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PubMed:25669997 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 122-149 HP_0000707 denotes neurodevelopmental disorder
T2 208-244 HP_0000707 denotes neurologic and communication defects
T3 208-244 HP_0012759 denotes neurologic and communication defects
T4 270-287 HP_0001423 denotes X-linked dominant
T5 270-278 HP_0001417 denotes X-linked
T6 577-583 HP_0000717 denotes autism
T7 660-667 HP_0012393 denotes allergy
T8 881-889 HP_0001250 denotes seizures
T9 1150-1169 HP_0002958 denotes dysregulated immune

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25669997-10#68#72#gene627 1609-1613 gene627 denotes BDNF
25669997-10#176#179#diseaseC1510586 1717-1720 diseaseC1510586 denotes ASD
25669997-8#56#60#gene627 1267-1271 gene627 denotes BDNF
25669997-8#83#96#diseaseC0035372 1294-1307 diseaseC0035372 denotes Rett syndrome
68#72#gene627176#179#diseaseC1510586 25669997-10#68#72#gene627 25669997-10#176#179#diseaseC1510586 associated_with BDNF,ASD
56#60#gene62783#96#diseaseC0035372 25669997-8#56#60#gene627 25669997-8#83#96#diseaseC0035372 associated_with BDNF,Rett syndrome

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders.
T2 103-245 Sentence denotes Rett syndrome is a neurodevelopmental disorder, which occurs in about 1:15,000 females and presents with neurologic and communication defects.
T3 246-478 Sentence denotes It is transmitted as an X-linked dominant linked to mutations of the methyl-CpG-binding protein (MeCP2), a gene transcription suppressor, but its definitive pathogenesis is unknown thus hindering development of effective treatments.
T4 479-610 Sentence denotes Almost half of children with Rett syndrome also have behavioral symptoms consistent with those of autism spectrum disorders (ASDs).
T5 611-913 Sentence denotes PubMed was searched (2005-2014) using the terms: allergy, atopy, brain, brain-derived neurotrophic factor (BDNF), corticotropin-releasing hormone (CRH), cytokines, gene mutations, inflammation, mast cells (MCs), microglia, mitochondria, neurotensin (NT), neurotrophins, seizures, stress, and treatment.
T6 914-1007 Sentence denotes There are a number of intriguing differences and similarities between Rett syndrome and ASDs.
T7 1008-1128 Sentence denotes Rett syndrome occurs in females, while ASDs more often in males, and the former has neurologic disabilities unlike ASDs.
T8 1129-1210 Sentence denotes There is evidence of dysregulated immune system early in life in both conditions.
T9 1211-1425 Sentence denotes Lack of microglial phagocytosis and decreased levels of BDNF appear to distinguish Rett syndrome from ASDs, in which there is instead microglia activation and/or proliferation and possibly defective BDNF signaling.
T10 1426-1540 Sentence denotes Moreover, brain mast cell (MC) activation and focal inflammation may be more prominent in ASDs than Rett syndrome.
T11 1541-1722 Sentence denotes The flavonoid luteolin blocks microglia and MC activation, provides BDNF-like activity, reverses Rett phenotype in mouse models, and has a significant benefit in children with ASDs.
T12 1723-1835 Sentence denotes Appropriate formulations of luteolin or other natural molecules may be useful in the treatment of Rett syndrome.
T1 0-102 Sentence denotes Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders.
T2 103-245 Sentence denotes Rett syndrome is a neurodevelopmental disorder, which occurs in about 1:15,000 females and presents with neurologic and communication defects.
T3 246-478 Sentence denotes It is transmitted as an X-linked dominant linked to mutations of the methyl-CpG-binding protein (MeCP2), a gene transcription suppressor, but its definitive pathogenesis is unknown thus hindering development of effective treatments.
T4 479-610 Sentence denotes Almost half of children with Rett syndrome also have behavioral symptoms consistent with those of autism spectrum disorders (ASDs).
T5 611-913 Sentence denotes PubMed was searched (2005-2014) using the terms: allergy, atopy, brain, brain-derived neurotrophic factor (BDNF), corticotropin-releasing hormone (CRH), cytokines, gene mutations, inflammation, mast cells (MCs), microglia, mitochondria, neurotensin (NT), neurotrophins, seizures, stress, and treatment.
T6 914-1007 Sentence denotes There are a number of intriguing differences and similarities between Rett syndrome and ASDs.
T7 1008-1128 Sentence denotes Rett syndrome occurs in females, while ASDs more often in males, and the former has neurologic disabilities unlike ASDs.
T8 1129-1210 Sentence denotes There is evidence of dysregulated immune system early in life in both conditions.
T9 1211-1425 Sentence denotes Lack of microglial phagocytosis and decreased levels of BDNF appear to distinguish Rett syndrome from ASDs, in which there is instead microglia activation and/or proliferation and possibly defective BDNF signaling.
T10 1426-1540 Sentence denotes Moreover, brain mast cell (MC) activation and focal inflammation may be more prominent in ASDs than Rett syndrome.
T11 1541-1722 Sentence denotes The flavonoid luteolin blocks microglia and MC activation, provides BDNF-like activity, reverses Rett phenotype in mouse models, and has a significant benefit in children with ASDs.
T12 1723-1835 Sentence denotes Appropriate formulations of luteolin or other natural molecules may be useful in the treatment of Rett syndrome.