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PubMed:25450481 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-83 Sentence denotes Early recognition of lung cancer by integrin targeted imaging in K-ras mouse model.
TextSentencer_T2 84-181 Sentence denotes Non-small cell lung cancer is characterized by slow progression and high heterogeneity of tumors.
TextSentencer_T3 182-358 Sentence denotes Integrins play an important role in lung cancer development and metastasis and were suggested as a tumor marker; however their role in anticancer therapy remains controversial.
TextSentencer_T4 359-578 Sentence denotes In this work, we demonstrate the potential of integrin-targeted imaging to recognize early lesions in transgenic mouse model of lung cancer based on spontaneous introduction of mutated human gene bearing K-ras mutation.
TextSentencer_T5 579-803 Sentence denotes We conducted ex vivo and fluorescence molecular tomography-X-ray computed tomography (FMT-XCT) in vivo imaging and analysis for specific targeting of early lung lesions and tumors in rodent preclinical model for lung cancer.
TextSentencer_T6 804-936 Sentence denotes The lesions and tumors were characterized by histology, immunofluorescence and immunohistochemistry using a panel of cancer markers.
TextSentencer_T7 937-1093 Sentence denotes Ex vivo, the integrin-targeted fluorescent signal significantly differed between wild type lung tissue and K-ras pulmonary lesions (PL) at all ages studied.
TextSentencer_T8 1094-1255 Sentence denotes The panel of immunofluorescence experiments demonstrated that PL, which only partially show cancer cell features were detected by αvβ3-integrin targeted imaging.
TextSentencer_T9 1256-1368 Sentence denotes Human patient material analysis confirmed the specificity of target localization in different lung cancer types.
TextSentencer_T10 1369-1514 Sentence denotes Most importantly, small tumors in the lungs of 4-week-old animals could be noninvasively detected in vivo on the fluorescence channel of FMT-XCT.
TextSentencer_T11 1515-1650 Sentence denotes Our findings demonstrated αvβ3-integrin targeted fluorescent imaging to specifically detect premalignant pleural lesions in K-ras mice.
TextSentencer_T12 1651-1838 Sentence denotes Integrin targeted imaging may find application areas in preclinical research and clinical practice, such as early lung cancer diagnostics, intraoperative assistance or therapy monitoring.
T1 0-83 Sentence denotes Early recognition of lung cancer by integrin targeted imaging in K-ras mouse model.
T2 84-181 Sentence denotes Non-small cell lung cancer is characterized by slow progression and high heterogeneity of tumors.
T3 182-358 Sentence denotes Integrins play an important role in lung cancer development and metastasis and were suggested as a tumor marker; however their role in anticancer therapy remains controversial.
T4 359-578 Sentence denotes In this work, we demonstrate the potential of integrin-targeted imaging to recognize early lesions in transgenic mouse model of lung cancer based on spontaneous introduction of mutated human gene bearing K-ras mutation.
T5 579-803 Sentence denotes We conducted ex vivo and fluorescence molecular tomography-X-ray computed tomography (FMT-XCT) in vivo imaging and analysis for specific targeting of early lung lesions and tumors in rodent preclinical model for lung cancer.
T6 804-936 Sentence denotes The lesions and tumors were characterized by histology, immunofluorescence and immunohistochemistry using a panel of cancer markers.
T7 937-1093 Sentence denotes Ex vivo, the integrin-targeted fluorescent signal significantly differed between wild type lung tissue and K-ras pulmonary lesions (PL) at all ages studied.
T8 1094-1255 Sentence denotes The panel of immunofluorescence experiments demonstrated that PL, which only partially show cancer cell features were detected by αvβ3-integrin targeted imaging.
T9 1256-1368 Sentence denotes Human patient material analysis confirmed the specificity of target localization in different lung cancer types.
T10 1369-1514 Sentence denotes Most importantly, small tumors in the lungs of 4-week-old animals could be noninvasively detected in vivo on the fluorescence channel of FMT-XCT.
T11 1515-1650 Sentence denotes Our findings demonstrated αvβ3-integrin targeted fluorescent imaging to specifically detect premalignant pleural lesions in K-ras mice.
T12 1651-1838 Sentence denotes Integrin targeted imaging may find application areas in preclinical research and clinical practice, such as early lung cancer diagnostics, intraoperative assistance or therapy monitoring.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25450481-4#86#89#gene123263 665-668 gene123263 denotes FMT
25450481-4#212#223#diseaseC0242379 791-802 diseaseC0242379 denotes lung cancer
25450481-4#212#223#diseaseC0684249 791-802 diseaseC0684249 denotes lung cancer
25450481-4#212#223#diseaseC1306460 791-802 diseaseC1306460 denotes lung cancer
86#89#gene123263212#223#diseaseC0242379 25450481-4#86#89#gene123263 25450481-4#212#223#diseaseC0242379 associated_with FMT,lung cancer
86#89#gene123263212#223#diseaseC0684249 25450481-4#86#89#gene123263 25450481-4#212#223#diseaseC0684249 associated_with FMT,lung cancer
86#89#gene123263212#223#diseaseC1306460 25450481-4#86#89#gene123263 25450481-4#212#223#diseaseC1306460 associated_with FMT,lung cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1623 665-668 gene:123263 denotes FMT
T1624 791-802 disease:C0242379 denotes lung cancer
R1 T1623 T1624 associated_with FMT,lung cancer
R2 T1623 T1624 associated_with FMT,lung cancer
R3 T1623 T1624 associated_with FMT,lung cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 21-25 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T2 99-103 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T3 218-222 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T4 487-491 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T5 735-739 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T6 791-795 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T7 1028-1032 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T8 1350-1354 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T9 1765-1769 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T10 1033-1039 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1033-1039 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 21-25 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T3 99-103 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T4 218-222 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T5 487-491 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T6 735-739 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T7 791-795 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T8 1028-1032 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T9 1350-1354 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T10 1407-1412 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lungs
PD-UBERON-AE-B_T11 1765-1769 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung