PubMed:2580365 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/2580365","sourcedb":"PubMed","sourceid":"2580365","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/2580365","text":"alpha 1-Microglobulin determination in urine for the early detection of renal tubular dysfunctions caused by exposure to cadmium.\nThe determination of alpha 1-microglobulin (alpha 1-m) in urine was compared with that of beta 2-microglobulin (beta 2-m) for the detection of renal tubular dysfunctions caused by exposure to cadmium. alpha 1-m In urine is stable down to pH 4.5, whereas beta 2-m degrades below pH 5.5. The relationship between the urinary pH and alpha 1-m or beta 2-m in urine showed that alpha 1-m was independent of urinary pH, whereas beta 2-m-concentration decreased as urinary pH fell to a pH level below 6. Without a pH effect, alpha 1-m was highly correlated with beta 2-m in urine (N = 174, r = 0.96) from Cd-polluted subjects with renal dysfunctions. Due to the greater stability of alpha 1-m in urine, alpha 1-m seemed to be more advantageous than beta 2-m for the detection of renal tubular dysfunctions caused by Cd.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":273,"end":299},"obj":"HP_0000124"},{"id":"T2","span":{"begin":902,"end":928},"obj":"HP_0000124"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#ecb993","default":true}]}]}}