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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 124-446 DRI_Challenge denotes As the mechanisms underlying PKC activation induced arrhythmias are not yet fully verified, we investigated the role of gap junctions in arrhythmias induced by PKC activation.Arterially-perfused rabbit left ventricular preparations were randomly assigned to perfusion with phorbol ester (PMA) or in combination with AAP10.
T2 447-584 DRI_Outcome denotes Transmural ECG as well as action potentials from both endocardium and epicardium were simultaneously recorded throughout all experiments.
T3 585-617 DRI_Background denotes Changes in connexin43 (Cx43) and
T4 641-918 DRI_Background denotes on S368 were measured by Western blot analysis.In the PMA group, the QT interval was shortened, the interval from the peak to the end of the electrocardiographic T wave (Tp-e) and induced nonsustained ventricular tachycardia (VT) were increased, and the expressions of Cx43 and
T5 942-997 DRI_Background denotes on S368 were decreased compared with the control group.
T6 998-1095 DRI_Outcome denotes Compared with the PMA group, without significant changes in the QT interval and the expression of
T7 1125-1207 DRI_Outcome denotes on S368, Tp-e and induced VT decreased and the expression of Cx43 increased in the
T8 1226-1356 DRI_Outcome denotes can prevent PMA-induced rabbit ventricular arrhythmias by attenuating the increase of Tp-e and the decrease of expression of Cx43.
T9 1357-1474 DRI_Background denotes These data suggest that increasing gap junction coupling prevents arrhythmias induced by protein kinase C activation.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 76-77 CVCL_S361|Finite_cell_line|Mus musculus denotes C
T2 78-88 CVCL_C410|Hybridoma|Mus musculus denotes activation
T3 157-167 CVCL_C410|Hybridoma|Mus musculus denotes activation
T4 216-218 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T5 585-592 CVCL_0238|Cancer_cell_line|Homo sapiens denotes Changes
T6 759-763 CVCL_3772|Transformed_cell_line|Homo sapiens denotes peak
T7 1047-1054 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T8 1461-1462 CVCL_S361|Finite_cell_line|Mus musculus denotes C
T9 1463-1473 CVCL_C410|Hybridoma|Mus musculus denotes activation

GoldHamster

Id Subject Object Predicate Lexical cue
T1 0-22 C029579 denotes Antiarrhythmic peptide
T2 0-22 C029579 denotes Antiarrhythmic peptide
T3 15-22 SO:0001064 denotes peptide
T4 15-22 PR:000018264 denotes peptide
T6 15-22 PR:000018263 denotes peptide
T8 23-26 PR:P08697 denotes AAP
T9 23-26 P08521 denotes AAP
T11 23-26 P22702 denotes AAP
T12 23-26 B9W4V6 denotes AAP
T13 23-26 PR:000014706 denotes AAP
T15 23-28 C090806 denotes AAP10
T16 23-28 C090806 denotes AAP10
T21 61-68 SO:0000104 denotes protein
T17 61-68 GO:0003675 denotes protein
T23 61-77 Q25378 denotes protein kinase C
T24 61-77 PR:000045382 denotes protein kinase C
T26 61-77 P13678 denotes protein kinase C
T25 61-77 D011493 denotes protein kinase C
T27 61-88 GO:1990051 denotes protein kinase C activation
T29 92-98 813859 denotes rabbit
T28 92-98 D011817 denotes rabbit
T30 92-98 9986 denotes rabbit
T40 153-156 P34722 denotes PKC
T41 153-156 P13678 denotes PKC
T42 153-156 P05130 denotes PKC
T44 153-156 PR:000045382 denotes PKC
T43 153-156 GO:0004697 denotes PKC
T45 153-156 C537180 denotes PKC
T46 153-167 GO:1990051 denotes PKC activation
T49 244-247 SO:0000730 denotes gap
T47 244-247 PR:P09124 denotes gap
T48 244-247 PR:P34288 denotes gap
T50 284-287 P34722 denotes PKC
T51 284-287 P13678 denotes PKC
T52 284-287 P05130 denotes PKC
T54 284-287 PR:000045382 denotes PKC
T53 284-287 GO:0004697 denotes PKC
T55 284-287 C537180 denotes PKC
T56 284-298 GO:1990051 denotes PKC activation
T58 319-325 813859 denotes rabbit
T57 319-325 D011817 denotes rabbit
T59 319-325 9986 denotes rabbit
T63 397-410 CHEBI:37532 denotes phorbol ester
T65 412-415 CHEBI:53780 denotes PMA
T67 412-415 CHEBI:37537 denotes PMA
T68 412-415 CHEBI:60755 denotes PMA
T66 412-415 UBERON:2005088 denotes PMA
T70 440-443 PR:P08697 denotes AAP
T71 440-443 P08521 denotes AAP
T73 440-443 P22702 denotes AAP
T74 440-443 B9W4V6 denotes AAP
T75 440-443 PR:000014706 denotes AAP
T77 440-445 C090806 denotes AAP10
T78 440-445 C090806 denotes AAP10
T79 458-461 CHEBI:70255 denotes ECG
T80 501-512 UBERON:0002165 denotes endocardium
T81 517-527 UBERON:0002425 denotes epicardium
T82 517-527 UBERON:0002348 denotes epicardium
T83 596-604 GO:0005243 denotes connexin
T84 596-606 Q6TYA9 denotes connexin43
T85 596-606 O57474 denotes connexin43
T86 596-606 Q4R4S7 denotes connexin43
T87 596-606 P23242 denotes connexin43
T88 596-606 P17302 denotes connexin43
T89 596-606 Q29101 denotes connexin43
T90 596-606 Q6TYA8 denotes connexin43
T91 596-606 P14154 denotes connexin43
T92 596-606 Q6TYA7 denotes connexin43
T94 596-606 P08050 denotes connexin43
T95 596-606 A6XKM2 denotes connexin43
T96 596-606 Q6S9C0 denotes connexin43
T97 596-606 P16863 denotes connexin43
T98 596-606 PR:000008373 denotes connexin43
T99 596-606 P18246 denotes connexin43
T93 596-606 D018031 denotes connexin43
T100 608-612 Q6TYA9 denotes Cx43
T101 608-612 O57474 denotes Cx43
T102 608-612 Q4R4S7 denotes Cx43
T103 608-612 P23242 denotes Cx43
T104 608-612 P17302 denotes Cx43
T105 608-612 Q29101 denotes Cx43
T106 608-612 Q6TYA8 denotes Cx43
T107 608-612 P14154 denotes Cx43
T108 608-612 PR:O57474 denotes Cx43
T109 608-612 Q6TYA7 denotes Cx43
T111 608-612 P08050 denotes Cx43
T112 608-612 A6XKM2 denotes Cx43
T113 608-612 Q6S9C0 denotes Cx43
T114 608-612 P16863 denotes Cx43
T115 608-612 PR:000008373 denotes Cx43
T116 608-612 P18246 denotes Cx43
T110 608-612 D018031 denotes Cx43
T117 636-640 Q6TYA9 denotes Cx43
T118 636-640 O57474 denotes Cx43
T119 636-640 Q4R4S7 denotes Cx43
T120 636-640 P23242 denotes Cx43
T121 636-640 P17302 denotes Cx43
T122 636-640 Q29101 denotes Cx43
T123 636-640 Q6TYA8 denotes Cx43
T124 636-640 P14154 denotes Cx43
T125 636-640 PR:O57474 denotes Cx43
T126 636-640 Q6TYA7 denotes Cx43
T128 636-640 P08050 denotes Cx43
T129 636-640 A6XKM2 denotes Cx43
T130 636-640 Q6S9C0 denotes Cx43
T131 636-640 P16863 denotes Cx43
T132 636-640 PR:000008373 denotes Cx43
T133 636-640 P18246 denotes Cx43
T127 636-640 D018031 denotes Cx43
T135 695-698 UBERON:2005088 denotes PMA
T134 695-698 CHEBI:53780 denotes PMA
T136 695-698 CHEBI:37537 denotes PMA
T137 695-698 CHEBI:60755 denotes PMA
T138 842-865 D017180 denotes ventricular tachycardia
T139 842-865 D017180 denotes ventricular tachycardia
T142 910-914 Q6TYA9 denotes Cx43
T143 910-914 O57474 denotes Cx43
T144 910-914 Q4R4S7 denotes Cx43
T145 910-914 P23242 denotes Cx43
T146 910-914 P17302 denotes Cx43
T147 910-914 Q29101 denotes Cx43
T148 910-914 Q6TYA8 denotes Cx43
T149 910-914 P14154 denotes Cx43
T150 910-914 PR:O57474 denotes Cx43
T151 910-914 Q6TYA7 denotes Cx43
T153 910-914 P08050 denotes Cx43
T154 910-914 A6XKM2 denotes Cx43
T155 910-914 Q6S9C0 denotes Cx43
T156 910-914 P16863 denotes Cx43
T157 910-914 PR:000008373 denotes Cx43
T158 910-914 P18246 denotes Cx43
T152 910-914 D018031 denotes Cx43
T159 937-941 Q6TYA9 denotes Cx43
T160 937-941 O57474 denotes Cx43
T161 937-941 Q4R4S7 denotes Cx43
T162 937-941 P23242 denotes Cx43
T163 937-941 P17302 denotes Cx43
T164 937-941 Q29101 denotes Cx43
T165 937-941 Q6TYA8 denotes Cx43
T166 937-941 P14154 denotes Cx43
T167 937-941 PR:O57474 denotes Cx43
T168 937-941 Q6TYA7 denotes Cx43
T170 937-941 P08050 denotes Cx43
T171 937-941 A6XKM2 denotes Cx43
T172 937-941 Q6S9C0 denotes Cx43
T173 937-941 P16863 denotes Cx43
T174 937-941 PR:000008373 denotes Cx43
T175 937-941 P18246 denotes Cx43
T169 937-941 D018031 denotes Cx43
T177 1016-1019 UBERON:2005088 denotes PMA
T176 1016-1019 CHEBI:53780 denotes PMA
T178 1016-1019 CHEBI:37537 denotes PMA
T179 1016-1019 CHEBI:60755 denotes PMA
T180 1114-1122 GO:0005243 denotes connexin
T181 1114-1124 Q6TYA9 denotes connexin43
T182 1114-1124 O57474 denotes connexin43
T183 1114-1124 Q4R4S7 denotes connexin43
T184 1114-1124 P23242 denotes connexin43
T185 1114-1124 P17302 denotes connexin43
T186 1114-1124 Q29101 denotes connexin43
T187 1114-1124 Q6TYA8 denotes connexin43
T188 1114-1124 P14154 denotes connexin43
T189 1114-1124 Q6TYA7 denotes connexin43
T191 1114-1124 P08050 denotes connexin43
T192 1114-1124 A6XKM2 denotes connexin43
T193 1114-1124 Q6S9C0 denotes connexin43
T194 1114-1124 P16863 denotes connexin43
T195 1114-1124 PR:000008373 denotes connexin43
T196 1114-1124 P18246 denotes connexin43
T190 1114-1124 D018031 denotes connexin43
T197 1186-1190 Q6TYA9 denotes Cx43
T198 1186-1190 O57474 denotes Cx43
T199 1186-1190 Q4R4S7 denotes Cx43
T200 1186-1190 P23242 denotes Cx43
T201 1186-1190 P17302 denotes Cx43
T202 1186-1190 Q29101 denotes Cx43
T203 1186-1190 Q6TYA8 denotes Cx43
T204 1186-1190 P14154 denotes Cx43
T205 1186-1190 PR:O57474 denotes Cx43
T206 1186-1190 Q6TYA7 denotes Cx43
T208 1186-1190 P08050 denotes Cx43
T209 1186-1190 A6XKM2 denotes Cx43
T210 1186-1190 Q6S9C0 denotes Cx43
T211 1186-1190 P16863 denotes Cx43
T212 1186-1190 PR:000008373 denotes Cx43
T213 1186-1190 P18246 denotes Cx43
T207 1186-1190 D018031 denotes Cx43
T215 1208-1211 PR:P08697 denotes AAP
T216 1208-1211 P08521 denotes AAP
T218 1208-1211 P22702 denotes AAP
T219 1208-1211 B9W4V6 denotes AAP
T220 1208-1211 PR:000014706 denotes AAP
T222 1208-1213 C090806 denotes AAP10
T223 1208-1213 C090806 denotes AAP10
T225 1220-1223 PR:P08697 denotes AAP
T226 1220-1223 P08521 denotes AAP
T228 1220-1223 P22702 denotes AAP
T229 1220-1223 B9W4V6 denotes AAP
T230 1220-1223 PR:000014706 denotes AAP
T232 1220-1225 C090806 denotes AAP10
T233 1220-1225 C090806 denotes AAP10
T235 1238-1241 UBERON:2005088 denotes PMA
T234 1238-1241 CHEBI:53780 denotes PMA
T236 1238-1241 CHEBI:37537 denotes PMA
T237 1238-1241 CHEBI:60755 denotes PMA
T239 1250-1256 813859 denotes rabbit
T238 1250-1256 D011817 denotes rabbit
T240 1250-1256 9986 denotes rabbit
T241 1351-1355 Q6TYA9 denotes Cx43
T242 1351-1355 O57474 denotes Cx43
T243 1351-1355 Q4R4S7 denotes Cx43
T244 1351-1355 P23242 denotes Cx43
T245 1351-1355 P17302 denotes Cx43
T246 1351-1355 Q29101 denotes Cx43
T247 1351-1355 Q6TYA8 denotes Cx43
T248 1351-1355 P14154 denotes Cx43
T249 1351-1355 PR:O57474 denotes Cx43
T250 1351-1355 Q6TYA7 denotes Cx43
T252 1351-1355 P08050 denotes Cx43
T253 1351-1355 A6XKM2 denotes Cx43
T254 1351-1355 Q6S9C0 denotes Cx43
T255 1351-1355 P16863 denotes Cx43
T256 1351-1355 PR:000008373 denotes Cx43
T257 1351-1355 P18246 denotes Cx43
T251 1351-1355 D018031 denotes Cx43
T260 1392-1395 SO:0000730 denotes gap
T258 1392-1395 PR:P09124 denotes gap
T259 1392-1395 PR:P34288 denotes gap
T261 1392-1404 GO:0005921 denotes gap junction
T263 1396-1404 SO:0000699 denotes junction
T262 1396-1404 UBERON:0007651 denotes junction
T268 1446-1453 SO:0000104 denotes protein
T264 1446-1453 GO:0003675 denotes protein
T270 1446-1462 Q25378 denotes protein kinase C
T271 1446-1462 PR:000045382 denotes protein kinase C
T273 1446-1462 P13678 denotes protein kinase C
T272 1446-1462 D011493 denotes protein kinase C
T274 1446-1473 GO:1990051 denotes protein kinase C activation

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 176-187 HP_0011675 denotes arrhythmias
T2 261-272 HP_0011675 denotes arrhythmias
T3 842-865 HP_0004756 denotes ventricular tachycardia
T4 854-865 HP_0001649 denotes tachycardia
T5 1257-1280 HP_0004308 denotes ventricular arrhythmias
T6 1269-1280 HP_0011675 denotes arrhythmias
T7 1423-1434 HP_0011675 denotes arrhythmias