PubMed:25622904
Annnotations
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-112 | Sentence | denotes | Inactivation of Sag/Rbx2/Roc2 e3 ubiquitin ligase triggers senescence and inhibits kras-induced immortalization. |
| T2 | 113-437 | Sentence | denotes | Our recent study showed that SAG/RBX2 E3 ubiquitin ligase regulates apoptosis and vasculogenesis by promoting degradation of NOXA and NF1, and co-operates with Kras to promote lung tumorigenesis by activating NFκB and mTOR pathways via targeted degradation of tumor suppressive substrates including IκB, DEPTOR, p21 and p27. |
| T3 | 438-672 | Sentence | denotes | Here we investigated the role of Sag/Rbx2 E3 ligase in cellular senescence and immortalization of mouse embryonic fibroblasts (MEFs) and report that Sag is required for proper cell proliferation and Kras(G12D)-induced immortalization. |
| T4 | 673-833 | Sentence | denotes | Sag inactivation by genetic deletion remarkably suppresses cell proliferation by inducing senescence, which is associated with accumulation of p16, but not p53. |
| T5 | 834-986 | Sentence | denotes | Mechanistically, Sag deletion caused accumulation of Jun-B, a substrate of Sag-Fbxw7 E3 ligase and a transcription factor that drives p16 transcription. |
| T6 | 987-1146 | Sentence | denotes | Importantly, senescence triggered by Sag deletion can be largely rescued by simultaneous deletion of Cdkn2a, the p16 encoding gene, indicating its causal role. |
| T7 | 1147-1317 | Sentence | denotes | Furthermore, Kras(G12D)-induced immortalization can also be abrogated by Sag deletion via senescence induction, which is again rescued by simultaneous deletion of Cdkn2a. |
| T8 | 1318-1476 | Sentence | denotes | Finally, we found that Sag deletion inactivates Kras(G12D) activity and block the MAPK signaling pathway, together with accumulated p16, to induce senescence. |
| T9 | 1477-1741 | Sentence | denotes | Taken together, our results demonstrated that Sag is a Kras(G12D)-cooperating oncogene required for Kras(G12D)-induced immortalization and transformation, and targeting SAG-SCF E3 ligase may, therefore, have therapeutic value for senescence-based cancer treatment. |
LitCoin-entities-OrganismTaxon-PD
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 142-145 | OrganismTaxon | denotes | SAG | NCBItxid:59303 |
| T2 | 536-541 | OrganismTaxon | denotes | mouse | NCBItxid:10090|NCBItxid:10088 |
| T4 | 1646-1649 | OrganismTaxon | denotes | SAG | NCBItxid:59303 |
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 10481 | 16-19 | GeneOrGeneProduct | denotes | Sag | NCBIGene:19823 |
| 10482 | 20-24 | GeneOrGeneProduct | denotes | Rbx2 | NCBIGene:19823 |
| 10483 | 25-29 | GeneOrGeneProduct | denotes | Roc2 | NCBIGene:19823 |
| 10484 | 30-49 | GeneOrGeneProduct | denotes | e3 ubiquitin ligase | NCBIGene:19823 |
| 10485 | 83-87 | GeneOrGeneProduct | denotes | kras | NCBIGene:16653 |
| 10486 | 142-145 | GeneOrGeneProduct | denotes | SAG | NCBIGene:19823 |
| 10487 | 146-150 | GeneOrGeneProduct | denotes | RBX2 | NCBIGene:19823 |
| 10488 | 151-170 | GeneOrGeneProduct | denotes | E3 ubiquitin ligase | NCBIGene:19823 |
| 10489 | 238-242 | GeneOrGeneProduct | denotes | NOXA | NCBIGene:58801 |
| 10490 | 247-250 | GeneOrGeneProduct | denotes | NF1 | NCBIGene:18015 |
| 10491 | 273-277 | GeneOrGeneProduct | denotes | Kras | NCBIGene:16653 |
| 10492 | 289-307 | DiseaseOrPhenotypicFeature | denotes | lung tumorigenesis | MESH:D008175 |
| 10493 | 322-326 | GeneOrGeneProduct | denotes | NFκB | NCBIGene:18033 |
| 10494 | 331-335 | GeneOrGeneProduct | denotes | mTOR | NCBIGene:56717 |
| 10495 | 373-378 | DiseaseOrPhenotypicFeature | denotes | tumor | MESH:D009369 |
| 10496 | 412-415 | GeneOrGeneProduct | denotes | IκB | NCBIGene:18033 |
| 10497 | 417-423 | GeneOrGeneProduct | denotes | DEPTOR | NCBIGene:97998 |
| 10498 | 425-428 | GeneOrGeneProduct | denotes | p21 | NCBIGene:12575 |
| 10499 | 433-436 | GeneOrGeneProduct | denotes | p27 | NCBIGene:12576 |
| 10500 | 471-474 | GeneOrGeneProduct | denotes | Sag | NCBIGene:19823 |
| 10501 | 475-479 | GeneOrGeneProduct | denotes | Rbx2 | NCBIGene:19823 |
| 10502 | 480-489 | GeneOrGeneProduct | denotes | E3 ligase | NCBIGene:19823 |
| 10503 | 536-541 | OrganismTaxon | denotes | mouse | NCBITaxon:10090 |
| 10504 | 587-590 | GeneOrGeneProduct | denotes | Sag | NCBIGene:19823 |
| 10505 | 637-641 | GeneOrGeneProduct | denotes | Kras | NCBIGene:16653 |
| 10506 | 642-646 | SequenceVariant | denotes | G12D | DBSNP:rs121913529 |
| 10507 | 673-676 | GeneOrGeneProduct | denotes | Sag | NCBIGene:19823 |
| 10508 | 816-819 | GeneOrGeneProduct | denotes | p16 | NCBIGene:12578 |
| 10509 | 829-832 | GeneOrGeneProduct | denotes | p53 | NCBIGene:22059 |
| 10510 | 851-854 | GeneOrGeneProduct | denotes | Sag | NCBIGene:19823 |
| 10511 | 887-892 | GeneOrGeneProduct | denotes | Jun-B | NCBIGene:16477 |
| 10512 | 909-912 | GeneOrGeneProduct | denotes | Sag | NCBIGene:19823 |
| 10513 | 913-918 | GeneOrGeneProduct | denotes | Fbxw7 | NCBIGene:50754 |
| 10514 | 919-928 | GeneOrGeneProduct | denotes | E3 ligase | NCBIGene:19823 |
| 10515 | 968-971 | GeneOrGeneProduct | denotes | p16 | NCBIGene:12578 |
| 10516 | 1024-1027 | GeneOrGeneProduct | denotes | Sag | NCBIGene:19823 |
| 10517 | 1088-1094 | GeneOrGeneProduct | denotes | Cdkn2a | NCBIGene:12578 |
| 10518 | 1100-1103 | GeneOrGeneProduct | denotes | p16 | NCBIGene:12578 |
| 10519 | 1160-1164 | GeneOrGeneProduct | denotes | Kras | NCBIGene:16653 |
| 10520 | 1165-1169 | SequenceVariant | denotes | G12D | DBSNP:rs121913529 |
| 10521 | 1220-1223 | GeneOrGeneProduct | denotes | Sag | NCBIGene:19823 |
| 10522 | 1310-1316 | GeneOrGeneProduct | denotes | Cdkn2a | NCBIGene:12578 |
| 10523 | 1341-1344 | GeneOrGeneProduct | denotes | Sag | NCBIGene:19823 |
| 10524 | 1366-1370 | GeneOrGeneProduct | denotes | Kras | NCBIGene:16653 |
| 10525 | 1371-1375 | SequenceVariant | denotes | G12D | DBSNP:rs121913529 |
| 10526 | 1400-1404 | GeneOrGeneProduct | denotes | MAPK | NCBIGene:26413 |
| 10527 | 1450-1453 | GeneOrGeneProduct | denotes | p16 | NCBIGene:12578 |
| 10528 | 1523-1526 | GeneOrGeneProduct | denotes | Sag | NCBIGene:19823 |
| 10529 | 1532-1536 | GeneOrGeneProduct | denotes | Kras | NCBIGene:16653 |
| 10530 | 1537-1541 | SequenceVariant | denotes | G12D | DBSNP:rs121913529 |
| 10531 | 1577-1581 | GeneOrGeneProduct | denotes | Kras | NCBIGene:16653 |
| 10532 | 1582-1586 | SequenceVariant | denotes | G12D | DBSNP:rs121913529 |
| 10533 | 1646-1649 | GeneOrGeneProduct | denotes | SAG | NCBIGene:19823 |
| 10534 | 1650-1653 | GeneOrGeneProduct | denotes | SCF | NCBIGene:50754 |
| 10535 | 1654-1663 | GeneOrGeneProduct | denotes | E3 ligase | NCBIGene:19823 |
| 10536 | 1724-1730 | DiseaseOrPhenotypicFeature | denotes | cancer | MESH:D009369 |
LitCoin_Mondo
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1724-1730 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
LitCoin-SeqVar
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 642-646 | SequenceVariant | denotes | G12D |
| T2 | 1076-1092 | SequenceVariant | denotes | deletion of Cdkn |
| T3 | 1165-1169 | SequenceVariant | denotes | G12D |
| T4 | 1298-1314 | SequenceVariant | denotes | deletion of Cdkn |
| T5 | 1371-1375 | SequenceVariant | denotes | G12D |
| T6 | 1537-1541 | SequenceVariant | denotes | G12D |
| T7 | 1582-1586 | SequenceVariant | denotes | G12D |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 20-24 | GeneOrGeneProduct | denotes | Rbx2 |
| T2 | 25-29 | GeneOrGeneProduct | denotes | Roc2 |
| T3 | 30-49 | GeneOrGeneProduct | denotes | e3 ubiquitin ligase |
| T4 | 83-87 | GeneOrGeneProduct | denotes | kras |
| T5 | 142-145 | GeneOrGeneProduct | denotes | SAG |
| T6 | 146-150 | GeneOrGeneProduct | denotes | RBX2 |
| T7 | 151-170 | GeneOrGeneProduct | denotes | E3 ubiquitin ligase |
| T8 | 181-190 | GeneOrGeneProduct | denotes | apoptosis |
| T9 | 238-242 | GeneOrGeneProduct | denotes | NOXA |
| T10 | 247-250 | GeneOrGeneProduct | denotes | NF1 |
| T11 | 273-277 | GeneOrGeneProduct | denotes | Kras |
| T12 | 331-335 | GeneOrGeneProduct | denotes | mTOR |
| T13 | 417-423 | GeneOrGeneProduct | denotes | DEPTOR |
| T14 | 475-479 | GeneOrGeneProduct | denotes | Rbx2 |
| T15 | 480-489 | GeneOrGeneProduct | denotes | E3 ligase |
| T16 | 614-618 | GeneOrGeneProduct | denotes | cell |
| T17 | 637-641 | GeneOrGeneProduct | denotes | Kras |
| T18 | 732-736 | GeneOrGeneProduct | denotes | cell |
| T19 | 887-892 | GeneOrGeneProduct | denotes | Jun-B |
| T20 | 913-918 | GeneOrGeneProduct | denotes | Fbxw7 |
| T21 | 919-928 | GeneOrGeneProduct | denotes | E3 ligase |
| T22 | 935-955 | GeneOrGeneProduct | denotes | transcription factor |
| T23 | 972-985 | GeneOrGeneProduct | denotes | transcription |
| T24 | 1088-1094 | GeneOrGeneProduct | denotes | Cdkn2a |
| T25 | 1160-1164 | GeneOrGeneProduct | denotes | Kras |
| T26 | 1310-1316 | GeneOrGeneProduct | denotes | Cdkn2a |
| T27 | 1366-1370 | GeneOrGeneProduct | denotes | Kras |
| T28 | 1400-1404 | GeneOrGeneProduct | denotes | MAPK |
| T29 | 1532-1536 | GeneOrGeneProduct | denotes | Kras |
| T30 | 1555-1563 | GeneOrGeneProduct | denotes | oncogene |
| T31 | 1577-1581 | GeneOrGeneProduct | denotes | Kras |
| T32 | 1646-1649 | GeneOrGeneProduct | denotes | SAG |
| T33 | 1654-1663 | GeneOrGeneProduct | denotes | E3 ligase |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 16-19 | GeneOrGeneProduct | denotes | Sag |
| T2 | 20-24 | GeneOrGeneProduct | denotes | Rbx2 |
| T3 | 25-29 | GeneOrGeneProduct | denotes | Roc2 |
| T4 | 30-49 | GeneOrGeneProduct | denotes | e3 ubiquitin ligase |
| T5 | 83-87 | GeneOrGeneProduct | denotes | kras |
| T6 | 88-95 | GeneOrGeneProduct | denotes | induced |
| T7 | 142-145 | GeneOrGeneProduct | denotes | SAG |
| T8 | 146-150 | GeneOrGeneProduct | denotes | RBX2 |
| T9 | 151-170 | GeneOrGeneProduct | denotes | E3 ubiquitin ligase |
| T10 | 171-180 | GeneOrGeneProduct | denotes | regulates |
| T11 | 181-190 | GeneOrGeneProduct | denotes | apoptosis |
| T12 | 238-242 | GeneOrGeneProduct | denotes | NOXA |
| T13 | 247-250 | GeneOrGeneProduct | denotes | NF1 |
| T14 | 273-277 | GeneOrGeneProduct | denotes | Kras |
| T15 | 289-293 | GeneOrGeneProduct | denotes | lung |
| T16 | 311-321 | GeneOrGeneProduct | denotes | activating |
| T17 | 331-335 | GeneOrGeneProduct | denotes | mTOR |
| T18 | 370-378 | GeneOrGeneProduct | denotes | of tumor |
| T19 | 417-423 | GeneOrGeneProduct | denotes | DEPTOR |
| T20 | 471-474 | GeneOrGeneProduct | denotes | Sag |
| T21 | 475-479 | GeneOrGeneProduct | denotes | Rbx2 |
| T22 | 480-489 | GeneOrGeneProduct | denotes | E3 ligase |
| T23 | 587-590 | GeneOrGeneProduct | denotes | Sag |
| T24 | 614-618 | GeneOrGeneProduct | denotes | cell |
| T25 | 637-641 | GeneOrGeneProduct | denotes | Kras |
| T26 | 648-655 | GeneOrGeneProduct | denotes | induced |
| T27 | 673-676 | GeneOrGeneProduct | denotes | Sag |
| T28 | 732-736 | GeneOrGeneProduct | denotes | cell |
| T29 | 754-762 | GeneOrGeneProduct | denotes | inducing |
| T30 | 851-854 | GeneOrGeneProduct | denotes | Sag |
| T31 | 887-892 | GeneOrGeneProduct | denotes | Jun-B |
| T32 | 909-912 | GeneOrGeneProduct | denotes | Sag |
| T33 | 913-918 | GeneOrGeneProduct | denotes | Fbxw7 |
| T34 | 919-928 | GeneOrGeneProduct | denotes | E3 ligase |
| T35 | 935-955 | GeneOrGeneProduct | denotes | transcription factor |
| T36 | 961-967 | GeneOrGeneProduct | denotes | drives |
| T37 | 972-985 | GeneOrGeneProduct | denotes | transcription |
| T38 | 1024-1027 | GeneOrGeneProduct | denotes | Sag |
| T39 | 1044-1051 | GeneOrGeneProduct | denotes | largely |
| T40 | 1088-1094 | GeneOrGeneProduct | denotes | Cdkn2a |
| T41 | 1160-1164 | GeneOrGeneProduct | denotes | Kras |
| T42 | 1171-1178 | GeneOrGeneProduct | denotes | induced |
| T43 | 1220-1223 | GeneOrGeneProduct | denotes | Sag |
| T44 | 1310-1316 | GeneOrGeneProduct | denotes | Cdkn2a |
| T45 | 1341-1344 | GeneOrGeneProduct | denotes | Sag |
| T46 | 1366-1370 | GeneOrGeneProduct | denotes | Kras |
| T47 | 1377-1385 | GeneOrGeneProduct | denotes | activity |
| T48 | 1390-1395 | GeneOrGeneProduct | denotes | block |
| T49 | 1400-1404 | GeneOrGeneProduct | denotes | MAPK |
| T50 | 1458-1464 | GeneOrGeneProduct | denotes | induce |
| T51 | 1523-1526 | GeneOrGeneProduct | denotes | Sag |
| T52 | 1532-1536 | GeneOrGeneProduct | denotes | Kras |
| T53 | 1555-1563 | GeneOrGeneProduct | denotes | oncogene |
| T54 | 1577-1581 | GeneOrGeneProduct | denotes | Kras |
| T55 | 1588-1595 | GeneOrGeneProduct | denotes | induced |
| T56 | 1616-1630 | GeneOrGeneProduct | denotes | transformation |
| T57 | 1646-1649 | GeneOrGeneProduct | denotes | SAG |
| T58 | 1654-1663 | GeneOrGeneProduct | denotes | E3 ligase |
| T59 | 1697-1702 | GeneOrGeneProduct | denotes | value |
| T60 | 1718-1723 | GeneOrGeneProduct | denotes | based |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 294-307 | DiseaseOrPhenotypicFeature | denotes | tumorigenesis | D063646 |
| T2 | 373-378 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 |
| T3 | 1724-1730 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
LitCoin-GeneOrGeneProduct-v3
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 20-24 | GeneOrGeneProduct | denotes | Rbx2 |
| T2 | 25-29 | GeneOrGeneProduct | denotes | Roc2 |
| T3 | 30-49 | GeneOrGeneProduct | denotes | e3 ubiquitin ligase |
| T4 | 83-87 | GeneOrGeneProduct | denotes | kras |
| T5 | 142-145 | GeneOrGeneProduct | denotes | SAG |
| T6 | 146-150 | GeneOrGeneProduct | denotes | RBX2 |
| T7 | 151-170 | GeneOrGeneProduct | denotes | E3 ubiquitin ligase |
| T8 | 238-242 | GeneOrGeneProduct | denotes | NOXA |
| T9 | 247-250 | GeneOrGeneProduct | denotes | NF1 |
| T10 | 273-277 | GeneOrGeneProduct | denotes | Kras |
| T11 | 331-335 | GeneOrGeneProduct | denotes | mTOR |
| T12 | 417-423 | GeneOrGeneProduct | denotes | DEPTOR |
| T13 | 475-479 | GeneOrGeneProduct | denotes | Rbx2 |
| T14 | 480-489 | GeneOrGeneProduct | denotes | E3 ligase |
| T15 | 637-641 | GeneOrGeneProduct | denotes | Kras |
| T16 | 887-892 | GeneOrGeneProduct | denotes | Jun-B |
| T17 | 913-918 | GeneOrGeneProduct | denotes | Fbxw7 |
| T18 | 919-928 | GeneOrGeneProduct | denotes | E3 ligase |
| T19 | 935-955 | GeneOrGeneProduct | denotes | transcription factor |
| T20 | 1088-1094 | GeneOrGeneProduct | denotes | Cdkn2a |
| T21 | 1160-1164 | GeneOrGeneProduct | denotes | Kras |
| T22 | 1310-1316 | GeneOrGeneProduct | denotes | Cdkn2a |
| T23 | 1366-1370 | GeneOrGeneProduct | denotes | Kras |
| T24 | 1400-1404 | GeneOrGeneProduct | denotes | MAPK |
| T25 | 1532-1536 | GeneOrGeneProduct | denotes | Kras |
| T26 | 1577-1581 | GeneOrGeneProduct | denotes | Kras |
| T27 | 1646-1649 | GeneOrGeneProduct | denotes | SAG |
| T28 | 1654-1663 | GeneOrGeneProduct | denotes | E3 ligase |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 247-250 | DiseaseOrPhenotypicFeature | denotes | NF1 | 0018975 |
| T2 | 289-293 | DiseaseOrPhenotypicFeature | denotes | lung | 0021117 |
| T3 | 373-378 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
| T4 | 1037-1040 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
| T5 | 1195-1198 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 294-307 | DiseaseOrPhenotypicFeature | denotes | tumorigenesis | D063646 |
| T2 | 373-378 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 |
| T3 | 1724-1730 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 294-307 | DiseaseOrPhenotypicFeature | denotes | tumorigenesis | D063646 |
| T2 | 373-378 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 |
| T3 | 1724-1730 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 30-49 | ChemicalEntity | denotes | e3 ubiquitin ligase | D044767 |
| T2 | 142-145 | ChemicalEntity | denotes | SAG | http://purl.obolibrary.org/obo/CHEBI_138438 |
| T3 | 151-170 | ChemicalEntity | denotes | E3 ubiquitin ligase | D044767 |
| T4 | 238-242 | ChemicalEntity | denotes | NOXA | http://purl.obolibrary.org/obo/CHEBI_50397 |
| T5 | 480-489 | ChemicalEntity | denotes | E3 ligase | D044767 |
| T6 | 919-928 | ChemicalEntity | denotes | E3 ligase | D044767 |
| T7 | 1646-1649 | ChemicalEntity | denotes | SAG | http://purl.obolibrary.org/obo/CHEBI_138438 |
| T8 | 1654-1663 | ChemicalEntity | denotes | E3 ligase | D044767 |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 536-541 | OrganismTaxon | denotes | mouse |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
|---|---|---|---|---|---|---|
| T8 | 1654-1663 | ChemicalEntity | denotes | E3 ligase | D044767 | |
| T7 | 1646-1649 | ChemicalEntity | denotes | SAG | http://purl.obolibrary.org/obo/CHEBI_138438 | |
| T6 | 919-928 | ChemicalEntity | denotes | E3 ligase | D044767 | |
| T5 | 480-489 | ChemicalEntity | denotes | E3 ligase | D044767 | |
| T4 | 238-242 | ChemicalEntity | denotes | NOXA | http://purl.obolibrary.org/obo/CHEBI_50397 | |
| T3 | 151-170 | ChemicalEntity | denotes | E3 ubiquitin ligase | D044767 | |
| T2 | 142-145 | ChemicalEntity | denotes | SAG | http://purl.obolibrary.org/obo/CHEBI_138438 | |
| T1 | 30-49 | ChemicalEntity | denotes | e3 ubiquitin ligase | D044767 | |
| T28 | 1654-1663 | GeneOrGeneProduct | denotes | E3 ligase | ||
| T27 | 1646-1649 | GeneOrGeneProduct | denotes | SAG | ||
| T26 | 1577-1581 | GeneOrGeneProduct | denotes | Kras | ||
| T25 | 1532-1536 | GeneOrGeneProduct | denotes | Kras | ||
| T24 | 1400-1404 | GeneOrGeneProduct | denotes | MAPK | ||
| T23 | 1366-1370 | GeneOrGeneProduct | denotes | Kras | ||
| T22 | 1310-1316 | GeneOrGeneProduct | denotes | Cdkn2a | ||
| T21 | 1160-1164 | GeneOrGeneProduct | denotes | Kras | ||
| T20 | 1088-1094 | GeneOrGeneProduct | denotes | Cdkn2a | ||
| T19 | 935-955 | GeneOrGeneProduct | denotes | transcription factor | ||
| T18 | 919-928 | GeneOrGeneProduct | denotes | E3 ligase | ||
| T17 | 913-918 | GeneOrGeneProduct | denotes | Fbxw7 | ||
| T16 | 887-892 | GeneOrGeneProduct | denotes | Jun-B | ||
| T15 | 637-641 | GeneOrGeneProduct | denotes | Kras | ||
| T14 | 480-489 | GeneOrGeneProduct | denotes | E3 ligase | ||
| T13 | 475-479 | GeneOrGeneProduct | denotes | Rbx2 | ||
| T12 | 417-423 | GeneOrGeneProduct | denotes | DEPTOR | ||
| T11 | 331-335 | GeneOrGeneProduct | denotes | mTOR | ||
| T10 | 273-277 | GeneOrGeneProduct | denotes | Kras | ||
| T9 | 247-250 | GeneOrGeneProduct | denotes | NF1 | ||
| T88339 | 238-242 | GeneOrGeneProduct | denotes | NOXA | ||
| T15433 | 151-170 | GeneOrGeneProduct | denotes | E3 ubiquitin ligase | ||
| T27966 | 146-150 | GeneOrGeneProduct | denotes | RBX2 | ||
| T88944 | 142-145 | GeneOrGeneProduct | denotes | SAG | ||
| T74733 | 83-87 | GeneOrGeneProduct | denotes | kras | ||
| T79792 | 30-49 | GeneOrGeneProduct | denotes | e3 ubiquitin ligase | ||
| T14355 | 25-29 | GeneOrGeneProduct | denotes | Roc2 | ||
| T78928 | 20-24 | GeneOrGeneProduct | denotes | Rbx2 | ||
| T64539 | 1724-1730 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 | |
| T67298 | 373-378 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 | |
| T47543 | 294-307 | DiseaseOrPhenotypicFeature | denotes | tumorigenesis | D063646 | |
| T70388 | 536-541 | OrganismTaxon | denotes | mouse | ||
| T19723 | 1582-1586 | SequenceVariant | denotes | G12D | ||
| T35001 | 1537-1541 | SequenceVariant | denotes | G12D | ||
| T28466 | 1371-1375 | SequenceVariant | denotes | G12D | ||
| T47448 | 1298-1314 | SequenceVariant | denotes | deletion of Cdkn | ||
| T94660 | 1165-1169 | SequenceVariant | denotes | G12D | ||
| T81588 | 1076-1092 | SequenceVariant | denotes | deletion of Cdkn | ||
| T51725 | 642-646 | SequenceVariant | denotes | G12D |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 373-378 | HP_0002664 | denotes | tumor |
| T2 | 1724-1730 | HP_0002664 | denotes | cancer |