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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 180-343 DRI_Background denotes (P. amarus) has been reported to exhibit anti-inflammation and antiarthritis properties leading to our interest to examine its beneficial effect in osteoarthritis.
T2 344-524 DRI_Background denotes Thus, this study aimed to explore the chondroprotective potential of P. amarus extract (PAE) and its major compounds, phyllanthin and hypophyllanthin, in a cartilage explant model.
T3 525-708 DRI_Background denotes Various concentrations of P. amarus extract, phyllanthin and hypophyllanthin, were treated on porcine articular cartilage explants induced with 25 ng/ml of interleukin-1 beta (IL-1β).
T4 709-923 DRI_Background denotes After 4 days of incubation, the culture medium was measured for the release of sulfate glycosaminoglycans (s-GAGs) and matrix metalloproteinase-2 (MMP-2) activity by DMMB binding assay and zymography, respectively.
T5 924-1091 DRI_Outcome denotes The explant tissues were analyzed for the remaining of uronic acid content by colorimetric assay and stained with safranin-O for investigation of proteoglycan content.
T6 1092-1172 DRI_Approach denotes Cell viability of this model was evaluated by lactate dehydrogenase (LDH) assay.
T7 1173-1488 DRI_Outcome denotes Chondroprotective potential of PAE and the major components against IL-1β-induced cartilage explant degradation were revealed by the decreased s-GAGs level and MMP-2 activity in culture medium consistent with an increase in uronic acid and proteoglycan contents in the explants when compared to the IL-1β treatment.
T8 1489-1578 DRI_Background denotes These results agreed with those of diacerein and sesamin which used as positive controls.
T9 1579-1723 DRI_Approach denotes In addition, better chondroprotective activities of P. amarus crude extracts than those of the purified components were disclosed in this study.
T10 1724-1888 DRI_Approach denotes Hence, this is a pioneering study presenting the chondroprotective potential of PAE which may augment its application for therapeutic use as an antiarthritic agent.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 192-195 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T2 192-195 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T3 498-499 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T4 672-674 CVCL_6D57|Cancer_cell_line|Rattus norvegicus denotes ng
T5 675-677 CVCL_F566|Transformed_cell_line|Homo sapiens denotes ml
T6 675-677 CVCL_W799|Cancer_cell_line|Homo sapiens denotes ml
T7 695-699 CVCL_R799|Transformed_cell_line|Gorilla gorilla gorilla denotes beta
T8 863-871 CVCL_C410|Hybridoma|Mus musculus denotes activity
T9 1339-1347 CVCL_C410|Hybridoma|Mus musculus denotes activity
T10 1382-1384 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T11 1382-1384 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T12 1617-1627 CVCL_C410|Hybridoma|Mus musculus denotes activities
T13 1739-1740 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T14 1814-1817 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may
T15 1865-1867 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T16 1865-1867 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an

GoldHamster

Id Subject Object Predicate Lexical cue
T2 31-49 293060 denotes Phyllanthus amarus
T3 31-49 D029803 denotes Phyllanthus amarus
T4 92-101 UBERON:0002418 denotes cartilage
T5 92-101 UBERON:0007844 denotes cartilage
T6 102-113 GO:0009056 denotes degradation
T7 226-238 GO:0006954 denotes inflammation
T8 226-238 D007249 denotes inflammation
T9 226-238 D007249 denotes inflammation
T10 328-342 D010003 denotes osteoarthritis
T11 328-342 D010003 denotes osteoarthritis
T12 432-435 P14756 denotes PAE
T13 462-473 C517985 denotes phyllanthin
T14 462-473 CHEBI:8177 denotes phyllanthin
T15 462-473 C517985 denotes phyllanthin
T16 478-493 C512682 denotes hypophyllanthin
T17 478-493 C512682 denotes hypophyllanthin
T18 500-509 UBERON:0002418 denotes cartilage
T19 500-509 UBERON:0007844 denotes cartilage
T20 570-581 C517985 denotes phyllanthin
T21 570-581 CHEBI:8177 denotes phyllanthin
T22 570-581 C517985 denotes phyllanthin
T23 586-601 C512682 denotes hypophyllanthin
T24 586-601 C512682 denotes hypophyllanthin
T27 627-646 UBERON:0010996 denotes articular cartilage
T35 681-699 P26889 denotes interleukin-1 beta
T36 681-699 Q865X8 denotes interleukin-1 beta
T37 681-699 A4UYK8 denotes interleukin-1 beta
T38 681-699 P79182 denotes interleukin-1 beta
T39 681-699 P51745 denotes interleukin-1 beta
T40 681-699 P51493 denotes interleukin-1 beta
T41 681-699 P14628 denotes interleukin-1 beta
T42 681-699 P09428 denotes interleukin-1 beta
T44 681-699 PR:000001136 denotes interleukin-1 beta
T45 681-699 Q8WNR2 denotes interleukin-1 beta
T46 681-699 Q6PUD2 denotes interleukin-1 beta
T47 681-699 Q6R2X3 denotes interleukin-1 beta
T48 681-699 Q2HZH0 denotes interleukin-1 beta
T49 681-699 P10749 denotes interleukin-1 beta
T50 681-699 P41687 denotes interleukin-1 beta
T51 681-699 P46648 denotes interleukin-1 beta
T52 681-699 Q63264 denotes interleukin-1 beta
T53 681-699 P79162 denotes interleukin-1 beta
T54 681-699 Q9XS77 denotes interleukin-1 beta
T55 681-699 P01584 denotes interleukin-1 beta
T56 681-699 Q2MH07 denotes interleukin-1 beta
T57 681-699 Q28386 denotes interleukin-1 beta
T58 681-699 Q9YGD3 denotes interleukin-1 beta
T60 681-699 P21621 denotes interleukin-1 beta
T61 681-699 Q28292 denotes interleukin-1 beta
T62 681-699 P48090 denotes interleukin-1 beta
T63 681-699 Q9WVG1 denotes interleukin-1 beta
T43 681-699 D053583 denotes interleukin-1 beta
T59 681-699 D053583 denotes interleukin-1 beta
T67 701-705 D007375 denotes IL-1
T68 701-705 D007375 denotes IL-1
T66 701-705 GO:0005149 denotes IL-1
T69 788-795 CHEBI:16189 denotes sulfate
T70 796-814 CHEBI:18085 denotes glycosaminoglycans
T71 796-814 D006025 denotes glycosaminoglycans
T72 796-814 D006025 denotes glycosaminoglycans
T73 828-834 UBERON:0027368 denotes matrix
T74 828-854 Q9GLE5 denotes matrix metalloproteinase-2
T75 828-854 P08253 denotes matrix metalloproteinase-2
T76 828-854 Q8MPP3 denotes matrix metalloproteinase-2
T77 828-854 Q90611 denotes matrix metalloproteinase-2
T79 828-854 PR:000010479 denotes matrix metalloproteinase-2
T80 828-854 P33436 denotes matrix metalloproteinase-2
T81 828-854 P33434 denotes matrix metalloproteinase-2
T82 828-854 P50757 denotes matrix metalloproteinase-2
T78 828-854 D020778 denotes matrix metalloproteinase-2
T84 853-859 PR:O04529 denotes 2 (MMP
T85 856-859 CHEBI:340824 denotes MMP
T88 856-859 CHEBI:59761 denotes MMP
T89 856-861 PR:P08253 denotes MMP-2
T90 856-861 Q9GLE5 denotes MMP-2
T91 856-861 P08253 denotes MMP-2
T92 856-861 Q90611 denotes MMP-2
T94 856-861 PR:Q8MPP3 denotes MMP-2
T95 856-861 P33436 denotes MMP-2
T96 856-861 PR:Q90611 denotes MMP-2
T97 856-861 PR:P33436 denotes MMP-2
T98 856-861 PR:000010479 denotes MMP-2
T99 856-861 PR:P33434 denotes MMP-2
T100 856-861 P33434 denotes MMP-2
T101 856-861 P50757 denotes MMP-2
T93 856-861 GO:0004228 denotes MMP-2
T102 875-879 C435946 denotes DMMB
T103 875-879 C435946 denotes DMMB
T104 880-887 SO:0100018 denotes binding
T105 880-887 SO:0001091 denotes binding
T106 880-887 GO:0005488 denotes binding
T107 979-990 CHEBI:27252 denotes uronic acid
T112 1038-1048 CHEBI:33601 denotes safranin-O
T113 1070-1082 CHEBI:37396 denotes proteoglycan
T115 1070-1082 D011509 denotes proteoglycan
T116 1070-1082 D011509 denotes proteoglycan
T114 1070-1082 GO:0005203 denotes proteoglycan
T120 1138-1145 114202 denotes lactate
T122 1138-1159 D007770 denotes lactate dehydrogenase
T123 1146-1159 A0A5C1RDA6 denotes dehydrogenase
T125 1161-1164 P29038 denotes LDH
T126 1161-1164 PR:A5I1Z6 denotes LDH
T127 1161-1164 Q99289 denotes LDH
T128 1161-1164 Q27888 denotes LDH
T129 1161-1164 P93052 denotes LDH
T130 1161-1164 Q27797 denotes LDH
T131 1161-1164 P33571 denotes LDH
T132 1204-1207 P14756 denotes PAE
T134 1241-1245 D007375 denotes IL-1
T135 1241-1245 D007375 denotes IL-1
T133 1241-1245 GO:0005149 denotes IL-1
T136 1255-1264 UBERON:0002418 denotes cartilage
T137 1255-1264 UBERON:0007844 denotes cartilage
T138 1273-1284 GO:0009056 denotes degradation
T139 1333-1336 CHEBI:340824 denotes MMP
T142 1333-1336 CHEBI:59761 denotes MMP
T143 1333-1338 PR:P08253 denotes MMP-2
T144 1333-1338 Q9GLE5 denotes MMP-2
T145 1333-1338 P08253 denotes MMP-2
T146 1333-1338 Q90611 denotes MMP-2
T148 1333-1338 PR:Q8MPP3 denotes MMP-2
T149 1333-1338 P33436 denotes MMP-2
T150 1333-1338 PR:Q90611 denotes MMP-2
T151 1333-1338 PR:P33436 denotes MMP-2
T152 1333-1338 PR:000010479 denotes MMP-2
T153 1333-1338 PR:P33434 denotes MMP-2
T154 1333-1338 P33434 denotes MMP-2
T155 1333-1338 P50757 denotes MMP-2
T147 1333-1338 GO:0004228 denotes MMP-2
T156 1397-1408 CHEBI:27252 denotes uronic acid
T158 1413-1425 CHEBI:37396 denotes proteoglycan
T160 1413-1425 D011509 denotes proteoglycan
T161 1413-1425 D011509 denotes proteoglycan
T159 1413-1425 GO:0005203 denotes proteoglycan
T163 1472-1476 D007375 denotes IL-1
T164 1472-1476 D007375 denotes IL-1
T162 1472-1476 GO:0005149 denotes IL-1
T165 1524-1533 C025292 denotes diacerein
T166 1524-1533 C025292 denotes diacerein
T167 1538-1545 CHEBI:66470 denotes sesamin
T168 1538-1545 CHEBI:9125 denotes sesamin
T169 1538-1545 C054125 denotes sesamin
T170 1538-1545 C054125 denotes sesamin
T171 1641-1655 D045424 denotes crude extracts
T172 1641-1655 D045424 denotes crude extracts
T173 1804-1807 P14756 denotes PAE

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes Chondroprotective potential of Phyllanthus amarus Schum. & Thonn. in experimentally induced cartilage degradation in the explants culture model.
T2 145-343 Sentence denotes Phyllanthus amarus Schum. & Thonn. (P. amarus) has been reported to exhibit anti-inflammation and antiarthritis properties leading to our interest to examine its beneficial effect in osteoarthritis.
T3 344-524 Sentence denotes Thus, this study aimed to explore the chondroprotective potential of P. amarus extract (PAE) and its major compounds, phyllanthin and hypophyllanthin, in a cartilage explant model.
T4 525-708 Sentence denotes Various concentrations of P. amarus extract, phyllanthin and hypophyllanthin, were treated on porcine articular cartilage explants induced with 25 ng/ml of interleukin-1 beta (IL-1β).
T5 709-923 Sentence denotes After 4 days of incubation, the culture medium was measured for the release of sulfate glycosaminoglycans (s-GAGs) and matrix metalloproteinase-2 (MMP-2) activity by DMMB binding assay and zymography, respectively.
T6 924-1091 Sentence denotes The explant tissues were analyzed for the remaining of uronic acid content by colorimetric assay and stained with safranin-O for investigation of proteoglycan content.
T7 1092-1172 Sentence denotes Cell viability of this model was evaluated by lactate dehydrogenase (LDH) assay.
T8 1173-1488 Sentence denotes Chondroprotective potential of PAE and the major components against IL-1β-induced cartilage explant degradation were revealed by the decreased s-GAGs level and MMP-2 activity in culture medium consistent with an increase in uronic acid and proteoglycan contents in the explants when compared to the IL-1β treatment.
T9 1489-1578 Sentence denotes These results agreed with those of diacerein and sesamin which used as positive controls.
T10 1579-1723 Sentence denotes In addition, better chondroprotective activities of P. amarus crude extracts than those of the purified components were disclosed in this study.
T11 1724-1888 Sentence denotes Hence, this is a pioneering study presenting the chondroprotective potential of PAE which may augment its application for therapeutic use as an antiarthritic agent.
T1 0-144 Sentence denotes Chondroprotective potential of Phyllanthus amarus Schum. & Thonn. in experimentally induced cartilage degradation in the explants culture model.
T2 145-343 Sentence denotes Phyllanthus amarus Schum. & Thonn. (P. amarus) has been reported to exhibit anti-inflammation and antiarthritis properties leading to our interest to examine its beneficial effect in osteoarthritis.
T3 344-524 Sentence denotes Thus, this study aimed to explore the chondroprotective potential of P. amarus extract (PAE) and its major compounds, phyllanthin and hypophyllanthin, in a cartilage explant model.
T4 525-708 Sentence denotes Various concentrations of P. amarus extract, phyllanthin and hypophyllanthin, were treated on porcine articular cartilage explants induced with 25 ng/ml of interleukin-1 beta (IL-1β).
T5 709-923 Sentence denotes After 4 days of incubation, the culture medium was measured for the release of sulfate glycosaminoglycans (s-GAGs) and matrix metalloproteinase-2 (MMP-2) activity by DMMB binding assay and zymography, respectively.
T6 924-1091 Sentence denotes The explant tissues were analyzed for the remaining of uronic acid content by colorimetric assay and stained with safranin-O for investigation of proteoglycan content.
T7 1092-1172 Sentence denotes Cell viability of this model was evaluated by lactate dehydrogenase (LDH) assay.
T8 1173-1488 Sentence denotes Chondroprotective potential of PAE and the major components against IL-1β-induced cartilage explant degradation were revealed by the decreased s-GAGs level and MMP-2 activity in culture medium consistent with an increase in uronic acid and proteoglycan contents in the explants when compared to the IL-1β treatment.
T9 1489-1578 Sentence denotes These results agreed with those of diacerein and sesamin which used as positive controls.
T10 1579-1723 Sentence denotes In addition, better chondroprotective activities of P. amarus crude extracts than those of the purified components were disclosed in this study.
T11 1724-1888 Sentence denotes Hence, this is a pioneering study presenting the chondroprotective potential of PAE which may augment its application for therapeutic use as an antiarthritic agent.