164 | 1590-1595 | GeneOrGeneProduct | denotes | CDC42 | ||
| T91295 | 1575-1588 | GeneOrGeneProduct | denotes | small GTPases | ||
| T80968 | 1566-1570 | GeneOrGeneProduct | denotes | PAK2 | ||
| T95853 | 1492-1496 | GeneOrGeneProduct | denotes | PAK2 | ||
| T73940 | 1479-1486 | GeneOrGeneProduct | denotes | Group-I | ||
| T28 | 1376-1383 | GeneOrGeneProduct | denotes | amylase | ||
| T18931 | 1354-1360 | GeneOrGeneProduct | denotes | ERK1/2 | ||
| T26 | 1306-1310 | GeneOrGeneProduct | denotes | PAK2 | ||
| T85992 | 1272-1285 | GeneOrGeneProduct | denotes | small-GTPases | ||
| T24 | 1256-1260 | GeneOrGeneProduct | denotes | PAK2 | ||
| T1066 | 1178-1182 | GeneOrGeneProduct | denotes | PI3K | ||
| T92479 | 1141-1144 | GeneOrGeneProduct | denotes | PKC | ||
| T21 | 1081-1085 | GeneOrGeneProduct | denotes | CCK1 | ||
| T20 | 1039-1043 | GeneOrGeneProduct | denotes | PAK2 | ||
| T53525 | 936-939 | GeneOrGeneProduct | denotes | PKC | ||
| T18 | 861-864 | GeneOrGeneProduct | denotes | PLC | ||
| T17 | 844-859 | GeneOrGeneProduct | denotes | phospholipase-C | ||
| T16 | 809-813 | GeneOrGeneProduct | denotes | bFGF | ||
| T96013 | 803-807 | GeneOrGeneProduct | denotes | PDGF | ||
| T10074 | 744-748 | GeneOrGeneProduct | denotes | PAK2 | ||
| T13 | 717-721 | GeneOrGeneProduct | denotes | PAK2 | ||
| T35996 | 670-674 | GeneOrGeneProduct | denotes | PAKs | ||
| T9803 | 662-669 | GeneOrGeneProduct | denotes | Group-I | ||
| T7920 | 453-457 | GeneOrGeneProduct | denotes | PAKs | ||
| T40733 | 280-284 | GeneOrGeneProduct | denotes | PAK4 | ||
| T83489 | 270-278 | GeneOrGeneProduct | denotes | group-II | ||
| T59808 | 262-266 | GeneOrGeneProduct | denotes | PAK1 | ||
| T11422 | 253-260 | GeneOrGeneProduct | denotes | group-I | ||
| T85347 | 181-205 | GeneOrGeneProduct | denotes | serine/threonine kinases | ||
| T38972 | 171-175 | GeneOrGeneProduct | denotes | PAKs | ||
| T59371 | 2142-2154 | DiseaseOrPhenotypicFeature | denotes | pancreatitis | D010195 | |
| T26555 | 1234-1237 | OrganismTaxon | denotes | IPA | ||
| T37501 | 558-561 | OrganismTaxon | denotes | rat |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 2113-2133 | Disease | denotes | pancreatic disorders | http://purl.obolibrary.org/obo/MONDO_0002356 |
| T2 | 2142-2154 | Disease | denotes | pancreatitis | http://purl.obolibrary.org/obo/MONDO_0004982 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 2142-2154 | Phenotype | denotes | pancreatitis | HP:0001733 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 558-561 | OrganismTaxon | denotes | rat | 10114|10116 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 102-125 | Body_part | denotes | pancreatic acinar cells | http://purl.obolibrary.org/obo/CL_0002064 |
| T2 | 562-578 | Body_part | denotes | pancreatic acini | http://purl.obolibrary.org/obo/UBERON_0001263 |
| T3 | 737-742 | Body_part | denotes | acini | http://purl.obolibrary.org/obo/UBERON_0009842 |
| T4 | 1444-1460 | Body_part | denotes | pancreatic acini | http://purl.obolibrary.org/obo/UBERON_0001263 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 102-125 | Cell | denotes | pancreatic acinar cells | http://purl.obolibrary.org/obo/CL:0002064 |