PubMed:25796077
Annnotations
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 221-230 | HP_0002090 | denotes | pneumonia |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 25796077-0#46#50#gene3576 | 46-50 | gene3576 | denotes | IL-8 |
| 25796077-0#69#106#diseaseC0035235 | 69-106 | diseaseC0035235 | denotes | respiratory syncytial virus infection |
| 25796077-6#21#25#gene1636 | 923-927 | gene1636 | denotes | DCP1 |
| 25796077-6#21#25#gene196513 | 923-927 | gene196513 | denotes | DCP1 |
| 25796077-6#59#63#gene3576 | 961-965 | gene3576 | denotes | IL-8 |
| 25796077-6#47#50#diseaseC0375023 | 949-952 | diseaseC0375023 | denotes | RSV |
| 25796077-6#47#50#diseaseC0375023 | 949-952 | diseaseC0375023 | denotes | RSV |
| 25796077-7#27#31#gene1636 | 1099-1103 | gene1636 | denotes | DCP1 |
| 25796077-7#27#31#gene196513 | 1099-1103 | gene196513 | denotes | DCP1 |
| 25796077-7#89#102#diseaseC0035235 | 1161-1174 | diseaseC0035235 | denotes | RSV infection |
| 46#50#gene357669#106#diseaseC0035235 | 25796077-0#46#50#gene3576 | 25796077-0#69#106#diseaseC0035235 | associated_with | IL-8,respiratory syncytial virus infection |
| 21#25#gene163647#50#diseaseC0375023 | 25796077-6#21#25#gene1636 | 25796077-6#47#50#diseaseC0375023 | associated_with | DCP1,RSV |
| 21#25#gene163647#50#diseaseC0375023 | 25796077-6#21#25#gene1636 | 25796077-6#47#50#diseaseC0375023 | associated_with | DCP1,RSV |
| 21#25#gene19651347#50#diseaseC0375023 | 25796077-6#21#25#gene196513 | 25796077-6#47#50#diseaseC0375023 | associated_with | DCP1,RSV |
| 21#25#gene19651347#50#diseaseC0375023 | 25796077-6#21#25#gene196513 | 25796077-6#47#50#diseaseC0375023 | associated_with | DCP1,RSV |
| 59#63#gene357647#50#diseaseC0375023 | 25796077-6#59#63#gene3576 | 25796077-6#47#50#diseaseC0375023 | associated_with | IL-8,RSV |
| 59#63#gene357647#50#diseaseC0375023 | 25796077-6#59#63#gene3576 | 25796077-6#47#50#diseaseC0375023 | associated_with | IL-8,RSV |
| 27#31#gene163689#102#diseaseC0035235 | 25796077-7#27#31#gene1636 | 25796077-7#89#102#diseaseC0035235 | associated_with | DCP1,RSV infection |
| 27#31#gene19651389#102#diseaseC0035235 | 25796077-7#27#31#gene196513 | 25796077-7#89#102#diseaseC0035235 | associated_with | DCP1,RSV infection |
DisGeNet-2017-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T31 | 923-927 | gene:1636 | denotes | DCP1 |
| T32 | 949-952 | disease:C0375023 | denotes | RSV |
| T33 | 1099-1103 | gene:1636 | denotes | DCP1 |
| T34 | 1161-1174 | disease:C0035235 | denotes | RSV infection |
| R1 | T31 | T32 | associated_with | DCP1,RSV |
| R2 | T31 | T32 | associated_with | DCP1,RSV |
| R3 | T33 | T34 | associated_with | DCP1,RSV infection |
| R4 | T33 | T34 | associated_with | DCP1,RSV infection |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-107 | Sentence | denotes | Decapping protein 1 phosphorylation modulates IL-8 expression during respiratory syncytial virus infection. |
| TextSentencer_T2 | 108-231 | Sentence | denotes | Respiratory syncytial virus (RSV) is a negative-strand RNA virus that is an important cause of bronchiolitis and pneumonia. |
| TextSentencer_T3 | 232-528 | Sentence | denotes | We investigated the effect of RSV infection on the expression patterns of cellular proteins involved in regulating mRNA translation and degradation, and found that a processing-body protein involved in mRNA degradation, decapping protein 1a (DCP1), was phosphorylated rapidly following infection. |
| TextSentencer_T4 | 529-696 | Sentence | denotes | UV-inactivated and sucrose-purified RSV were sufficient to mediate DCP1 phosphorylation, indicating that it occurs as a consequence of an early event in RSV infection. |
| TextSentencer_T5 | 697-811 | Sentence | denotes | Analysis using kinase inhibitors showed that RSV-induced DCP1 phosphorylation occurred through the ERK1/2 pathway. |
| TextSentencer_T6 | 812-901 | Sentence | denotes | The DCP1 phosphorylation sites were limited to serine 315, serine 319, and threonine 321. |
| TextSentencer_T7 | 902-1071 | Sentence | denotes | Overexpression of wt DCP1 led to a decrease in RSV-induced IL-8 production, but this effect was abrogated in cells overexpressing phosphorylation-deficient DCP1 mutants. |
| TextSentencer_T8 | 1072-1175 | Sentence | denotes | These results suggest that DCP1 phosphorylation modulates the host chemokine response to RSV infection. |
| T1 | 0-107 | Sentence | denotes | Decapping protein 1 phosphorylation modulates IL-8 expression during respiratory syncytial virus infection. |
| T2 | 108-231 | Sentence | denotes | Respiratory syncytial virus (RSV) is a negative-strand RNA virus that is an important cause of bronchiolitis and pneumonia. |
| T3 | 232-528 | Sentence | denotes | We investigated the effect of RSV infection on the expression patterns of cellular proteins involved in regulating mRNA translation and degradation, and found that a processing-body protein involved in mRNA degradation, decapping protein 1a (DCP1), was phosphorylated rapidly following infection. |
| T4 | 529-696 | Sentence | denotes | UV-inactivated and sucrose-purified RSV were sufficient to mediate DCP1 phosphorylation, indicating that it occurs as a consequence of an early event in RSV infection. |
| T5 | 697-811 | Sentence | denotes | Analysis using kinase inhibitors showed that RSV-induced DCP1 phosphorylation occurred through the ERK1/2 pathway. |
| T6 | 812-901 | Sentence | denotes | The DCP1 phosphorylation sites were limited to serine 315, serine 319, and threonine 321. |
| T7 | 902-1071 | Sentence | denotes | Overexpression of wt DCP1 led to a decrease in RSV-induced IL-8 production, but this effect was abrogated in cells overexpressing phosphorylation-deficient DCP1 mutants. |
| T8 | 1072-1175 | Sentence | denotes | These results suggest that DCP1 phosphorylation modulates the host chemokine response to RSV infection. |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 203-216 | http://purl.obolibrary.org/obo/UBERON_0002186 | denotes | bronchiolitis |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 203-216 | http://purl.obolibrary.org/obo/UBERON_0002186 | denotes | bronchiolitis |