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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-84 Sentence denotes Treatment of keratosis pilaris with 810-nm diode laser: a randomized clinical trial.
T2 85-96 Sentence denotes IMPORTANCE:
T3 97-289 Sentence denotes Keratosis pilaris (KP) is a common skin disorder of follicular prominence and erythema that typically affects the proximal extremities, can be disfiguring, and is often resistant to treatment.
T4 290-408 Sentence denotes Shorter-wavelength vascular lasers have been used to reduce the associated erythema but not the textural irregularity.
T5 409-419 Sentence denotes OBJECTIVE:
T6 420-599 Sentence denotes To determine whether the longer-wavelength 810-nm diode laser may be effective for treatment of KP, particularly the associated skin roughness/bumpiness and textural irregularity.
T7 600-634 Sentence denotes DESIGN, SETTING, AND PARTICIPANTS:
T8 635-859 Sentence denotes We performed a split-body, rater-blinded, parallel-group, balanced (1:1), placebo-controlled randomized clinical trial at a dermatology outpatient practice of an urban academic medical center from March 1 to October 1, 2011.
T9 860-962 Sentence denotes We included all patients diagnosed as having KP on both arms and Fitzpatrick skin types I through III.
T10 963-1038 Sentence denotes Of the 26 patients who underwent screening, 23 met our enrollment criteria.
T11 1039-1208 Sentence denotes Of these, 18 patients completed the study, 3 were lost to or unavailable for follow-up, and 2 withdrew owing to inflammatory hyperpigmentation after the laser treatment.
T12 1209-1223 Sentence denotes INTERVENTIONS:
T13 1224-1301 Sentence denotes Patients were randomized to receive laser treatment on the right or left arm.
T14 1302-1416 Sentence denotes Each patient received treatment with the 810-nm pulsed diode laser to the arm randomized to be the treatment site.
T15 1417-1509 Sentence denotes Treatments were repeated twice, for a total of 3 treatment visits spaced 4 to 5 weeks apart.
T16 1510-1537 Sentence denotes MAIN OUTCOMES AND MEASURES:
T17 1538-1761 Sentence denotes The primary outcome measure was the difference in disease severity score, including redness and roughness/bumpiness, with each graded on a scale of 0 (least severe) to 3 (most severe), between the treated and control sites.
T18 1762-1841 Sentence denotes Two blinded dermatologists rated the sites at 12 weeks after the initial visit.
T19 1842-1850 Sentence denotes RESULTS:
T20 1851-2009 Sentence denotes At follow-up, the median redness score reported by the 2 blinded raters for the treatment and control sides was 2.0 (interquartile range [IQR], 1-2; P = .11).
T21 2010-2161 Sentence denotes The median roughness/bumpiness score was 1.0 (IQR, 1-2) for the treatment sides and 2.0 (IQR, 1-2) for the control sides, a difference of 1 (P = .004).
T22 2162-2344 Sentence denotes The median overall score combining erythema and roughness/bumpiness was 3.0 (IQR, 2-4) for the treatment sides and 4.0 (IQR, 3-5) for the control sides, a difference of 1 (P = .005).
T23 2345-2371 Sentence denotes CONCLUSIONS AND RELEVANCE:
T24 2372-2589 Sentence denotes Three treatments with the 810-nm diode laser may induce significant improvements in skin texture and roughness/bumpiness in KP patients with Fitzpatrick skin types I through III, but baseline erythema is not improved.
T25 2590-2742 Sentence denotes Complete treatment of erythema and texture in KP may require diode laser treatment combined with other laser or medical modalities that address redness.
T26 2743-2806 Sentence denotes TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01281644.
T1 0-84 Sentence denotes Treatment of keratosis pilaris with 810-nm diode laser: a randomized clinical trial.
T2 85-96 Sentence denotes IMPORTANCE:
T3 97-289 Sentence denotes Keratosis pilaris (KP) is a common skin disorder of follicular prominence and erythema that typically affects the proximal extremities, can be disfiguring, and is often resistant to treatment.
T4 290-408 Sentence denotes Shorter-wavelength vascular lasers have been used to reduce the associated erythema but not the textural irregularity.
T5 409-419 Sentence denotes OBJECTIVE:
T6 420-599 Sentence denotes To determine whether the longer-wavelength 810-nm diode laser may be effective for treatment of KP, particularly the associated skin roughness/bumpiness and textural irregularity.
T7 600-634 Sentence denotes DESIGN, SETTING, AND PARTICIPANTS:
T8 635-859 Sentence denotes We performed a split-body, rater-blinded, parallel-group, balanced (1:1), placebo-controlled randomized clinical trial at a dermatology outpatient practice of an urban academic medical center from March 1 to October 1, 2011.
T9 860-962 Sentence denotes We included all patients diagnosed as having KP on both arms and Fitzpatrick skin types I through III.
T10 963-1038 Sentence denotes Of the 26 patients who underwent screening, 23 met our enrollment criteria.
T11 1039-1208 Sentence denotes Of these, 18 patients completed the study, 3 were lost to or unavailable for follow-up, and 2 withdrew owing to inflammatory hyperpigmentation after the laser treatment.
T12 1209-1223 Sentence denotes INTERVENTIONS:
T13 1224-1301 Sentence denotes Patients were randomized to receive laser treatment on the right or left arm.
T14 1302-1416 Sentence denotes Each patient received treatment with the 810-nm pulsed diode laser to the arm randomized to be the treatment site.
T15 1417-1509 Sentence denotes Treatments were repeated twice, for a total of 3 treatment visits spaced 4 to 5 weeks apart.
T16 1510-1537 Sentence denotes MAIN OUTCOMES AND MEASURES:
T17 1538-1761 Sentence denotes The primary outcome measure was the difference in disease severity score, including redness and roughness/bumpiness, with each graded on a scale of 0 (least severe) to 3 (most severe), between the treated and control sites.
T18 1762-1841 Sentence denotes Two blinded dermatologists rated the sites at 12 weeks after the initial visit.
T19 1842-1850 Sentence denotes RESULTS:
T20 1851-2009 Sentence denotes At follow-up, the median redness score reported by the 2 blinded raters for the treatment and control sides was 2.0 (interquartile range [IQR], 1-2; P = .11).
T21 2010-2161 Sentence denotes The median roughness/bumpiness score was 1.0 (IQR, 1-2) for the treatment sides and 2.0 (IQR, 1-2) for the control sides, a difference of 1 (P = .004).
T22 2162-2344 Sentence denotes The median overall score combining erythema and roughness/bumpiness was 3.0 (IQR, 2-4) for the treatment sides and 4.0 (IQR, 3-5) for the control sides, a difference of 1 (P = .005).
T23 2345-2371 Sentence denotes CONCLUSIONS AND RELEVANCE:
T24 2372-2589 Sentence denotes Three treatments with the 810-nm diode laser may induce significant improvements in skin texture and roughness/bumpiness in KP patients with Fitzpatrick skin types I through III, but baseline erythema is not improved.
T25 2590-2742 Sentence denotes Complete treatment of erythema and texture in KP may require diode laser treatment combined with other laser or medical modalities that address redness.
T26 2743-2806 Sentence denotes TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01281644.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 132-145 HP_0000951 denotes skin disorder
T2 175-183 HP_0010783 denotes erythema
T3 365-373 HP_0010783 denotes erythema

chenxin_473849_800

Id Subject Object Predicate Lexical cue
T1 97-114 DP denotes Keratosis pilaris
T2 116-118 DP denotes KP
T3 516-518 DP denotes KP
T4 905-907 DP denotes KP
T5 2496-2498 DP denotes KP
T6 2636-2638 DP denotes KP

yangbin123xm_800_3

Id Subject Object Predicate Lexical cue
T1 97-114 DP denotes Keratosis pilaris
T2 13-30 DP denotes keratosis pilaris
T3 116-118 DP denotes KP
T4 516-518 DP denotes KP
T5 905-907 DP denotes KP
T6 2496-2498 DP denotes KP
T7 2636-2638 DP denotes KP

chenxin_473849_800_3

Id Subject Object Predicate Lexical cue
T1 97-114 DP denotes Keratosis pilaris
T2 13-30 DP denotes keratosis pilaris
T3 116-118 DP denotes KP
T4 516-518 DP denotes KP
T5 905-907 DP denotes KP
T6 2496-2498 DP denotes KP
T7 2636-2638 DP denotes KP