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PubMed:25503524 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 65-204 DRI_Background denotes Arteries often endure axial twist due to body movement and surgical procedures, but how arteries remodel under axial twist remains unclear.
T2 205-307 DRI_Background denotes The objective of this study was to investigate early stage arterial wall remodeling under axial twist.
T3 308-485 DRI_Background denotes Porcine carotid arteries were twisted axially and maintained for three days in ex vivo organ culture systems while the pressure and flow remained the same as untwisted controls.
T4 486-816 DRI_Outcome denotes Cell proliferation, internal elastic lamina (IEL) fenestrae shape and size, endothelial cell (EC) morphology and orientation, as well as the expression of matrix metalloproteinases (MMPs), MMP-2 and MMP-9, and tissue inhibitor of metalloproteinase-2 (TIMP-2) were quantified using immunohistochemistry staining and immunoblotting.
T5 817-970 DRI_Outcome denotes Our results demonstrated that cell proliferation in both the intima and media were significantly higher in the twisted arteries compared to the controls.
T6 971-1115 DRI_Outcome denotes The cell proliferation in the intima increased from 1.33 ± 0.21% to 7.63 ± 1.89%, and in the media from 1.93 ± 0.84% to 8.27 ± 2.92% (p < 0.05).
T7 1364-1491 DRI_Approach denotes MMP-2 expression significantly increased (p < 0.05) while MMP-9 and TIMP-2 showed no significant difference in the twist group.
T8 1492-1595 DRI_Approach denotes The ECs in the twisted arteries were significantly elongated compared to the controls after three days.
T9 1596-1778 DRI_Approach denotes The angle between the major axis of the ECs and blood flow direction under twist was 7.46 ± 2.44 degrees after 3 days organ culture, a decrease from the initial 15.58 ± 1.29 degrees.
T10 1779-1854 DRI_Outcome denotes These results demonstrate that axial twist can stimulate artery remodeling.
T11 1855-1995 DRI_Outcome denotes These findings complement our understanding of arterial wall remodeling under mechanical stress resulting from pressure and flow variations.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 580-582 CVCL_DG46|Spontaneously_immortalized_cell_line|Oncorhynchus tshawytscha denotes EC
T2 1235-1239 CVCL_M543|Cancer_cell_line|Homo sapiens denotes m(2)
T3 1235-1239 CVCL_T296|Cancer_cell_line|Homo sapiens denotes m(2)
T4 1235-1239 CVCL_U035|Hybridoma|Mus musculus denotes m(2)
T5 1235-1239 CVCL_W291|Cancer_cell_line|Homo sapiens denotes m(2)
T6 1235-1239 CVCL_XD77|Embryonic_stem_cell|Homo sapiens denotes m(2)
T7 1257-1261 CVCL_M543|Cancer_cell_line|Homo sapiens denotes m(2)
T8 1257-1261 CVCL_T296|Cancer_cell_line|Homo sapiens denotes m(2)
T9 1257-1261 CVCL_U035|Hybridoma|Mus musculus denotes m(2)
T10 1257-1261 CVCL_W291|Cancer_cell_line|Homo sapiens denotes m(2)
T11 1257-1261 CVCL_XD77|Embryonic_stem_cell|Homo sapiens denotes m(2)
T12 1496-1499 CVCL_Z893|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes ECs
T13 1636-1639 CVCL_Z893|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes ECs
T14 1729-1730 CVCL_6479|Finite_cell_line|Mus musculus denotes a

GoldHamster

Id Subject Object Predicate Lexical cue
T1 0-6 UBERON:0001637 denotes Artery
T2 24-29 PR:Q07342 denotes Axial
T3 30-35 PR:P26687 denotes Twist
T4 30-35 PR:000016846 denotes Twist
T5 30-35 PR:000027825 denotes Twist
T6 30-35 PR:Q15672 denotes Twist
T7 87-92 PR:Q07342 denotes axial
T8 93-98 PR:P26687 denotes twist
T9 93-98 PR:000016846 denotes twist
T10 93-98 PR:000027825 denotes twist
T11 93-98 PR:Q15672 denotes twist
T12 153-161 UBERON:0001637 denotes arteries
T13 176-181 PR:Q07342 denotes axial
T14 182-187 PR:P26687 denotes twist
T15 182-187 PR:000016846 denotes twist
T16 182-187 PR:000027825 denotes twist
T17 182-187 PR:Q15672 denotes twist
T18 264-277 UBERON:0000415 denotes arterial wall
T20 295-300 PR:Q07342 denotes axial
T21 301-306 PR:P26687 denotes twist
T22 301-306 PR:000016846 denotes twist
T23 301-306 PR:000027825 denotes twist
T24 301-306 PR:Q15672 denotes twist
T25 316-323 UBERON:0005396 denotes carotid
T26 324-332 UBERON:0001637 denotes arteries
T27 395-400 UBERON:0000062 denotes organ
T28 395-400 UBERON:0003103 denotes organ
T29 486-504 GO:0008283 denotes Cell proliferation
T30 491-504 UBERON:2000098 denotes proliferation
T31 506-529 UBERON:0011392 denotes internal elastic lamina
T36 531-534 CL:0002496 denotes IEL
T37 531-534 CL:0000801 denotes IEL
T38 531-534 CL:0000797 denotes IEL
T39 531-534 CL:0000796 denotes IEL
T40 531-534 CL:0000802 denotes IEL
T41 531-534 CL:0000793 denotes IEL
T42 531-534 CL:0000803 denotes IEL
T43 536-545 UBERON:0004705 denotes fenestrae
T44 562-578 CL:0000115 denotes endothelial cell
T45 641-647 UBERON:0027368 denotes matrix
T46 641-666 D020782 denotes matrix metalloproteinases
T48 668-672 D020782 denotes MMPs
T49 675-678 CHEBI:340824 denotes MMP
T52 675-678 CHEBI:59761 denotes MMP
T53 675-680 PR:P08253 denotes MMP-2
T54 675-680 Q9GLE5 denotes MMP-2
T55 675-680 P08253 denotes MMP-2
T56 675-680 Q90611 denotes MMP-2
T58 675-680 PR:Q8MPP3 denotes MMP-2
T59 675-680 P33436 denotes MMP-2
T60 675-680 PR:Q90611 denotes MMP-2
T61 675-680 PR:P33436 denotes MMP-2
T62 675-680 PR:000010479 denotes MMP-2
T63 675-680 PR:P33434 denotes MMP-2
T64 675-680 P33434 denotes MMP-2
T65 675-680 P50757 denotes MMP-2
T57 675-680 GO:0004228 denotes MMP-2
T66 685-688 CHEBI:340824 denotes MMP
T69 685-688 CHEBI:59761 denotes MMP
T70 685-690 PR:P50282 denotes MMP-9
T71 685-690 PR:P14780 denotes MMP-9
T72 685-690 P14780 denotes MMP-9
T73 685-690 PR:P41245 denotes MMP-9
T74 685-690 P41246 denotes MMP-9
T75 685-690 P41245 denotes MMP-9
T76 685-690 PR:P52176 denotes MMP-9
T77 685-690 P50282 denotes MMP-9
T79 685-690 PR:000010491 denotes MMP-9
T80 685-690 P52176 denotes MMP-9
T81 685-690 O18733 denotes MMP-9
T78 685-690 GO:0004229 denotes MMP-9
T82 696-702 UBERON:0000479 denotes tissue
T83 696-733 Q9VH14 denotes tissue inhibitor of metalloproteinase
T84 696-735 D019716 denotes tissue inhibitor of metalloproteinase-2
T86 716-735 C5PE62 denotes metalloproteinase-2
T91 737-743 PR:P16035 denotes TIMP-2
T92 737-743 PR:000016353 denotes TIMP-2
T93 737-743 O42146 denotes TIMP-2
T94 737-743 Q9TRZ7 denotes TIMP-2
T95 737-743 Q9TTY1 denotes TIMP-2
T96 737-743 Q60453 denotes TIMP-2
T97 737-743 P16035 denotes TIMP-2
T99 737-743 P25785 denotes TIMP-2
T100 737-743 P16368 denotes TIMP-2
T101 737-743 O77717 denotes TIMP-2
T102 737-743 PR:P25785 denotes TIMP-2
T103 737-743 P30121 denotes TIMP-2
T104 737-743 Q9WUC6 denotes TIMP-2
T105 737-743 PR:P30121 denotes TIMP-2
T106 737-743 PR:O42146 denotes TIMP-2
T98 737-743 D019716 denotes TIMP-2
T107 847-865 GO:0008283 denotes cell proliferation
T108 852-865 UBERON:2000098 denotes proliferation
T109 878-884 UBERON:0002523 denotes intima
T110 936-944 UBERON:0001637 denotes arteries
T111 975-993 GO:0008283 denotes cell proliferation
T112 980-993 UBERON:2000098 denotes proliferation
T113 1001-1007 UBERON:0002523 denotes intima
T115 1116-1119 CL:0002496 denotes IEL
T116 1116-1119 CL:0000801 denotes IEL
T117 1116-1119 CL:0000797 denotes IEL
T118 1116-1119 CL:0000796 denotes IEL
T119 1116-1119 CL:0000802 denotes IEL
T120 1116-1119 CL:0000793 denotes IEL
T121 1116-1119 CL:0000803 denotes IEL
T122 1120-1129 UBERON:0004705 denotes fenestrae
T132 1308-1313 PR:P26687 denotes twist
T133 1308-1313 PR:000016846 denotes twist
T134 1308-1313 PR:000027825 denotes twist
T135 1308-1313 PR:Q15672 denotes twist
T138 1364-1367 CHEBI:340824 denotes MMP
T141 1364-1367 CHEBI:59761 denotes MMP
T142 1364-1369 PR:P08253 denotes MMP-2
T143 1364-1369 Q9GLE5 denotes MMP-2
T144 1364-1369 P08253 denotes MMP-2
T145 1364-1369 Q90611 denotes MMP-2
T147 1364-1369 PR:Q8MPP3 denotes MMP-2
T148 1364-1369 P33436 denotes MMP-2
T149 1364-1369 PR:Q90611 denotes MMP-2
T150 1364-1369 PR:P33436 denotes MMP-2
T151 1364-1369 PR:000010479 denotes MMP-2
T152 1364-1369 PR:P33434 denotes MMP-2
T153 1364-1369 P33434 denotes MMP-2
T154 1364-1369 P50757 denotes MMP-2
T146 1364-1369 GO:0004228 denotes MMP-2
T155 1422-1425 CHEBI:340824 denotes MMP
T158 1422-1425 CHEBI:59761 denotes MMP
T159 1422-1427 PR:P50282 denotes MMP-9
T160 1422-1427 PR:P14780 denotes MMP-9
T161 1422-1427 P14780 denotes MMP-9
T162 1422-1427 PR:P41245 denotes MMP-9
T163 1422-1427 P41246 denotes MMP-9
T164 1422-1427 P41245 denotes MMP-9
T165 1422-1427 PR:P52176 denotes MMP-9
T166 1422-1427 P50282 denotes MMP-9
T168 1422-1427 PR:000010491 denotes MMP-9
T169 1422-1427 P52176 denotes MMP-9
T170 1422-1427 O18733 denotes MMP-9
T167 1422-1427 GO:0004229 denotes MMP-9
T175 1432-1438 PR:P16035 denotes TIMP-2
T176 1432-1438 PR:000016353 denotes TIMP-2
T177 1432-1438 O42146 denotes TIMP-2
T178 1432-1438 Q9TRZ7 denotes TIMP-2
T179 1432-1438 Q9TTY1 denotes TIMP-2
T180 1432-1438 Q60453 denotes TIMP-2
T181 1432-1438 P16035 denotes TIMP-2
T183 1432-1438 P25785 denotes TIMP-2
T184 1432-1438 P16368 denotes TIMP-2
T185 1432-1438 O77717 denotes TIMP-2
T186 1432-1438 PR:P25785 denotes TIMP-2
T187 1432-1438 P30121 denotes TIMP-2
T188 1432-1438 Q9WUC6 denotes TIMP-2
T189 1432-1438 PR:P30121 denotes TIMP-2
T190 1432-1438 PR:O42146 denotes TIMP-2
T182 1432-1438 D019716 denotes TIMP-2
T191 1479-1484 PR:P26687 denotes twist
T192 1479-1484 PR:000016846 denotes twist
T193 1479-1484 PR:000027825 denotes twist
T194 1479-1484 PR:Q15672 denotes twist
T195 1496-1499 CVCL_Z893 denotes ECs
T196 1515-1523 UBERON:0001637 denotes arteries
T197 1624-1628 UBERON:0001093 denotes axis
T198 1636-1639 CVCL_Z893 denotes ECs
T199 1671-1676 PR:P26687 denotes twist
T200 1671-1676 PR:000016846 denotes twist
T201 1671-1676 PR:000027825 denotes twist
T202 1671-1676 PR:Q15672 denotes twist
T203 1714-1719 UBERON:0000062 denotes organ
T204 1714-1719 UBERON:0003103 denotes organ
T205 1810-1815 PR:Q07342 denotes axial
T206 1816-1821 PR:P26687 denotes twist
T207 1816-1821 PR:000016846 denotes twist
T208 1816-1821 PR:000027825 denotes twist
T209 1816-1821 PR:Q15672 denotes twist
T210 1836-1842 UBERON:0001637 denotes artery
T211 1870-1880 D003165 denotes complement
T212 1902-1915 UBERON:0000415 denotes arterial wall