> top > docs > PubMed:25477513 > annotations

PubMed:25477513 JSONTXT

Annnotations TAB JSON ListView MergeView

GlyCosmos15-Species

Id Subject Object Predicate Lexical cue db_id
5 75-80 Species denotes human 9606
27 165-170 Species denotes human 9606

sentences

Id Subject Object Predicate Lexical cue
T1 0-137 Sentence denotes Structural and thermodynamic insights into chitooligosaccharide binding to human cartilage chitinase 3-like protein 2 (CHI3L2 or YKL-39).
T2 138-243 Sentence denotes Four crystal structures of human YKL-39 were solved in the absence and presence of chitooligosaccharides.
T3 244-369 Sentence denotes The structure of YKL-39 comprises a major (β/α)8 triose-phosphate isomerase barrel domain and a small α + β insertion domain.
T4 370-504 Sentence denotes Structural analysis demonstrates that YKL-39 interacts with chitooligosaccharides through hydrogen bonds and hydrophobic interactions.
T5 505-604 Sentence denotes The binding of chitin fragments induces local conformational changes that facilitate tight binding.
T6 605-872 Sentence denotes Compared with other GH-18 members, YKL-39 has the least extended chitin-binding cleft, containing five subsites for sugars, namely (-3)(-2)(-1)(+1)(+2), with Trp-360 playing a prominent role in the sugar-protein interactions at the center of the chitin-binding cleft.
T7 873-1159 Sentence denotes Evaluation of binding affinities obtained from isothermal titration calorimetry and intrinsic fluorescence spectroscopy suggests that YKL-39 binds to chitooligosaccharides with Kd values in the micromolar concentration range and that the binding energies increase with the chain length.
T8 1160-1328 Sentence denotes There were no significant differences between the Kd values of chitopentaose and chitohexaose, supporting the structural evidence for the five binding subsite topology.
T9 1329-1438 Sentence denotes Thermodynamic analysis indicates that binding of chitooligosaccharide to YKL-39 is mainly driven by enthalpy.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 81-90 http://purl.obolibrary.org/obo/MAT_0000189 denotes cartilage

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 520-526 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T2 670-676 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T3 851-857 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 81-90 Body_part denotes cartilage http://purl.obolibrary.org/obo/MAT_0000189

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 520-526 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T2 670-676 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T3 851-857 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 81-90 Body_part denotes cartilage http://purl.obolibrary.org/obo/UBERON_0002418|http://purl.obolibrary.org/obo/UBERON_0007844

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-137 Sentence denotes Structural and thermodynamic insights into chitooligosaccharide binding to human cartilage chitinase 3-like protein 2 (CHI3L2 or YKL-39).
T2 138-243 Sentence denotes Four crystal structures of human YKL-39 were solved in the absence and presence of chitooligosaccharides.
T3 244-369 Sentence denotes The structure of YKL-39 comprises a major (β/α)8 triose-phosphate isomerase barrel domain and a small α + β insertion domain.
T4 370-504 Sentence denotes Structural analysis demonstrates that YKL-39 interacts with chitooligosaccharides through hydrogen bonds and hydrophobic interactions.
T5 505-604 Sentence denotes The binding of chitin fragments induces local conformational changes that facilitate tight binding.
T6 605-872 Sentence denotes Compared with other GH-18 members, YKL-39 has the least extended chitin-binding cleft, containing five subsites for sugars, namely (-3)(-2)(-1)(+1)(+2), with Trp-360 playing a prominent role in the sugar-protein interactions at the center of the chitin-binding cleft.
T7 873-1159 Sentence denotes Evaluation of binding affinities obtained from isothermal titration calorimetry and intrinsic fluorescence spectroscopy suggests that YKL-39 binds to chitooligosaccharides with Kd values in the micromolar concentration range and that the binding energies increase with the chain length.
T8 1160-1328 Sentence denotes There were no significant differences between the Kd values of chitopentaose and chitohexaose, supporting the structural evidence for the five binding subsite topology.
T9 1329-1438 Sentence denotes Thermodynamic analysis indicates that binding of chitooligosaccharide to YKL-39 is mainly driven by enthalpy.

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 75-80 OrganismTaxon denotes human 9606
T2 165-170 OrganismTaxon denotes human 9606
T3 781-790 OrganismTaxon denotes prominent 37571

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 81-90 Body_part denotes cartilage FMA:71500

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 81-90 Body_part denotes cartilage http://purl.obolibrary.org/obo/MAT_0000189

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 75-80 OrganismTaxon denotes human 9606
T2 165-170 OrganismTaxon denotes human 9606
T3 781-790 OrganismTaxon denotes prominent 37571

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 81-90 Body_part denotes cartilage http://purl.obolibrary.org/obo/UBERON_0002418|http://purl.obolibrary.org/obo/UBERON_0007844