PubMed:25694232
Annnotations
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 89-188 | DRI_Background | denotes | Suncus murinus (house musk shrew; suncus) is a species of insectivore that has an ability to vomit. |
T2 | 189-347 | DRI_Background | denotes | Although longitudinal movement of the esophagus would be related to the emetic response, regulatory mechanisms for the suncus esophageal motility are unclear. |
T3 | 348-462 | DRI_Background | denotes | Therefore, the aim of the present study was to clarify components that regulate esophageal motility in the suncus. |
T4 | 463-613 | DRI_Background | denotes | An isolated segment of the suncus esophagus was placed in an organ bath, and longitudinal mechanical responses were recorded using a force transducer. |
T5 | 614-695 | DRI_Background | denotes | Electrical stimulation of the vagus trunk evoked a biphasic contractile response. |
T6 | 696-963 | DRI_Outcome | denotes | The first phase of the contractile response was blocked by α-bungarotoxin, a blocker of nicotinic acetylcholine receptors on striated muscle cells, whereas the second one was blocked by atropine, a blocker of muscarinic acetylcholine receptors on smooth muscle cells. |
T7 | 964-1061 | DRI_Approach | denotes | Next, we investigated whether mast cells are involved in motor functions of the suncus esophagus. |
T8 | 1062-1185 | DRI_Background | denotes | Application of a mast cell stimulator, compound 48/80, elicited contractile responses, which was resistant to tetrodotoxin. |
T9 | 1186-1265 | DRI_Background | denotes | Exogenous application of serotonin and histamine induced contractile responses. |
T10 | 1266-1443 | DRI_Background | denotes | The mast cell activation-mediated contraction was abolished by double desensitization by serotonin and histamine and pre-treatment with indomethacin, a cyclooxygenase inhibitor. |
T11 | 1444-1631 | DRI_Outcome | denotes | The findings show that cholinergic and non-cholinergic transmitters induce longitudinal contraction in the suncus esophagus, which might contribute to esophageal shortening during emesis. |
T12 | 1632-1819 | DRI_Background | denotes | Cholinergic transmitters are derived from vagal efferents, and non-cholinergic transmitters, which are thought to be serotonin, histamine and prostaglandins, are released from mast cells. |
Goldhamster2_Cellosaurus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 134-135 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T2 | 164-167 | CVCL_6758|Undefined_cell_line_type|Cricetulus griseus | denotes | has |
T3 | 164-167 | CVCL_E689|Transformed_cell_line|Homo sapiens | denotes | has |
T4 | 168-170 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
T5 | 168-170 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
T6 | 463-465 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | An |
T7 | 463-465 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | An |
T8 | 521-523 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
T9 | 521-523 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
T10 | 594-595 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T11 | 663-664 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T12 | 771-772 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T13 | 863-866 | CVCL_Z424|Spontaneously_immortalized_cell_line|Ostrinia nubilalis | denotes | one |
T14 | 892-893 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T15 | 970-972 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | we |
T16 | 994-998 | CVCL_M374|Cancer_cell_line|Homo sapiens | denotes | mast |
T17 | 1077-1078 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T18 | 1079-1083 | CVCL_M374|Cancer_cell_line|Homo sapiens | denotes | mast |
T19 | 1110-1112 | CVCL_J728|Hybridoma|Mus musculus | denotes | 48 |
T20 | 1270-1274 | CVCL_M374|Cancer_cell_line|Homo sapiens | denotes | mast |
T21 | 1280-1290 | CVCL_C410|Hybridoma|Mus musculus | denotes | activation |
T22 | 1416-1417 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T23 | 1808-1812 | CVCL_M374|Cancer_cell_line|Homo sapiens | denotes | mast |
GoldHamster
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 60-64 | O15146 | denotes | musk |
T2 | 60-64 | PR:O15146 | denotes | musk |
T3 | 60-64 | PR:Q62838 | denotes | musk |
T5 | 60-64 | Q62838 | denotes | musk |
T6 | 60-64 | Q61006 | denotes | musk |
T7 | 60-64 | PR:000010780 | denotes | musk |
T9 | 60-64 | PR:Q61006 | denotes | musk |
T10 | 60-64 | PR:Q8AXY6 | denotes | musk |
T11 | 60-64 | Q8AXY6 | denotes | musk |
T8 | 60-64 | UBERON:0013212 | denotes | musk |
T4 | 60-64 | C008563 | denotes | musk |
T12 | 60-64 | C008563 | denotes | musk |
T13 | 65-70 | D012788 | denotes | shrew |
T14 | 72-86 | 9378 | denotes | Suncus murinus |
T15 | 111-115 | O15146 | denotes | musk |
T16 | 111-115 | PR:O15146 | denotes | musk |
T17 | 111-115 | PR:Q62838 | denotes | musk |
T19 | 111-115 | Q62838 | denotes | musk |
T20 | 111-115 | Q61006 | denotes | musk |
T21 | 111-115 | PR:000010780 | denotes | musk |
T23 | 111-115 | PR:Q61006 | denotes | musk |
T24 | 111-115 | PR:Q8AXY6 | denotes | musk |
T25 | 111-115 | Q8AXY6 | denotes | musk |
T22 | 111-115 | UBERON:0013212 | denotes | musk |
T18 | 111-115 | C008563 | denotes | musk |
T26 | 111-115 | C008563 | denotes | musk |
T27 | 116-121 | D012788 | denotes | shrew |
T28 | 182-187 | UBERON:0000172 | denotes | vomit |
T29 | 227-236 | UBERON:0015232 | denotes | esophagus |
T30 | 227-236 | UBERON:0001043 | denotes | esophagus |
T31 | 475-482 | UBERON:0000914 | denotes | segment |
T32 | 497-506 | UBERON:0015232 | denotes | esophagus |
T33 | 497-506 | UBERON:0001043 | denotes | esophagus |
T34 | 524-529 | UBERON:0000062 | denotes | organ |
T35 | 524-529 | UBERON:0003103 | denotes | organ |
T36 | 644-649 | UBERON:0001759 | denotes | vagus |
T38 | 650-655 | UBERON:0002100 | denotes | trunk |
T39 | 650-655 | UBERON:0014479 | denotes | trunk |
T37 | 650-655 | GO:0043198 | denotes | trunk |
T40 | 784-817 | D011978 | denotes | nicotinic acetylcholine receptors |
T42 | 794-807 | 194 | denotes | acetylcholine |
T46 | 821-836 | UBERON:0002036 | denotes | striated muscle |
T51 | 882-890 | 1223 | denotes | atropine |
T49 | 882-890 | D001285 | denotes | atropine |
T50 | 882-890 | CHEBI:16684 | denotes | atropine |
T52 | 882-890 | CHEBI:57858 | denotes | atropine |
T53 | 882-890 | CHEBI:17486 | denotes | atropine |
T54 | 882-890 | CHEBI:48882 | denotes | atropine |
T55 | 882-890 | D001285 | denotes | atropine |
T56 | 905-939 | D011976 | denotes | muscarinic acetylcholine receptors |
T58 | 916-929 | 194 | denotes | acetylcholine |
T62 | 943-956 | UBERON:0001135 | denotes | smooth muscle |
T63 | 943-956 | UBERON:0000953 | denotes | smooth muscle |
T66 | 994-998 | PR:Q9NBD7 | denotes | mast |
T67 | 994-998 | PR:000008154 | denotes | mast |
T69 | 994-998 | Q9NBD7 | denotes | mast |
T70 | 994-998 | Q7TPM5 | denotes | mast |
T68 | 994-998 | CVCL_M374 | denotes | mast |
T71 | 1051-1060 | UBERON:0015232 | denotes | esophagus |
T72 | 1051-1060 | UBERON:0001043 | denotes | esophagus |
T73 | 1079-1083 | PR:Q9NBD7 | denotes | mast |
T74 | 1079-1083 | PR:000008154 | denotes | mast |
T76 | 1079-1083 | Q9NBD7 | denotes | mast |
T77 | 1079-1083 | Q7TPM5 | denotes | mast |
T75 | 1079-1083 | CVCL_M374 | denotes | mast |
T80 | 1079-1088 | CL:0000097 | denotes | mast cell |
T78 | 1079-1088 | D008415 | denotes | mast cell |
T79 | 1079-1088 | D008415 | denotes | mast cell |
T81 | 1101-1115 | D003189 | denotes | compound 48/80 |
T82 | 1101-1115 | D003189 | denotes | compound 48/80 |
T83 | 1101-1115 | CHEBI:75295 | denotes | compound 48/80 |
T84 | 1172-1184 | D013779 | denotes | tetrodotoxin |
T85 | 1172-1184 | D013779 | denotes | tetrodotoxin |
T86 | 1172-1184 | CHEBI:9506 | denotes | tetrodotoxin |
T87 | 1211-1220 | CHEBI:28790 | denotes | serotonin |
T88 | 1211-1220 | D012701 | denotes | serotonin |
T89 | 1211-1220 | CHEBI:350546 | denotes | serotonin |
T90 | 1211-1220 | D012701 | denotes | serotonin |
T92 | 1225-1234 | 5333 | denotes | histamine |
T91 | 1225-1234 | CHEBI:58432 | denotes | histamine |
T93 | 1225-1234 | CHEBI:18295 | denotes | histamine |
T94 | 1225-1234 | D006632 | denotes | histamine |
T95 | 1225-1234 | D006632 | denotes | histamine |
T96 | 1270-1274 | PR:Q9NBD7 | denotes | mast |
T97 | 1270-1274 | PR:000008154 | denotes | mast |
T99 | 1270-1274 | Q9NBD7 | denotes | mast |
T100 | 1270-1274 | Q7TPM5 | denotes | mast |
T98 | 1270-1274 | CVCL_M374 | denotes | mast |
T103 | 1270-1279 | CL:0000097 | denotes | mast cell |
T104 | 1270-1290 | GO:0045576 | denotes | mast cell activation |
T105 | 1270-1290 | D008415 | denotes | mast cell activation |
T106 | 1270-1290 | D008415 | denotes | mast cell activation |
T108 | 1329-1335 | SO:0000985 | denotes | double |
T109 | 1355-1364 | CHEBI:28790 | denotes | serotonin |
T110 | 1355-1364 | D012701 | denotes | serotonin |
T111 | 1355-1364 | CHEBI:350546 | denotes | serotonin |
T112 | 1355-1364 | D012701 | denotes | serotonin |
T114 | 1369-1378 | 5333 | denotes | histamine |
T113 | 1369-1378 | CHEBI:58432 | denotes | histamine |
T115 | 1369-1378 | CHEBI:18295 | denotes | histamine |
T116 | 1369-1378 | D006632 | denotes | histamine |
T117 | 1369-1378 | D006632 | denotes | histamine |
T120 | 1383-1386 | SO:0002045 | denotes | pre |
T119 | 1383-1386 | PR:Q8LLD0 | denotes | pre |
T121 | 1383-1386 | UBERON:0001782 | denotes | pre |
T118 | 1383-1386 | GO:0003904 | denotes | pre |
T122 | 1402-1414 | 5781 | denotes | indomethacin |
T123 | 1402-1414 | D007213 | denotes | indomethacin |
T124 | 1402-1414 | D007213 | denotes | indomethacin |
T125 | 1402-1414 | CHEBI:49662 | denotes | indomethacin |
T127 | 1418-1442 | CHEBI:35544 | denotes | cyclooxygenase inhibitor |
T129 | 1558-1567 | UBERON:0015232 | denotes | esophagus |
T130 | 1558-1567 | UBERON:0001043 | denotes | esophagus |
T131 | 1624-1630 | D014839 | denotes | emesis |
T132 | 1624-1630 | D014839 | denotes | emesis |
T133 | 1749-1758 | CHEBI:28790 | denotes | serotonin |
T134 | 1749-1758 | D012701 | denotes | serotonin |
T135 | 1749-1758 | CHEBI:350546 | denotes | serotonin |
T136 | 1749-1758 | D012701 | denotes | serotonin |
T138 | 1760-1769 | 5333 | denotes | histamine |
T137 | 1760-1769 | CHEBI:58432 | denotes | histamine |
T139 | 1760-1769 | CHEBI:18295 | denotes | histamine |
T140 | 1760-1769 | D006632 | denotes | histamine |
T141 | 1760-1769 | D006632 | denotes | histamine |
T142 | 1774-1788 | CHEBI:26333 | denotes | prostaglandins |
T143 | 1774-1788 | D011453 | denotes | prostaglandins |
T144 | 1774-1788 | D011453 | denotes | prostaglandins |
T145 | 1808-1812 | PR:Q9NBD7 | denotes | mast |
T146 | 1808-1812 | PR:000008154 | denotes | mast |
T148 | 1808-1812 | Q9NBD7 | denotes | mast |
T149 | 1808-1812 | Q7TPM5 | denotes | mast |
T147 | 1808-1812 | CVCL_M374 | denotes | mast |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 674-685 | HP_0001371 | denotes | contractile |
T2 | 719-730 | HP_0001371 | denotes | contractile |
T3 | 1126-1137 | HP_0001371 | denotes | contractile |
T4 | 1243-1254 | HP_0001371 | denotes | contractile |
T5 | 1300-1311 | HP_0001371 | denotes | contraction |
T6 | 1532-1543 | HP_0001371 | denotes | contraction |
T7 | 1624-1630 | HP_0002013 | denotes | emesis |