> top > docs > PubMed:25347992 > annotations

PubMed:25347992 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-89 Sentence denotes Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activation.
TextSentencer_T2 90-244 Sentence denotes Over the last four decades, increases in the incidence of immune-mediated diseases in the Western world have been linked to changes in microbial exposure.
TextSentencer_T3 245-517 Sentence denotes It is becoming increasingly clear that the normal microbiota in the gut can profoundly alter susceptibility to a wide range of diseases, such as asthma, in which immune homeostasis is disrupted, yet the mechanisms governing this microbial influence remains poorly defined.
TextSentencer_T4 518-741 Sentence denotes In this study, we show that gastrointestinal exposure to PSA, a capsular polysaccharide derived from the commensal bacterium Bacteroides fragilis, significantly limits susceptibility to the induction of experimental asthma.
TextSentencer_T5 742-936 Sentence denotes We report that direct treatment of mice with PSA generates protection from asthma, and this effect can be given to a naïve recipient by adoptive transfer of CD4(+) T cells from PSA-exposed mice.
TextSentencer_T6 937-1131 Sentence denotes Remarkably, we found that these PSA-induced T cells are not canonical FoxP3(+) regulatory T cells, but that they potently inhibit both Th1 and Th2 models of asthma in an IL-10-dependent fashion.
TextSentencer_T7 1132-1399 Sentence denotes These findings reveal that bacterial polysaccharides link the microbiota with the peripheral immune system by activating CD4(+)Foxp3(-) T cells upon exposure in the gut, and they facilitate resistance to unnecessary inflammatory responses via the production of IL-10.
T1 0-89 Sentence denotes Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activation.
T2 90-244 Sentence denotes Over the last four decades, increases in the incidence of immune-mediated diseases in the Western world have been linked to changes in microbial exposure.
T3 245-517 Sentence denotes It is becoming increasingly clear that the normal microbiota in the gut can profoundly alter susceptibility to a wide range of diseases, such as asthma, in which immune homeostasis is disrupted, yet the mechanisms governing this microbial influence remains poorly defined.
T4 518-741 Sentence denotes In this study, we show that gastrointestinal exposure to PSA, a capsular polysaccharide derived from the commensal bacterium Bacteroides fragilis, significantly limits susceptibility to the induction of experimental asthma.
T5 742-936 Sentence denotes We report that direct treatment of mice with PSA generates protection from asthma, and this effect can be given to a naïve recipient by adoptive transfer of CD4(+) T cells from PSA-exposed mice.
T6 937-1131 Sentence denotes Remarkably, we found that these PSA-induced T cells are not canonical FoxP3(+) regulatory T cells, but that they potently inhibit both Th1 and Th2 models of asthma in an IL-10-dependent fashion.
T7 1132-1399 Sentence denotes These findings reveal that bacterial polysaccharides link the microbiota with the peripheral immune system by activating CD4(+)Foxp3(-) T cells upon exposure in the gut, and they facilitate resistance to unnecessary inflammatory responses via the production of IL-10.
T1 0-89 Sentence denotes Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activation.
T2 90-244 Sentence denotes Over the last four decades, increases in the incidence of immune-mediated diseases in the Western world have been linked to changes in microbial exposure.
T3 245-517 Sentence denotes It is becoming increasingly clear that the normal microbiota in the gut can profoundly alter susceptibility to a wide range of diseases, such as asthma, in which immune homeostasis is disrupted, yet the mechanisms governing this microbial influence remains poorly defined.
T4 518-741 Sentence denotes In this study, we show that gastrointestinal exposure to PSA, a capsular polysaccharide derived from the commensal bacterium Bacteroides fragilis, significantly limits susceptibility to the induction of experimental asthma.
T5 742-936 Sentence denotes We report that direct treatment of mice with PSA generates protection from asthma, and this effect can be given to a naïve recipient by adoptive transfer of CD4(+) T cells from PSA-exposed mice.
T6 937-1131 Sentence denotes Remarkably, we found that these PSA-induced T cells are not canonical FoxP3(+) regulatory T cells, but that they potently inhibit both Th1 and Th2 models of asthma in an IL-10-dependent fashion.
T7 1132-1399 Sentence denotes These findings reveal that bacterial polysaccharides link the microbiota with the peripheral immune system by activating CD4(+)Foxp3(-) T cells upon exposure in the gut, and they facilitate resistance to unnecessary inflammatory responses via the production of IL-10.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 313-316 http://purl.obolibrary.org/obo/MAT_0000043 denotes gut
T2 1297-1300 http://purl.obolibrary.org/obo/MAT_0000043 denotes gut

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 390-396 HP_0002099 denotes asthma
T2 734-740 HP_0002099 denotes asthma
T3 817-823 HP_0002099 denotes asthma
T4 1094-1100 HP_0002099 denotes asthma

ICD10

Id Subject Object Predicate Lexical cue
T1 56-62 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T2 390-396 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T3 734-740 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T4 817-823 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T5 1094-1100 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T6 56-62 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T7 390-396 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T8 734-740 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T9 817-823 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T10 1094-1100 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 19-33 FMAID:82785 denotes polysaccharide
_T2 19-33 FMAID:82746 denotes polysaccharide
_T3 19-33 FMAID:196735 denotes polysaccharide
_T4 19-33 FMAID:196779 denotes polysaccharide
_T5 313-316 FMAID:45615 denotes gut
_T6 313-316 FMAID:141929 denotes gut
_T7 591-605 FMAID:196779 denotes polysaccharide
_T8 591-605 FMAID:82746 denotes polysaccharide
_T9 591-605 FMAID:196735 denotes polysaccharide
_T10 591-605 FMAID:82785 denotes polysaccharide
_T11 908-913 FMAID:169002 denotes cells
_T12 908-913 FMAID:68646 denotes cells
_T13 983-988 FMAID:68646 denotes cells
_T14 983-988 FMAID:169002 denotes cells
_T15 1029-1034 FMAID:169002 denotes cells
_T16 1029-1034 FMAID:68646 denotes cells
_T17 1169-1184 FMAID:196735 denotes polysaccharides
_T18 1169-1184 FMAID:82746 denotes polysaccharides
_T19 1169-1184 FMAID:82785 denotes polysaccharides
_T20 1169-1184 FMAID:196779 denotes polysaccharides
_T21 1214-1224 FMAID:222825 denotes peripheral
_T22 1214-1224 FMAID:74552 denotes peripheral
_T23 1214-1224 FMAID:179289 denotes peripheral
_T24 1225-1238 FMAID:9825 denotes immune system
_T25 1225-1238 FMAID:97740 denotes immune system
_T26 1270-1275 FMAID:169002 denotes cells
_T27 1270-1275 FMAID:68646 denotes cells
_T28 1297-1300 FMAID:45615 denotes gut
_T29 1297-1300 FMAID:141929 denotes gut

uniprot-human

Id Subject Object Predicate Lexical cue
T1 575-578 http://www.uniprot.org/uniprot/Q9Y617 denotes PSA
T2 787-790 http://www.uniprot.org/uniprot/Q9Y617 denotes PSA
T3 919-922 http://www.uniprot.org/uniprot/Q9Y617 denotes PSA
T4 969-972 http://www.uniprot.org/uniprot/Q9Y617 denotes PSA
T5 575-578 http://www.uniprot.org/uniprot/P55786 denotes PSA
T6 787-790 http://www.uniprot.org/uniprot/P55786 denotes PSA
T7 919-922 http://www.uniprot.org/uniprot/P55786 denotes PSA
T8 969-972 http://www.uniprot.org/uniprot/P55786 denotes PSA
T9 575-578 http://www.uniprot.org/uniprot/P07288 denotes PSA
T10 787-790 http://www.uniprot.org/uniprot/P07288 denotes PSA
T11 919-922 http://www.uniprot.org/uniprot/P07288 denotes PSA
T12 969-972 http://www.uniprot.org/uniprot/P07288 denotes PSA
T13 899-902 http://www.uniprot.org/uniprot/P01730 denotes CD4
T14 1253-1256 http://www.uniprot.org/uniprot/P01730 denotes CD4
T15 1107-1112 http://www.uniprot.org/uniprot/P22301 denotes IL-10
T16 1393-1398 http://www.uniprot.org/uniprot/P22301 denotes IL-10

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 575-578 http://www.uniprot.org/uniprot/Q11011 denotes PSA
T2 787-790 http://www.uniprot.org/uniprot/Q11011 denotes PSA
T3 919-922 http://www.uniprot.org/uniprot/Q11011 denotes PSA
T4 969-972 http://www.uniprot.org/uniprot/Q11011 denotes PSA
T5 899-902 http://www.uniprot.org/uniprot/P06332 denotes CD4
T6 1253-1256 http://www.uniprot.org/uniprot/P06332 denotes CD4
T7 1072-1075 http://www.uniprot.org/uniprot/Q64279 denotes Th1
T8 1072-1075 http://www.uniprot.org/uniprot/Q922L6 denotes Th1
T9 1107-1112 http://www.uniprot.org/uniprot/P18893 denotes IL-10
T10 1393-1398 http://www.uniprot.org/uniprot/P18893 denotes IL-10

GO-BP

Id Subject Object Predicate Lexical cue
T1 71-88 http://purl.obolibrary.org/obo/GO_0032393 denotes T-cell activation
T2 71-88 http://purl.obolibrary.org/obo/GO_0032394 denotes T-cell activation
T3 71-88 http://purl.obolibrary.org/obo/GO_0032395 denotes T-cell activation
T4 71-88 http://purl.obolibrary.org/obo/GO_0042110 denotes T-cell activation
T5 71-88 http://purl.obolibrary.org/obo/GO_0045582 denotes T-cell activation
T6 71-88 http://purl.obolibrary.org/obo/GO_0050798 denotes T-cell activation
T7 71-88 http://purl.obolibrary.org/obo/GO_0050863 denotes T-cell activation
T8 71-88 http://purl.obolibrary.org/obo/GO_0051132 denotes T-cell activation
T9 71-88 http://purl.obolibrary.org/obo/GO_1903905 denotes T-cell activation
T10 71-88 http://purl.obolibrary.org/obo/GO_0042102 denotes T-cell activation
T11 73-88 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T12 414-425 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T13 414-425 http://purl.obolibrary.org/obo/GO_0033484 denotes homeostasis
T14 623-632 http://purl.obolibrary.org/obo/GO_0085031 denotes commensal
T15 1225-1252 http://purl.obolibrary.org/obo/GO_0002684 denotes immune system by activating
T16 1348-1370 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T17 1379-1398 http://purl.obolibrary.org/obo/GO_0032613 denotes production of IL-10
T18 1379-1398 http://purl.obolibrary.org/obo/GO_0032653 denotes production of IL-10

GO-MF

Id Subject Object Predicate Lexical cue
T1 1107-1112 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T2 1393-1398 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10

GO-CC

Id Subject Object Predicate Lexical cue
T1 73-77 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 908-913 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 983-988 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4 1029-1034 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 1270-1275 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 1225-1238 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 164-172 http://edamontology.org/topic_0634 denotes diseases
T2 372-380 http://edamontology.org/topic_0634 denotes diseases
T3 526-531 http://edamontology.org/topic_3678 denotes study

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 288-294 http://edamontology.org/operation_3435 denotes normal
T2 745-751 http://edamontology.org/data_2048 denotes report
T3 791-800 http://edamontology.org/operation_3429 denotes generates

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 313-316 http://purl.obolibrary.org/obo/MAT_0000043 denotes gut
T2 633-642 http://purl.obolibrary.org/obo/MAT_0000191 denotes bacterium
T3 1297-1300 http://purl.obolibrary.org/obo/MAT_0000043 denotes gut

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1225-1238 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 575-578 https://acgg.asia/db/lfdb/LfDB0181 denotes PSA
Lectin_T2 787-790 https://acgg.asia/db/lfdb/LfDB0181 denotes PSA
Lectin_T3 919-922 https://acgg.asia/db/lfdb/LfDB0181 denotes PSA
Lectin_T4 969-972 https://acgg.asia/db/lfdb/LfDB0181 denotes PSA

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 313-316 Body_part denotes gut http://purl.obolibrary.org/obo/MAT_0000043
T2 1297-1300 Body_part denotes gut http://purl.obolibrary.org/obo/MAT_0000043

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 56-62 Phenotype denotes asthma HP:0002099
T2 390-396 Phenotype denotes asthma HP:0002099
T3 734-740 Phenotype denotes asthma HP:0002099
T4 817-823 Phenotype denotes asthma HP:0002099
T5 1094-1100 Phenotype denotes asthma HP:0002099

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 56-62 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T2 390-396 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T3 734-740 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T4 817-823 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T5 1094-1100 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 295-305 OrganismTaxon denotes microbiota 13613
T2 643-663 OrganismTaxon denotes Bacteroides fragilis 817
T3 777-781 OrganismTaxon denotes mice 10088
T4 931-935 OrganismTaxon denotes mice 10088
T5 1194-1204 OrganismTaxon denotes microbiota 13613

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 71-77 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T2 313-316 Body_part denotes gut http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0004907
T5 1225-1238 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T6 1297-1300 Body_part denotes gut http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0004907

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 71-77 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T2 906-913 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 981-988 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T4 1016-1034 Cell denotes regulatory T cells http://purl.obolibrary.org/obo/CL:0000815
T5 1268-1275 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084