PubMed:25881289 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/25881289","sourcedb":"PubMed","sourceid":"25881289","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/25881289","text":"STOPPIT Baby Follow-up Study: the effect of prophylactic progesterone in twin pregnancy on childhood outcome.\nOBJECTIVES: To determine the long-term effects of in utero progesterone exposure in twin children.\nMETHODS: This study evaluated the health and developmental outcomes of all surviving children born to mothers who participated in a double-blind, placebo-controlled trial of progesterone given for the prevention of preterm birth in twin pregnancies (STOPPIT, ISRCTN35782581). Follow-up was performed via record linkage and two parent-completed validated questionnaires, the Child Development Inventory and the Health Utilities Index.\nRESULTS: Record linkage was successfully performed on at least one record in 759/781 (97%) children eligible for follow-up. There were no differences between progesterone-exposed and placebo-exposed twins with respect to incidence of death, congenital anomalies and hospitalisation, nor on routine national child health assessments. Questionnaire responses were received for 324/738 (44%) children. The mean age at questionnaire follow-up was 55.5 months. Delay in at least one developmental domain on the Child Development Inventory was observed in 107/324 (33%) children, with no evidence of difference between progesterone-exposed and placebo-exposed twins. There was no evidence of difference between the progesterone and placebo groups in global health status assessed using the Health Utilities Index: 89% of children were rated as having 'excellent' health and a further 8% as having 'very good' health.\nCONCLUSIONS: In this cohort of twin children there was no evidence of a detrimental or beneficial impact on health and developmental outcomes at three to six years of age due to in utero exposure to progesterone.","tracks":[{"project":"yaoziqian_800_3","denotations":[{"id":"T1","span":{"begin":57,"end":69},"obj":"CI"},{"id":"T2","span":{"begin":169,"end":181},"obj":"CI"},{"id":"T3","span":{"begin":383,"end":395},"obj":"CI"},{"id":"T4","span":{"begin":801,"end":813},"obj":"CI"},{"id":"T5","span":{"begin":1256,"end":1268},"obj":"CI"},{"id":"T6","span":{"begin":1352,"end":1364},"obj":"CI"},{"id":"T7","span":{"begin":1753,"end":1765},"obj":"CI"},{"id":"T8","span":{"begin":826,"end":833},"obj":"CI"},{"id":"T9","span":{"begin":355,"end":362},"obj":"CI"},{"id":"T10","span":{"begin":1281,"end":1288},"obj":"CI"},{"id":"T11","span":{"begin":1369,"end":1376},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T2","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T3","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T4","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T5","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T6","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T7","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T8","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T9","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T10","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T11","pred":"source","obj":"yaoziqian_800_3"}]},{"project":"Zierdiyeerkenaili_800_3","denotations":[{"id":"T1","span":{"begin":383,"end":395},"obj":"CI"},{"id":"T2","span":{"begin":57,"end":69},"obj":"CI"},{"id":"T3","span":{"begin":169,"end":181},"obj":"CI"},{"id":"T4","span":{"begin":801,"end":813},"obj":"CI"},{"id":"T5","span":{"begin":1256,"end":1268},"obj":"CI"},{"id":"T6","span":{"begin":1352,"end":1364},"obj":"CI"},{"id":"T7","span":{"begin":1753,"end":1765},"obj":"CI"},{"id":"T8","span":{"begin":826,"end":833},"obj":"CI"},{"id":"T9","span":{"begin":355,"end":362},"obj":"CI"},{"id":"T10","span":{"begin":1281,"end":1288},"obj":"CI"},{"id":"T11","span":{"begin":1369,"end":1376},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T2","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T3","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T4","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T5","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T6","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T7","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T8","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T9","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T10","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T11","pred":"source","obj":"Zierdiyeerkenaili_800_3"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"yaoziqian_800_3","color":"#93ecd8","default":true},{"id":"Zierdiyeerkenaili_800_3","color":"#ecbe93"}]}]}}