
PubMed:25589620
Annnotations
PubTator4TogoVar
Id | Subject | Object | Predicate | Lexical cue | proteinmutation |
---|---|---|---|---|---|
25589620_0 | 1202-1211 | ProteinMutation | denotes | Ile105Val | rs1695 |
25589620_1 | 1542-1547 | ProteinMutation | denotes | H472Q | rs1870377 |
LitCoin-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T6 | 812-958 | Sentence | denotes | EXPERIMENTAL DESIGN: DNA from 746 stage II/III rectal patients enrolled in the Southwest Oncology Group (SWOG) S9304 phase III trial was analyzed. |
T1 | 0-43 | Sentence | denotes | Pharmacogenetic Analysis of INT 0144 Trial: |
T2 | 44-158 | Sentence | denotes | Association of Polymorphisms with Survival and Toxicity in Rectal Cancer Patients Treated with 5-FU and Radiation. |
T3 | 159-167 | Sentence | denotes | PURPOSE: |
T4 | 168-579 | Sentence | denotes | We tested whether 18 polymorphisms in 16 genes (GSTP1, COX2, IL10, EGFR, EGF, FGFR4, CCDN1, VEGFR2, VEGF, CXCR2, IL8, MMP3, ICAM1, ERCC1, RAD51, and XRCC3) would predict disease-free survival (DFS), overall survival (OS), and toxicity in the INT0144 trial, which was designed to investigate different postoperative regimens of 5-fluorouracil (5-FU)-based chemoradiation (CRT) in locally advanced rectal cancers: |
T5 | 580-811 | Sentence | denotes | Arm 1 consisted of bolus 5-FU followed by 5-FU protracted venous infusion (PVI) with radiotherapy; arm 2 was induction and concomitant PVI 5-FU with radiotherapy and arm 3 was induction and concomitant bolus 5-FU with radiotherapy. |
T7 | 959-1044 | Sentence | denotes | Genomic DNA was extracted from formalin-fixed, paraffin-embedded (FFPE) tumor tissue. |
T8 | 1045-1186 | Sentence | denotes | The polymorphisms were analyzed using direct DNA-sequencing or polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). |
T9 | 1187-1311 | Sentence | denotes | RESULTS: GSTP1-Ile105Val (rs1695) was significantly associated with DFS and OS and its effect did not vary by treatment arm. |
T10 | 1312-1432 | Sentence | denotes | The five-year DFS and OS were 53% and 58%, respectively, for G/G, 66% and 72% for G/A, and 57% and 66% for A/A patients. |
T11 | 1433-1530 | Sentence | denotes | In arm 2, IL8-251A/A genotype (rs4073) was associated with a lower risk of toxicities (P = 0.04). |
T12 | 1531-1696 | Sentence | denotes | The VEGFR2 H472Q Q/Q genotype (rs1870377) was associated with a higher risk of grade 3-5 proximal upper gastrointestinal tract (PUGIT) mucositis (P = 0.04) in arm 2. |
T13 | 1697-1794 | Sentence | denotes | However, in arm 1, this genotype was associated with a lower risk of PUGIT mucositis (P = 0.004). |
T14 | 1795-1992 | Sentence | denotes | CONCLUSION: rs1695 may be prognostic in patients with rectal cancer treated with adjuvant CRT. rs4073 and rs1870377 may exhibit different associations with toxicity, according to the 5-FU schedule. |
LitCoin-entities
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
10429 | 91-99 | DiseaseOrPhenotypicFeature | denotes | Toxicity | MESH:D064420 |
10430 | 103-116 | DiseaseOrPhenotypicFeature | denotes | Rectal Cancer | MESH:D012004 |
10431 | 117-125 | OrganismTaxon | denotes | Patients | NCBITaxon:9606 |
10432 | 139-143 | ChemicalEntity | denotes | 5-FU | MESH:D005472 |
10433 | 216-221 | GeneOrGeneProduct | denotes | GSTP1 | NCBIGene:2950 |
10434 | 223-227 | GeneOrGeneProduct | denotes | COX2 | NCBIGene:4513 |
10435 | 229-233 | GeneOrGeneProduct | denotes | IL10 | NCBIGene:3586 |
10436 | 235-239 | GeneOrGeneProduct | denotes | EGFR | NCBIGene:1956 |
10437 | 241-244 | GeneOrGeneProduct | denotes | EGF | NCBIGene:1950 |
10438 | 246-251 | GeneOrGeneProduct | denotes | FGFR4 | NCBIGene:2264 |
10439 | 253-258 | GeneOrGeneProduct | denotes | CCDN1 | NCBIGene:595 |
10440 | 260-266 | GeneOrGeneProduct | denotes | VEGFR2 | NCBIGene:3791 |
10441 | 268-272 | GeneOrGeneProduct | denotes | VEGF | NCBIGene:7422 |
10442 | 274-279 | GeneOrGeneProduct | denotes | CXCR2 | NCBIGene:3579 |
10443 | 281-284 | GeneOrGeneProduct | denotes | IL8 | NCBIGene:3576 |
10444 | 286-290 | GeneOrGeneProduct | denotes | MMP3 | NCBIGene:4314 |
10445 | 292-297 | GeneOrGeneProduct | denotes | ICAM1 | NCBIGene:3383 |
10446 | 299-304 | GeneOrGeneProduct | denotes | ERCC1 | NCBIGene:2067 |
10447 | 306-311 | GeneOrGeneProduct | denotes | RAD51 | NCBIGene:5888 |
10448 | 317-322 | GeneOrGeneProduct | denotes | XRCC3 | NCBIGene:7517 |
10449 | 394-402 | DiseaseOrPhenotypicFeature | denotes | toxicity | MESH:D064420 |
10450 | 495-509 | ChemicalEntity | denotes | 5-fluorouracil | MESH:D005472 |
10451 | 511-515 | ChemicalEntity | denotes | 5-FU | MESH:D005472 |
10452 | 564-578 | DiseaseOrPhenotypicFeature | denotes | rectal cancers | MESH:D012004 |
10453 | 605-609 | ChemicalEntity | denotes | 5-FU | MESH:D005472 |
10454 | 622-626 | ChemicalEntity | denotes | 5-FU | MESH:D005472 |
10455 | 719-723 | ChemicalEntity | denotes | 5-FU | MESH:D005472 |
10456 | 788-792 | ChemicalEntity | denotes | 5-FU | MESH:D005472 |
10457 | 866-874 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
10458 | 990-998 | ChemicalEntity | denotes | formalin | MESH:D005557 |
10459 | 1006-1014 | ChemicalEntity | denotes | paraffin | MESH:D010232 |
10460 | 1031-1036 | DiseaseOrPhenotypicFeature | denotes | tumor | MESH:D009369 |
10461 | 1196-1201 | GeneOrGeneProduct | denotes | GSTP1 | NCBIGene:2950 |
10462 | 1202-1211 | SequenceVariant | denotes | Ile105Val | DBSNP:rs1695 |
10463 | 1213-1219 | SequenceVariant | denotes | rs1695 | DBSNP:rs1695 |
10464 | 1423-1431 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
10465 | 1443-1446 | GeneOrGeneProduct | denotes | IL8 | NCBIGene:3576 |
10466 | 1446-1453 | SequenceVariant | denotes | -251A/A | DBSNP:rs4073 |
10467 | 1464-1470 | SequenceVariant | denotes | rs4073 | DBSNP:rs4073 |
10468 | 1508-1518 | DiseaseOrPhenotypicFeature | denotes | toxicities | MESH:D064420 |
10469 | 1535-1541 | GeneOrGeneProduct | denotes | VEGFR2 | NCBIGene:3791 |
10470 | 1542-1547 | SequenceVariant | denotes | H472Q | DBSNP:rs1870377 |
10471 | 1562-1571 | SequenceVariant | denotes | rs1870377 | DBSNP:rs1870377 |
10472 | 1666-1675 | DiseaseOrPhenotypicFeature | denotes | mucositis | MESH:D052016 |
10473 | 1772-1781 | DiseaseOrPhenotypicFeature | denotes | mucositis | MESH:D052016 |
10474 | 1807-1813 | SequenceVariant | denotes | rs1695 | DBSNP:rs1695 |
10475 | 1835-1843 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
10476 | 1849-1862 | DiseaseOrPhenotypicFeature | denotes | rectal cancer | MESH:D012004 |
10477 | 1890-1896 | SequenceVariant | denotes | rs4073 | DBSNP:rs4073 |
10478 | 1901-1910 | SequenceVariant | denotes | rs1870377 | DBSNP:rs1870377 |
10479 | 1951-1959 | DiseaseOrPhenotypicFeature | denotes | toxicity | MESH:D064420 |
10480 | 1978-1982 | ChemicalEntity | denotes | 5-FU | MESH:D005472 |
LitCoin_Mondo
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 103-116 | DiseaseOrPhenotypicFeature | denotes | Rectal Cancer | 0006519 |
T2 | 564-578 | DiseaseOrPhenotypicFeature | denotes | rectal cancers | 0006519 |
T3 | 1666-1675 | DiseaseOrPhenotypicFeature | denotes | mucositis | 0020579 |
T4 | 1772-1781 | DiseaseOrPhenotypicFeature | denotes | mucositis | 0020579 |
T5 | 1849-1862 | DiseaseOrPhenotypicFeature | denotes | rectal cancer | 0006519 |
T6 | 1856-1862 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
LitCoin-SeqVar
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1202-1211 | SequenceVariant | denotes | Ile105Val |
T2 | 1213-1219 | SequenceVariant | denotes | rs1695 |
T3 | 1446-1451 | SequenceVariant | denotes | -251A |
T4 | 1464-1470 | SequenceVariant | denotes | rs4073 |
T5 | 1542-1547 | SequenceVariant | denotes | H472Q |
T6 | 1562-1571 | SequenceVariant | denotes | rs1870377 |
T7 | 1807-1813 | SequenceVariant | denotes | rs1695 |
T8 | 1890-1896 | SequenceVariant | denotes | rs4073 |
T9 | 1901-1910 | SequenceVariant | denotes | rs1870377 |
LitCoin-GeneOrGeneProduct-v2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 216-221 | GeneOrGeneProduct | denotes | GSTP1 |
T2 | 223-227 | GeneOrGeneProduct | denotes | COX2 |
T3 | 229-233 | GeneOrGeneProduct | denotes | IL10 |
T4 | 235-239 | GeneOrGeneProduct | denotes | EGFR |
T5 | 246-251 | GeneOrGeneProduct | denotes | FGFR4 |
T6 | 260-266 | GeneOrGeneProduct | denotes | VEGFR2 |
T7 | 268-272 | GeneOrGeneProduct | denotes | VEGF |
T8 | 274-279 | GeneOrGeneProduct | denotes | CXCR2 |
T9 | 281-284 | GeneOrGeneProduct | denotes | IL8 |
T10 | 286-290 | GeneOrGeneProduct | denotes | MMP3 |
T11 | 292-297 | GeneOrGeneProduct | denotes | ICAM1 |
T12 | 299-304 | GeneOrGeneProduct | denotes | ERCC1 |
T13 | 306-311 | GeneOrGeneProduct | denotes | RAD51 |
T14 | 317-322 | GeneOrGeneProduct | denotes | XRCC3 |
T15 | 580-585 | GeneOrGeneProduct | denotes | Arm 1 |
T16 | 679-684 | GeneOrGeneProduct | denotes | arm 2 |
T17 | 1108-1118 | GeneOrGeneProduct | denotes | polymerase |
T18 | 1119-1124 | GeneOrGeneProduct | denotes | chain |
T19 | 1196-1201 | GeneOrGeneProduct | denotes | GSTP1 |
T20 | 1436-1441 | GeneOrGeneProduct | denotes | arm 2 |
T21 | 1443-1446 | GeneOrGeneProduct | denotes | IL8 |
T22 | 1535-1541 | GeneOrGeneProduct | denotes | VEGFR2 |
T23 | 1690-1695 | GeneOrGeneProduct | denotes | arm 2 |
T24 | 1709-1714 | GeneOrGeneProduct | denotes | arm 1 |
LitCoin-GeneOrGeneProduct-v0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 28-31 | GeneOrGeneProduct | denotes | INT |
T2 | 171-177 | GeneOrGeneProduct | denotes | tested |
T3 | 203-208 | GeneOrGeneProduct | denotes | in 16 |
T4 | 216-221 | GeneOrGeneProduct | denotes | GSTP1 |
T5 | 223-227 | GeneOrGeneProduct | denotes | COX2 |
T6 | 229-233 | GeneOrGeneProduct | denotes | IL10 |
T7 | 235-239 | GeneOrGeneProduct | denotes | EGFR |
T8 | 246-251 | GeneOrGeneProduct | denotes | FGFR4 |
T9 | 260-266 | GeneOrGeneProduct | denotes | VEGFR2 |
T10 | 268-272 | GeneOrGeneProduct | denotes | VEGF |
T11 | 274-279 | GeneOrGeneProduct | denotes | CXCR2 |
T12 | 281-284 | GeneOrGeneProduct | denotes | IL8 |
T13 | 286-290 | GeneOrGeneProduct | denotes | MMP3 |
T14 | 292-297 | GeneOrGeneProduct | denotes | ICAM1 |
T15 | 299-304 | GeneOrGeneProduct | denotes | ERCC1 |
T16 | 306-311 | GeneOrGeneProduct | denotes | RAD51 |
T17 | 317-322 | GeneOrGeneProduct | denotes | XRCC3 |
T18 | 330-345 | GeneOrGeneProduct | denotes | predict disease |
T19 | 517-522 | GeneOrGeneProduct | denotes | based |
T20 | 580-585 | GeneOrGeneProduct | denotes | Arm 1 |
T21 | 679-684 | GeneOrGeneProduct | denotes | arm 2 |
T22 | 852-854 | GeneOrGeneProduct | denotes | II |
T23 | 855-858 | GeneOrGeneProduct | denotes | III |
T24 | 935-938 | GeneOrGeneProduct | denotes | III |
T25 | 1031-1036 | GeneOrGeneProduct | denotes | tumor |
T26 | 1108-1118 | GeneOrGeneProduct | denotes | polymerase |
T27 | 1119-1124 | GeneOrGeneProduct | denotes | chain |
T28 | 1180-1184 | GeneOrGeneProduct | denotes | RFLP |
T29 | 1196-1201 | GeneOrGeneProduct | denotes | GSTP1 |
T30 | 1289-1293 | GeneOrGeneProduct | denotes | vary |
T31 | 1321-1325 | GeneOrGeneProduct | denotes | year |
T32 | 1386-1393 | GeneOrGeneProduct | denotes | 72% for |
T33 | 1411-1418 | GeneOrGeneProduct | denotes | 66% for |
T34 | 1436-1441 | GeneOrGeneProduct | denotes | arm 2 |
T35 | 1443-1446 | GeneOrGeneProduct | denotes | IL8 |
T36 | 1535-1541 | GeneOrGeneProduct | denotes | VEGFR2 |
T37 | 1690-1695 | GeneOrGeneProduct | denotes | arm 2 |
T38 | 1709-1714 | GeneOrGeneProduct | denotes | arm 1 |
LitCoin-Disease-MeSH
Id | Subject | Object | Predicate | Lexical cue | originalLabel |
---|---|---|---|---|---|
T1 | 91-99 | DiseaseOrPhenotypicFeature | denotes | Toxicity | DISEASE |
T2 | 103-116 | DiseaseOrPhenotypicFeature | denotes | Rectal Cancer | D012004 |
T3 | 338-345 | DiseaseOrPhenotypicFeature | denotes | disease | D004194 |
T4 | 394-402 | DiseaseOrPhenotypicFeature | denotes | toxicity | DISEASE |
T5 | 564-578 | DiseaseOrPhenotypicFeature | denotes | rectal cancers | D012004 |
T6 | 1031-1036 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 |
T7 | 1666-1675 | DiseaseOrPhenotypicFeature | denotes | mucositis | D052016 |
T8 | 1772-1781 | DiseaseOrPhenotypicFeature | denotes | mucositis | D052016 |
T9 | 1849-1862 | DiseaseOrPhenotypicFeature | denotes | rectal cancer | D012004 |
T10 | 1951-1959 | DiseaseOrPhenotypicFeature | denotes | toxicity | DISEASE |
LitCoin-GeneOrGeneProduct-v3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 216-221 | GeneOrGeneProduct | denotes | GSTP1 |
T2 | 223-227 | GeneOrGeneProduct | denotes | COX2 |
T3 | 229-233 | GeneOrGeneProduct | denotes | IL10 |
T4 | 235-239 | GeneOrGeneProduct | denotes | EGFR |
T5 | 246-251 | GeneOrGeneProduct | denotes | FGFR4 |
T6 | 260-266 | GeneOrGeneProduct | denotes | VEGFR2 |
T7 | 268-272 | GeneOrGeneProduct | denotes | VEGF |
T8 | 274-279 | GeneOrGeneProduct | denotes | CXCR2 |
T9 | 281-284 | GeneOrGeneProduct | denotes | IL8 |
T10 | 286-290 | GeneOrGeneProduct | denotes | MMP3 |
T11 | 292-297 | GeneOrGeneProduct | denotes | ICAM1 |
T12 | 299-304 | GeneOrGeneProduct | denotes | ERCC1 |
T13 | 306-311 | GeneOrGeneProduct | denotes | RAD51 |
T14 | 317-322 | GeneOrGeneProduct | denotes | XRCC3 |
T15 | 580-585 | GeneOrGeneProduct | denotes | Arm 1 |
T16 | 1196-1201 | GeneOrGeneProduct | denotes | GSTP1 |
T17 | 1443-1446 | GeneOrGeneProduct | denotes | IL8 |
T18 | 1535-1541 | GeneOrGeneProduct | denotes | VEGFR2 |
T19 | 1709-1714 | GeneOrGeneProduct | denotes | arm 1 |
LitCoin_Mondo_095
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 1031-1036 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
T2 | 1666-1675 | DiseaseOrPhenotypicFeature | denotes | mucositis | 0020579|0000888 |
T4 | 1772-1781 | DiseaseOrPhenotypicFeature | denotes | mucositis | 0020579|0000888 |
T6 | 1849-1862 | DiseaseOrPhenotypicFeature | denotes | rectal cancer | 0044937|0006519 |
LitCoin-MeSH-Disease-2
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 91-99 | DiseaseOrPhenotypicFeature | denotes | Toxicity | DISEASE |
T2 | 103-116 | DiseaseOrPhenotypicFeature | denotes | Rectal Cancer | D012004 |
T3 | 338-345 | DiseaseOrPhenotypicFeature | denotes | disease | D004194 |
T4 | 394-402 | DiseaseOrPhenotypicFeature | denotes | toxicity | DISEASE |
T5 | 564-578 | DiseaseOrPhenotypicFeature | denotes | rectal cancers | D012004 |
T6 | 1031-1036 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 |
T7 | 1508-1518 | DiseaseOrPhenotypicFeature | denotes | toxicities | DISEASE |
T8 | 1666-1675 | DiseaseOrPhenotypicFeature | denotes | mucositis | D052016 |
T9 | 1772-1781 | DiseaseOrPhenotypicFeature | denotes | mucositis | D052016 |
T10 | 1849-1862 | DiseaseOrPhenotypicFeature | denotes | rectal cancer | D012004 |
T11 | 1951-1959 | DiseaseOrPhenotypicFeature | denotes | toxicity | DISEASE |
LitCoin-MONDO_bioort2019
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T1 | 91-99 | DiseaseOrPhenotypicFeature | denotes | Toxicity | DISEASE |
T2 | 103-116 | DiseaseOrPhenotypicFeature | denotes | Rectal Cancer | D012004 |
T3 | 394-402 | DiseaseOrPhenotypicFeature | denotes | toxicity | DISEASE |
T4 | 564-578 | DiseaseOrPhenotypicFeature | denotes | rectal cancers | D012004 |
T5 | 1031-1036 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 |
T6 | 1508-1518 | DiseaseOrPhenotypicFeature | denotes | toxicities | DISEASE |
T7 | 1666-1675 | DiseaseOrPhenotypicFeature | denotes | mucositis | D052016 |
T8 | 1772-1781 | DiseaseOrPhenotypicFeature | denotes | mucositis | D052016 |
T9 | 1849-1862 | DiseaseOrPhenotypicFeature | denotes | rectal cancer | D012004 |
T10 | 1951-1959 | DiseaseOrPhenotypicFeature | denotes | toxicity | DISEASE |
LitCoin-Chemical-MeSH-CHEBI
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 139-143 | ChemicalEntity | denotes | 5-FU | D005472|http://purl.obolibrary.org/obo/CHEBI_46345 |
T3 | 241-244 | ChemicalEntity | denotes | EGF | http://purl.obolibrary.org/obo/CHEBI_140739 |
T4 | 281-284 | ChemicalEntity | denotes | IL8 | http://purl.obolibrary.org/obo/CHEBI_138181 |
T5 | 495-509 | ChemicalEntity | denotes | 5-fluorouracil | D005472|http://purl.obolibrary.org/obo/CHEBI_46345 |
T7 | 511-515 | ChemicalEntity | denotes | 5-FU | D005472|http://purl.obolibrary.org/obo/CHEBI_46345 |
T9 | 605-609 | ChemicalEntity | denotes | 5-FU | D005472|http://purl.obolibrary.org/obo/CHEBI_46345 |
T11 | 622-626 | ChemicalEntity | denotes | 5-FU | D005472|http://purl.obolibrary.org/obo/CHEBI_46345 |
T13 | 719-723 | ChemicalEntity | denotes | 5-FU | D005472|http://purl.obolibrary.org/obo/CHEBI_46345 |
T15 | 788-792 | ChemicalEntity | denotes | 5-FU | D005472|http://purl.obolibrary.org/obo/CHEBI_46345 |
T17 | 990-998 | ChemicalEntity | denotes | formalin | D005557 |
T18 | 1006-1014 | ChemicalEntity | denotes | paraffin | D010232|ChemicalEntity |
T20 | 1443-1446 | ChemicalEntity | denotes | IL8 | http://purl.obolibrary.org/obo/CHEBI_138181 |
T21 | 1978-1982 | ChemicalEntity | denotes | 5-FU | D005472|http://purl.obolibrary.org/obo/CHEBI_46345 |
LitCoin-NCBITaxon-2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 866-874 | OrganismTaxon | denotes | patients |
T2 | 1423-1431 | OrganismTaxon | denotes | patients |
T3 | 1835-1843 | OrganismTaxon | denotes | patients |
LitCoin-training-merged
Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
---|---|---|---|---|---|---|
T21 | 1978-1982 | ChemicalEntity | denotes | 5-FU | http://purl.obolibrary.org/obo/CHEBI_46345|D005472 | |
T20 | 1443-1446 | ChemicalEntity | denotes | IL8 | http://purl.obolibrary.org/obo/CHEBI_138181 | |
T18 | 1006-1014 | ChemicalEntity | denotes | paraffin | ChemicalEntity|D010232 | |
T17 | 990-998 | ChemicalEntity | denotes | formalin | D005557 | |
T15 | 788-792 | ChemicalEntity | denotes | 5-FU | http://purl.obolibrary.org/obo/CHEBI_46345|D005472 | |
T13 | 719-723 | ChemicalEntity | denotes | 5-FU | http://purl.obolibrary.org/obo/CHEBI_46345|D005472 | |
T11 | 622-626 | ChemicalEntity | denotes | 5-FU | http://purl.obolibrary.org/obo/CHEBI_46345|D005472 | |
T9 | 605-609 | ChemicalEntity | denotes | 5-FU | http://purl.obolibrary.org/obo/CHEBI_46345|D005472 | |
T7 | 511-515 | ChemicalEntity | denotes | 5-FU | http://purl.obolibrary.org/obo/CHEBI_46345|D005472 | |
T5 | 495-509 | ChemicalEntity | denotes | 5-fluorouracil | http://purl.obolibrary.org/obo/CHEBI_46345|D005472 | |
T4 | 281-284 | ChemicalEntity | denotes | IL8 | http://purl.obolibrary.org/obo/CHEBI_138181 | |
T3 | 241-244 | ChemicalEntity | denotes | EGF | http://purl.obolibrary.org/obo/CHEBI_140739 | |
T1 | 139-143 | ChemicalEntity | denotes | 5-FU | http://purl.obolibrary.org/obo/CHEBI_46345|D005472 | |
T19 | 1709-1714 | GeneOrGeneProduct | denotes | arm 1 | ||
T44313 | 1535-1541 | GeneOrGeneProduct | denotes | VEGFR2 | ||
T9341 | 1443-1446 | GeneOrGeneProduct | denotes | IL8 | ||
T16 | 1196-1201 | GeneOrGeneProduct | denotes | GSTP1 | ||
T11011 | 580-585 | GeneOrGeneProduct | denotes | Arm 1 | ||
T14 | 317-322 | GeneOrGeneProduct | denotes | XRCC3 | ||
T37430 | 306-311 | GeneOrGeneProduct | denotes | RAD51 | ||
T12 | 299-304 | GeneOrGeneProduct | denotes | ERCC1 | ||
T93406 | 292-297 | GeneOrGeneProduct | denotes | ICAM1 | ||
T10 | 286-290 | GeneOrGeneProduct | denotes | MMP3 | ||
T17644 | 281-284 | GeneOrGeneProduct | denotes | IL8 | ||
T8 | 274-279 | GeneOrGeneProduct | denotes | CXCR2 | ||
T8234 | 268-272 | GeneOrGeneProduct | denotes | VEGF | ||
T6 | 260-266 | GeneOrGeneProduct | denotes | VEGFR2 | ||
T80266 | 246-251 | GeneOrGeneProduct | denotes | FGFR4 | ||
T61221 | 235-239 | GeneOrGeneProduct | denotes | EGFR | ||
T66909 | 229-233 | GeneOrGeneProduct | denotes | IL10 | ||
T2 | 223-227 | GeneOrGeneProduct | denotes | COX2 | ||
T92556 | 216-221 | GeneOrGeneProduct | denotes | GSTP1 | ||
T93010 | 1951-1959 | DiseaseOrPhenotypicFeature | denotes | toxicity | DISEASE | |
T10698 | 1849-1862 | DiseaseOrPhenotypicFeature | denotes | rectal cancer | D012004 | |
T46952 | 1772-1781 | DiseaseOrPhenotypicFeature | denotes | mucositis | D052016 | |
T90258 | 1666-1675 | DiseaseOrPhenotypicFeature | denotes | mucositis | D052016 | |
T14663 | 1508-1518 | DiseaseOrPhenotypicFeature | denotes | toxicities | DISEASE | |
T45062 | 1031-1036 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 | |
T90570 | 564-578 | DiseaseOrPhenotypicFeature | denotes | rectal cancers | D012004 | |
T52800 | 394-402 | DiseaseOrPhenotypicFeature | denotes | toxicity | DISEASE | |
T37712 | 103-116 | DiseaseOrPhenotypicFeature | denotes | Rectal Cancer | D012004 | |
T84313 | 91-99 | DiseaseOrPhenotypicFeature | denotes | Toxicity | DISEASE | |
T79210 | 1835-1843 | OrganismTaxon | denotes | patients | ||
T32207 | 1423-1431 | OrganismTaxon | denotes | patients | ||
T81674 | 866-874 | OrganismTaxon | denotes | patients | ||
T11383 | 1901-1910 | SequenceVariant | denotes | rs1870377 | ||
T47744 | 1890-1896 | SequenceVariant | denotes | rs4073 | ||
T63948 | 1807-1813 | SequenceVariant | denotes | rs1695 | ||
T7172 | 1562-1571 | SequenceVariant | denotes | rs1870377 | ||
T47503 | 1542-1547 | SequenceVariant | denotes | H472Q | ||
T69073 | 1464-1470 | SequenceVariant | denotes | rs4073 | ||
T50845 | 1446-1451 | SequenceVariant | denotes | -251A | ||
T76587 | 1213-1219 | SequenceVariant | denotes | rs1695 | ||
T87977 | 1202-1211 | SequenceVariant | denotes | Ile105Val |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 571-578 | HP_0002664 | denotes | cancers |
DisGeNET5_variant_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
25589620-10#94#103#geners1870377 | 1901-1910 | geners1870377 | denotes | rs1870377 |
25589620-10#0#6#geners1695 | 1807-1813 | geners1695 | denotes | rs1695 |
25589620-10#78#81#diseaseC1559154 | 1885-1888 | diseaseC1559154 | denotes | CRT |
25589620-10#42#55#diseaseC0007113 | 1849-1862 | diseaseC0007113 | denotes | rectal cancer |
25589620-10#78#81#diseaseC1559154 | 1885-1888 | diseaseC1559154 | denotes | CRT |
25589620-8#31#40#geners1870377 | 1562-1571 | geners1870377 | denotes | rs1870377 |
25589620-8#11#16#geners1870377 | 1542-1547 | geners1870377 | denotes | H472Q |
25589620-8#135#144#diseaseC0521585 | 1666-1675 | diseaseC0521585 | denotes | mucositis |
94#103#geners187037778#81#diseaseC1559154 | 25589620-10#94#103#geners1870377 | 25589620-10#78#81#diseaseC1559154 | associated_with | rs1870377,CRT |
94#103#geners187037742#55#diseaseC0007113 | 25589620-10#94#103#geners1870377 | 25589620-10#42#55#diseaseC0007113 | associated_with | rs1870377,rectal cancer |
94#103#geners187037778#81#diseaseC1559154 | 25589620-10#94#103#geners1870377 | 25589620-10#78#81#diseaseC1559154 | associated_with | rs1870377,CRT |
0#6#geners169578#81#diseaseC1559154 | 25589620-10#0#6#geners1695 | 25589620-10#78#81#diseaseC1559154 | associated_with | rs1695,CRT |
0#6#geners169542#55#diseaseC0007113 | 25589620-10#0#6#geners1695 | 25589620-10#42#55#diseaseC0007113 | associated_with | rs1695,rectal cancer |
0#6#geners169578#81#diseaseC1559154 | 25589620-10#0#6#geners1695 | 25589620-10#78#81#diseaseC1559154 | associated_with | rs1695,CRT |
31#40#geners1870377135#144#diseaseC0521585 | 25589620-8#31#40#geners1870377 | 25589620-8#135#144#diseaseC0521585 | associated_with | rs1870377,mucositis |
11#16#geners1870377135#144#diseaseC0521585 | 25589620-8#11#16#geners1870377 | 25589620-8#135#144#diseaseC0521585 | associated_with | H472Q,mucositis |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
25589620-0#28#31#gene27152 | 28-31 | gene27152 | denotes | INT |
25589620-0#103#116#diseaseC0007113 | 103-116 | diseaseC0007113 | denotes | Rectal Cancer |
25589620-1#412#417#gene11047 | 580-585 | gene11047 | denotes | Arm 1 |
25589620-1#412#417#gene9622 | 580-585 | gene9622 | denotes | Arm 1 |
25589620-1#412#417#gene11047 | 580-585 | gene11047 | denotes | Arm 1 |
25589620-1#412#417#gene9622 | 580-585 | gene9622 | denotes | Arm 1 |
25589620-1#412#417#gene11047 | 580-585 | gene11047 | denotes | Arm 1 |
25589620-1#412#417#gene9622 | 580-585 | gene9622 | denotes | Arm 1 |
25589620-1#149#154#gene7517 | 317-322 | gene7517 | denotes | XRCC3 |
25589620-1#355#369#diseaseC1559154 | 523-537 | diseaseC1559154 | denotes | chemoradiation |
25589620-1#371#374#diseaseC1559154 | 539-542 | diseaseC1559154 | denotes | CRT |
25589620-1#396#410#diseaseC0007113 | 564-578 | diseaseC0007113 | denotes | rectal cancers |
25589620-1#355#369#diseaseC1559154 | 523-537 | diseaseC1559154 | denotes | chemoradiation |
25589620-1#371#374#diseaseC1559154 | 539-542 | diseaseC1559154 | denotes | CRT |
25589620-1#396#410#diseaseC0007113 | 564-578 | diseaseC0007113 | denotes | rectal cancers |
25589620-8#4#10#gene3791 | 1535-1541 | gene3791 | denotes | VEGFR2 |
25589620-8#135#144#diseaseC0521585 | 1666-1675 | diseaseC0521585 | denotes | mucositis |
28#31#gene27152103#116#diseaseC0007113 | 25589620-0#28#31#gene27152 | 25589620-0#103#116#diseaseC0007113 | associated_with | INT,Rectal Cancer |
412#417#gene11047355#369#diseaseC1559154 | 25589620-1#412#417#gene11047 | 25589620-1#355#369#diseaseC1559154 | associated_with | Arm 1,chemoradiation |
412#417#gene11047371#374#diseaseC1559154 | 25589620-1#412#417#gene11047 | 25589620-1#371#374#diseaseC1559154 | associated_with | Arm 1,CRT |
412#417#gene11047396#410#diseaseC0007113 | 25589620-1#412#417#gene11047 | 25589620-1#396#410#diseaseC0007113 | associated_with | Arm 1,rectal cancers |
412#417#gene11047355#369#diseaseC1559154 | 25589620-1#412#417#gene11047 | 25589620-1#355#369#diseaseC1559154 | associated_with | Arm 1,chemoradiation |
412#417#gene11047371#374#diseaseC1559154 | 25589620-1#412#417#gene11047 | 25589620-1#371#374#diseaseC1559154 | associated_with | Arm 1,CRT |
412#417#gene11047396#410#diseaseC0007113 | 25589620-1#412#417#gene11047 | 25589620-1#396#410#diseaseC0007113 | associated_with | Arm 1,rectal cancers |
412#417#gene9622355#369#diseaseC1559154 | 25589620-1#412#417#gene9622 | 25589620-1#355#369#diseaseC1559154 | associated_with | Arm 1,chemoradiation |
412#417#gene9622371#374#diseaseC1559154 | 25589620-1#412#417#gene9622 | 25589620-1#371#374#diseaseC1559154 | associated_with | Arm 1,CRT |
412#417#gene9622396#410#diseaseC0007113 | 25589620-1#412#417#gene9622 | 25589620-1#396#410#diseaseC0007113 | associated_with | Arm 1,rectal cancers |
412#417#gene9622355#369#diseaseC1559154 | 25589620-1#412#417#gene9622 | 25589620-1#355#369#diseaseC1559154 | associated_with | Arm 1,chemoradiation |
412#417#gene9622371#374#diseaseC1559154 | 25589620-1#412#417#gene9622 | 25589620-1#371#374#diseaseC1559154 | associated_with | Arm 1,CRT |
412#417#gene9622396#410#diseaseC0007113 | 25589620-1#412#417#gene9622 | 25589620-1#396#410#diseaseC0007113 | associated_with | Arm 1,rectal cancers |
412#417#gene11047355#369#diseaseC1559154 | 25589620-1#412#417#gene11047 | 25589620-1#355#369#diseaseC1559154 | associated_with | Arm 1,chemoradiation |
412#417#gene11047371#374#diseaseC1559154 | 25589620-1#412#417#gene11047 | 25589620-1#371#374#diseaseC1559154 | associated_with | Arm 1,CRT |
412#417#gene11047396#410#diseaseC0007113 | 25589620-1#412#417#gene11047 | 25589620-1#396#410#diseaseC0007113 | associated_with | Arm 1,rectal cancers |
412#417#gene11047355#369#diseaseC1559154 | 25589620-1#412#417#gene11047 | 25589620-1#355#369#diseaseC1559154 | associated_with | Arm 1,chemoradiation |
412#417#gene11047371#374#diseaseC1559154 | 25589620-1#412#417#gene11047 | 25589620-1#371#374#diseaseC1559154 | associated_with | Arm 1,CRT |
412#417#gene11047396#410#diseaseC0007113 | 25589620-1#412#417#gene11047 | 25589620-1#396#410#diseaseC0007113 | associated_with | Arm 1,rectal cancers |
412#417#gene9622355#369#diseaseC1559154 | 25589620-1#412#417#gene9622 | 25589620-1#355#369#diseaseC1559154 | associated_with | Arm 1,chemoradiation |
412#417#gene9622371#374#diseaseC1559154 | 25589620-1#412#417#gene9622 | 25589620-1#371#374#diseaseC1559154 | associated_with | Arm 1,CRT |
412#417#gene9622396#410#diseaseC0007113 | 25589620-1#412#417#gene9622 | 25589620-1#396#410#diseaseC0007113 | associated_with | Arm 1,rectal cancers |
412#417#gene9622355#369#diseaseC1559154 | 25589620-1#412#417#gene9622 | 25589620-1#355#369#diseaseC1559154 | associated_with | Arm 1,chemoradiation |
412#417#gene9622371#374#diseaseC1559154 | 25589620-1#412#417#gene9622 | 25589620-1#371#374#diseaseC1559154 | associated_with | Arm 1,CRT |
412#417#gene9622396#410#diseaseC0007113 | 25589620-1#412#417#gene9622 | 25589620-1#396#410#diseaseC0007113 | associated_with | Arm 1,rectal cancers |
412#417#gene11047355#369#diseaseC1559154 | 25589620-1#412#417#gene11047 | 25589620-1#355#369#diseaseC1559154 | associated_with | Arm 1,chemoradiation |
412#417#gene11047371#374#diseaseC1559154 | 25589620-1#412#417#gene11047 | 25589620-1#371#374#diseaseC1559154 | associated_with | Arm 1,CRT |
412#417#gene11047396#410#diseaseC0007113 | 25589620-1#412#417#gene11047 | 25589620-1#396#410#diseaseC0007113 | associated_with | Arm 1,rectal cancers |
412#417#gene11047355#369#diseaseC1559154 | 25589620-1#412#417#gene11047 | 25589620-1#355#369#diseaseC1559154 | associated_with | Arm 1,chemoradiation |
412#417#gene11047371#374#diseaseC1559154 | 25589620-1#412#417#gene11047 | 25589620-1#371#374#diseaseC1559154 | associated_with | Arm 1,CRT |
412#417#gene11047396#410#diseaseC0007113 | 25589620-1#412#417#gene11047 | 25589620-1#396#410#diseaseC0007113 | associated_with | Arm 1,rectal cancers |
412#417#gene9622355#369#diseaseC1559154 | 25589620-1#412#417#gene9622 | 25589620-1#355#369#diseaseC1559154 | associated_with | Arm 1,chemoradiation |
412#417#gene9622371#374#diseaseC1559154 | 25589620-1#412#417#gene9622 | 25589620-1#371#374#diseaseC1559154 | associated_with | Arm 1,CRT |
412#417#gene9622396#410#diseaseC0007113 | 25589620-1#412#417#gene9622 | 25589620-1#396#410#diseaseC0007113 | associated_with | Arm 1,rectal cancers |
412#417#gene9622355#369#diseaseC1559154 | 25589620-1#412#417#gene9622 | 25589620-1#355#369#diseaseC1559154 | associated_with | Arm 1,chemoradiation |
412#417#gene9622371#374#diseaseC1559154 | 25589620-1#412#417#gene9622 | 25589620-1#371#374#diseaseC1559154 | associated_with | Arm 1,CRT |
412#417#gene9622396#410#diseaseC0007113 | 25589620-1#412#417#gene9622 | 25589620-1#396#410#diseaseC0007113 | associated_with | Arm 1,rectal cancers |
149#154#gene7517355#369#diseaseC1559154 | 25589620-1#149#154#gene7517 | 25589620-1#355#369#diseaseC1559154 | associated_with | XRCC3,chemoradiation |
149#154#gene7517371#374#diseaseC1559154 | 25589620-1#149#154#gene7517 | 25589620-1#371#374#diseaseC1559154 | associated_with | XRCC3,CRT |
149#154#gene7517396#410#diseaseC0007113 | 25589620-1#149#154#gene7517 | 25589620-1#396#410#diseaseC0007113 | associated_with | XRCC3,rectal cancers |
149#154#gene7517355#369#diseaseC1559154 | 25589620-1#149#154#gene7517 | 25589620-1#355#369#diseaseC1559154 | associated_with | XRCC3,chemoradiation |
149#154#gene7517371#374#diseaseC1559154 | 25589620-1#149#154#gene7517 | 25589620-1#371#374#diseaseC1559154 | associated_with | XRCC3,CRT |
149#154#gene7517396#410#diseaseC0007113 | 25589620-1#149#154#gene7517 | 25589620-1#396#410#diseaseC0007113 | associated_with | XRCC3,rectal cancers |
4#10#gene3791135#144#diseaseC0521585 | 25589620-8#4#10#gene3791 | 25589620-8#135#144#diseaseC0521585 | associated_with | VEGFR2,mucositis |