PubMed:25733690
Annnotations
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 231-248 | HP_0002894 | denotes | pancreatic cancer |
| T2 | 242-248 | HP_0002664 | denotes | cancer |
| T3 | 292-310 | HP_0002894 | denotes | pancreatic cancers |
| T4 | 303-310 | HP_0002664 | denotes | cancers |
| T5 | 380-386 | HP_0002664 | denotes | tumors |
| T6 | 625-632 | HP_0002664 | denotes | cancers |
| T7 | 705-712 | HP_0000618 | denotes | blinded |
| T8 | 829-836 | HP_0002664 | denotes | cancers |
| T9 | 946-953 | HP_0002664 | denotes | cancers |
| T10 | 1035-1053 | HP_0002894 | denotes | pancreatic cancers |
| T11 | 1046-1053 | HP_0002664 | denotes | cancers |
| T12 | 1292-1298 | HP_0002664 | denotes | tumors |
| T13 | 1623-1640 | HP_0002894 | denotes | pancreatic cancer |
| T14 | 1634-1640 | HP_0002664 | denotes | cancer |
| T15 | 1726-1743 | HP_0002894 | denotes | pancreatic cancer |
| T16 | 1737-1743 | HP_0002664 | denotes | cancer |
| T17 | 1886-1904 | HP_0002894 | denotes | pancreatic cancers |
| T18 | 1897-1904 | HP_0002664 | denotes | cancers |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 25733690-0#45#52#gene2526 | 45-52 | gene2526 | denotes | lewis x |
| 25733690-0#67#85#diseaseC0346647 | 67-85 | diseaseC0346647 | denotes | pancreatic cancers |
| 45#52#gene252667#85#diseaseC0346647 | 25733690-0#45#52#gene2526 | 25733690-0#67#85#diseaseC0346647 | associated_with | lewis x,pancreatic cancers |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 67-85 | Disease | denotes | pancreatic cancers | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T3 | 231-248 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T5 | 292-310 | Disease | denotes | pancreatic cancers | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T7 | 380-386 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T8 | 1035-1053 | Disease | denotes | pancreatic cancers | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T10 | 1069-1088 | Disease | denotes | pancreatic diseases | http://purl.obolibrary.org/obo/MONDO_0002356 |
| T11 | 1292-1298 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T12 | 1375-1396 | Disease | denotes | ductal adenocarcinoma | http://purl.obolibrary.org/obo/MONDO_0004953|http://purl.obolibrary.org/obo/MONDO_0005590 |
| T14 | 1623-1640 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T16 | 1726-1743 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T18 | 1886-1904 | Disease | denotes | pancreatic cancers | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 38-52 | Glycan | denotes | sialyl-lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T2 | 108-122 | Glycan | denotes | sialyl-lewis A | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T3 | 128-142 | Glycan | denotes | sialyl-Lewis A | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T4 | 144-148 | Glycan | denotes | sLeA | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T5 | 371-375 | Glycan | denotes | sLeA | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T6 | 423-427 | Glycan | denotes | sLeA | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T7 | 548-552 | Glycan | denotes | sLeA | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T8 | 560-574 | Glycan | denotes | sialyl-Lewis X | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T9 | 576-580 | Glycan | denotes | sLeX | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T10 | 616-620 | Glycan | denotes | sLeA | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T11 | 799-803 | Glycan | denotes | sLeX | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T12 | 863-867 | Glycan | denotes | sLeA | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T13 | 897-901 | Glycan | denotes | sLeA | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T14 | 914-918 | Glycan | denotes | sLeX | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T15 | 937-941 | Glycan | denotes | sLeA | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T16 | 992-996 | Glycan | denotes | sLeA | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T17 | 1001-1005 | Glycan | denotes | sLeX | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T18 | 1172-1176 | Glycan | denotes | sLeA | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T19 | 1263-1267 | Glycan | denotes | sLeX | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T20 | 1326-1330 | Glycan | denotes | sLeA | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T21 | 1512-1516 | Glycan | denotes | sLeA | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T22 | 1521-1525 | Glycan | denotes | sLeX | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 67-85 | Phenotype | denotes | pancreatic cancers | HP:0002894 |
| T2 | 231-248 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
| T3 | 292-310 | Phenotype | denotes | pancreatic cancers | HP:0002894 |
| T4 | 1035-1053 | Phenotype | denotes | pancreatic cancers | HP:0002894 |
| T5 | 1069-1088 | Phenotype | denotes | pancreatic diseases | HP:0001732 |
| T6 | 1623-1640 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
| T7 | 1726-1743 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
| T8 | 1886-1904 | Phenotype | denotes | pancreatic cancers | HP:0002894 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 45-52 | Glycan | denotes | lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00051MO |
| T2 | 135-142 | Glycan | denotes | Lewis A | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39023AU |
| T3 | 567-574 | Glycan | denotes | Lewis X | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00051MO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 38-52 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T2 | 128-142 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Lewis A | http://www.glycoepitope.jp/epitopes/EP0008 |
| T3 | 144-148 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T4 | 371-375 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T5 | 423-427 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T6 | 548-552 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T7 | 560-574 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Lewis X | http://www.glycoepitope.jp/epitopes/EP0012 |
| T8 | 576-580 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeX | http://www.glycoepitope.jp/epitopes/EP0012 |
| T9 | 616-620 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T10 | 799-803 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeX | http://www.glycoepitope.jp/epitopes/EP0012 |
| T11 | 863-867 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T12 | 897-901 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T13 | 914-918 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeX | http://www.glycoepitope.jp/epitopes/EP0012 |
| T14 | 937-941 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T15 | 992-996 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T16 | 1001-1005 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeX | http://www.glycoepitope.jp/epitopes/EP0012 |
| T17 | 1172-1176 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T18 | 1263-1267 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeX | http://www.glycoepitope.jp/epitopes/EP0012 |
| T19 | 1326-1330 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T20 | 1512-1516 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T21 | 1521-1525 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeX | http://www.glycoepitope.jp/epitopes/EP0012 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 67-85 | Phenotype | denotes | pancreatic cancers | HP:0002894 |
| T2 | 231-248 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
| T3 | 292-310 | Phenotype | denotes | pancreatic cancers | HP:0002894 |
| T4 | 1035-1053 | Phenotype | denotes | pancreatic cancers | HP:0002894 |
| T5 | 1069-1088 | Phenotype | denotes | pancreatic diseases | HP:0001732 |
| T6 | 1623-1640 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
| T7 | 1726-1743 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
| T8 | 1886-1904 | Phenotype | denotes | pancreatic cancers | HP:0002894 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1469-1477 | Organism | denotes | patients | 9606 |
| T2 | 1642-1648 | Organism | denotes | Précis | 311126 |
| T3 | 1782-1790 | Organism | denotes | patients | 9606 |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 38-52 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T2 | 128-142 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Lewis A | http://www.glycoepitope.jp/epitopes/EP0008 |
| T3 | 144-148 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T4 | 371-375 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T5 | 423-427 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T6 | 548-552 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T7 | 560-574 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Lewis X | http://www.glycoepitope.jp/epitopes/EP0012 |
| T8 | 576-580 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeX | http://www.glycoepitope.jp/epitopes/EP0012 |
| T9 | 616-620 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T10 | 799-803 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeX | http://www.glycoepitope.jp/epitopes/EP0012 |
| T11 | 863-867 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T12 | 897-901 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T13 | 914-918 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeX | http://www.glycoepitope.jp/epitopes/EP0012 |
| T14 | 937-941 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T15 | 992-996 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T16 | 1001-1005 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeX | http://www.glycoepitope.jp/epitopes/EP0012 |
| T17 | 1172-1176 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T18 | 1263-1267 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeX | http://www.glycoepitope.jp/epitopes/EP0012 |
| T19 | 1326-1330 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T20 | 1512-1516 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeA | http://www.glycoepitope.jp/epitopes/EP0008 |
| T21 | 1521-1525 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sLeX | http://www.glycoepitope.jp/epitopes/EP0012 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-123 | Sentence | denotes | Glycan motif profiling reveals plasma sialyl-lewis x elevations in pancreatic cancers that are negative for sialyl-lewis A. |
| T2 | 124-349 | Sentence | denotes | The sialyl-Lewis A (sLeA) glycan forms the basis of the CA19-9 assay and is the current best biomarker for pancreatic cancer, but because it is not elevated in ∼25% of pancreatic cancers, it is not useful for early diagnosis. |
| T3 | 350-468 | Sentence | denotes | We hypothesized that sLeA-low tumors secrete glycans that are related to sLeA but not detectable by CA19-9 antibodies. |
| T4 | 469-633 | Sentence | denotes | We used a method called motif profiling to predict that a structural isomer of sLeA called sialyl-Lewis X (sLeX) is elevated in the plasma of some sLeA-low cancers. |
| T5 | 634-732 | Sentence | denotes | We corroborated this prediction in a set of 48 plasma samples and in a blinded set of 200 samples. |
| T6 | 733-954 | Sentence | denotes | An antibody sandwich assay formed by the capture and detection of sLeX was elevated in 13 of 69 cancers that were not elevated in sLeA, and a novel hybrid assay of sLeA capture and sLeX detected 24 of 69 sLeA-low cancers. |
| T7 | 955-1249 | Sentence | denotes | A two-marker panel based on combined sLeA and sLeX detection differentiated 109 pancreatic cancers from 91 benign pancreatic diseases with 79% accuracy (74% sensitivity and 78% specificity), significantly better than sLeA alone, which yielded 68% accuracy (65% sensitivity and 71% specificity). |
| T8 | 1250-1397 | Sentence | denotes | Furthermore, sLeX staining was evident in tumors that do not elevate plasma sLeA, including those with poorly differentiated ductal adenocarcinoma. |
| T9 | 1398-1478 | Sentence | denotes | Thus, glycan-based biomarkers could characterize distinct subgroups of patients. |
| T10 | 1479-1641 | Sentence | denotes | In addition, the combined use of sLeA and sLeX, or related glycans, could lead to a biomarker panel that is useful in the clinical diagnosis of pancreatic cancer. |
| T11 | 1642-1649 | Sentence | denotes | Précis: |
| T12 | 1650-1905 | Sentence | denotes | This paper shows that a structural isomer of the current best biomarker for pancreatic cancer, CA19-9, is elevated in the plasma of patients who are low in CA19-9, potentially enabling more comprehensive detection and classification of pancreatic cancers. |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 67-85 | Disease | denotes | pancreatic cancers | MONDO:0005192|MONDO:0009831 |
| T3 | 231-248 | Disease | denotes | pancreatic cancer | MONDO:0005192|MONDO:0009831 |
| T5 | 292-310 | Disease | denotes | pancreatic cancers | MONDO:0005192|MONDO:0009831 |
| T7 | 1035-1053 | Disease | denotes | pancreatic cancers | MONDO:0005192|MONDO:0009831 |
| T9 | 1069-1088 | Disease | denotes | pancreatic diseases | MONDO:0002356 |
| T10 | 1375-1396 | Disease | denotes | ductal adenocarcinoma | MONDO:0004953|MONDO:0005590 |
| T12 | 1623-1640 | Disease | denotes | pancreatic cancer | MONDO:0005192|MONDO:0009831 |
| T14 | 1726-1743 | Disease | denotes | pancreatic cancer | MONDO:0005192|MONDO:0009831 |
| T16 | 1886-1904 | Disease | denotes | pancreatic cancers | MONDO:0005192|MONDO:0009831 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 31-37 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T2 | 601-607 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T3 | 681-687 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T4 | 1319-1325 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T5 | 1772-1778 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 31-37 | Body_part | denotes | plasma | FMA:62970 |
| T2 | 601-607 | Body_part | denotes | plasma | FMA:62970 |
| T3 | 681-687 | Body_part | denotes | plasma | FMA:62970 |
| T4 | 1319-1325 | Body_part | denotes | plasma | FMA:62970 |
| T5 | 1772-1778 | Body_part | denotes | plasma | FMA:62970 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1642-1648 | OrganismTaxon | denotes | Précis | 311126 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 31-37 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T2 | 601-607 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T3 | 681-687 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T4 | 1319-1325 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T5 | 1772-1778 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |