PubMed:25535111
Annnotations
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 137-325 | DRI_Background | denotes | Effects of severe hypercapnia have been extensively studied in marine fishes, while knowledge on the impacts of moderately elevated CO2 levels and their combination with warming is scarce. |
T2 | 326-497 | DRI_Background | denotes | Here we investigate ion regulation mechanisms and energy budget in gills from Atlantic cod acclimated long-term to elevated PCO2 levels (2500 μatm) and temperature (18°C). |
T3 | 498-696 | DRI_Background | denotes | Isolated perfused gill preparations were established to determine gill thermal plasticity during acute exposures (10-22°C) and in vivo costs of Na(+)/K(+)-ATPase activity, protein and RNA synthesis. |
T4 | 697-822 | DRI_Approach | denotes | Maximum enzyme capacities of F1Fo-ATPase, H(+)-ATPase and Na(+)/K(+)-ATPase were measured in vitro in crude gill homogenates. |
T5 | 823-968 | DRI_Challenge | denotes | After whole animal acclimation to elevated PCO2 and/or warming, branchial oxygen consumption responded more strongly to acute temperature change. |
T6 | 969-1061 | DRI_Background | denotes | The fractions of gill respiration allocated to protein and RNA synthesis remained unchanged. |
T7 | 1062-1219 | DRI_Background | denotes | In gills of fish CO2-exposed at both temperatures, energy turnover associated with Na(+)/K(+)-ATPase activity was reduced by 30% below rates of control fish. |
T8 | 1220-1414 | DRI_Approach | denotes | This contrasted in vitro capacities of Na(+)/K(+)-ATPase, which remained unchanged under elevated CO2 at 10°C, and earlier studies which had found a strong upregulation under severe hypercapnia. |
T9 | 1656-1858 | DRI_Challenge | denotes | We conclude that in vivo ion regulatory energy demand is lowered under moderately elevated CO2 levels despite the stronger thermal response of total gill respiration and the upregulation of F1Fo-ATPase. |
T10 | 1859-1909 | DRI_Approach | denotes | This effect is maintained at elevated temperature. |
Goldhamster2_Cellosaurus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 99-104 | CVCL_R842|Spontaneously_immortalized_cell_line|Cyprinus carpio | denotes | gills |
T2 | 331-333 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | we |
T3 | 393-398 | CVCL_R842|Spontaneously_immortalized_cell_line|Cyprinus carpio | denotes | gills |
T4 | 491-495 | CVCL_8995|Induced_pluripotent_stem_cell|Homo sapiens | denotes | 18°C |
T5 | 491-493 | CVCL_T367|Transformed_cell_line|Chlorocebus aethiops | denotes | 18 |
T6 | 494-495 | CVCL_S361|Finite_cell_line|Mus musculus | denotes | C |
T7 | 516-520 | CVCL_R842|Spontaneously_immortalized_cell_line|Cyprinus carpio | denotes | gill |
T8 | 564-568 | CVCL_R842|Spontaneously_immortalized_cell_line|Cyprinus carpio | denotes | gill |
T9 | 615-619 | CVCL_UL45|Induced_pluripotent_stem_cell|Homo sapiens | denotes | 22°C |
T10 | 615-617 | CVCL_WT45|Hybridoma|Mus musculus | denotes | 22 |
T11 | 633-638 | CVCL_9491|Cancer_cell_line|Homo sapiens | denotes | costs |
T12 | 642-644 | CVCL_7082|Cancer_cell_line|Homo sapiens | denotes | Na |
T13 | 660-668 | CVCL_C410|Hybridoma|Mus musculus | denotes | activity |
T14 | 755-757 | CVCL_7082|Cancer_cell_line|Homo sapiens | denotes | Na |
T15 | 805-809 | CVCL_R842|Spontaneously_immortalized_cell_line|Cyprinus carpio | denotes | gill |
T16 | 961-967 | CVCL_0238|Cancer_cell_line|Homo sapiens | denotes | change |
T17 | 986-990 | CVCL_R842|Spontaneously_immortalized_cell_line|Cyprinus carpio | denotes | gill |
T18 | 1065-1070 | CVCL_R842|Spontaneously_immortalized_cell_line|Cyprinus carpio | denotes | gills |
T19 | 1145-1147 | CVCL_7082|Cancer_cell_line|Homo sapiens | denotes | Na |
T20 | 1163-1171 | CVCL_C410|Hybridoma|Mus musculus | denotes | activity |
T21 | 1187-1189 | CVCL_J925|Hybridoma|Mus musculus | denotes | 30 |
T22 | 1259-1261 | CVCL_7082|Cancer_cell_line|Homo sapiens | denotes | Na |
T23 | 1328-1329 | CVCL_S361|Finite_cell_line|Mus musculus | denotes | C |
T24 | 1367-1368 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T25 | 1463-1468 | CVCL_R842|Spontaneously_immortalized_cell_line|Cyprinus carpio | denotes | gills |
T26 | 1499-1501 | CVCL_7082|Cancer_cell_line|Homo sapiens | denotes | Na |
T27 | 1656-1658 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | We |
T28 | 1805-1809 | CVCL_R842|Spontaneously_immortalized_cell_line|Cyprinus carpio | denotes | gill |
GoldHamster
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-6 | PR:Q5GFD9 | denotes | Impact |
T2 | 0-6 | PR:O55091 | denotes | Impact |
T3 | 15-19 | original_id | denotes | term |
T4 | 29-40 | D006935 | denotes | hypercapnia |
T5 | 29-40 | D006935 | denotes | hypercapnia |
T6 | 99-104 | UBERON:0011150 | denotes | gills |
T7 | 108-120 | 8049 | denotes | Atlantic cod |
T8 | 108-120 | D048389 | denotes | Atlantic cod |
T13 | 117-120 | 892543 | denotes | cod |
T9 | 117-120 | Q3Z280 | denotes | cod |
T10 | 117-120 | B7M1E5 | denotes | cod |
T11 | 117-120 | B5RAY7 | denotes | cod |
T12 | 117-120 | Q57PW7 | denotes | cod |
T14 | 117-120 | B4TUD7 | denotes | cod |
T15 | 117-120 | PR:000029730 | denotes | cod |
T16 | 117-120 | Q8FH10 | denotes | cod |
T17 | 117-120 | B5QWH6 | denotes | cod |
T18 | 117-120 | A9N261 | denotes | cod |
T19 | 117-120 | Q5PHB3 | denotes | cod |
T20 | 117-120 | A1ABR4 | denotes | cod |
T21 | 117-120 | B1JR86 | denotes | cod |
T22 | 117-120 | Q1CKI2 | denotes | cod |
T23 | 117-120 | A1JKF8 | denotes | cod |
T24 | 117-120 | Q0T4U2 | denotes | cod |
T25 | 117-120 | B5XT26 | denotes | cod |
T26 | 117-120 | B5YQ20 | denotes | cod |
T27 | 117-120 | Q1RB62 | denotes | cod |
T28 | 117-120 | B4EZQ3 | denotes | cod |
T29 | 117-120 | B5BA58 | denotes | cod |
T30 | 117-120 | Q667R4 | denotes | cod |
T31 | 117-120 | B7NT44 | denotes | cod |
T32 | 117-120 | B5F7H6 | denotes | cod |
T33 | 117-120 | C0Q659 | denotes | cod |
T34 | 117-120 | B1IPJ7 | denotes | cod |
T35 | 117-120 | Q8L3B9 | denotes | cod |
T36 | 117-120 | B7MAU4 | denotes | cod |
T37 | 117-120 | Q0TH97 | denotes | cod |
T38 | 117-120 | P59746 | denotes | cod |
T39 | 117-120 | B7L6K7 | denotes | cod |
T40 | 117-120 | B1XGJ4 | denotes | cod |
T41 | 117-120 | A7FFP8 | denotes | cod |
T42 | 117-120 | A4TL15 | denotes | cod |
T43 | 117-120 | B1LDZ8 | denotes | cod |
T44 | 117-120 | B7USB4 | denotes | cod |
T45 | 117-120 | A8A0S5 | denotes | cod |
T46 | 117-120 | Q8ZDA6 | denotes | cod |
T47 | 117-120 | Q8XE10 | denotes | cod |
T48 | 117-120 | B6IBF3 | denotes | cod |
T49 | 117-120 | A4W9L0 | denotes | cod |
T50 | 117-120 | A6T7U7 | denotes | cod |
T51 | 117-120 | A7ZMK0 | denotes | cod |
T52 | 117-120 | B7N569 | denotes | cod |
T53 | 117-120 | Q8ZPU1 | denotes | cod |
T54 | 117-120 | B5FJC2 | denotes | cod |
T55 | 117-120 | Q1C596 | denotes | cod |
T56 | 117-120 | Q8Z6H0 | denotes | cod |
T57 | 117-120 | A8AHC4 | denotes | cod |
T58 | 117-120 | C4ZZ89 | denotes | cod |
T59 | 117-120 | B7MVL2 | denotes | cod |
T60 | 117-120 | A9R3W4 | denotes | cod |
T61 | 117-120 | B2KA89 | denotes | cod |
T62 | 117-120 | B4TGF6 | denotes | cod |
T63 | 117-120 | B7LQ59 | denotes | cod |
T64 | 117-120 | P37794 | denotes | cod |
T65 | 117-120 | PR:P14678 | denotes | cod |
T66 | 117-120 | B4T4L5 | denotes | cod |
T67 | 122-134 | 8049 | denotes | Gadus morhua |
T68 | 122-134 | D048389 | denotes | Gadus morhua |
T69 | 155-166 | D006935 | denotes | hypercapnia |
T70 | 155-166 | D006935 | denotes | hypercapnia |
T71 | 207-213 | D005399 | denotes | fishes |
T72 | 269-272 | CHEBI:29325 | denotes | CO2 |
T73 | 269-272 | CHEBI:48828 | denotes | CO2 |
T74 | 269-272 | CHEBI:16526 | denotes | CO2 |
T75 | 269-272 | CHEBI:29334 | denotes | CO2 |
T76 | 346-349 | CHEBI:24870 | denotes | ion |
T77 | 350-360 | GO:0065007 | denotes | regulation |
T78 | 393-398 | UBERON:0011150 | denotes | gills |
T79 | 404-416 | 8049 | denotes | Atlantic cod |
T80 | 404-416 | D048389 | denotes | Atlantic cod |
T85 | 413-416 | 892543 | denotes | cod |
T81 | 413-416 | Q3Z280 | denotes | cod |
T82 | 413-416 | B7M1E5 | denotes | cod |
T83 | 413-416 | B5RAY7 | denotes | cod |
T84 | 413-416 | Q57PW7 | denotes | cod |
T86 | 413-416 | B4TUD7 | denotes | cod |
T87 | 413-416 | PR:000029730 | denotes | cod |
T88 | 413-416 | Q8FH10 | denotes | cod |
T89 | 413-416 | B5QWH6 | denotes | cod |
T90 | 413-416 | A9N261 | denotes | cod |
T91 | 413-416 | Q5PHB3 | denotes | cod |
T92 | 413-416 | A1ABR4 | denotes | cod |
T93 | 413-416 | B1JR86 | denotes | cod |
T94 | 413-416 | Q1CKI2 | denotes | cod |
T95 | 413-416 | A1JKF8 | denotes | cod |
T96 | 413-416 | Q0T4U2 | denotes | cod |
T97 | 413-416 | B5XT26 | denotes | cod |
T98 | 413-416 | B5YQ20 | denotes | cod |
T99 | 413-416 | Q1RB62 | denotes | cod |
T100 | 413-416 | B4EZQ3 | denotes | cod |
T101 | 413-416 | B5BA58 | denotes | cod |
T102 | 413-416 | Q667R4 | denotes | cod |
T103 | 413-416 | B7NT44 | denotes | cod |
T104 | 413-416 | B5F7H6 | denotes | cod |
T105 | 413-416 | C0Q659 | denotes | cod |
T106 | 413-416 | B1IPJ7 | denotes | cod |
T107 | 413-416 | Q8L3B9 | denotes | cod |
T108 | 413-416 | B7MAU4 | denotes | cod |
T109 | 413-416 | Q0TH97 | denotes | cod |
T110 | 413-416 | P59746 | denotes | cod |
T111 | 413-416 | B7L6K7 | denotes | cod |
T112 | 413-416 | B1XGJ4 | denotes | cod |
T113 | 413-416 | A7FFP8 | denotes | cod |
T114 | 413-416 | A4TL15 | denotes | cod |
T115 | 413-416 | B1LDZ8 | denotes | cod |
T116 | 413-416 | B7USB4 | denotes | cod |
T117 | 413-416 | A8A0S5 | denotes | cod |
T118 | 413-416 | Q8ZDA6 | denotes | cod |
T119 | 413-416 | Q8XE10 | denotes | cod |
T120 | 413-416 | B6IBF3 | denotes | cod |
T121 | 413-416 | A4W9L0 | denotes | cod |
T122 | 413-416 | A6T7U7 | denotes | cod |
T123 | 413-416 | A7ZMK0 | denotes | cod |
T124 | 413-416 | B7N569 | denotes | cod |
T125 | 413-416 | Q8ZPU1 | denotes | cod |
T126 | 413-416 | B5FJC2 | denotes | cod |
T127 | 413-416 | Q1C596 | denotes | cod |
T128 | 413-416 | Q8Z6H0 | denotes | cod |
T129 | 413-416 | A8AHC4 | denotes | cod |
T130 | 413-416 | C4ZZ89 | denotes | cod |
T131 | 413-416 | B7MVL2 | denotes | cod |
T132 | 413-416 | A9R3W4 | denotes | cod |
T133 | 413-416 | B2KA89 | denotes | cod |
T134 | 413-416 | B4TGF6 | denotes | cod |
T135 | 413-416 | B7LQ59 | denotes | cod |
T136 | 413-416 | P37794 | denotes | cod |
T137 | 413-416 | PR:P14678 | denotes | cod |
T138 | 413-416 | B4T4L5 | denotes | cod |
T139 | 433-437 | original_id | denotes | term |
T140 | 450-453 | D011085 | denotes | PCO |
T141 | 450-454 | PR:Q8LGJ5 | denotes | PCO2 |
T147 | 516-520 | CVCL_R842 | denotes | gill |
T146 | 516-520 | UBERON:0002535 | denotes | gill |
T149 | 564-568 | CVCL_R842 | denotes | gill |
T148 | 564-568 | UBERON:0002535 | denotes | gill |
T150 | 642-668 | GO:0005391 | denotes | Na(+)/K(+)-ATPase activity |
T151 | 653-659 | A3DIJ8 | denotes | ATPase |
T153 | 653-659 | Q9SIY3 | denotes | ATPase |
T152 | 653-659 | D000251 | denotes | ATPase |
T155 | 670-677 | GO:0003675 | denotes | protein |
T159 | 670-677 | SO:0000104 | denotes | protein |
T158 | 670-677 | PR:000000001 | denotes | protein |
T156 | 670-677 | CHEBI:36080 | denotes | protein |
T157 | 670-677 | CHEBI:11122 | denotes | protein |
T162 | 682-685 | GO:0005562 | denotes | RNA |
T163 | 682-685 | SO:0000356 | denotes | RNA |
T160 | 682-685 | CHEBI:33697 | denotes | RNA |
T161 | 682-685 | D012313 | denotes | RNA |
T164 | 682-695 | GO:0032774 | denotes | RNA synthesis |
T166 | 731-737 | A3DIJ8 | denotes | ATPase |
T168 | 731-737 | Q9SIY3 | denotes | ATPase |
T169 | 731-740 | D006180 | denotes | ATPase, H |
T170 | 739-750 | D006180 | denotes | H(+)-ATPase |
T171 | 744-750 | A3DIJ8 | denotes | ATPase |
T173 | 744-750 | Q9SIY3 | denotes | ATPase |
T174 | 766-772 | A3DIJ8 | denotes | ATPase |
T176 | 766-772 | Q9SIY3 | denotes | ATPase |
T175 | 766-772 | D000251 | denotes | ATPase |
T178 | 805-809 | CVCL_R842 | denotes | gill |
T177 | 805-809 | UBERON:0002535 | denotes | gill |
T179 | 835-841 | UBERON:3010325 | denotes | animal |
T180 | 835-841 | UBERON:0000468 | denotes | animal |
T181 | 866-869 | D011085 | denotes | PCO |
T182 | 866-870 | PR:Q8LGJ5 | denotes | PCO2 |
T184 | 897-903 | 7806 | denotes | oxygen |
T183 | 897-903 | CHEBI:25805 | denotes | oxygen |
T186 | 986-990 | CVCL_R842 | denotes | gill |
T185 | 986-990 | UBERON:0002535 | denotes | gill |
T187 | 991-1002 | GO:0045333 | denotes | respiration |
T188 | 991-1002 | GO:0007585 | denotes | respiration |
T193 | 1016-1023 | SO:0000104 | denotes | protein |
T190 | 1016-1023 | CHEBI:36080 | denotes | protein |
T191 | 1016-1023 | CHEBI:11122 | denotes | protein |
T192 | 1016-1023 | PR:000000001 | denotes | protein |
T189 | 1016-1023 | GO:0003675 | denotes | protein |
T197 | 1028-1031 | SO:0000356 | denotes | RNA |
T194 | 1028-1031 | CHEBI:33697 | denotes | RNA |
T195 | 1028-1031 | D012313 | denotes | RNA |
T196 | 1028-1031 | GO:0005562 | denotes | RNA |
T198 | 1028-1041 | GO:0032774 | denotes | RNA synthesis |
T200 | 1065-1070 | UBERON:0011150 | denotes | gills |
T201 | 1074-1078 | PR:Q24533 | denotes | fish |
T202 | 1079-1082 | CHEBI:29325 | denotes | CO2 |
T203 | 1079-1082 | CHEBI:48828 | denotes | CO2 |
T204 | 1079-1082 | CHEBI:16526 | denotes | CO2 |
T205 | 1079-1082 | CHEBI:29334 | denotes | CO2 |
T206 | 1145-1171 | GO:0005391 | denotes | Na(+)/K(+)-ATPase activity |
T207 | 1156-1162 | A3DIJ8 | denotes | ATPase |
T209 | 1156-1162 | Q9SIY3 | denotes | ATPase |
T208 | 1156-1162 | D000251 | denotes | ATPase |
T211 | 1214-1218 | PR:Q24533 | denotes | fish |
T212 | 1270-1276 | A3DIJ8 | denotes | ATPase |
T214 | 1270-1276 | Q9SIY3 | denotes | ATPase |
T213 | 1270-1276 | D000251 | denotes | ATPase |
T215 | 1318-1321 | CHEBI:29325 | denotes | CO2 |
T216 | 1318-1321 | CHEBI:48828 | denotes | CO2 |
T217 | 1318-1321 | CHEBI:16526 | denotes | CO2 |
T218 | 1318-1321 | CHEBI:29334 | denotes | CO2 |
T224 | 1402-1413 | D006935 | denotes | hypercapnia |
T225 | 1402-1413 | D006935 | denotes | hypercapnia |
T226 | 1420-1426 | A3DIJ8 | denotes | ATPase |
T228 | 1420-1426 | Q9SIY3 | denotes | ATPase |
T227 | 1420-1426 | D000251 | denotes | ATPase |
T229 | 1463-1468 | UBERON:0011150 | denotes | gills |
T230 | 1509-1515 | A3DIJ8 | denotes | ATPase |
T232 | 1509-1515 | Q9SIY3 | denotes | ATPase |
T231 | 1509-1515 | D000251 | denotes | ATPase |
T233 | 1520-1531 | D006180 | denotes | H(+)-ATPase |
T234 | 1525-1531 | A3DIJ8 | denotes | ATPase |
T236 | 1525-1531 | Q9SIY3 | denotes | ATPase |
T237 | 1582-1585 | CHEBI:29325 | denotes | CO2 |
T238 | 1582-1585 | CHEBI:48828 | denotes | CO2 |
T239 | 1582-1585 | CHEBI:16526 | denotes | CO2 |
T240 | 1582-1585 | CHEBI:29334 | denotes | CO2 |
T241 | 1651-1654 | CHEBI:29325 | denotes | CO2 |
T242 | 1651-1654 | CHEBI:48828 | denotes | CO2 |
T243 | 1651-1654 | CHEBI:16526 | denotes | CO2 |
T244 | 1651-1654 | CHEBI:29334 | denotes | CO2 |
T245 | 1681-1684 | CHEBI:24870 | denotes | ion |
T246 | 1747-1750 | CHEBI:29325 | denotes | CO2 |
T247 | 1747-1750 | CHEBI:48828 | denotes | CO2 |
T248 | 1747-1750 | CHEBI:16526 | denotes | CO2 |
T249 | 1747-1750 | CHEBI:29334 | denotes | CO2 |
T251 | 1805-1809 | CVCL_R842 | denotes | gill |
T250 | 1805-1809 | UBERON:0002535 | denotes | gill |
T252 | 1810-1821 | GO:0045333 | denotes | respiration |
T253 | 1810-1821 | GO:0007585 | denotes | respiration |
T254 | 1851-1857 | A3DIJ8 | denotes | ATPase |
T256 | 1851-1857 | Q9SIY3 | denotes | ATPase |
T255 | 1851-1857 | D000251 | denotes | ATPase |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 155-166 | HP_0012416 | denotes | hypercapnia |
T2 | 1402-1413 | HP_0012416 | denotes | hypercapnia |