PubMed:25372662 / 850-1590 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/25372662","sourcedb":"PubMed","sourceid":"25372662","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/25372662","text":"We validated three SNPs (rs78142040, rs9605146 and rs3848719) in additional ARDS patients to substantiate their associations with susceptibility, severity and outcome of ARDS. rs78142040 (C\u003eT) occurs within a histone mark (intron 6) of the Arylsulfatase D gene. rs9605146 (G\u003eA) causes a deleterious coding change (proline to leucine) in the XK, Kell blood group complex subunit-related family, member 3 gene. rs3848719 (G\u003eA) is a synonymous SNP in the Zinc-Finger/Leucine-Zipper Co-Transducer NIF1 gene. rs78142040, rs9605146, and rs3848719 are associated significantly with susceptibility to ARDS. rs3848719 is associated with APACHE II score quartile. rs78142040 is associated with 60-day mortality in the overall ARDS patient 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