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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-122 Sentence denotes Probiotics prevent Hirschsprung's disease-associated enterocolitis: a prospective multicenter randomized controlled trial.
T2 123-134 Sentence denotes BACKGROUND:
T3 135-243 Sentence denotes Enterocolitis (EC) is the most common and serious postoperative complication of Hirschsprung's disease (HD).
T4 244-334 Sentence denotes Probiotics potentially play a protective role in maintaining intestinal mucosal integrity.
T5 335-519 Sentence denotes Based on the beneficial effects of probiotics, we hypothesized that oral probiotics could decrease the incidence and severity of Hirschsprung's disease-associated enterocolitis (HAEC).
T6 520-528 Sentence denotes METHODS:
T7 529-687 Sentence denotes We conducted a prospective, multicenter, randomized, and controlled trial to assess whether oral probiotics could decrease the incidence and severity of HAEC.
T8 688-774 Sentence denotes HD patients were randomly assigned into the control group and probiotic-treated group.
T9 775-860 Sentence denotes All children in probiotic-treated group were fed with probiotics per day for 4 weeks.
T10 861-928 Sentence denotes In next 3 months, the incidence and severity of HAEC were analyzed.
T11 929-1088 Sentence denotes The peripheral blood T lymphocyte subsets and cytokines, including TNF-α, IFN-γ, IL-6, and IL-10, were analyzed by flow cytometry and enzyme immunoassay (EIA).
T12 1089-1097 Sentence denotes RESULTS:
T13 1098-1213 Sentence denotes Compared with the control group, the incidence of HAEC in the probiotic-treated group was significantly diminished.
T14 1214-1263 Sentence denotes The severity of EC was also remarkably decreased.
T15 1264-1318 Sentence denotes Furthermore, probiotics balanced T lymphocyte subsets.
T16 1319-1494 Sentence denotes Moreover, pro-inflammatory cytokines TNF-α, IFN-γ, and IL-6 were significantly decreased and anti-inflammatory cytokine IL-10 was notably increased in probiotic-treated group.
T17 1495-1507 Sentence denotes CONCLUSIONS:
T18 1508-1607 Sentence denotes Probiotics not only significantly diminished the incidence but also decreased the severity of HAEC.
T19 1608-1831 Sentence denotes Moreover, our study revealed that probiotics decreased pro-inflammatory cytokine and increased anti-inflammatory cytokine and furthermore balanced T lymphocytes (registered with ClinicalTrials.gov, NCT number: NCT01934959).
T1 0-122 Sentence denotes Probiotics prevent Hirschsprung's disease-associated enterocolitis: a prospective multicenter randomized controlled trial.
T2 123-134 Sentence denotes BACKGROUND:
T3 135-243 Sentence denotes Enterocolitis (EC) is the most common and serious postoperative complication of Hirschsprung's disease (HD).
T4 244-334 Sentence denotes Probiotics potentially play a protective role in maintaining intestinal mucosal integrity.
T5 335-519 Sentence denotes Based on the beneficial effects of probiotics, we hypothesized that oral probiotics could decrease the incidence and severity of Hirschsprung's disease-associated enterocolitis (HAEC).
T6 520-528 Sentence denotes METHODS:
T7 529-687 Sentence denotes We conducted a prospective, multicenter, randomized, and controlled trial to assess whether oral probiotics could decrease the incidence and severity of HAEC.
T8 688-774 Sentence denotes HD patients were randomly assigned into the control group and probiotic-treated group.
T9 775-860 Sentence denotes All children in probiotic-treated group were fed with probiotics per day for 4 weeks.
T10 861-928 Sentence denotes In next 3 months, the incidence and severity of HAEC were analyzed.
T11 929-1088 Sentence denotes The peripheral blood T lymphocyte subsets and cytokines, including TNF-α, IFN-γ, IL-6, and IL-10, were analyzed by flow cytometry and enzyme immunoassay (EIA).
T12 1089-1097 Sentence denotes RESULTS:
T13 1098-1213 Sentence denotes Compared with the control group, the incidence of HAEC in the probiotic-treated group was significantly diminished.
T14 1214-1263 Sentence denotes The severity of EC was also remarkably decreased.
T15 1264-1318 Sentence denotes Furthermore, probiotics balanced T lymphocyte subsets.
T16 1319-1494 Sentence denotes Moreover, pro-inflammatory cytokines TNF-α, IFN-γ, and IL-6 were significantly decreased and anti-inflammatory cytokine IL-10 was notably increased in probiotic-treated group.
T17 1495-1507 Sentence denotes CONCLUSIONS:
T18 1508-1607 Sentence denotes Probiotics not only significantly diminished the incidence but also decreased the severity of HAEC.
T19 1608-1831 Sentence denotes Moreover, our study revealed that probiotics decreased pro-inflammatory cytokine and increased anti-inflammatory cytokine and furthermore balanced T lymphocytes (registered with ClinicalTrials.gov, NCT number: NCT01934959).

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 215-237 HP_0002251 denotes Hirschsprung's disease
T2 464-486 HP_0002251 denotes Hirschsprung's disease

wangzhuo19_800

Id Subject Object Predicate Lexical cue
T1 0-10 CI denotes Probiotics
T2 244-254 CI denotes Probiotics
T3 370-380 CI denotes probiotics
T4 408-418 CI denotes probiotics
T5 626-636 CI denotes probiotics
T6 750-773 CI denotes probiotic-treated group
T7 791-814 CI denotes probiotic-treated group
T8 829-839 CI denotes probiotics
T9 1160-1183 CI denotes probiotic-treated group
T10 1277-1287 CI denotes probiotics
T11 1470-1493 CI denotes probiotic-treated group
T12 1508-1518 CI denotes Probiotics
T13 1642-1652 CI denotes probiotics
T14 215-237 DP denotes Hirschsprung's disease
T15 238-242 DP denotes (HD)
T16 688-699 DP denotes HD patients

Zierdiyeerkenaili_800_3

Id Subject Object Predicate Lexical cue
T1 0-10 CI denotes Probiotics
T10 408-418 CI denotes probiotics
T11 626-636 CI denotes probiotics
T12 1277-1287 CI denotes probiotics
T13 1642-1652 CI denotes probiotics
T14 688-690 DP denotes HD
T15 239-241 DP denotes HD
T16 215-237 DP denotes Hirschsprung's disease
T2 244-254 CI denotes Probiotics
T3 1508-1518 CI denotes Probiotics
T4 750-759 CI denotes probiotic
T5 791-800 CI denotes probiotic
T6 1160-1169 CI denotes probiotic
T7 1470-1479 CI denotes probiotic
T8 829-839 CI denotes probiotics
T9 370-380 CI denotes probiotics
T19 19-66 DP denotes Hirschsprung's disease-associated enterocolitis
T20 464-511 DP denotes Hirschsprung's disease-associated enterocolitis
T21 513-517 DP denotes HAEC
T22 682-686 DP denotes HAEC
T23 909-913 DP denotes HAEC
T24 1148-1152 DP denotes HAEC
T25 1602-1606 DP denotes HAEC
T26 150-152 DP denotes EC
T27 1230-1232 DP denotes EC
T28 135-148 DP denotes Enterocolitis

yaoziqian_800_3

Id Subject Object Predicate Lexical cue
T1 19-66 DP denotes Hirschsprung's disease-associated enterocolitis
T10 1508-1518 CI denotes Probiotics
T13 1230-1232 DP denotes EC
T14 215-237 DP denotes Hirschsprung's disease
T15 239-241 DP denotes HD
T16 688-690 DP denotes HD
T17 135-148 DP denotes Enterocolitis
T18 150-152 DP denotes EC
T19 829-839 CI denotes probiotics
T2 464-511 DP denotes Hirschsprung's disease-associated enterocolitis
T20 370-380 CI denotes probiotics
T21 408-418 CI denotes probiotics
T22 626-636 CI denotes probiotics
T23 1277-1287 CI denotes probiotics
T24 1642-1652 CI denotes probiotics
T3 513-517 DP denotes HAEC
T4 682-686 DP denotes HAEC
T5 909-913 DP denotes HAEC
T6 1148-1152 DP denotes HAEC
T7 1602-1606 DP denotes HAEC
T8 0-10 CI denotes Probiotics
T9 244-254 CI denotes Probiotics
T25 750-759 CI denotes probiotic
T26 791-800 CI denotes probiotic
T27 1160-1169 CI denotes probiotic
T28 1470-1479 CI denotes probiotic