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PubMed:25804954 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T1 47-53 SO:0000985 denotes double
T2 54-64 SO:0000781 denotes transgenic
T3 54-70 D008822 denotes transgenic mouse
T6 87-92 PR:Q5S006 denotes LRRK2
T7 87-92 PR:000003033 denotes LRRK2
T8 87-92 PR:Q5S007 denotes LRRK2
T9 97-100 PR:P16525 denotes tau
T10 97-100 PR:000024142 denotes tau
T11 97-100 PR:P10636 denotes tau
T12 97-100 PR:000010173 denotes tau
T13 97-100 PR:P19332 denotes tau
T15 97-100 PR:P10637 denotes tau
T14 97-100 CHEBI:36355 denotes tau
T17 109-116 6308 denotes leucine
T18 109-116 SO:0001437 denotes leucine
T16 109-116 CHEBI:15603 denotes leucine
T19 109-116 D007930 denotes leucine
T20 109-116 CHEBI:25017 denotes leucine
T21 109-116 D007930 denotes leucine
T22 122-128 SO:0001068 denotes repeat
T27 192-211 D010300 denotes Parkinson's disease
T28 192-211 D010300 denotes Parkinson's disease
T31 218-229 GO:0005874 denotes Microtubule
T33 218-252 P19332 denotes Microtubule-associated protein tau
T34 218-252 PR:000010173 denotes Microtubule-associated protein tau
T35 218-252 P57786 denotes Microtubule-associated protein tau
T36 218-252 P29172 denotes Microtubule-associated protein tau
T37 218-252 P10636 denotes Microtubule-associated protein tau
T38 218-252 Q9MYX8 denotes Microtubule-associated protein tau
T39 218-252 Q6TS35 denotes Microtubule-associated protein tau
T40 218-252 Q5YCW0 denotes Microtubule-associated protein tau
T41 218-252 O02828 denotes Microtubule-associated protein tau
T42 218-252 Q5YCW1 denotes Microtubule-associated protein tau
T43 218-252 Q5S6V2 denotes Microtubule-associated protein tau
T44 218-252 P10637 denotes Microtubule-associated protein tau
T45 218-252 Q5YCV9 denotes Microtubule-associated protein tau
T50 241-248 SO:0000104 denotes protein
T46 241-248 GO:0003675 denotes protein
T51 241-252 D016875 denotes protein tau
T61 280-306 D019636 denotes neurodegenerative diseases
T62 280-306 D019636 denotes neurodegenerative diseases
T63 314-325 D024801 denotes tauopathies
T64 314-325 D024801 denotes tauopathies
T65 327-333 SO:0001026 denotes Genome
T67 378-387 P37379 denotes synuclein
T66 378-387 D051843 denotes synuclein
T68 410-413 PR:P16525 denotes tau
T69 410-413 PR:000024142 denotes tau
T70 410-413 PR:P10636 denotes tau
T71 410-413 PR:000010173 denotes tau
T72 410-413 PR:P19332 denotes tau
T74 410-413 PR:P10637 denotes tau
T73 410-413 CHEBI:36355 denotes tau
T75 414-418 SO:0000704 denotes gene
T76 510-515 PR:Q5S006 denotes LRRK2
T77 510-515 PR:000003033 denotes LRRK2
T78 510-515 PR:Q5S007 denotes LRRK2
T79 542-552 SO:0000781 denotes transgenic
T80 542-559 D030801 denotes transgenic animal
T81 553-559 UBERON:3010325 denotes animal
T82 553-559 UBERON:0000468 denotes animal
T83 570-575 PR:Q5S006 denotes LRRK2
T84 570-575 PR:000003033 denotes LRRK2
T85 570-575 PR:Q5S007 denotes LRRK2
T86 577-580 PR:P16525 denotes tau
T87 577-580 PR:000024142 denotes tau
T88 577-580 PR:P10636 denotes tau
T89 577-580 PR:000010173 denotes tau
T90 577-580 PR:P19332 denotes tau
T92 577-580 PR:P10637 denotes tau
T91 577-580 CHEBI:36355 denotes tau
T93 581-601 GO:0048151 denotes hyperphosphorylation
T95 633-642 P37379 denotes synuclein
T94 633-642 D051843 denotes synuclein
T96 749-754 PR:Q5S006 denotes LRRK2
T97 749-754 PR:000003033 denotes LRRK2
T98 749-754 PR:Q5S007 denotes LRRK2
T99 759-762 PR:P16525 denotes tau
T100 759-762 PR:000024142 denotes tau
T101 759-762 PR:P10636 denotes tau
T102 759-762 PR:000010173 denotes tau
T103 759-762 PR:P19332 denotes tau
T105 759-762 PR:P10637 denotes tau
T104 759-762 CHEBI:36355 denotes tau
T106 775-780 PR:Q5S006 denotes LRRK2
T107 775-780 PR:000003033 denotes LRRK2
T108 775-780 PR:Q5S007 denotes LRRK2
T109 786-791 C091422 denotes G BAC
T110 786-791 C091422 denotes G BAC
T111 788-791 SO:0000153 denotes BAC
T112 792-802 SO:0000781 denotes transgenic
T113 792-807 10090 denotes transgenic mice
T114 792-807 D008822 denotes transgenic mice
T115 803-807 PR:000005054 denotes mice
T117 803-807 O89094 denotes mice
T120 809-821 10090 denotes Mus musculus
T121 809-821 D051379 denotes Mus musculus
T122 813-821 UBERON:0005090 denotes musculus
T123 828-831 PR:P16525 denotes tau
T124 828-831 PR:000024142 denotes tau
T125 828-831 PR:P10636 denotes tau
T126 828-831 PR:000010173 denotes tau
T127 828-831 PR:P19332 denotes tau
T129 828-831 PR:P10637 denotes tau
T128 828-831 CHEBI:36355 denotes tau
T130 845-855 SO:0000781 denotes transgenic
T131 845-860 10090 denotes transgenic mice
T132 845-860 D008822 denotes transgenic mice
T133 856-860 PR:000005054 denotes mice
T135 856-860 O89094 denotes mice
T137 1012-1015 PR:P16525 denotes tau
T138 1012-1015 PR:000024142 denotes tau
T139 1012-1015 PR:P10636 denotes tau
T140 1012-1015 PR:000010173 denotes tau
T141 1012-1015 PR:P19332 denotes tau
T143 1012-1015 PR:P10637 denotes tau
T142 1012-1015 CHEBI:36355 denotes tau
T144 1016-1036 GO:0048151 denotes hyperphosphorylation
T145 1144-1147 PR:P16525 denotes tau
T146 1144-1147 PR:000024142 denotes tau
T147 1144-1147 PR:P10636 denotes tau
T148 1144-1147 PR:000010173 denotes tau
T149 1144-1147 PR:P19332 denotes tau
T151 1144-1147 PR:P10637 denotes tau
T150 1144-1147 CHEBI:36355 denotes tau
T152 1154-1158 PR:000005054 denotes mice
T154 1154-1158 O89094 denotes mice
T153 1154-1158 D051379 denotes mice
T155 1154-1158 10095 denotes mice
T156 1164-1170 SO:0000985 denotes double
T157 1178-1182 PR:000005054 denotes mice
T159 1178-1182 O89094 denotes mice
T158 1178-1182 D051379 denotes mice
T160 1178-1182 10095 denotes mice
T161 1204-1212 UBERON:0000104 denotes lifespan
T162 1242-1248 GO:0007613 denotes memory
T163 1242-1257 D008569 denotes memory deficits
T164 1242-1257 D008569 denotes memory deficits
T165 1303-1306 PR:P16525 denotes tau
T166 1303-1306 PR:000024142 denotes tau
T167 1303-1306 PR:P10636 denotes tau
T168 1303-1306 PR:000010173 denotes tau
T169 1303-1306 PR:P19332 denotes tau
T171 1303-1306 PR:P10637 denotes tau
T170 1303-1306 CHEBI:36355 denotes tau
T173 1312-1321 P37379 denotes synuclein
T172 1312-1321 D051843 denotes synuclein
T174 1323-1342 CL:0000700 denotes Dopaminergic neuron
T180 1378-1386 3628 denotes dopamine
T176 1378-1386 CHEBI:59905 denotes dopamine
T177 1378-1386 CHEBI:18243 denotes dopamine
T178 1378-1386 D004298 denotes dopamine
T179 1378-1386 D004298 denotes dopamine
T181 1395-1406 CHEBI:25212 denotes metabolites
T182 1504-1509 UBERON:6110636 denotes brain
T183 1504-1509 UBERON:0000955 denotes brain
T184 1546-1551 PR:Q5S006 denotes LRRK2
T185 1546-1551 PR:000003033 denotes LRRK2
T186 1546-1551 PR:Q5S007 denotes LRRK2
T187 1556-1559 PR:P16525 denotes tau
T188 1556-1559 PR:000024142 denotes tau
T189 1556-1559 PR:P10636 denotes tau
T190 1556-1559 PR:000010173 denotes tau
T191 1556-1559 PR:P19332 denotes tau
T193 1556-1559 PR:P10637 denotes tau
T192 1556-1559 CHEBI:36355 denotes tau
T194 1674-1679 PR:Q5S006 denotes LRRK2
T195 1674-1679 PR:000003033 denotes LRRK2
T196 1674-1679 PR:Q5S007 denotes LRRK2
T197 1684-1687 PR:P16525 denotes tau
T198 1684-1687 PR:000024142 denotes tau
T199 1684-1687 PR:P10636 denotes tau
T200 1684-1687 PR:000010173 denotes tau
T201 1684-1687 PR:P19332 denotes tau
T203 1684-1687 PR:P10637 denotes tau
T202 1684-1687 CHEBI:36355 denotes tau

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 192-201 HP_0001300 denotes Parkinson
T2 1647-1664 HP_0002180 denotes neurodegeneration

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 102-217 DRI_Approach denotes LRRK2 (leucine-rich repeat kinase) mutations constitute the most common cause of familial Parkinson's disease (PD).
T2 218-326 DRI_Challenge denotes Microtubule-associated protein tau mutations cause a group of neurodegenerative diseases termed tauopathies.
T3 327-473 DRI_Background denotes Genome-wide association studies show that, after α-synuclein, polymorphisms in the tau gene have the second strongest genetic association with PD.
T4 474-704 DRI_Outcome denotes In a proportion of PD patients with LRRK2 mutations, and in several transgenic animal models of LRRK2, tau hyperphosphorylation and aggregation, rather than α-synuclein aggregation, are the most prominent neuropathologic findings.
T5 705-774 DRI_Approach denotes To further examine the relationship between LRRK2 and tau, we crossed
T6 788-942 DRI_Approach denotes BAC transgenic mice (Mus musculus) with tau P301S mutant transgenic mice and characterized their behavioral, neuropathological and biochemical phenotypes.
T7 943-1159 DRI_Outcome denotes We found that the combination of the two mutations does not increase tau hyperphosphorylation or aggregation nor does it exacerbate the behavioral and pathological deficits previously described in the tau P301S mice.
T8 1160-1258 DRI_Outcome denotes The double-mutant mice had no shortening of lifespan and no worsening of motor or memory deficits.
T9 1259-1322 DRI_Outcome denotes There was no increase in the aggregation of tau or α-synuclein.
T10 1323-1422 DRI_Background denotes Dopaminergic neuron cell counts and striatal levels of dopamine and its metabolites were unaltered.
T11 1423-1518 DRI_Challenge denotes There was no exacerbation of cell loss, microgliosis or astrogliosis in multiple brain regions.
T12 1519-1750 DRI_Challenge denotes These results suggest that LRRK2 and tau do not interact to exacerbate behavioral, biochemical or pathological abnormalities in neurodegeneration and that LRRK2 and tau exert their pathogenic effects through independent mechanisms.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25804954-1#0#5#gene120892 102-107 gene120892 denotes LRRK2
25804954-1#90#109#diseaseC0030567 192-211 diseaseC0030567 denotes Parkinson's disease
25804954-1#111#113#diseaseC0030567 213-215 diseaseC0030567 denotes PD
25804954-2#0#34#gene4137 218-252 gene4137 denotes Microtubule-associated protein tau
25804954-2#62#88#diseaseC0524851 280-306 diseaseC0524851 denotes neurodegenerative diseases
25804954-2#96#107#diseaseC0949664 314-325 diseaseC0949664 denotes tauopathies
25804954-3#83#86#gene4137 410-413 gene4137 denotes tau
25804954-3#143#145#diseaseC0030567 470-472 diseaseC0030567 denotes PD
0#5#gene12089290#109#diseaseC0030567 25804954-1#0#5#gene120892 25804954-1#90#109#diseaseC0030567 associated_with LRRK2,Parkinson's disease
0#5#gene120892111#113#diseaseC0030567 25804954-1#0#5#gene120892 25804954-1#111#113#diseaseC0030567 associated_with LRRK2,PD
0#34#gene413762#88#diseaseC0524851 25804954-2#0#34#gene4137 25804954-2#62#88#diseaseC0524851 associated_with Microtubule-associated protein tau,neurodegenerative diseases
0#34#gene413796#107#diseaseC0949664 25804954-2#0#34#gene4137 25804954-2#96#107#diseaseC0949664 associated_with Microtubule-associated protein tau,tauopathies
83#86#gene4137143#145#diseaseC0030567 25804954-3#83#86#gene4137 25804954-3#143#145#diseaseC0030567 associated_with tau,PD