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PubMed:25854766 JSONTXT

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GoldHamster

Id Subject Object Predicate Lexical cue
T2 27-34 D027622 denotes saffron
T1 27-34 CHEBI:79068 denotes saffron
T5 58-69 3639 denotes doxorubicin
T3 58-69 D004317 denotes doxorubicin
T4 58-69 CHEBI:64816 denotes doxorubicin
T6 58-69 CHEBI:28748 denotes doxorubicin
T7 58-69 D004317 denotes doxorubicin
T9 91-97 813859 denotes rabbit
T8 91-97 D011817 denotes rabbit
T10 91-97 9986 denotes rabbit
T13 118-145 D015427 denotes ischemia-reperfusion injury
T14 118-145 D015427 denotes ischemia-reperfusion injury
T18 171-195 CHEBI:49322 denotes anthracycline antibiotic
T22 322-336 D066126 denotes cardiotoxicity
T23 322-336 D066126 denotes cardiotoxicity
T24 344-356 CHEBI:26519 denotes free radical
T26 450-457 CHEBI:79068 denotes saffron
T28 450-465 D027622 denotes saffron (Crocus
T29 450-465 82528 denotes saffron (Crocus
T31 459-473 D027622 denotes Crocus sativus
T32 459-473 82528 denotes Crocus sativus
T33 510-524 D066126 denotes cardiotoxicity
T34 510-524 D066126 denotes cardiotoxicity
T36 537-543 813859 denotes rabbit
T35 537-543 D011817 denotes rabbit
T37 537-543 9986 denotes rabbit
T38 567-570 CVCL_E777 denotes min
T39 578-586 D007511 denotes ischemia
T40 578-586 D007511 denotes ischemia
T41 596-601 CVCL_XH58 denotes by 40
T42 602-605 CVCL_E777 denotes min
T44 673-680 D027622 denotes saffron
T43 673-680 CHEBI:79068 denotes saffron
T45 689-692 CVCL_E777 denotes min
T46 700-708 D007511 denotes ischemia
T47 700-708 D007511 denotes ischemia
T48 854-857 PR:000029189 denotes AKT
T49 854-857 PR:P54644 denotes AKT
T50 854-857 PR:P31750 denotes AKT
T51 854-857 PR:000002190 denotes AKT
T52 854-857 Q8INB9 denotes AKT
T53 858-862 PR:A1Z8P9 denotes mTOR
T54 858-862 Q9JLN9 denotes mTOR
T55 858-862 PR:P42345 denotes mTOR
T56 858-862 P42346 denotes mTOR
T57 858-862 P42345 denotes mTOR
T58 858-862 PR:000003041 denotes mTOR
T59 858-862 PR:Q9JLN9 denotes mTOR
T60 858-862 PR:P42346 denotes mTOR
T72 864-868 PR:P50580 denotes EBP1
T73 864-868 PR:000001754 denotes EBP1
T74 864-868 PR:Q96327 denotes EBP1
T75 864-868 PR:000012202 denotes EBP1
T76 864-868 P25799 denotes EBP1
T77 864-868 PR:Q9UQ80 denotes EBP1
T78 864-868 P19838 denotes EBP1
T79 864-868 Q63369 denotes EBP1
T80 869-876 CHEBI:34922 denotes pathway
T109 892-900 O62618 denotes p38 MAPK
T108 892-900 D048051 denotes p38 MAPK
T114 896-900 GO:0004707 denotes MAPK
T118 913-923 Q9XZ71 denotes troponin T
T120 913-923 Q27371 denotes troponin T
T119 913-923 D020107 denotes troponin T
T121 1011-1014 CVCL_E777 denotes min
T122 1049-1055 UBERON:0000479 denotes tissue
T124 1115-1122 D027622 denotes saffron
T123 1115-1122 CHEBI:79068 denotes saffron
T125 1264-1272 D007511 denotes ischemia
T126 1264-1272 D007511 denotes ischemia
T128 1321-1328 D027622 denotes saffron
T127 1321-1328 CHEBI:79068 denotes saffron
T130 1362-1372 Q9XZ71 denotes troponin T
T132 1362-1372 Q27371 denotes troponin T
T131 1362-1372 D020107 denotes troponin T
T133 1373-1381 CHEBI:36080 denotes proteins
T162 1397-1405 O62618 denotes p38 MAPK
T161 1397-1405 D048051 denotes p38 MAPK
T167 1401-1405 GO:0004707 denotes MAPK
T170 1406-1413 CHEBI:34922 denotes pathway
T171 1433-1436 PR:000029189 denotes AKT
T172 1433-1436 PR:P54644 denotes AKT
T173 1433-1436 PR:P31750 denotes AKT
T174 1433-1436 PR:000002190 denotes AKT
T175 1433-1436 Q8INB9 denotes AKT
T176 1437-1441 PR:A1Z8P9 denotes mTOR
T177 1437-1441 Q9JLN9 denotes mTOR
T178 1437-1441 PR:P42345 denotes mTOR
T179 1437-1441 P42346 denotes mTOR
T180 1437-1441 P42345 denotes mTOR
T181 1437-1441 PR:000003041 denotes mTOR
T182 1437-1441 PR:Q9JLN9 denotes mTOR
T183 1437-1441 PR:P42346 denotes mTOR
T195 1443-1447 PR:P50580 denotes EBP1
T196 1443-1447 PR:000001754 denotes EBP1
T197 1443-1447 PR:Q96327 denotes EBP1
T198 1443-1447 PR:000012202 denotes EBP1
T199 1443-1447 P25799 denotes EBP1
T200 1443-1447 PR:Q9UQ80 denotes EBP1
T201 1443-1447 P19838 denotes EBP1
T202 1443-1447 Q63369 denotes EBP1
T203 1448-1455 CHEBI:34922 denotes pathway
T204 1488-1494 D011817 denotes rabbit
T206 1488-1494 9986 denotes rabbit
T205 1488-1494 813859 denotes rabbit
T208 1518-1525 D027622 denotes saffron
T207 1518-1525 CHEBI:79068 denotes saffron
T209 1551-1562 CHEBI:22586 denotes antioxidant
T210 1643-1657 D066126 denotes cardiotoxicity
T211 1643-1657 D066126 denotes cardiotoxicity

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 147-274 DRI_Background denotes Doxorubicin (DOX) is an anthracycline antibiotic routinely used as a chemotherapeutic agent for the treatment of solid tumours.
T2 275-368 DRI_Background denotes However, DOX possesses an acute and cumulative cardiotoxicity due to free radical production.
T3 369-618 DRI_Background denotes The present study was designed to investigate the possible protective effects of saffron (Crocus sativus) extracts against DOX-induced acute cardiotoxicity in isolated rabbit hearts submitted to 30 min global ischemia followed by 40 min reperfusion.
T4 619-727 DRI_Background denotes DOX was delivered during reperfusion, without or with saffron given 5 min before ischemia or at reperfusion.
T5 728-805 DRI_Background denotes Cardiodynamic, biochemical, and histopathological parameters were determined.
T6 806-981 DRI_Outcome denotes In addition, to determine the expression of the AKT/mTOR/4EBP1 pathway, the levels of p38 MAPK and cardiac troponin T in heart homogenates were visualized by Western blotting.
T7 982-1096 DRI_Background denotes DOX administration during 40 min of reperfusion increased ischemic tissue damage, but did not act synergistically.
T8 1097-1273 DRI_Outcome denotes Administration of saffron extracts during the first minutes of reperfusion significantly reduced oxidative myocardial damage, but was less effective when given before ischemia.
T9 1274-1502 DRI_Outcome denotes Subsequent Western blot analysis revealed that saffron administration preserved cardiac troponin T proteins, inhibited the p38 MAPK pathway, and activated the AKT/mTOR/4EBP1 pathway in reperfusion- and DOX-treated rabbit hearts.
T10 1503-1683 DRI_Background denotes In conclusion, saffron extracts, acting through antioxidant and antiapoptotic mechanisms, exhibited a protective effect against DOX-induced cardiotoxicity under ischemic condition.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 168-170 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T2 168-170 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T3 214-215 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T4 298-300 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T5 298-300 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T6 564-566 CVCL_J925|Hybridoma|Mus musculus denotes 30
T7 567-570 CVCL_E777|Transformed_cell_line|Homo sapiens denotes min
T8 599-601 CVCL_IW90|Cancer_cell_line|Mus musculus denotes 40
T9 602-605 CVCL_E777|Transformed_cell_line|Homo sapiens denotes min
T10 689-692 CVCL_E777|Transformed_cell_line|Homo sapiens denotes min
T11 1008-1010 CVCL_IW90|Cancer_cell_line|Mus musculus denotes 40
T12 1011-1014 CVCL_E777|Transformed_cell_line|Homo sapiens denotes min
T13 1419-1428 CVCL_C410|Hybridoma|Mus musculus denotes activated
T14 1603-1604 CVCL_6479|Finite_cell_line|Mus musculus denotes a

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 266-273 HP_0002664 denotes tumours