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sentences

Id Subject Object Predicate Lexical cue
T1 0-139 Sentence denotes Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets.
T2 140-232 Sentence denotes Tyrosine kinase pathways are known to play an important role in the activation of platelets.
T3 233-406 Sentence denotes In particular, the GPVI and CLEC-2 receptors are known to activate Syk upon tyrosine phosphorylation of an immune tyrosine activation motif (ITAM) and hemITAM, respectively.
T4 407-510 Sentence denotes However, unlike GPVI, the CLEC-2 receptor contains only one tyrosine motif in the intracellular domain.
T5 511-593 Sentence denotes The mechanisms by which this receptor activates Syk are not completely understood.
T6 594-685 Sentence denotes In this study, we identified a novel signaling mechanism in CLEC-2-mediated Syk activation.
T7 686-872 Sentence denotes CLEC-2-mediated, but not GPVI-mediated, platelet activation and Syk phosphorylation were abolished by inhibition of PI3K, which demonstrates that PI3K regulates Syk downstream of CLEC-2.
T8 873-1023 Sentence denotes Ibrutinib, a Tec family kinase inhibitor, also completely abolished CLEC-2-mediated aggregation and Syk phosphorylation in human and murine platelets.
T9 1024-1207 Sentence denotes Furthermore, embryos lacking both Btk and Tec exhibited cutaneous edema associated with blood-filled vessels in a typical lymphatic pattern similar to CLEC-2 or Syk-deficient embryos.
T10 1208-1401 Sentence denotes Thus, our data show, for the first time, that PI3K and Tec family kinases play a crucial role in the regulation of platelet activation and Syk phosphorylation downstream of the CLEC-2 receptor.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1037-1044 http://purl.obolibrary.org/obo/MAT_0000226 denotes embryos
T2 1112-1117 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T3 1112-1117 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T4 1125-1132 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessels
T5 1199-1206 http://purl.obolibrary.org/obo/MAT_0000226 denotes embryos

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1090-1095 HP_0000969 denotes edema

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1037-1044 Body_part denotes embryos http://purl.obolibrary.org/obo/MAT_0000226
T2 1112-1117 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T4 1125-1132 Body_part denotes vessels http://purl.obolibrary.org/obo/MAT_0000393
T5 1199-1206 Body_part denotes embryos http://purl.obolibrary.org/obo/MAT_0000226

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1090-1095 Phenotype denotes edema HP:0000969

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-139 Sentence denotes Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets.
T2 140-232 Sentence denotes Tyrosine kinase pathways are known to play an important role in the activation of platelets.
T3 233-406 Sentence denotes In particular, the GPVI and CLEC-2 receptors are known to activate Syk upon tyrosine phosphorylation of an immune tyrosine activation motif (ITAM) and hemITAM, respectively.
T4 407-510 Sentence denotes However, unlike GPVI, the CLEC-2 receptor contains only one tyrosine motif in the intracellular domain.
T5 511-593 Sentence denotes The mechanisms by which this receptor activates Syk are not completely understood.
T6 594-685 Sentence denotes In this study, we identified a novel signaling mechanism in CLEC-2-mediated Syk activation.
T7 686-872 Sentence denotes CLEC-2-mediated, but not GPVI-mediated, platelet activation and Syk phosphorylation were abolished by inhibition of PI3K, which demonstrates that PI3K regulates Syk downstream of CLEC-2.
T8 873-1023 Sentence denotes Ibrutinib, a Tec family kinase inhibitor, also completely abolished CLEC-2-mediated aggregation and Syk phosphorylation in human and murine platelets.
T9 1024-1207 Sentence denotes Furthermore, embryos lacking both Btk and Tec exhibited cutaneous edema associated with blood-filled vessels in a typical lymphatic pattern similar to CLEC-2 or Syk-deficient embryos.
T10 1208-1401 Sentence denotes Thus, our data show, for the first time, that PI3K and Tec family kinases play a crucial role in the regulation of platelet activation and Syk phosphorylation downstream of the CLEC-2 receptor.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 996-1001 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 129-138 Body_part denotes platelets http://purl.obolibrary.org/obo/CL_0000233
T2 222-231 Body_part denotes platelets http://purl.obolibrary.org/obo/CL_0000233
T3 489-502 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T4 726-734 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T5 1013-1022 Body_part denotes platelets http://purl.obolibrary.org/obo/CL_0000233
T6 1112-1117 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T7 1323-1331 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 129-138 Cell denotes platelets http://purl.obolibrary.org/obo/CL:0000233
T2 222-231 Cell denotes platelets http://purl.obolibrary.org/obo/CL:0000233
T3 726-734 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T4 1013-1022 Cell denotes platelets http://purl.obolibrary.org/obo/CL:0000233
T5 1323-1331 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233