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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes Soluble epoxide hydrolase as an anti-inflammatory target of the thrombolytic stroke drug SMTP-7.
T2 97-314 Sentence denotes Although ischemic stroke is a major cause of death and disability worldwide, only a small fraction of patients benefit from the current thrombolytic therapy due to a risk of cerebral hemorrhage caused by inflammation.
T3 315-418 Sentence denotes Thus, the development of a new strategy to combat inflammation during thrombolysis is an urgent demand.
T4 419-552 Sentence denotes The small molecule thrombolytic SMTP-7 effectively treats ischemic stroke in several animal models with reducing cerebral hemorrhage.
T5 553-648 Sentence denotes Here we revealed that SMTP-7 targeted soluble epoxide hydrolase (sEH) to suppress inflammation.
T6 649-811 Sentence denotes SMTP-7 inhibited both of the two sEH enzyme activities: epoxide hydrolase (which inactivates anti-inflammatory epoxy-fatty acids) and lipid phosphate phosphatase.
T7 812-951 Sentence denotes SMTP-7 suppressed epoxy-fatty acid hydrolysis in HepG2 cells in culture, implicating the sEH inhibition in the anti-inflammatory mechanism.
T8 952-1026 Sentence denotes The sEH inhibition by SMTP-7 was independent of its thrombolytic activity.
T9 1027-1167 Sentence denotes The simultaneous targeting of thrombolysis and sEH by a single molecule is a promising strategy to revolutionize the current stroke therapy.
T1 0-96 Sentence denotes Soluble epoxide hydrolase as an anti-inflammatory target of the thrombolytic stroke drug SMTP-7.
T2 97-314 Sentence denotes Although ischemic stroke is a major cause of death and disability worldwide, only a small fraction of patients benefit from the current thrombolytic therapy due to a risk of cerebral hemorrhage caused by inflammation.
T3 315-418 Sentence denotes Thus, the development of a new strategy to combat inflammation during thrombolysis is an urgent demand.
T4 419-552 Sentence denotes The small molecule thrombolytic SMTP-7 effectively treats ischemic stroke in several animal models with reducing cerebral hemorrhage.
T5 553-648 Sentence denotes Here we revealed that SMTP-7 targeted soluble epoxide hydrolase (sEH) to suppress inflammation.
T6 649-811 Sentence denotes SMTP-7 inhibited both of the two sEH enzyme activities: epoxide hydrolase (which inactivates anti-inflammatory epoxy-fatty acids) and lipid phosphate phosphatase.
T7 812-951 Sentence denotes SMTP-7 suppressed epoxy-fatty acid hydrolysis in HepG2 cells in culture, implicating the sEH inhibition in the anti-inflammatory mechanism.
T8 952-1026 Sentence denotes The sEH inhibition by SMTP-7 was independent of its thrombolytic activity.
T9 1027-1167 Sentence denotes The simultaneous targeting of thrombolysis and sEH by a single molecule is a promising strategy to revolutionize the current stroke therapy.

sentences

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes Soluble epoxide hydrolase as an anti-inflammatory target of the thrombolytic stroke drug SMTP-7.
T2 97-314 Sentence denotes Although ischemic stroke is a major cause of death and disability worldwide, only a small fraction of patients benefit from the current thrombolytic therapy due to a risk of cerebral hemorrhage caused by inflammation.
T3 315-418 Sentence denotes Thus, the development of a new strategy to combat inflammation during thrombolysis is an urgent demand.
T4 419-552 Sentence denotes The small molecule thrombolytic SMTP-7 effectively treats ischemic stroke in several animal models with reducing cerebral hemorrhage.
T5 553-648 Sentence denotes Here we revealed that SMTP-7 targeted soluble epoxide hydrolase (sEH) to suppress inflammation.
T6 649-811 Sentence denotes SMTP-7 inhibited both of the two sEH enzyme activities: epoxide hydrolase (which inactivates anti-inflammatory epoxy-fatty acids) and lipid phosphate phosphatase.
T7 812-951 Sentence denotes SMTP-7 suppressed epoxy-fatty acid hydrolysis in HepG2 cells in culture, implicating the sEH inhibition in the anti-inflammatory mechanism.
T8 952-1026 Sentence denotes The sEH inhibition by SMTP-7 was independent of its thrombolytic activity.
T9 1027-1167 Sentence denotes The simultaneous targeting of thrombolysis and sEH by a single molecule is a promising strategy to revolutionize the current stroke therapy.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 106-121 HP_0002140 denotes ischemic stroke
T2 115-121 HP_0001297 denotes stroke
T3 271-290 HP_0001342 denotes cerebral hemorrhage
T4 477-492 HP_0002140 denotes ischemic stroke
T5 486-492 HP_0001297 denotes stroke
T6 532-551 HP_0001342 denotes cerebral hemorrhage
T7 1152-1158 HP_0001297 denotes stroke

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 77-83 Disease denotes stroke http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057
T3 115-121 Disease denotes stroke http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057
T5 301-313 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T6 365-377 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T7 486-492 Disease denotes stroke http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057
T9 635-647 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T10 1152-1158 Disease denotes stroke http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 77-83 Phenotype denotes stroke HP:0001297
T2 106-121 Phenotype denotes ischemic stroke HP:0002140
T3 271-290 Phenotype denotes cerebral hemorrhage HP:0001342
T4 477-492 Phenotype denotes ischemic stroke HP:0002140
T5 532-551 Phenotype denotes cerebral hemorrhage HP:0001342
T6 1152-1158 Phenotype denotes stroke HP:0001297