PubMed:25818061
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/25818061","sourcedb":"PubMed","sourceid":"25818061","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/25818061","text":"Bupropion for the treatment of methamphetamine dependence in non-daily users: a randomized, double-blind, placebo-controlled trial.\nAIM: Bupropion was tested for efficacy to achieve methamphetamine (MA) abstinence in dependent, non-daily users.\nMETHODS: A randomized, double-blind, placebo-controlled trial, with 12-week treatment and 4-week follow-up, was conducted with 204 treatment-seeking participants having MA dependence per DSM-IV, who used MA on a less-than-daily basis. 104 were randomized to matched placebo and 100 to bupropion, sustained-release 150mg, twice daily. Participants were seen three times weekly to obtain urine for MA and bupropion assays, study assessments, and thrice weekly, 90-min, group psychotherapy. There was no biomarker for placebo adherence. The primary outcome was achievement of abstinence throughout the last two weeks of treatment; 'success' requiring at least two urine samples during each of Weeks 11 and 12, and all samples MA-negative (\u003c300ng/mL).\nRESULTS: Bupropion and placebo groups did not differ significantly in the percentage achieving abstinence for the last 2 weeks of treatment (chi-square, p=0.32). Subgroup analysis of participants with lower baseline MA use (≤18 of last 30 days before consent) also revealed no difference in success between groups (p=0.73). Medication adherence per protocol (detectable bupropion, \u003e5ng/mL, in ≥50% of urine samples from Study Weeks 1-10 and ≥66% of urine samples from Weeks 11 to 12) was achieved by 47% of participants taking bupropion.\nCONCLUSIONS: These data indicate that bupropion did not increase abstinence in dependent participants who were using MA less-than-daily. Medication non-adherence was a limitation in this trial. Psychosocial therapy remains the mainstay of treatment for MA dependence. Further research on subgroups who may respond to bupropion may be warranted.","tracks":[{"project":"maxiaofeng52_800","denotations":[{"id":"T1","span":{"begin":31,"end":46},"obj":"DP"},{"id":"T2","span":{"begin":182,"end":197},"obj":"DP"},{"id":"T3","span":{"begin":199,"end":201},"obj":"DP"},{"id":"T4","span":{"begin":0,"end":9},"obj":"CI"},{"id":"T5","span":{"begin":137,"end":146},"obj":"CI"},{"id":"T6","span":{"begin":530,"end":539},"obj":"CI"},{"id":"T7","span":{"begin":648,"end":657},"obj":"CI"},{"id":"T8","span":{"begin":1002,"end":1011},"obj":"CI"},{"id":"T9","span":{"begin":1363,"end":1372},"obj":"CI"},{"id":"T10","span":{"begin":1520,"end":1529},"obj":"CI"},{"id":"T11","span":{"begin":1569,"end":1578},"obj":"CI"},{"id":"T12","span":{"begin":1848,"end":1857},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"maxiaofeng52_800"},{"subj":"T2","pred":"source","obj":"maxiaofeng52_800"},{"subj":"T3","pred":"source","obj":"maxiaofeng52_800"},{"subj":"T4","pred":"source","obj":"maxiaofeng52_800"},{"subj":"T5","pred":"source","obj":"maxiaofeng52_800"},{"subj":"T6","pred":"source","obj":"maxiaofeng52_800"},{"subj":"T7","pred":"source","obj":"maxiaofeng52_800"},{"subj":"T8","pred":"source","obj":"maxiaofeng52_800"},{"subj":"T9","pred":"source","obj":"maxiaofeng52_800"},{"subj":"T10","pred":"source","obj":"maxiaofeng52_800"},{"subj":"T11","pred":"source","obj":"maxiaofeng52_800"},{"subj":"T12","pred":"source","obj":"maxiaofeng52_800"}]},{"project":"Zierdiyeerkenaili_800_3","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"CI"},{"id":"T2","span":{"begin":137,"end":146},"obj":"CI"},{"id":"T3","span":{"begin":1002,"end":1011},"obj":"CI"},{"id":"T4","span":{"begin":31,"end":57},"obj":"DP"},{"id":"T5","span":{"begin":414,"end":427},"obj":"DP"},{"id":"T6","span":{"begin":1784,"end":1797},"obj":"DP"},{"id":"T7","span":{"begin":282,"end":289},"obj":"CI"},{"id":"T8","span":{"begin":106,"end":113},"obj":"CI"},{"id":"T9","span":{"begin":511,"end":518},"obj":"CI"},{"id":"T10","span":{"begin":760,"end":767},"obj":"CI"},{"id":"T11","span":{"begin":1016,"end":1023},"obj":"CI"},{"id":"T12","span":{"begin":648,"end":657},"obj":"CI"},{"id":"T13","span":{"begin":530,"end":539},"obj":"CI"},{"id":"T14","span":{"begin":1363,"end":1372},"obj":"CI"},{"id":"T15","span":{"begin":1520,"end":1529},"obj":"CI"},{"id":"T16","span":{"begin":1569,"end":1578},"obj":"CI"},{"id":"T17","span":{"begin":1848,"end":1857},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T2","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T3","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T4","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T5","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T6","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T7","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T8","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T9","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T10","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T11","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T12","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T13","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T14","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T15","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T16","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T17","pred":"source","obj":"Zierdiyeerkenaili_800_3"}]},{"project":"yaoziqian_800_3","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"CI"},{"id":"T10","span":{"begin":1848,"end":1857},"obj":"CI"},{"id":"T2","span":{"begin":137,"end":146},"obj":"CI"},{"id":"T3","span":{"begin":1002,"end":1011},"obj":"CI"},{"id":"T5","span":{"begin":1520,"end":1529},"obj":"CI"},{"id":"T6","span":{"begin":1363,"end":1372},"obj":"CI"},{"id":"T7","span":{"begin":530,"end":539},"obj":"CI"},{"id":"T8","span":{"begin":648,"end":657},"obj":"CI"},{"id":"T9","span":{"begin":1569,"end":1578},"obj":"CI"},{"id":"T11","span":{"begin":106,"end":113},"obj":"CI"},{"id":"T12","span":{"begin":282,"end":289},"obj":"CI"},{"id":"T13","span":{"begin":511,"end":518},"obj":"CI"},{"id":"T14","span":{"begin":760,"end":767},"obj":"CI"},{"id":"T15","span":{"begin":1016,"end":1023},"obj":"CI"},{"id":"T16","span":{"begin":31,"end":57},"obj":"DP"},{"id":"T17","span":{"begin":414,"end":427},"obj":"DP"},{"id":"T18","span":{"begin":1784,"end":1797},"obj":"DP"}],"attributes":[{"subj":"T1","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T10","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T2","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T3","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T5","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T6","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T7","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T8","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T9","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T11","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T12","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T13","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T14","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T15","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T16","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T17","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T18","pred":"source","obj":"yaoziqian_800_3"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"maxiaofeng52_800","color":"#aa93ec","default":true},{"id":"Zierdiyeerkenaili_800_3","color":"#95ec93"},{"id":"yaoziqian_800_3","color":"#ec93af"}]}]}}