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PubMed:25446991 JSONTXT

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test-210614

Id Subject Object Predicate Lexical cue proteinmutation
25446991_0 60-66 ProteinMutation denotes G2019S rs34637584
25446991_1 794-800 ProteinMutation denotes G2019S rs34637584
25446991_2 722-728 ProteinMutation denotes G2019S rs34637584
25446991_3 591-597 ProteinMutation denotes G2019S rs34637584
25446991_4 377-383 ProteinMutation denotes G2019S rs34637584
25446991_5 288-294 ProteinMutation denotes G2019S rs34637584
25446991_6 123-129 ProteinMutation denotes G2019S rs34637584

PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
25446991_0 60-66 ProteinMutation denotes G2019S rs34637584
25446991_1 794-800 ProteinMutation denotes G2019S rs34637584
25446991_2 722-728 ProteinMutation denotes G2019S rs34637584
25446991_3 591-597 ProteinMutation denotes G2019S rs34637584
25446991_4 377-383 ProteinMutation denotes G2019S rs34637584
25446991_5 288-294 ProteinMutation denotes G2019S rs34637584
25446991_6 123-129 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T2 0-9 10524 denotes Threonine
T1 0-9 SO:0001445 denotes Threonine
T3 0-9 CHEBI:16857 denotes Threonine
T4 0-9 CHEBI:26986 denotes Threonine
T5 0-9 D013912 denotes Threonine
T6 0-9 D013912 denotes Threonine
T7 13-28 GO:0016310 denotes phosphorylation
T9 32-37 PR:P49950 denotes Bcl-2
T10 32-37 PR:000002307 denotes Bcl-2
T11 32-37 PR:P10417 denotes Bcl-2
T12 32-37 PR:Q00709 denotes Bcl-2
T13 32-37 PR:P10415 denotes Bcl-2
T8 32-37 GO:0015283 denotes Bcl-2
T14 54-59 PR:Q5S006 denotes LRRK2
T15 54-59 PR:000003033 denotes LRRK2
T16 54-59 PR:Q5S007 denotes LRRK2
T17 75-103 GO:0051882 denotes mitochondrial depolarization
T18 108-117 GO:0016236 denotes autophagy
T19 108-117 GO:0006914 denotes autophagy
T20 128-137 CHEBI:15603 denotes S leucine
T22 130-137 6308 denotes leucine
T23 130-137 SO:0001437 denotes leucine
T27 143-149 SO:0001068 denotes repeat
T28 160-165 PR:Q5S006 denotes LRRK2
T29 160-165 PR:000003033 denotes LRRK2
T30 160-165 PR:Q5S007 denotes LRRK2
T31 167-175 SO:0000109 denotes mutation
T36 212-231 D010300 denotes Parkinson's disease
T37 212-231 D010300 denotes Parkinson's disease
T40 282-287 PR:Q5S006 denotes LRRK2
T41 282-287 PR:000003033 denotes LRRK2
T42 282-287 PR:Q5S007 denotes LRRK2
T43 371-376 PR:Q5S006 denotes LRRK2
T44 371-376 PR:000003033 denotes LRRK2
T45 371-376 PR:Q5S007 denotes LRRK2
T47 412-417 PR:P49950 denotes Bcl-2
T48 412-417 PR:000002307 denotes Bcl-2
T49 412-417 PR:P10417 denotes Bcl-2
T50 412-417 PR:Q00709 denotes Bcl-2
T51 412-417 PR:P10415 denotes Bcl-2
T46 412-417 GO:0015283 denotes Bcl-2
T56 450-457 SO:0000104 denotes protein
T55 450-457 PR:000000001 denotes protein
T52 450-457 GO:0003675 denotes protein
T53 450-457 CHEBI:36080 denotes protein
T54 450-457 CHEBI:11122 denotes protein
T58 462-471 10524 denotes Threonine
T57 462-471 SO:0001445 denotes Threonine
T59 462-471 CHEBI:16857 denotes Threonine
T60 462-471 CHEBI:26986 denotes Threonine
T61 462-471 D013912 denotes Threonine
T62 462-471 D013912 denotes Threonine
T64 504-509 PR:P49950 denotes Bcl-2
T65 504-509 PR:000002307 denotes Bcl-2
T66 504-509 PR:P10417 denotes Bcl-2
T67 504-509 PR:Q00709 denotes Bcl-2
T68 504-509 PR:P10415 denotes Bcl-2
T63 504-509 GO:0015283 denotes Bcl-2
T70 539-544 PR:P49950 denotes Bcl-2
T71 539-544 PR:000002307 denotes Bcl-2
T72 539-544 PR:P10417 denotes Bcl-2
T73 539-544 PR:Q00709 denotes Bcl-2
T74 539-544 PR:P10415 denotes Bcl-2
T69 539-544 GO:0015283 denotes Bcl-2
T76 562-567 PR:P49950 denotes Bcl-2
T77 562-567 PR:000002307 denotes Bcl-2
T78 562-567 PR:P10417 denotes Bcl-2
T79 562-567 PR:Q00709 denotes Bcl-2
T80 562-567 PR:P10415 denotes Bcl-2
T75 562-567 GO:0015283 denotes Bcl-2
T81 585-590 PR:Q5S006 denotes LRRK2
T82 585-590 PR:000003033 denotes LRRK2
T83 585-590 PR:Q5S007 denotes LRRK2
T84 606-634 GO:0051882 denotes mitochondrial depolarization
T85 639-648 GO:0016236 denotes autophagy
T86 639-648 GO:0006914 denotes autophagy
T87 693-705 32644 denotes unidentified
T88 716-721 PR:Q5S006 denotes LRRK2
T89 716-721 PR:000003033 denotes LRRK2
T90 716-721 PR:Q5S007 denotes LRRK2
T92 743-748 PR:P49950 denotes Bcl-2
T93 743-748 PR:000002307 denotes Bcl-2
T94 743-748 PR:P10417 denotes Bcl-2
T95 743-748 PR:Q00709 denotes Bcl-2
T96 743-748 PR:P10415 denotes Bcl-2
T91 743-748 GO:0015283 denotes Bcl-2
T97 788-793 PR:Q5S006 denotes LRRK2
T98 788-793 PR:000003033 denotes LRRK2
T99 788-793 PR:Q5S007 denotes LRRK2
T100 810-832 D028361 denotes mitochondrial disorder
T101 810-832 D028361 denotes mitochondrial disorder
T102 854-863 GO:0016236 denotes autophagy
T103 854-863 GO:0006914 denotes autophagy

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 212-221 HP_0001300 denotes Parkinson
T2 421-434 HP_0001427 denotes mitochondrial
T3 606-619 HP_0001427 denotes mitochondrial
T4 810-823 HP_0001427 denotes mitochondrial

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 119-237 DRI_Approach denotes The G2019S leucine-rich repeat kinase 2 (LRRK2) mutation is the most common cause of genetic Parkinson's disease (PD).
T2 238-281 DRI_Background denotes However, the molecular mechanism underlying
T3 303-343 DRI_Background denotes cellular pathology is poorly understood.
T4 344-370 DRI_Outcome denotes Here, we demonstrated that
T5 384-475 DRI_Outcome denotes bound to and phosphorylated Bcl-2, a mitochondrial anti-apoptotic protein, at Threonine 56.
T6 476-584 DRI_Background denotes Either stable expression of Bcl-2 or transient expression of a Bcl-2 phosphor mutant (Bcl-2(T56A)) abolished
T7 606-649 DRI_Background denotes mitochondrial depolarization and autophagy.
T8 650-715 DRI_Outcome denotes Together, our findings reveal a previously unidentified target of
T9 728-787 DRI_Outcome denotes , showing that Bcl-2 serves as a point of crosstalk between
T10 810-864 DRI_Outcome denotes mitochondrial disorder and dysregulation of autophagy.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 212-231 Disease denotes Parkinson's disease http://purl.obolibrary.org/obo/MONDO_0005180
T2 233-235 Disease denotes PD http://purl.obolibrary.org/obo/MONDO_0005180