> top > docs > PubMed:25874935 > annotations

PubMed:25874935 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Neuroprotective effect of neuroserpin in oxygen-glucose deprivation- and reoxygenation-treated rat astrocytes in vitro.
T2 120-287 Sentence denotes Neuroserpin (NSP) reportedly exerts neuroprotective effects in cerebral ischemic animal models and patients; however, the mechanism of protection is poorly understood.
T3 288-426 Sentence denotes We thus attempted to confirm neuroprotective effects of NSP on astrocytes in the ischemic state and then explored the relative mechanisms.
T4 427-542 Sentence denotes Astrocytes from neonatal rats were treated with oxygen-glucose deprivation (OGD) followed by reoxygenation (OGD/R).
T5 543-763 Sentence denotes To confirm the neuroprotective effects of NSP, we measured the cell survival rate, relative lactate dehydrogenase (LDH) release; we also performed morphological methods, namely Hoechst 33342 staining and Annexin V assay.
T6 764-932 Sentence denotes To explore the potential mechanisms of NSP, the release of nitric oxide (NO) and TNF-α related to NSP administration were measured by enzyme-linked immunosorbent assay.
T7 933-1036 Sentence denotes The proteins related to the NF-κB, ERK1/2, and PI3K/Akt pathways were investigated by Western blotting.
T8 1037-1228 Sentence denotes To verify the cause-and-effect relationship between neuroprotection and the NF-κB pathway, a NF-κB pathway inhibitor sc3060 was employed to observe the effects of NSP-induced neuroprotection.
T9 1229-1346 Sentence denotes We found that NSP significantly increased the cell survival rate and reduced LDH release in OGD/R-treated astrocytes.
T10 1347-1380 Sentence denotes It also reduced NO/TNF-α release.
T11 1381-1558 Sentence denotes Western blotting showed that the protein levels of p-IKKBα/β and P65 were upregulated by the OGD/R treatment and such effects were significantly inhibited by NSP administration.
T12 1559-1825 Sentence denotes The NSP-induced inhibition could be significantly reversed by administration of the NF-κB pathway inhibitor sc3060, whereas, expressions of p-ERK1, p-ERK2, and p-AKT were upregulated by the OGD/R treatment; however, their levels were unchanged by NSP administration.
T13 1826-1910 Sentence denotes Our results thus verified the neuroprotective effects of NSP in ischemic astrocytes.
T14 1911-2029 Sentence denotes The potential mechanisms include inhibition of the release of NO/TNF-α and repression of the NF-κB signaling pathways.
T15 2030-2118 Sentence denotes Our data also indicated that NSP has little influence on the MAPK and PI3K/Akt pathways.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 95-98 OrganismTaxon denotes rat NCBItxid:10116|NCBItxid:10114
T3 452-456 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
10537 26-37 GeneOrGeneProduct denotes neuroserpin NCBIGene:116459
10538 41-47 ChemicalEntity denotes oxygen MESH:D010100
10539 48-55 ChemicalEntity denotes glucose MESH:D005947
10540 95-98 OrganismTaxon denotes rat NCBITaxon:10116
10541 120-131 GeneOrGeneProduct denotes Neuroserpin NCBIGene:116459|NCBIGene:5274
10542 133-136 GeneOrGeneProduct denotes NSP NCBIGene:116459|NCBIGene:5274
10543 183-200 DiseaseOrPhenotypicFeature denotes cerebral ischemic MESH:D002545
10544 219-227 OrganismTaxon denotes patients NCBITaxon:9606
10545 344-347 GeneOrGeneProduct denotes NSP NCBIGene:116459
10546 369-377 DiseaseOrPhenotypicFeature denotes ischemic MESH:D007511
10547 452-456 OrganismTaxon denotes rats NCBITaxon:10116
10548 475-481 ChemicalEntity denotes oxygen MESH:D010100
10549 482-489 ChemicalEntity denotes glucose MESH:D005947
10550 585-588 GeneOrGeneProduct denotes NSP NCBIGene:116459
10551 635-656 GeneOrGeneProduct denotes lactate dehydrogenase NCBIGene:24533
10552 658-661 GeneOrGeneProduct denotes LDH NCBIGene:24533
10553 747-756 GeneOrGeneProduct denotes Annexin V NCBIGene:25673
10554 803-806 GeneOrGeneProduct denotes NSP NCBIGene:116459
10555 823-835 ChemicalEntity denotes nitric oxide MESH:D009569
10556 837-839 ChemicalEntity denotes NO MESH:D009569
10557 845-850 GeneOrGeneProduct denotes TNF-α NCBIGene:24835
10558 862-865 GeneOrGeneProduct denotes NSP NCBIGene:116459
10559 961-966 GeneOrGeneProduct denotes NF-κB NCBIGene:309165
10560 968-974 GeneOrGeneProduct denotes ERK1/2 NCBIGene:5594|NCBIGene:5595
10561 980-984 GeneOrGeneProduct denotes PI3K NCBIGene:298947
10562 985-988 GeneOrGeneProduct denotes Akt NCBIGene:24185
10563 1113-1118 GeneOrGeneProduct denotes NF-κB NCBIGene:309165
10564 1130-1135 GeneOrGeneProduct denotes NF-κB NCBIGene:309165
10565 1154-1160 ChemicalEntity denotes sc3060 MESH:C118258
10566 1200-1203 GeneOrGeneProduct denotes NSP NCBIGene:116459
10567 1243-1246 GeneOrGeneProduct denotes NSP NCBIGene:116459
10568 1306-1309 GeneOrGeneProduct denotes LDH NCBIGene:24533
10569 1363-1365 ChemicalEntity denotes NO MESH:D009569
10570 1366-1371 GeneOrGeneProduct denotes TNF-α NCBIGene:24835
10571 1434-1441 GeneOrGeneProduct denotes IKKBα/β NCBIGene:309361|NCBIGene:84351
10572 1446-1449 GeneOrGeneProduct denotes P65 NCBIGene:309165
10573 1539-1542 GeneOrGeneProduct denotes NSP NCBIGene:116459
10574 1563-1566 GeneOrGeneProduct denotes NSP NCBIGene:116459
10575 1643-1648 GeneOrGeneProduct denotes NF-κB NCBIGene:309165
10576 1667-1673 ChemicalEntity denotes sc3060 MESH:C118258
10577 1701-1705 GeneOrGeneProduct denotes ERK1 NCBIGene:50689
10578 1709-1713 GeneOrGeneProduct denotes ERK2 NCBIGene:116590
10579 1721-1724 GeneOrGeneProduct denotes AKT NCBIGene:24185
10580 1806-1809 GeneOrGeneProduct denotes NSP NCBIGene:116459
10581 1883-1886 GeneOrGeneProduct denotes NSP NCBIGene:116459
10582 1890-1898 DiseaseOrPhenotypicFeature denotes ischemic MESH:D007511
10583 1973-1975 ChemicalEntity denotes NO MESH:D009569
10584 1976-1981 GeneOrGeneProduct denotes TNF-α NCBIGene:24835
10585 2004-2009 GeneOrGeneProduct denotes NF-κB NCBIGene:309165
10586 2059-2062 GeneOrGeneProduct denotes NSP NCBIGene:116459
10587 2091-2095 GeneOrGeneProduct denotes MAPK NCBIGene:116590|NCBIGene:50689
10588 2100-2104 GeneOrGeneProduct denotes PI3K NCBIGene:298947
10589 2105-2108 GeneOrGeneProduct denotes Akt NCBIGene:24185

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 183-191 DiseaseOrPhenotypicFeature denotes cerebral 0002645

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 26-37 GeneOrGeneProduct denotes neuroserpin
T2 120-131 GeneOrGeneProduct denotes Neuroserpin
T3 133-136 GeneOrGeneProduct denotes NSP
T4 344-347 GeneOrGeneProduct denotes NSP
T5 585-588 GeneOrGeneProduct denotes NSP
T6 606-610 GeneOrGeneProduct denotes cell
T7 635-656 GeneOrGeneProduct denotes lactate dehydrogenase
T8 658-661 GeneOrGeneProduct denotes LDH
T9 747-756 GeneOrGeneProduct denotes Annexin V
T10 803-806 GeneOrGeneProduct denotes NSP
T11 862-865 GeneOrGeneProduct denotes NSP
T12 898-904 GeneOrGeneProduct denotes enzyme
T13 937-953 GeneOrGeneProduct denotes proteins related
T14 968-974 GeneOrGeneProduct denotes ERK1/2
T15 980-984 GeneOrGeneProduct denotes PI3K
T16 1144-1153 GeneOrGeneProduct denotes inhibitor
T17 1200-1203 GeneOrGeneProduct denotes NSP
T18 1243-1246 GeneOrGeneProduct denotes NSP
T19 1275-1279 GeneOrGeneProduct denotes cell
T20 1298-1305 GeneOrGeneProduct denotes reduced
T21 1306-1309 GeneOrGeneProduct denotes LDH
T22 1355-1362 GeneOrGeneProduct denotes reduced
T23 1414-1421 GeneOrGeneProduct denotes protein
T24 1434-1438 GeneOrGeneProduct denotes IKKB
T25 1539-1542 GeneOrGeneProduct denotes NSP
T26 1563-1566 GeneOrGeneProduct denotes NSP
T27 1657-1666 GeneOrGeneProduct denotes inhibitor
T28 1701-1705 GeneOrGeneProduct denotes ERK1
T29 1709-1713 GeneOrGeneProduct denotes ERK2
T30 1719-1724 GeneOrGeneProduct denotes p-AKT
T31 1806-1809 GeneOrGeneProduct denotes NSP
T32 1883-1886 GeneOrGeneProduct denotes NSP
T33 2059-2062 GeneOrGeneProduct denotes NSP
T34 2067-2073 GeneOrGeneProduct denotes little
T35 2091-2095 GeneOrGeneProduct denotes MAPK
T36 2100-2104 GeneOrGeneProduct denotes PI3K

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 26-37 GeneOrGeneProduct denotes neuroserpin
T2 120-131 GeneOrGeneProduct denotes Neuroserpin
T3 133-136 GeneOrGeneProduct denotes NSP
T4 344-347 GeneOrGeneProduct denotes NSP
T5 585-588 GeneOrGeneProduct denotes NSP
T6 606-610 GeneOrGeneProduct denotes cell
T7 635-656 GeneOrGeneProduct denotes lactate dehydrogenase
T8 658-661 GeneOrGeneProduct denotes LDH
T9 704-711 GeneOrGeneProduct denotes methods
T10 747-756 GeneOrGeneProduct denotes Annexin V
T11 803-806 GeneOrGeneProduct denotes NSP
T12 862-865 GeneOrGeneProduct denotes NSP
T13 898-904 GeneOrGeneProduct denotes enzyme
T14 905-911 GeneOrGeneProduct denotes linked
T15 937-953 GeneOrGeneProduct denotes proteins related
T16 968-974 GeneOrGeneProduct denotes ERK1/2
T17 980-984 GeneOrGeneProduct denotes PI3K
T18 1027-1035 GeneOrGeneProduct denotes blotting
T19 1144-1153 GeneOrGeneProduct denotes inhibitor
T20 1200-1203 GeneOrGeneProduct denotes NSP
T21 1204-1211 GeneOrGeneProduct denotes induced
T22 1243-1246 GeneOrGeneProduct denotes NSP
T23 1275-1279 GeneOrGeneProduct denotes cell
T24 1298-1305 GeneOrGeneProduct denotes reduced
T25 1306-1309 GeneOrGeneProduct denotes LDH
T26 1355-1362 GeneOrGeneProduct denotes reduced
T27 1389-1397 GeneOrGeneProduct denotes blotting
T28 1414-1421 GeneOrGeneProduct denotes protein
T29 1434-1438 GeneOrGeneProduct denotes IKKB
T30 1539-1542 GeneOrGeneProduct denotes NSP
T31 1563-1566 GeneOrGeneProduct denotes NSP
T32 1567-1574 GeneOrGeneProduct denotes induced
T33 1657-1666 GeneOrGeneProduct denotes inhibitor
T34 1701-1705 GeneOrGeneProduct denotes ERK1
T35 1709-1713 GeneOrGeneProduct denotes ERK2
T36 1719-1724 GeneOrGeneProduct denotes p-AKT
T37 1806-1809 GeneOrGeneProduct denotes NSP
T38 1883-1886 GeneOrGeneProduct denotes NSP
T39 2059-2062 GeneOrGeneProduct denotes NSP
T40 2067-2073 GeneOrGeneProduct denotes little
T41 2091-2095 GeneOrGeneProduct denotes MAPK
T42 2100-2104 GeneOrGeneProduct denotes PI3K

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 192-200 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T2 369-377 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T3 1890-1898 DiseaseOrPhenotypicFeature denotes ischemic DISEASE

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 26-37 GeneOrGeneProduct denotes neuroserpin
T2 120-131 GeneOrGeneProduct denotes Neuroserpin
T3 133-136 GeneOrGeneProduct denotes NSP
T4 344-347 GeneOrGeneProduct denotes NSP
T5 585-588 GeneOrGeneProduct denotes NSP
T6 635-656 GeneOrGeneProduct denotes lactate dehydrogenase
T7 658-661 GeneOrGeneProduct denotes LDH
T8 747-756 GeneOrGeneProduct denotes Annexin V
T9 803-806 GeneOrGeneProduct denotes NSP
T10 862-865 GeneOrGeneProduct denotes NSP
T11 937-953 GeneOrGeneProduct denotes proteins related
T12 968-974 GeneOrGeneProduct denotes ERK1/2
T13 980-984 GeneOrGeneProduct denotes PI3K
T14 985-988 GeneOrGeneProduct denotes Akt
T15 1200-1203 GeneOrGeneProduct denotes NSP
T16 1243-1246 GeneOrGeneProduct denotes NSP
T17 1306-1309 GeneOrGeneProduct denotes LDH
T18 1434-1438 GeneOrGeneProduct denotes IKKB
T19 1539-1542 GeneOrGeneProduct denotes NSP
T20 1563-1566 GeneOrGeneProduct denotes NSP
T21 1701-1705 GeneOrGeneProduct denotes ERK1
T22 1709-1713 GeneOrGeneProduct denotes ERK2
T23 1719-1724 GeneOrGeneProduct denotes p-AKT
T24 1806-1809 GeneOrGeneProduct denotes NSP
T25 1883-1886 GeneOrGeneProduct denotes NSP
T26 2059-2062 GeneOrGeneProduct denotes NSP
T27 2091-2095 GeneOrGeneProduct denotes MAPK
T28 2100-2104 GeneOrGeneProduct denotes PI3K
T29 2105-2108 GeneOrGeneProduct denotes Akt

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 503-506 DiseaseOrPhenotypicFeature denotes OGD 0008150
T2 535-538 DiseaseOrPhenotypicFeature denotes OGD 0008150
T3 1321-1324 DiseaseOrPhenotypicFeature denotes OGD 0008150
T4 1474-1477 DiseaseOrPhenotypicFeature denotes OGD 0008150
T5 1749-1752 DiseaseOrPhenotypicFeature denotes OGD 0008150

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 183-200 DiseaseOrPhenotypicFeature denotes cerebral ischemic DISEASE
T2 369-377 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T3 1890-1898 DiseaseOrPhenotypicFeature denotes ischemic DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 183-200 DiseaseOrPhenotypicFeature denotes cerebral ischemic DISEASE
T2 369-377 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T3 1890-1898 DiseaseOrPhenotypicFeature denotes ischemic DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 41-47 ChemicalEntity denotes oxygen D010100|http://purl.obolibrary.org/obo/CHEBI_25805
T3 48-55 ChemicalEntity denotes glucose D005947|http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234
T6 475-481 ChemicalEntity denotes oxygen D010100|http://purl.obolibrary.org/obo/CHEBI_25805
T8 482-489 ChemicalEntity denotes glucose D005947|http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234
T11 635-656 ChemicalEntity denotes lactate dehydrogenase D007770
T12 658-661 ChemicalEntity denotes LDH ChemicalEntity|D007770
T14 720-733 ChemicalEntity denotes Hoechst 33342 http://purl.obolibrary.org/obo/CHEBI_51232
T15 823-835 ChemicalEntity denotes nitric oxide D009569|http://purl.obolibrary.org/obo/CHEBI_16480
T17 1154-1160 ChemicalEntity denotes sc3060 ChemicalEntity
T18 1306-1309 ChemicalEntity denotes LDH ChemicalEntity|D007770
T20 1667-1673 ChemicalEntity denotes sc3060 ChemicalEntity

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 95-98 OrganismTaxon denotes rat
T2 219-227 OrganismTaxon denotes patients
T3 452-456 OrganismTaxon denotes rats

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T20 1667-1673 ChemicalEntity denotes sc3060 ChemicalEntity
T18 1306-1309 ChemicalEntity denotes LDH D007770|ChemicalEntity
T17 1154-1160 ChemicalEntity denotes sc3060 ChemicalEntity
T15 823-835 ChemicalEntity denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480|D009569
T14 720-733 ChemicalEntity denotes Hoechst 33342 http://purl.obolibrary.org/obo/CHEBI_51232
T12 658-661 ChemicalEntity denotes LDH D007770|ChemicalEntity
T11 635-656 ChemicalEntity denotes lactate dehydrogenase D007770
T8 482-489 ChemicalEntity denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167|D005947
T6 475-481 ChemicalEntity denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805|D010100
T3 48-55 ChemicalEntity denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167|D005947
T1 41-47 ChemicalEntity denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805|D010100
T29 2105-2108 GeneOrGeneProduct denotes Akt
T28 2100-2104 GeneOrGeneProduct denotes PI3K
T27 2091-2095 GeneOrGeneProduct denotes MAPK
T26 2059-2062 GeneOrGeneProduct denotes NSP
T25 1883-1886 GeneOrGeneProduct denotes NSP
T24 1806-1809 GeneOrGeneProduct denotes NSP
T23 1719-1724 GeneOrGeneProduct denotes p-AKT
T22 1709-1713 GeneOrGeneProduct denotes ERK2
T21 1701-1705 GeneOrGeneProduct denotes ERK1
T38541 1563-1566 GeneOrGeneProduct denotes NSP
T19 1539-1542 GeneOrGeneProduct denotes NSP
T72333 1434-1438 GeneOrGeneProduct denotes IKKB
T46153 1306-1309 GeneOrGeneProduct denotes LDH
T16 1243-1246 GeneOrGeneProduct denotes NSP
T15835 1200-1203 GeneOrGeneProduct denotes NSP
T99723 985-988 GeneOrGeneProduct denotes Akt
T13 980-984 GeneOrGeneProduct denotes PI3K
T59057 968-974 GeneOrGeneProduct denotes ERK1/2
T91413 937-953 GeneOrGeneProduct denotes proteins related
T10 862-865 GeneOrGeneProduct denotes NSP
T9 803-806 GeneOrGeneProduct denotes NSP
T9001 747-756 GeneOrGeneProduct denotes Annexin V
T7 658-661 GeneOrGeneProduct denotes LDH
T53613 635-656 GeneOrGeneProduct denotes lactate dehydrogenase
T5 585-588 GeneOrGeneProduct denotes NSP
T4 344-347 GeneOrGeneProduct denotes NSP
T15556 133-136 GeneOrGeneProduct denotes NSP
T2 120-131 GeneOrGeneProduct denotes Neuroserpin
T65847 26-37 GeneOrGeneProduct denotes neuroserpin
T43588 1890-1898 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T89477 369-377 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T76317 183-200 DiseaseOrPhenotypicFeature denotes cerebral ischemic DISEASE
T57612 452-456 OrganismTaxon denotes rats
T22481 219-227 OrganismTaxon denotes patients
T13458 95-98 OrganismTaxon denotes rat