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PubMed:25576852 JSONTXT

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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 92-1680 UNLABELLED denotes Ticks rely exclusively on vertebrate blood for their survival. During feeding ticks inject into their hosts a sophisticated salivary potion that overcomes host hemostasis and adverse inflammatory responses. These mediators may also enhance pathogen transmission. Knowledge of the tick salivary protein repertoire may lead to vaccine targets to disrupt feeding and/or parasite transmission as well as to the discovery of novel pharmacological agents. Male saliva may also assist reproduction because males use their mouthparts to lubricate and introduce their spermatophores into the females' genital pore. The analyses of the sialomes of male and female ticks independently allow us to understand the strategy used by each gender to feed successfully. We sequenced cDNA libraries from pools of salivary glands from adult male and female Rhipicephalus pulchellus feeding at different time points, using the Illumina HiSeq protocol. De novo assembly of a total of 241,229,128 paired-end reads lead to extraction of 50,460 coding sequences (CDS), 11,277 of which had more than 75% coverage to known transcripts, or represented novel sequences, and were submitted to GenBank. Additionally, we generated the proteome, from the salivary gland extracts of male and female R. pulchellus, yielding a total of 454 and 2063 proteins respectively which were identified by one or more peptides with at least 95% confidence. The data set is presented as an annotated hyperlinked Excel spreadsheet, describing 121 putative secreted protein families. Female and male specific transcripts were identified.
T2 1706-2187 UNASSIGNED denotes This annotated R. pulchellus database represents a mining field for future experiments involving the resolution of time-dependent transcript expression in this tick species, as well as to define novel vaccine targets and discover novel pharmaceuticals. Gender specific proteins may represent different repertoires of pharmacological reagents to assist feeding by each sex, and in males may represent proteins that assist reproduction similarly to seminal proteins in other animals.

sentences

Id Subject Object Predicate Lexical cue
T1 0-79 Sentence denotes Sexual differences in the sialomes of the zebra tick, Rhipicephalus pulchellus.
T2 80-91 Sentence denotes UNLABELLED:
T3 92-154 Sentence denotes Ticks rely exclusively on vertebrate blood for their survival.
T4 155-298 Sentence denotes During feeding ticks inject into their hosts a sophisticated salivary potion that overcomes host hemostasis and adverse inflammatory responses.
T5 299-354 Sentence denotes These mediators may also enhance pathogen transmission.
T6 355-541 Sentence denotes Knowledge of the tick salivary protein repertoire may lead to vaccine targets to disrupt feeding and/or parasite transmission as well as to the discovery of novel pharmacological agents.
T7 542-697 Sentence denotes Male saliva may also assist reproduction because males use their mouthparts to lubricate and introduce their spermatophores into the females' genital pore.
T8 698-843 Sentence denotes The analyses of the sialomes of male and female ticks independently allow us to understand the strategy used by each gender to feed successfully.
T9 844-1022 Sentence denotes We sequenced cDNA libraries from pools of salivary glands from adult male and female Rhipicephalus pulchellus feeding at different time points, using the Illumina HiSeq protocol.
T10 1023-1263 Sentence denotes De novo assembly of a total of 241,229,128 paired-end reads lead to extraction of 50,460 coding sequences (CDS), 11,277 of which had more than 75% coverage to known transcripts, or represented novel sequences, and were submitted to GenBank.
T11 1264-1502 Sentence denotes Additionally, we generated the proteome, from the salivary gland extracts of male and female R. pulchellus, yielding a total of 454 and 2063 proteins respectively which were identified by one or more peptides with at least 95% confidence.
T12 1503-1626 Sentence denotes The data set is presented as an annotated hyperlinked Excel spreadsheet, describing 121 putative secreted protein families.
T13 1627-1680 Sentence denotes Female and male specific transcripts were identified.
T14 1681-1705 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T15 1706-1958 Sentence denotes This annotated R. pulchellus database represents a mining field for future experiments involving the resolution of time-dependent transcript expression in this tick species, as well as to define novel vaccine targets and discover novel pharmaceuticals.
T16 1959-2187 Sentence denotes Gender specific proteins may represent different repertoires of pharmacological reagents to assist feeding by each sex, and in males may represent proteins that assist reproduction similarly to seminal proteins in other animals.
T1 0-79 Sentence denotes Sexual differences in the sialomes of the zebra tick, Rhipicephalus pulchellus.
T2 80-91 Sentence denotes UNLABELLED:
T3 92-154 Sentence denotes Ticks rely exclusively on vertebrate blood for their survival.
T4 155-298 Sentence denotes During feeding ticks inject into their hosts a sophisticated salivary potion that overcomes host hemostasis and adverse inflammatory responses.
T5 299-354 Sentence denotes These mediators may also enhance pathogen transmission.
T6 355-541 Sentence denotes Knowledge of the tick salivary protein repertoire may lead to vaccine targets to disrupt feeding and/or parasite transmission as well as to the discovery of novel pharmacological agents.
T7 542-697 Sentence denotes Male saliva may also assist reproduction because males use their mouthparts to lubricate and introduce their spermatophores into the females' genital pore.
T8 698-843 Sentence denotes The analyses of the sialomes of male and female ticks independently allow us to understand the strategy used by each gender to feed successfully.
T9 844-1022 Sentence denotes We sequenced cDNA libraries from pools of salivary glands from adult male and female Rhipicephalus pulchellus feeding at different time points, using the Illumina HiSeq protocol.
T10 1023-1263 Sentence denotes De novo assembly of a total of 241,229,128 paired-end reads lead to extraction of 50,460 coding sequences (CDS), 11,277 of which had more than 75% coverage to known transcripts, or represented novel sequences, and were submitted to GenBank.
T11 1264-1502 Sentence denotes Additionally, we generated the proteome, from the salivary gland extracts of male and female R. pulchellus, yielding a total of 454 and 2063 proteins respectively which were identified by one or more peptides with at least 95% confidence.
T12 1503-1626 Sentence denotes The data set is presented as an annotated hyperlinked Excel spreadsheet, describing 121 putative secreted protein families.
T13 1627-1680 Sentence denotes Female and male specific transcripts were identified.
T14 1681-1705 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T15 1706-1958 Sentence denotes This annotated R. pulchellus database represents a mining field for future experiments involving the resolution of time-dependent transcript expression in this tick species, as well as to define novel vaccine targets and discover novel pharmaceuticals.
T16 1959-2187 Sentence denotes Gender specific proteins may represent different repertoires of pharmacological reagents to assist feeding by each sex, and in males may represent proteins that assist reproduction similarly to seminal proteins in other animals.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 118-128 http://purl.obolibrary.org/obo/MAT_0000373 denotes vertebrate
T2 129-134 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T3 129-134 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T4 542-546 http://purl.obolibrary.org/obo/MAT_0000029 denotes Male
T5 547-553 http://purl.obolibrary.org/obo/MAT_0000444 denotes saliva
T6 591-596 http://purl.obolibrary.org/obo/MAT_0000029 denotes males
T7 730-734 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T8 886-901 http://purl.obolibrary.org/obo/MAT_0000079 denotes salivary glands
T9 913-917 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T10 1314-1328 http://purl.obolibrary.org/obo/MAT_0000079 denotes salivary gland
T11 1323-1328 http://purl.obolibrary.org/obo/MAT_0000021 denotes gland
T12 1341-1345 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T13 1638-1642 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T14 2086-2091 http://purl.obolibrary.org/obo/MAT_0000029 denotes males

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 118-128 Body_part denotes vertebrate http://purl.obolibrary.org/obo/MAT_0000373
T2 129-134 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T4 542-546 Body_part denotes Male http://purl.obolibrary.org/obo/MAT_0000029
T5 547-553 Body_part denotes saliva http://purl.obolibrary.org/obo/MAT_0000444
T6 591-596 Body_part denotes males http://purl.obolibrary.org/obo/MAT_0000029
T7 730-734 Body_part denotes male http://purl.obolibrary.org/obo/MAT_0000029
T8 886-901 Body_part denotes salivary glands http://purl.obolibrary.org/obo/MAT_0000079
T9 913-917 Body_part denotes male http://purl.obolibrary.org/obo/MAT_0000029
T10 1314-1328 Body_part denotes salivary gland http://purl.obolibrary.org/obo/MAT_0000079
T11 1341-1345 Body_part denotes male http://purl.obolibrary.org/obo/MAT_0000029
T12 1638-1642 Body_part denotes male http://purl.obolibrary.org/obo/MAT_0000029
T13 2086-2091 Body_part denotes males http://purl.obolibrary.org/obo/MAT_0000029

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 54-78 OrganismTaxon denotes Rhipicephalus pulchellus 72859
T2 929-953 OrganismTaxon denotes Rhipicephalus pulchellus 72859

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 118-134 Body_part denotes vertebrate blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 547-553 Body_part denotes saliva http://purl.obolibrary.org/obo/UBERON_0001836
T3 607-617 Body_part denotes mouthparts http://purl.obolibrary.org/obo/UBERON_6001845
T4 684-696 Body_part denotes genital pore http://purl.obolibrary.org/obo/UBERON_0008936
T5 886-901 Body_part denotes salivary glands http://purl.obolibrary.org/obo/UBERON_0001044
T6 1314-1328 Body_part denotes salivary gland http://purl.obolibrary.org/obo/UBERON_0001044
T7 1638-1651 Body_part denotes male specific http://purl.obolibrary.org/obo/UBERON_0014403
T8 1959-1974 Body_part denotes Gender specific http://purl.obolibrary.org/obo/UBERON_0014402