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PubMed:25675535 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-101 Sentence denotes Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.
TextSentencer_T2 102-200 Sentence denotes Colorectal cancers (CRCs) account for nearly 10% of all cancer deaths in industrialized countries.
TextSentencer_T3 201-328 Sentence denotes Recent evidence points to a central role for the nuclear receptor liver receptor homolog-1 (LRH-1) in intestinal tumorigenesis.
TextSentencer_T4 329-509 Sentence denotes Interaction of LRH-1 with the Wnt/β-catenin pathway, highly active in a critical subpopulation of CRC cells, underscores the importance of elucidating LRH-1's role in this disease.
TextSentencer_T5 510-679 Sentence denotes Reduction of LRH-1 diminishes tumor burden in murine models of CRC; however, it is not known whether LRH-1 is required for tumorigenesis, for proliferation, or for both.
TextSentencer_T6 680-791 Sentence denotes In this work, we address this question through shRNA-mediated silencing of LRH-1 in established CRC cell lines.
TextSentencer_T7 792-980 Sentence denotes LRH-1 mRNA knockdown results in significantly impaired proliferation in a cell line highly expressing the receptor and more modest impairment in a cell line with moderate LRH-1 expression.
TextSentencer_T8 981-1112 Sentence denotes Cell-cycle analysis shows prolongation of G0/G1 with LRH-1 silencing, consistent with LRH-1 cell-cycle influences in other tissues.
TextSentencer_T9 1113-1338 Sentence denotes Cluster analysis of microarray gene expression demonstrates significant genome wide alterations with major effects in cell-cycle regulation, signal transduction, bile acid and cholesterol metabolism, and control of apoptosis.
TextSentencer_T10 1339-1445 Sentence denotes This study demonstrates a critical proproliferative role for LRH-1 in established colon cancer cell lines.
TextSentencer_T11 1446-1503 Sentence denotes LRH-1 exerts its effects via multiple signaling networks.
TextSentencer_T12 1504-1587 Sentence denotes Our results suggest that selected CRC patients could benefit from LRH-1 inhibitors.
T1 0-101 Sentence denotes Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.
T2 102-200 Sentence denotes Colorectal cancers (CRCs) account for nearly 10% of all cancer deaths in industrialized countries.
T3 201-328 Sentence denotes Recent evidence points to a central role for the nuclear receptor liver receptor homolog-1 (LRH-1) in intestinal tumorigenesis.
T4 329-509 Sentence denotes Interaction of LRH-1 with the Wnt/β-catenin pathway, highly active in a critical subpopulation of CRC cells, underscores the importance of elucidating LRH-1's role in this disease.
T5 510-679 Sentence denotes Reduction of LRH-1 diminishes tumor burden in murine models of CRC; however, it is not known whether LRH-1 is required for tumorigenesis, for proliferation, or for both.
T6 680-791 Sentence denotes In this work, we address this question through shRNA-mediated silencing of LRH-1 in established CRC cell lines.
T7 792-980 Sentence denotes LRH-1 mRNA knockdown results in significantly impaired proliferation in a cell line highly expressing the receptor and more modest impairment in a cell line with moderate LRH-1 expression.
T8 981-1112 Sentence denotes Cell-cycle analysis shows prolongation of G0/G1 with LRH-1 silencing, consistent with LRH-1 cell-cycle influences in other tissues.
T9 1113-1338 Sentence denotes Cluster analysis of microarray gene expression demonstrates significant genome wide alterations with major effects in cell-cycle regulation, signal transduction, bile acid and cholesterol metabolism, and control of apoptosis.
T10 1339-1445 Sentence denotes This study demonstrates a critical proproliferative role for LRH-1 in established colon cancer cell lines.
T11 1446-1503 Sentence denotes LRH-1 exerts its effects via multiple signaling networks.
T12 1504-1587 Sentence denotes Our results suggest that selected CRC patients could benefit from LRH-1 inhibitors.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 113-120 HP_0002664 denotes cancers
T2 158-164 HP_0002664 denotes cancer
T3 540-545 HP_0002664 denotes tumor
T4 1421-1433 HP_0003003 denotes colon cancer
T5 1421-1433 HP_0100273 denotes colon cancer
T6 1427-1433 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25675535-0#10#15#gene2494 10-15 gene2494 denotes LRH-1
25675535-0#10#15#gene5026 10-15 gene5026 denotes LRH-1
25675535-0#19#31#diseaseC0007102 19-31 diseaseC0007102 denotes colon cancer
25675535-0#19#31#diseaseC0699790 19-31 diseaseC0699790 denotes colon cancer
25675535-0#19#31#diseaseC0007102 19-31 diseaseC0007102 denotes colon cancer
25675535-0#19#31#diseaseC0699790 19-31 diseaseC0699790 denotes colon cancer
25675535-4#101#106#gene2494 611-616 gene2494 denotes LRH-1
25675535-4#123#136#diseaseC0596263 633-646 diseaseC0596263 denotes tumorigenesis
25675535-5#75#80#gene2494 755-760 gene2494 denotes LRH-1
25675535-5#96#99#diseaseC1527249 776-779 diseaseC1527249 denotes CRC
10#15#gene249419#31#diseaseC0007102 25675535-0#10#15#gene2494 25675535-0#19#31#diseaseC0007102 associated_with LRH-1,colon cancer
10#15#gene249419#31#diseaseC0699790 25675535-0#10#15#gene2494 25675535-0#19#31#diseaseC0699790 associated_with LRH-1,colon cancer
10#15#gene249419#31#diseaseC0007102 25675535-0#10#15#gene2494 25675535-0#19#31#diseaseC0007102 associated_with LRH-1,colon cancer
10#15#gene249419#31#diseaseC0699790 25675535-0#10#15#gene2494 25675535-0#19#31#diseaseC0699790 associated_with LRH-1,colon cancer
10#15#gene502619#31#diseaseC0007102 25675535-0#10#15#gene5026 25675535-0#19#31#diseaseC0007102 associated_with LRH-1,colon cancer
10#15#gene502619#31#diseaseC0699790 25675535-0#10#15#gene5026 25675535-0#19#31#diseaseC0699790 associated_with LRH-1,colon cancer
10#15#gene502619#31#diseaseC0007102 25675535-0#10#15#gene5026 25675535-0#19#31#diseaseC0007102 associated_with LRH-1,colon cancer
10#15#gene502619#31#diseaseC0699790 25675535-0#10#15#gene5026 25675535-0#19#31#diseaseC0699790 associated_with LRH-1,colon cancer
101#106#gene2494123#136#diseaseC0596263 25675535-4#101#106#gene2494 25675535-4#123#136#diseaseC0596263 associated_with LRH-1,tumorigenesis
75#80#gene249496#99#diseaseC1527249 25675535-5#75#80#gene2494 25675535-5#96#99#diseaseC1527249 associated_with LRH-1,CRC

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2142 10-15 gene:2494 denotes LRH-1
T2143 19-31 disease:C0007102 denotes colon cancer
R1 T2142 T2143 associated_with LRH-1,colon cancer
R2 T2142 T2143 associated_with LRH-1,colon cancer
R3 T2142 T2143 associated_with LRH-1,colon cancer
R4 T2142 T2143 associated_with LRH-1,colon cancer

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1104-1111 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 229-236 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
PD-UBERON-AE-B_T3 267-272 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T4 19-24 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T5 1421-1426 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T6 303-313 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
PD-UBERON-AE-B_T7 1275-1279 http://purl.obolibrary.org/obo/UBERON_0001970 denotes bile

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 19-24 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T2 1421-1426 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T3 229-236 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
PD-UBERON-AE-B_T4 267-272 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T5 303-313 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
PD-UBERON-AE-B_T6 1104-1111 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T7 1275-1279 http://purl.obolibrary.org/obo/UBERON_0001970 denotes bile