PubMed:25740757 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/25740757","sourcedb":"PubMed","sourceid":"25740757","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/25740757","text":"Effects of different parenteral nutrition infusions in a patient with short bowel syndrome.\nIn this case study, we demonstrate the effects of different lipid emulsions on liver function in a 52-year-old woman with short bowel syndrome who was totally dependent on parenteral nutrition. Over a 13-month period after small bowel resection and jejunostomy, we followed the patient's plasma triglycerides and liver enzyme levels as well as body weight and discomfort levels. During the first 3 months when parenteral nutrition including a lipid emulsion containing 50% soybean oil/50% medium-chain triglyerides was administered daily, the patient reported feeling unwell (experiencing dizziness and palpitations) and her triglycerides and liver enzyme levels rose to 366 mg/dL and 145 U/L (alanine aminotransferase [ALT]), respectively; these levels recovered when this emulsion was discontinued. For the following 9 months, an emulsion containing 80% olive oil and 20% soybean oil was administered, and the patient's triglycerides (182 mg/dL) did not increase to abnormal levels and liver enzyme levels were only mildly elevated (109 U/L). The patient felt well and her body weight increased from 51 kg to 55 kg during this period. These results suggest that parenteral nutrition with a reduced soybean oil content may better preserve liver function in patients with short bowel syndrome.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":695,"end":707},"obj":"HP_0001962"},{"id":"T2","span":{"begin":1060,"end":1085},"obj":"HP_0001392"},{"id":"T3","span":{"begin":1060,"end":1092},"obj":"HP_0002910"},{"id":"T4","span":{"begin":1167,"end":1188},"obj":"HP_0004324"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"}]},{"project":"PubCasesHPO","denotations":[{"id":"AB1","span":{"begin":695,"end":707},"obj":"HP:0001962"}],"attributes":[{"subj":"AB1","pred":"source","obj":"PubCasesHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#ec93a3","default":true},{"id":"PubCasesHPO","color":"#93bdec"}]}]}}