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GoldHamster

Id Subject Object Predicate Lexical cue
T1 22-35 CHEBI:29888 denotes pyrophosphate
T2 22-35 CHEBI:18361 denotes pyrophosphate
T3 22-35 C107241 denotes pyrophosphate
T4 22-35 C107241 denotes pyrophosphate
T6 39-51 UBERON:0002137 denotes aortic valve
T5 39-51 109730 denotes aortic valve
T8 78-81 1481724 denotes AND
T10 82-85 Q07108 denotes AIM
T11 82-85 PR:000006606 denotes AIM
T12 82-85 PR:P26358 denotes AIM
T13 82-85 PR:000001343 denotes AIM
T14 82-85 PR:Q92072 denotes AIM
T9 82-85 CHEBI:3416 denotes AIM
T16 100-112 UBERON:0002137 denotes Aortic valve
T15 100-112 109730 denotes Aortic valve
T18 289-292 CVCL_HC48 denotes AVs
T19 336-350 D010710 denotes orthophosphate
T20 336-350 CHEBI:18367 denotes orthophosphate
T21 336-350 D010710 denotes orthophosphate
T22 355-368 CHEBI:29888 denotes pyrophosphate
T23 355-368 CHEBI:18361 denotes pyrophosphate
T24 355-368 C107241 denotes pyrophosphate
T25 355-368 C107241 denotes pyrophosphate
T31 370-373 GO:0060134 denotes PPi
T28 370-373 P00784 denotes PPi
T26 370-373 CHEBI:35782 denotes PPi
T27 370-373 CHEBI:60614 denotes PPi
T29 370-373 CHEBI:18361 denotes PPi
T30 370-373 CHEBI:53266 denotes PPi
T32 421-443 D061205 denotes vascular calcification
T33 421-443 D061205 denotes vascular calcification
T34 491-496 UBERON:0001977 denotes serum
T43 694-706 CHEBI:40863 denotes Alizarin Red
T44 694-706 C010078 denotes Alizarin Red
T45 694-706 CHEBI:16866 denotes Alizarin Red
T46 694-706 C010078 denotes Alizarin Red
T47 703-706 PR:Q9Z1M8 denotes Red
T48 761-770 D010710 denotes phosphate
T49 761-770 CHEBI:26020 denotes phosphate
T50 761-770 CHEBI:14792 denotes phosphate
T51 761-770 CHEBI:35780 denotes phosphate
T52 761-770 CHEBI:18367 denotes phosphate
T53 761-770 CHEBI:26078 denotes phosphate
T54 761-770 D010710 denotes phosphate
T55 761-770 CHEBI:43474 denotes phosphate
T58 809-812 P00784 denotes PPi
T56 809-812 CHEBI:35782 denotes PPi
T57 809-812 CHEBI:60614 denotes PPi
T59 809-812 CHEBI:18361 denotes PPi
T60 809-812 CHEBI:53266 denotes PPi
T61 809-812 GO:0060134 denotes PPi
T62 818-838 P19147 denotes alkaline phosphatase
T63 818-838 P83456 denotes alkaline phosphatase
T65 818-838 PR:000023540 denotes alkaline phosphatase
T66 818-838 O60109 denotes alkaline phosphatase
T67 818-838 P21948 denotes alkaline phosphatase
T68 818-838 P00634 denotes alkaline phosphatase
T69 818-838 P86348 denotes alkaline phosphatase
T70 818-838 P81800 denotes alkaline phosphatase
T71 818-838 Q05205 denotes alkaline phosphatase
T64 818-838 D000469 denotes alkaline phosphatase
T72 827-838 GO:0016791 denotes phosphatase
T74 842-867 P57190 denotes inorganic pyrophosphatase
T75 842-867 Q92LH1 denotes inorganic pyrophosphatase
T76 842-867 Q5R8T6 denotes inorganic pyrophosphatase
T77 842-867 O69540 denotes inorganic pyrophosphatase
T78 842-867 Q8TMI3 denotes inorganic pyrophosphatase
T79 842-867 B0B8Z8 denotes inorganic pyrophosphatase
T80 842-867 Q6MVH7 denotes inorganic pyrophosphatase
T81 842-867 P77992 denotes inorganic pyrophosphatase
T82 842-867 Q8SR69 denotes inorganic pyrophosphatase
T83 842-867 Q9C0T9 denotes inorganic pyrophosphatase
T84 842-867 Q8PH18 denotes inorganic pyrophosphatase
T85 842-867 Q974Y8 denotes inorganic pyrophosphatase
T86 842-867 Q9RGQ1 denotes inorganic pyrophosphatase
T87 842-867 Q8KA31 denotes inorganic pyrophosphatase
T88 842-867 P75250 denotes inorganic pyrophosphatase
T89 842-867 O26363 denotes inorganic pyrophosphatase
T90 842-867 P65745 denotes inorganic pyrophosphatase
T91 842-867 P65744 denotes inorganic pyrophosphatase
T92 842-867 P38576 denotes inorganic pyrophosphatase
T93 842-867 Q6KZB3 denotes inorganic pyrophosphatase
T94 842-867 Q8DHR2 denotes inorganic pyrophosphatase
T95 842-867 Q9PHM9 denotes inorganic pyrophosphatase
T96 842-867 P44529 denotes inorganic pyrophosphatase
T97 842-867 P65747 denotes inorganic pyrophosphatase
T98 842-867 Q821T4 denotes inorganic pyrophosphatase
T99 842-867 Q9PLF1 denotes inorganic pyrophosphatase
T100 842-867 Q9YBA5 denotes inorganic pyrophosphatase
T101 842-867 P83777 denotes inorganic pyrophosphatase
T102 842-867 Q8TVE2 denotes inorganic pyrophosphatase
T103 842-867 Q5JIY3 denotes inorganic pyrophosphatase
T104 842-867 Q8NM79 denotes inorganic pyrophosphatase
T105 842-867 Q89WY0 denotes inorganic pyrophosphatase
T106 842-867 P37981 denotes inorganic pyrophosphatase
T107 842-867 Q9KP34 denotes inorganic pyrophosphatase
T108 842-867 Q5B912 denotes inorganic pyrophosphatase
T109 842-867 P56153 denotes inorganic pyrophosphatase
T110 842-867 Q6FRB7 denotes inorganic pyrophosphatase
T111 842-867 Q757J8 denotes inorganic pyrophosphatase
T112 842-867 P13998 denotes inorganic pyrophosphatase
T113 842-867 Q8FAG0 denotes inorganic pyrophosphatase
T114 842-867 P9WI54 denotes inorganic pyrophosphatase
T115 842-867 Q9X8I9 denotes inorganic pyrophosphatase
T116 842-867 Q68WE9 denotes inorganic pyrophosphatase
T117 842-867 O67501 denotes inorganic pyrophosphatase
T118 842-867 Q92H74 denotes inorganic pyrophosphatase
T119 842-867 PR:000013048 denotes inorganic pyrophosphatase
T120 842-867 P0A7B0 denotes inorganic pyrophosphatase
T121 842-867 O05724 denotes inorganic pyrophosphatase
T122 842-867 P00817 denotes inorganic pyrophosphatase
T123 842-867 Q7VPC0 denotes inorganic pyrophosphatase
T124 842-867 P65751 denotes inorganic pyrophosphatase
T125 842-867 Q88QF6 denotes inorganic pyrophosphatase
T126 842-867 Q15181 denotes inorganic pyrophosphatase
T127 842-867 Q8UC37 denotes inorganic pyrophosphatase
T128 842-867 Q9AC20 denotes inorganic pyrophosphatase
T129 842-867 P57918 denotes inorganic pyrophosphatase
T130 842-867 Q8EZ21 denotes inorganic pyrophosphatase
T131 842-867 Q54PV8 denotes inorganic pyrophosphatase
T132 842-867 Q9PQH6 denotes inorganic pyrophosphatase
T133 842-867 Q9ZCW5 denotes inorganic pyrophosphatase
T134 842-867 P19117 denotes inorganic pyrophosphatase
T135 842-867 Q8FMF8 denotes inorganic pyrophosphatase
T136 842-867 O13505 denotes inorganic pyrophosphatase
T137 842-867 Q9HSF3 denotes inorganic pyrophosphatase
T138 842-867 P59417 denotes inorganic pyrophosphatase
T139 842-867 Q8DE89 denotes inorganic pyrophosphatase
T140 842-867 Q8PWY5 denotes inorganic pyrophosphatase
T141 842-867 Q9K0G4 denotes inorganic pyrophosphatase
T142 842-867 Q9JVG3 denotes inorganic pyrophosphatase
T143 842-867 P0CAP8 denotes inorganic pyrophosphatase
T144 842-867 P19514 denotes inorganic pyrophosphatase
T145 842-867 P81987 denotes inorganic pyrophosphatase
T146 842-867 Q8XWX1 denotes inorganic pyrophosphatase
T147 842-867 P81988 denotes inorganic pyrophosphatase
T148 842-867 Q8EVW9 denotes inorganic pyrophosphatase
T149 842-867 P80562 denotes inorganic pyrophosphatase
T150 842-867 Q72MG4 denotes inorganic pyrophosphatase
T151 842-867 P9WI55 denotes inorganic pyrophosphatase
T152 842-867 P47593 denotes inorganic pyrophosphatase
T153 842-867 Q1RIN6 denotes inorganic pyrophosphatase
T154 842-867 P0A7A9 denotes inorganic pyrophosphatase
T155 842-867 O05545 denotes inorganic pyrophosphatase
T156 842-867 B0BAM7 denotes inorganic pyrophosphatase
T157 842-867 P51064 denotes inorganic pyrophosphatase
T158 842-867 Q9ZLL5 denotes inorganic pyrophosphatase
T159 842-867 Q8P5M4 denotes inorganic pyrophosphatase
T160 842-867 Q97W51 denotes inorganic pyrophosphatase
T161 842-867 Q4UKW0 denotes inorganic pyrophosphatase
T162 842-867 O77460 denotes inorganic pyrophosphatase
T163 842-867 P65749 denotes inorganic pyrophosphatase
T164 842-867 Q87SW1 denotes inorganic pyrophosphatase
T165 842-867 Q98Q96 denotes inorganic pyrophosphatase
T166 842-867 Q8GQS5 denotes inorganic pyrophosphatase
T167 842-867 P65748 denotes inorganic pyrophosphatase
T168 842-867 O84777 denotes inorganic pyrophosphatase
T169 842-867 Q6C1T4 denotes inorganic pyrophosphatase
T170 842-867 Q979E6 denotes inorganic pyrophosphatase
T171 842-867 Q74MY6 denotes inorganic pyrophosphatase
T172 842-867 Q8U438 denotes inorganic pyrophosphatase
T173 842-867 Q9KCG7 denotes inorganic pyrophosphatase
T174 842-867 O34955 denotes inorganic pyrophosphatase
T175 842-867 Q6ACP7 denotes inorganic pyrophosphatase
T176 842-867 Q6BWA5 denotes inorganic pyrophosphatase
T177 842-867 Q9UY24 denotes inorganic pyrophosphatase
T178 842-867 Q9D819 denotes inorganic pyrophosphatase
T179 842-867 P19371 denotes inorganic pyrophosphatase
T180 842-867 Q98ER2 denotes inorganic pyrophosphatase
T181 842-867 P37980 denotes inorganic pyrophosphatase
T182 842-867 P80887 denotes inorganic pyrophosphatase
T183 842-867 P58733 denotes inorganic pyrophosphatase
T184 842-867 Q7MPD2 denotes inorganic pyrophosphatase
T185 842-867 P80507 denotes inorganic pyrophosphatase
T186 842-867 D4GT97 denotes inorganic pyrophosphatase
T187 842-867 Q9HWZ6 denotes inorganic pyrophosphatase
T188 842-867 Q8ZB98 denotes inorganic pyrophosphatase
T189 842-867 P82992 denotes inorganic pyrophosphatase
T190 842-867 P65750 denotes inorganic pyrophosphatase
T191 842-867 Q3KKS0 denotes inorganic pyrophosphatase
T192 842-867 Q9Z6Y8 denotes inorganic pyrophosphatase
T194 842-867 O59570 denotes inorganic pyrophosphatase
T195 842-867 Q4R543 denotes inorganic pyrophosphatase
T196 842-867 Q8D274 denotes inorganic pyrophosphatase
T197 842-867 P50308 denotes inorganic pyrophosphatase
T193 842-867 D043564 denotes inorganic pyrophosphatase
T198 945-959 CHEBI:77383 denotes bisphosphonate
T201 960-970 42682 denotes etidronate
T199 960-970 D012968 denotes etidronate
T200 960-970 D012968 denotes etidronate
T202 960-970 CHEBI:4907 denotes etidronate
T205 1001-1004 P00784 denotes PPi
T203 1001-1004 CHEBI:35782 denotes PPi
T204 1001-1004 CHEBI:60614 denotes PPi
T206 1001-1004 CHEBI:18361 denotes PPi
T207 1001-1004 CHEBI:53266 denotes PPi
T208 1001-1004 GO:0060134 denotes PPi
T214 1024-1027 GO:0060134 denotes PPi
T211 1024-1027 P00784 denotes PPi
T209 1024-1027 CHEBI:35782 denotes PPi
T210 1024-1027 CHEBI:60614 denotes PPi
T212 1024-1027 CHEBI:18361 denotes PPi
T213 1024-1027 CHEBI:53266 denotes PPi
T217 1070-1073 PR:Q9LZC3 denotes MLS
T215 1070-1073 CVCL_RB32 denotes MLS
T216 1070-1073 C537466 denotes MLS
T218 1091-1100 CHEBI:35222 denotes inhibitor
T219 1104-1110 UBERON:0000479 denotes tissue
T220 1124-1144 P19147 denotes alkaline phosphatase
T221 1124-1144 P83456 denotes alkaline phosphatase
T223 1124-1144 PR:000023540 denotes alkaline phosphatase
T224 1124-1144 O60109 denotes alkaline phosphatase
T225 1124-1144 P21948 denotes alkaline phosphatase
T226 1124-1144 P00634 denotes alkaline phosphatase
T227 1124-1144 P86348 denotes alkaline phosphatase
T228 1124-1144 P81800 denotes alkaline phosphatase
T229 1124-1144 Q05205 denotes alkaline phosphatase
T222 1124-1144 D000469 denotes alkaline phosphatase
T230 1133-1144 GO:0016791 denotes phosphatase
T237 1187-1190 GO:0060134 denotes PPi
T234 1187-1190 P00784 denotes PPi
T232 1187-1190 CHEBI:35782 denotes PPi
T233 1187-1190 CHEBI:60614 denotes PPi
T235 1187-1190 CHEBI:18361 denotes PPi
T236 1187-1190 CHEBI:53266 denotes PPi
T238 1196-1209 GO:0005576 denotes extracellular
T240 1210-1213 318 denotes ATP
T239 1210-1213 D000255 denotes ATP
T241 1210-1213 CHEBI:30616 denotes ATP
T242 1210-1213 D000255 denotes ATP
T243 1210-1213 CHEBI:15422 denotes ATP
T244 1240-1249 CHEBI:29358 denotes methylene
T245 1240-1249 CHEBI:29357 denotes methylene
T247 1250-1253 318 denotes ATP
T246 1250-1253 D000255 denotes ATP
T248 1250-1253 CHEBI:30616 denotes ATP
T249 1250-1253 D000255 denotes ATP
T250 1250-1253 CHEBI:15422 denotes ATP
T251 1258-1267 CHEBI:35222 denotes inhibitor
T252 1304-1321 Q1M964 denotes phosphodiesterase
T253 1304-1321 Q45087 denotes phosphodiesterase
T254 1304-1321 GO:0008081 denotes phosphodiesterase
T255 1323-1326 CHEBI:7468 denotes NPP
T256 1323-1326 CHEBI:7525 denotes NPP
T257 1323-1327 PR:P25353 denotes NPP1
T258 1420-1433 GO:0005576 denotes extracellular
T264 1434-1437 GO:0060134 denotes PPi
T261 1434-1437 P00784 denotes PPi
T259 1434-1437 CHEBI:35782 denotes PPi
T260 1434-1437 CHEBI:60614 denotes PPi
T262 1434-1437 CHEBI:18361 denotes PPi
T263 1434-1437 CHEBI:53266 denotes PPi
T265 1460-1466 UBERON:0000479 denotes tissue
T266 1480-1489 CHEBI:35222 denotes inhibitor
T267 1532-1541 GO:0009058 denotes synthesis
T268 1543-1553 MOP:0000619 denotes hydrolysis
T271 1576-1579 P00784 denotes PPi
T269 1576-1579 CHEBI:35782 denotes PPi
T270 1576-1579 CHEBI:60614 denotes PPi
T272 1576-1579 CHEBI:18361 denotes PPi
T273 1576-1579 CHEBI:53266 denotes PPi
T274 1576-1579 GO:0060134 denotes PPi
T275 1643-1652 GO:0009058 denotes synthesis
T276 1666-1676 MOP:0000619 denotes hydrolysis
T277 1680-1693 CHEBI:29888 denotes pyrophosphate
T278 1680-1693 CHEBI:18361 denotes pyrophosphate
T279 1680-1693 C107241 denotes pyrophosphate
T280 1680-1693 C107241 denotes pyrophosphate
T281 1745-1760 D004164 denotes bisphosphonates
T282 1745-1760 CHEBI:77383 denotes bisphosphonates
T283 1745-1760 D004164 denotes bisphosphonates
T284 1764-1774 CHEBI:35222 denotes inhibitors

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 100-444 OBJECTIVE denotes Aortic valve (AV) calcification is a major cause of morbidity and mortality, yet the molecular mechanisms involved are poorly understood. Hence, an ex vivo model of calcification in intact AVs was developed in order to test the role of orthophosphate and pyrophosphate (PPi), both of which factors are known to influence vascular calcification.
T2 454-716 METHODS denotes Porcine AV leaflets were cultured in serum-free medium under static conditions for eight days, over which time leaflet architecture and viability were preserved. Calcification was measured as the incorporation of 45Ca, with confirmation by Alizarin Red staining.
T3 726-1329 RESULTS denotes Calcification required both a high phosphate concentration (3.8 mM) and removal of PPi with alkaline phosphatase or inorganic pyrophosphatase. Calcification occurred predominantly on the fibrosa and was arrested by the bisphosphonate etidronate, a non-hydrolyzable analog of PPi. Leaflets released PPi into the medium, and this was enhanced by MLS38949, a specific inhibitor of tissue non-specific alkaline phosphatase (TNAP). Furthermore, leaflets synthesized PPi from extracellular ATP, which was reduced by β,γ-methylene-ATP, an inhibitor of ectonucleotide pyrophosphorylase phosphodiesterase (NPP1).
T4 1342-1876 CONCLUSIONS denotes The ex vivo AV calcification model developed in the present study showed that extracellular PPi, produced by valvular tissue, is a potent inhibitor of valvular calcification. In addition to synthesis, hydrolysis by TNAP also controls PPi levels and calcification. The results suggest that a decreased synthesis or increased hydrolysis of pyrophosphate may contribute to valvular calcification, and that bisphosphonates or inhibitors of TNAP are potential preventive strategies of the process. TNAP are potential preventive strategies.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 135-136 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T2 245-247 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T3 245-247 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T4 289-292 CVCL_HC48|Transformed_cell_line|Oryctolagus cuniculus denotes AVs
T5 560-564 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T6 754-755 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T7 972-973 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T8 1080-1081 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T9 1255-1257 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T10 1255-1257 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T11 1471-1472 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T12 1631-1632 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T13 1694-1697 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 421-443 HP_0004934 denotes vascular calcification