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PubMed:25400108 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-62 Sentence denotes Essential role of Her3 in two signaling transduction patterns:
TextSentencer_T2 63-127 Sentence denotes Her2/Her3 and MET/Her3 in proliferation of human gastric cancer.
TextSentencer_T3 128-359 Sentence denotes Various receptor tyrosine kinase (RTK) pathways were verified in many cancers including gastric cancer (GC), We sought to investigate the expression of RTKs including Her2, Her3, and Met and their transduction patterns in human GC.
TextSentencer_T4 360-511 Sentence denotes Over-expression of Her2, Her3, and c-Met in human GC was verified by immunohistochemistry leading to constitutive activation of RTK signaling pathways.
TextSentencer_T5 512-595 Sentence denotes Combined RTKs expression was valuable indicators for poor prognosis of GC patients.
TextSentencer_T6 596-795 Sentence denotes Using ErbB2 specific inhibitor Lapatinib and c-Met specific inhibitor PHA-665752, we further demonstrated that this constitutive activation of RTK signaling is necessary for the survival of GC cells.
TextSentencer_T7 796-825 Sentence denotes However, various RTK pattern:
TextSentencer_T8 826-944 Sentence denotes Her3/Her2 and Met/Her3 were verified in the transduction growth stimulus from outside via both AKT and MAPK signaling.
TextSentencer_T9 945-1122 Sentence denotes Moreover, the essential roles of Her3 in both two heterodimers were obtained which showed significantly attenuated growth effect due to Her3 knockdown both in vitro and in vivo.
TextSentencer_T10 1123-1178 Sentence denotes In conclusion, various molecular transduction patterns:
TextSentencer_T11 1179-1288 Sentence denotes Her2/Her3 and Met/Her3 were verified in human GC, and Her3 could serve as a potential target in GC treatment.
T1 0-62 Sentence denotes Essential role of Her3 in two signaling transduction patterns:
T2 63-127 Sentence denotes Her2/Her3 and MET/Her3 in proliferation of human gastric cancer.
T3 128-359 Sentence denotes Various receptor tyrosine kinase (RTK) pathways were verified in many cancers including gastric cancer (GC), We sought to investigate the expression of RTKs including Her2, Her3, and Met and their transduction patterns in human GC.
T4 360-511 Sentence denotes Over-expression of Her2, Her3, and c-Met in human GC was verified by immunohistochemistry leading to constitutive activation of RTK signaling pathways.
T5 512-595 Sentence denotes Combined RTKs expression was valuable indicators for poor prognosis of GC patients.
T6 596-795 Sentence denotes Using ErbB2 specific inhibitor Lapatinib and c-Met specific inhibitor PHA-665752, we further demonstrated that this constitutive activation of RTK signaling is necessary for the survival of GC cells.
T7 796-825 Sentence denotes However, various RTK pattern:
T8 826-944 Sentence denotes Her3/Her2 and Met/Her3 were verified in the transduction growth stimulus from outside via both AKT and MAPK signaling.
T9 945-1122 Sentence denotes Moreover, the essential roles of Her3 in both two heterodimers were obtained which showed significantly attenuated growth effect due to Her3 knockdown both in vitro and in vivo.
T10 1123-1178 Sentence denotes In conclusion, various molecular transduction patterns:
T11 1179-1288 Sentence denotes Her2/Her3 and Met/Her3 were verified in human GC, and Her3 could serve as a potential target in GC treatment.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25400108-0#18#22#gene2065 18-22 gene2065 denotes Her3
25400108-0#81#85#gene2065 81-85 gene2065 denotes Her3
25400108-0#112#126#diseaseC0024623 112-126 diseaseC0024623 denotes gastric cancer
25400108-0#112#126#diseaseC0699791 112-126 diseaseC0699791 denotes gastric cancer
25400108-0#112#126#diseaseC0024623 112-126 diseaseC0024623 denotes gastric cancer
25400108-0#112#126#diseaseC0699791 112-126 diseaseC0699791 denotes gastric cancer
25400108-2#25#29#gene2065 385-389 gene2065 denotes Her3
25400108-2#128#131#diseaseC0854917 488-491 diseaseC0854917 denotes RTK
25400108-4#6#11#gene2064 602-607 gene2064 denotes ErbB2
25400108-4#70#73#gene3930 666-669 gene3930 denotes PHA
25400108-4#6#11#gene2064 602-607 gene2064 denotes ErbB2
25400108-4#190#192#diseaseC0024623 786-788 diseaseC0024623 denotes GC
25400108-4#190#192#diseaseC0699791 786-788 diseaseC0699791 denotes GC
25400108-4#190#192#diseaseC0024623 786-788 diseaseC0024623 denotes GC
25400108-4#190#192#diseaseC0699791 786-788 diseaseC0699791 denotes GC
25400108-4#143#146#diseaseC0854917 739-742 diseaseC0854917 denotes RTK
18#22#gene2065112#126#diseaseC0024623 25400108-0#18#22#gene2065 25400108-0#112#126#diseaseC0024623 associated_with Her3,gastric cancer
18#22#gene2065112#126#diseaseC0699791 25400108-0#18#22#gene2065 25400108-0#112#126#diseaseC0699791 associated_with Her3,gastric cancer
18#22#gene2065112#126#diseaseC0024623 25400108-0#18#22#gene2065 25400108-0#112#126#diseaseC0024623 associated_with Her3,gastric cancer
18#22#gene2065112#126#diseaseC0699791 25400108-0#18#22#gene2065 25400108-0#112#126#diseaseC0699791 associated_with Her3,gastric cancer
81#85#gene2065112#126#diseaseC0024623 25400108-0#81#85#gene2065 25400108-0#112#126#diseaseC0024623 associated_with Her3,gastric cancer
81#85#gene2065112#126#diseaseC0699791 25400108-0#81#85#gene2065 25400108-0#112#126#diseaseC0699791 associated_with Her3,gastric cancer
81#85#gene2065112#126#diseaseC0024623 25400108-0#81#85#gene2065 25400108-0#112#126#diseaseC0024623 associated_with Her3,gastric cancer
81#85#gene2065112#126#diseaseC0699791 25400108-0#81#85#gene2065 25400108-0#112#126#diseaseC0699791 associated_with Her3,gastric cancer
25#29#gene2065128#131#diseaseC0854917 25400108-2#25#29#gene2065 25400108-2#128#131#diseaseC0854917 associated_with Her3,RTK
6#11#gene2064190#192#diseaseC0024623 25400108-4#6#11#gene2064 25400108-4#190#192#diseaseC0024623 associated_with ErbB2,GC
6#11#gene2064190#192#diseaseC0699791 25400108-4#6#11#gene2064 25400108-4#190#192#diseaseC0699791 associated_with ErbB2,GC
6#11#gene2064190#192#diseaseC0024623 25400108-4#6#11#gene2064 25400108-4#190#192#diseaseC0024623 associated_with ErbB2,GC
6#11#gene2064190#192#diseaseC0699791 25400108-4#6#11#gene2064 25400108-4#190#192#diseaseC0699791 associated_with ErbB2,GC
6#11#gene2064143#146#diseaseC0854917 25400108-4#6#11#gene2064 25400108-4#143#146#diseaseC0854917 associated_with ErbB2,RTK
70#73#gene3930190#192#diseaseC0024623 25400108-4#70#73#gene3930 25400108-4#190#192#diseaseC0024623 associated_with PHA,GC
70#73#gene3930190#192#diseaseC0699791 25400108-4#70#73#gene3930 25400108-4#190#192#diseaseC0699791 associated_with PHA,GC
70#73#gene3930190#192#diseaseC0024623 25400108-4#70#73#gene3930 25400108-4#190#192#diseaseC0024623 associated_with PHA,GC
70#73#gene3930190#192#diseaseC0699791 25400108-4#70#73#gene3930 25400108-4#190#192#diseaseC0699791 associated_with PHA,GC
70#73#gene3930143#146#diseaseC0854917 25400108-4#70#73#gene3930 25400108-4#143#146#diseaseC0854917 associated_with PHA,RTK
6#11#gene2064190#192#diseaseC0024623 25400108-4#6#11#gene2064 25400108-4#190#192#diseaseC0024623 associated_with ErbB2,GC
6#11#gene2064190#192#diseaseC0699791 25400108-4#6#11#gene2064 25400108-4#190#192#diseaseC0699791 associated_with ErbB2,GC
6#11#gene2064190#192#diseaseC0024623 25400108-4#6#11#gene2064 25400108-4#190#192#diseaseC0024623 associated_with ErbB2,GC
6#11#gene2064190#192#diseaseC0699791 25400108-4#6#11#gene2064 25400108-4#190#192#diseaseC0699791 associated_with ErbB2,GC
6#11#gene2064143#146#diseaseC0854917 25400108-4#6#11#gene2064 25400108-4#143#146#diseaseC0854917 associated_with ErbB2,RTK

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2196 18-22 gene:2065 denotes Her3
T2197 112-126 disease:C0024623 denotes gastric cancer
T2198 81-85 gene:2065 denotes Her3
T2199 602-607 gene:2064 denotes ErbB2
T2200 786-788 disease:C0024623 denotes GC
T2201 666-669 gene:3930 denotes PHA
R1 T2196 T2197 associated_with Her3,gastric cancer
R2 T2196 T2197 associated_with Her3,gastric cancer
R3 T2198 T2197 associated_with Her3,gastric cancer
R4 T2198 T2197 associated_with Her3,gastric cancer
R5 T2199 T2200 associated_with ErbB2,GC
R6 T2199 T2200 associated_with ErbB2,GC
R7 T2201 T2200 associated_with PHA,GC
R8 T2201 T2200 associated_with PHA,GC