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c_corpus

Id Subject Object Predicate Lexical cue
T1 4-13 SO:0001185 denotes enzymatic
T2 15-20 UBERON:0001977 denotes serum
T3 26-32 UBERON:0000479 denotes tissue
T6 44-47 SO:0002045 denotes pre
T5 44-47 PR:Q8LLD0 denotes pre
T7 44-47 UBERON:0001782 denotes pre
T4 44-47 GO:0003904 denotes pre
T8 57-63 UBERON:0000310 denotes breast
T11 123-147 D002285 denotes ductal carcinoma in situ
T12 123-147 D002285 denotes ductal carcinoma in situ
T18 149-153 CVCL_5552 denotes DCIS
T17 149-153 D002285 denotes DCIS
T19 149-153 D002285 denotes DCIS
T20 174-187 UBERON:2000098 denotes proliferation
T21 246-252 UBERON:0000310 denotes breast
T22 253-257 UBERON:0000025 denotes duct
T23 253-257 UBERON:0000058 denotes duct
T25 293-310 UBERON:0005769 denotes basement membrane
T24 293-310 GO:0005604 denotes basement membrane
T30 318-322 CVCL_5552 denotes DCIS
T29 318-322 D002285 denotes DCIS
T31 318-322 D002285 denotes DCIS
T32 341-350 PR:000000230 denotes precursor
T33 341-350 PR:000000291 denotes precursor
T34 363-369 UBERON:0000310 denotes breast
T35 370-377 D009369 denotes cancers
T36 370-377 D009369 denotes cancers
T37 430-436 173331 denotes permit
T39 561-565 CVCL_5552 denotes DCIS
T38 561-565 D002285 denotes DCIS
T40 561-565 D002285 denotes DCIS
T41 647-652 D006801 denotes human
T42 653-659 UBERON:0000310 denotes breast
T43 660-666 UBERON:0000479 denotes tissue
T44 699-708 SO:0001185 denotes enzymatic
T45 723-729 UBERON:0000479 denotes tissue
T46 739-745 UBERON:0000310 denotes breast
T47 746-752 UBERON:0000479 denotes tissue
T48 817-823 UBERON:0000310 denotes breast
T49 824-830 UBERON:0000479 denotes tissue
T51 893-897 CVCL_5552 denotes DCIS
T50 893-897 D002285 denotes DCIS
T52 893-897 D002285 denotes DCIS
T53 911-919 CHEBI:33284 denotes nutrient
T54 926-936 D000900 denotes antibiotic
T55 926-936 D000900 denotes antibiotic
T56 926-936 CHEBI:33281 denotes antibiotic
T57 949-954 UBERON:0001977 denotes serum
T58 991-997 UBERON:0000479 denotes tissue
T59 1022-1028 UBERON:0000310 denotes breast
T60 1029-1035 UBERON:0000479 denotes tissue
T61 1098-1104 UBERON:0000310 denotes breast
T62 1105-1111 UBERON:0000479 denotes tissue
T63 1165-1170 UBERON:0001977 denotes serum
T64 1211-1214 PR:Q9VMJ7 denotes lid
T65 1274-1284 CL:0000057 denotes fibroblast
T66 1397-1412 CL:0000066 denotes epithelial cell
T67 1537-1546 SO:0001185 denotes enzymatic
T68 1547-1553 UBERON:0000479 denotes tissue
T69 1649-1654 D006801 denotes human
T71 1655-1659 CVCL_5552 denotes DCIS
T70 1655-1659 D002285 denotes DCIS
T72 1655-1659 D002285 denotes DCIS

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 363-377 HP_0003002 denotes breast cancers
T2 363-377 HP_0100013 denotes breast cancers
T3 370-377 HP_0002664 denotes cancers
T4 461-467 HP_0002664 denotes cancer

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-115 DRI_Background denotes Non-enzymatic, serum-free tissue culture of pre-invasive breast lesions for spontaneous generation of mammospheres.
T2 116-311 DRI_Background denotes Breast ductal carcinoma in situ (DCIS), by definition, is proliferation of neoplastic epithelial cells within the confines of the breast duct, without breaching the collagenous basement membrane.
T3 312-488 DRI_Background denotes While DCIS is a non-obligate precursor to invasive breast cancers, the molecular mechanisms and cell populations that permit progression to invasive cancer are not fully known.
T4 489-730 DRI_Challenge denotes To determine if progenitor cells capable of invasion existed within the DCIS cell population, we developed a methodology for collecting and culturing sterile human breast tissue at the time of surgery, without enzymatic disruption of tissue.
T5 731-874 DRI_Background denotes Sterile breast tissue containing ductal segments is harvested from surgically excised breast tissue following routine pathological examination.
T6 875-1017 DRI_Background denotes Tissue containing DCIS is placed in nutrient rich, antibiotic-containing, serum free medium, and transported to the tissue culture laboratory.
T7 1018-1088 DRI_Approach denotes The breast tissue is further dissected to isolate the calcified areas.
T8 1089-1258 DRI_Background denotes Multiple breast tissue pieces (organoids) are placed in a minimal volume of serum free medium in a flask with a removable lid and cultured in a humidified CO₂ incubator.
T9 1259-1346 DRI_Background denotes Epithelial and fibroblast cell populations emerge from the organoid after 10 - 14 days.
T10 1347-1423 DRI_Background denotes Mammospheres spontaneously form on and around the epithelial cell monolayer.
T11 1424-1528 DRI_Approach denotes Specific cell populations can be harvested directly from the flask without disrupting neighboring cells.
T12 1529-1668 DRI_Outcome denotes Our non-enzymatic tissue culture system reliably reveals cytogenetically abnormal, invasive progenitor cells from fresh human DCIS lesions.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 116-311 DRI_Background denotes Breast ductal carcinoma in situ (DCIS), by definition, is proliferation of neoplastic epithelial cells within the confines of the breast duct, without breaching the collagenous basement membrane.
T2 312-488 DRI_Background denotes While DCIS is a non-obligate precursor to invasive breast cancers, the molecular mechanisms and cell populations that permit progression to invasive cancer are not fully known.
T3 489-730 DRI_Challenge denotes To determine if progenitor cells capable of invasion existed within the DCIS cell population, we developed a methodology for collecting and culturing sterile human breast tissue at the time of surgery, without enzymatic disruption of tissue.
T4 731-874 DRI_Background denotes Sterile breast tissue containing ductal segments is harvested from surgically excised breast tissue following routine pathological examination.
T5 875-1017 DRI_Background denotes Tissue containing DCIS is placed in nutrient rich, antibiotic-containing, serum free medium, and transported to the tissue culture laboratory.
T6 1018-1088 DRI_Approach denotes The breast tissue is further dissected to isolate the calcified areas.
T7 1089-1258 DRI_Background denotes Multiple breast tissue pieces (organoids) are placed in a minimal volume of serum free medium in a flask with a removable lid and cultured in a humidified CO₂ incubator.
T8 1259-1346 DRI_Background denotes Epithelial and fibroblast cell populations emerge from the organoid after 10 - 14 days.
T9 1347-1423 DRI_Background denotes Mammospheres spontaneously form on and around the epithelial cell monolayer.
T10 1424-1528 DRI_Approach denotes Specific cell populations can be harvested directly from the flask without disrupting neighboring cells.
T11 1529-1668 DRI_Outcome denotes Our non-enzymatic tissue culture system reliably reveals cytogenetically abnormal, invasive progenitor cells from fresh human DCIS lesions.