PubMed:25653440 / 1820-2751 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/25653440","sourcedb":"PubMed","sourceid":"25653440","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/25653440","text":"Human metapneumovirus (HMPV) is a leading cause of acute respiratory illness. CD8(+) T cells are critical for clearing viral infection, yet recent evidence shows that HMPV and other respiratory viruses induce CD8(+) T cell impairment via PD-1-PD-L1 signaling. We sought to understand the role of type I interferon (IFN) in the innate and adaptive immune responses to HMPV by using a mouse model lacking IFN signaling. Although HMPV titers were higher in the absence of type I IFN, virus was nonetheless cleared and mice were less ill, indicating that type I IFN is not required to resolve HMPV infection but contributes to pathogenesis. Further, despite lower levels of the inhibitory ligand PD-L1 in mice lacking type I IFN, CD8(+) T cells were more impaired in these mice than in WT mice. Our data suggest that specific antigen-presenting cell subsets and the inhibitory receptor Tim-3 may contribute to CD8(+) T cell impairment.","tracks":[{"project":"Inflammaging","denotations":[{"id":"T14","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"T15","span":{"begin":78,"end":259},"obj":"Sentence"},{"id":"T16","span":{"begin":260,"end":417},"obj":"Sentence"},{"id":"T17","span":{"begin":418,"end":636},"obj":"Sentence"},{"id":"T18","span":{"begin":637,"end":790},"obj":"Sentence"},{"id":"T19","span":{"begin":791,"end":931},"obj":"Sentence"},{"id":"T14","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"T15","span":{"begin":78,"end":259},"obj":"Sentence"},{"id":"T16","span":{"begin":260,"end":417},"obj":"Sentence"},{"id":"T17","span":{"begin":418,"end":636},"obj":"Sentence"},{"id":"T18","span":{"begin":637,"end":790},"obj":"Sentence"},{"id":"T19","span":{"begin":791,"end":931},"obj":"Sentence"}],"attributes":[{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"},{"subj":"T16","pred":"source","obj":"Inflammaging"},{"subj":"T17","pred":"source","obj":"Inflammaging"},{"subj":"T18","pred":"source","obj":"Inflammaging"},{"subj":"T19","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"},{"subj":"T16","pred":"source","obj":"Inflammaging"},{"subj":"T17","pred":"source","obj":"Inflammaging"},{"subj":"T18","pred":"source","obj":"Inflammaging"},{"subj":"T19","pred":"source","obj":"Inflammaging"}]},{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T2","span":{"begin":0,"end":931},"obj":"OBJECTIVE"}],"attributes":[{"subj":"T2","pred":"source","obj":"PubMed_Structured_Abstracts"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Inflammaging","color":"#93ecbb","default":true},{"id":"PubMed_Structured_Abstracts","color":"#eca193"}]}]}}