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sentences

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Identification and Pharmacological Inactivation of the MYCN Gene Network as a Therapeutic Strategy for Neuroblastic Tumor Cells.
T2 129-284 Sentence denotes The MYC family of transcription factors consists of three well characterized members, c-MYC, L-MYC, and MYCN, deregulated in the majority of human cancers.
T3 285-496 Sentence denotes In neuronal tumors such as neuroblastoma, MYCN is frequently activated by gene amplification, and reducing its expression by RNA interference has been shown to promote growth arrest and apoptosis of tumor cells.
T4 497-651 Sentence denotes From a clinical perspective, RNA interference is not yet a viable option, and small molecule inhibitors of transcription factors are difficult to develop.
T5 652-819 Sentence denotes We therefore planned to identify, at the global level, the genes interacting functionally with MYCN required to promote fitness of tumor cells facing oncogenic stress.
T6 820-1093 Sentence denotes To find genes whose inactivation is synthetically lethal to MYCN, we implemented a genome-wide approach in which we carried out a drop-out shRNA screen using a whole genome library that was delivered into isogenic neuroblastoma cell lines expressing or not expressing MYCN.
T7 1094-1197 Sentence denotes After the screen, we selected for in-depth analysis four shRNAs targeting AHCY, BLM, PKMYT1, and CKS1B.
T8 1198-1375 Sentence denotes These genes were chosen because they are directly regulated by MYC proteins, associated with poor prognosis of neuroblastoma patients, and inhibited by small molecule compounds.
T9 1376-1507 Sentence denotes Mechanistically, we found that BLM and PKMYT1 are required to limit oncogenic stress and promote stabilization of the MYCN protein.
T10 1508-1695 Sentence denotes Cocktails of small molecule inhibitors of CKS1B, AHCY, BLM, and PKMYT1 profoundly affected the growth of all neuroblastoma cell lines but selectively caused death of MYCN-amplified cells.
T11 1696-1823 Sentence denotes Our findings suggest that drugging the MYCN network is a promising avenue for the treatment of high risk, neuroblastic cancers.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 276-283 HP_0002664 denotes cancers
T2 297-303 HP_0002664 denotes tumors
T3 312-325 HP_0003006 denotes neuroblastoma
T4 484-489 HP_0002664 denotes tumor
T5 783-788 HP_0002664 denotes tumor
T6 1034-1047 HP_0003006 denotes neuroblastoma
T7 1309-1322 HP_0003006 denotes neuroblastoma
T8 1617-1630 HP_0003006 denotes neuroblastoma
T9 1802-1814 HP_0003006 denotes neuroblastic
T10 1802-1822 HP_0004376 denotes neuroblastic cancers
T11 1815-1822 HP_0002664 denotes cancers

NEUROSES

Id Subject Object Predicate Lexical cue
T1 410-413 CHEBI_18273 denotes RNA
T2 526-529 CHEBI_18273 denotes RNA
T3 410-413 CHEBI_33697 denotes RNA
T4 526-529 CHEBI_33697 denotes RNA
T5 556-562 PATO_0000719 denotes viable
T6 575-580 PATO_0000587 denotes small
T7 1350-1355 PATO_0000587 denotes small
T8 1521-1526 PATO_0000587 denotes small
T9 581-589 CHEBI_25367 denotes molecule
T10 1356-1364 CHEBI_25367 denotes molecule
T11 1527-1535 CHEBI_25367 denotes molecule
T12 590-600 CHEBI_35222 denotes inhibitors
T13 1536-1546 CHEBI_35222 denotes inhibitors
T14 910-914 PATO_0000600 denotes wide
T15 1131-1136 PATO_0001595 denotes depth
T16 1265-1273 CHEBI_36080 denotes proteins
T17 1499-1506 CHEBI_36080 denotes protein
T19 1499-1506 CHEBI_16541 denotes protein
T20 1791-1795 PATO_0000469 denotes high

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25477524-0#55#59#gene4613 55-59 gene4613 denotes MYCN
25477524-0#103#121#diseaseC1334953 1129-1457 diseaseC1334953 denotes n-depth analysis four shRNAs targeting AHCY, BLM, PKMYT1, and CKS1B. These genes were chosen because they are directly regulated by MYC proteins, associated with poor prognosis of neuroblastoma patients, and inhibited by small molecule compounds. Mechanistically, we found that BLM and PKMYT1 are required to limit oncogenic str
25477524-9#64#70#gene9088 1572-1578 gene9088 denotes PKMYT1
25477524-9#166#170#gene4613 1674-1678 gene4613 denotes MYCN
25477524-9#109#122#diseaseC0027819 1617-1630 diseaseC0027819 denotes neuroblastoma
25477524-9#109#122#diseaseC0700095 1617-1630 diseaseC0700095 denotes neuroblastoma
25477524-9#109#122#diseaseC0027819 1617-1630 diseaseC0027819 denotes neuroblastoma
25477524-9#109#122#diseaseC0700095 1617-1630 diseaseC0700095 denotes neuroblastoma
55#59#gene4613103#121#diseaseC1334953 25477524-0#55#59#gene4613 25477524-0#103#121#diseaseC1334953 associated_with MYCN,"n-depth analysis four shRNAs targeting AHCY, BLM, PKMYT1, and CKS1B. These genes were chosen because they are directly regulated by MYC proteins, associated with poor prognosis of neuroblastoma patients, and inhibited by small molecule compounds. Mechanistically, we found that BLM and PKMYT1 are required to limit oncogenic str"
64#70#gene9088109#122#diseaseC0027819 25477524-9#64#70#gene9088 25477524-9#109#122#diseaseC0027819 associated_with PKMYT1,neuroblastoma
64#70#gene9088109#122#diseaseC0700095 25477524-9#64#70#gene9088 25477524-9#109#122#diseaseC0700095 associated_with PKMYT1,neuroblastoma
64#70#gene9088109#122#diseaseC0027819 25477524-9#64#70#gene9088 25477524-9#109#122#diseaseC0027819 associated_with PKMYT1,neuroblastoma
64#70#gene9088109#122#diseaseC0700095 25477524-9#64#70#gene9088 25477524-9#109#122#diseaseC0700095 associated_with PKMYT1,neuroblastoma
166#170#gene4613109#122#diseaseC0027819 25477524-9#166#170#gene4613 25477524-9#109#122#diseaseC0027819 associated_with MYCN,neuroblastoma
166#170#gene4613109#122#diseaseC0700095 25477524-9#166#170#gene4613 25477524-9#109#122#diseaseC0700095 associated_with MYCN,neuroblastoma
166#170#gene4613109#122#diseaseC0027819 25477524-9#166#170#gene4613 25477524-9#109#122#diseaseC0027819 associated_with MYCN,neuroblastoma
166#170#gene4613109#122#diseaseC0700095 25477524-9#166#170#gene4613 25477524-9#109#122#diseaseC0700095 associated_with MYCN,neuroblastoma

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 103-121 Phenotype denotes Neuroblastic Tumor HP:0004376
T2 312-325 Phenotype denotes neuroblastoma HP:0003006
T3 484-489 Phenotype denotes tumor HP:0002664
T4 783-788 Phenotype denotes tumor HP:0002664
T5 1034-1047 Phenotype denotes neuroblastoma HP:0003006
T6 1309-1322 Phenotype denotes neuroblastoma HP:0003006
T7 1617-1630 Phenotype denotes neuroblastoma HP:0003006

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 103-121 Disease denotes Neuroblastic Tumor http://purl.obolibrary.org/obo/MONDO_0006316
T2 288-303 Disease denotes neuronal tumors http://purl.obolibrary.org/obo/MONDO_0016726
T3 312-325 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T4 484-489 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T5 783-788 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T6 1034-1047 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T7 1174-1177 Disease denotes BLM http://purl.obolibrary.org/obo/MONDO_0008876
T8 1309-1322 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T9 1407-1410 Disease denotes BLM http://purl.obolibrary.org/obo/MONDO_0008876
T10 1563-1566 Disease denotes BLM http://purl.obolibrary.org/obo/MONDO_0008876
T11 1617-1630 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 270-275 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1802-1814 Body_part denotes neuroblastic http://purl.obolibrary.org/obo/CL_0000031

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 103-115 Cell denotes Neuroblastic http://purl.obolibrary.org/obo/CL:0000031|http://purl.obolibrary.org/obo/CL:0000338
T3 116-127 Cell denotes Tumor Cells http://purl.obolibrary.org/obo/CL:0001063
T4 288-296 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540
T5 484-495 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063
T6 783-794 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063
T7 1802-1814 Cell denotes neuroblastic http://purl.obolibrary.org/obo/CL:0000031|http://purl.obolibrary.org/obo/CL:0000338