PubMed:25893979 JSONTXT

{"project":"maxiaofeng52_800","denotations":[{"id":"T1","span":{"begin":213,"end":247},"obj":"DP"},{"id":"T2","span":{"begin":437,"end":452},"obj":"DP"},{"id":"T3","span":{"begin":772,"end":787},"obj":"DP"},{"id":"T4","span":{"begin":1078,"end":1093},"obj":"DP"},{"id":"T5","span":{"begin":1375,"end":1390},"obj":"DP"},{"id":"T6","span":{"begin":99,"end":107},"obj":"CI"},{"id":"T7","span":{"begin":56,"end":97},"obj":"CI"},{"id":"T8","span":{"begin":119,"end":129},"obj":"CI"},{"id":"T9","span":{"begin":134,"end":181},"obj":"CI"},{"id":"T10","span":{"begin":183,"end":190},"obj":"CI"},{"id":"T11","span":{"begin":325,"end":333},"obj":"CI"},{"id":"T12","span":{"begin":282,"end":323},"obj":"CI"},{"id":"T13","span":{"begin":345,"end":355},"obj":"CI"},{"id":"T14","span":{"begin":360,"end":390},"obj":"CI"},{"id":"T15","span":{"begin":392,"end":409},"obj":"CI"},{"id":"T16","span":{"begin":411,"end":418},"obj":"CI"},{"id":"T17","span":{"begin":641,"end":649},"obj":"CI"},{"id":"T18","span":{"begin":923,"end":931},"obj":"CI"},{"id":"T19","span":{"begin":1167,"end":1175},"obj":"CI"},{"id":"T20","span":{"begin":692,"end":702},"obj":"CI"},{"id":"T21","span":{"begin":867,"end":877},"obj":"CI"},{"id":"T22","span":{"begin":1115,"end":1125},"obj":"CI"},{"id":"T23","span":{"begin":1335,"end":1345},"obj":"CI"},{"id":"T24","span":{"begin":708,"end":715},"obj":"CI"},{"id":"T25","span":{"begin":720,"end":727},"obj":"CI"},{"id":"T26","span":{"begin":883,"end":890},"obj":"CI"},{"id":"T27","span":{"begin":981,"end":988},"obj":"CI"},{"id":"T28","span":{"begin":1225,"end":1232},"obj":"CI"},{"id":"T29","span":{"begin":1131,"end":1138},"obj":"CI"},{"id":"T30","span":{"begin":1392,"end":1399},"obj":"CI"}],"text":"A randomised trial comparing the efficacy and safety of topical ketoprofen in Transfersome(®) gel (IDEA-033) with oral ketoprofen and drug-free ultra-deformable Sequessome™ vesicles (TDT 064) for the treatment of muscle soreness following exercise.\nWe compared the effectiveness of topical ketoprofen in Transfersome(®) gel (IDEA-033) with oral ketoprofen and drug-free Sequessome™ vesicles (FLEXISEQ(®) Sport; TDT 064) in reducing calf muscle soreness. One hundred and sixty eight healthy individuals with a pain score ≥3 (10-point scale) 12-16 h post-exercise (walking down stairs with an altitude of 300-400 m) were randomised to receive IDEA-033 plus oral placebo (two dose groups), oral ketoprofen plus TDT 064, or TDT 064 plus oral placebo. The primary endpoint was muscle soreness reduction from pre-dosing to Day 7. Higher pain scores were recorded with oral ketoprofen plus TDT 064 (mean ± s 462.4 ± 160.4) versus IDEA-033 plus oral placebo (434.7 ± 190.8; P = 0.2931) or TDT 064 plus oral placebo (376.2 ± 159.1; P = 0.0240) in the 7 days post-exercise. Recovery from muscle soreness was longer with oral ketoprofen plus TDT 064 (mean 91.0 ± 19.5 h) versus IDEA-033 plus placebo (mean 81.4 ± 22.9 h; P = 0.5964) or TDT 064 plus placebo (mean 78.9 ± 22.8 h; P = 0.0262). In conclusion, ultradeformable phospholipid vesicles ± ketoprofen did not retard recovery from muscle soreness. TDT 064 improves osteoarthritis-related pain and could be of interest as a treatment for joint pain during and post-exercise."}

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