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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 44-59 REPLACED denotes High-conductive
T2 78-257 DRI_Background denotes potassium channels (BK+Ca) and ATP-sensitive potassium (K+ATP) channels play a significant role in the airway smooth muscle cell and goblet cell function, and cytokine production.
T3 258-427 DRI_Background denotes The present study evaluated the therapeutic potential of BK+Ca and K+ATP openers, NS 1619 and pinacidil, respectively, in an experimental model of allergic inflammation.
T4 428-586 DRI_Background denotes Airway allergic inflammation was induced with ovalbumine in guinea pigs during 21 days, which was followed by a 14-day treatment with BK+Ca and K+ATP openers.
T5 587-823 DRI_Background denotes The outcome measures were airway smooth muscle cells reactivity in vivo and in vitro, cilia beating frequency and the level of exhaled NO (ENO), and the level of pro-inflammatory cytokines in the plasma and bronchoalveolar lavage fluid.
T6 824-960 DRI_Outcome denotes The openers of both channels decreased airway smooth muscle cells reactivity, cilia beating frequency, and cytokine levels in the serum.
T7 961-1029 DRI_Background denotes Furthermore, NS1619 reduced ENO and inflammatory cells infiltration.
T8 1030-1144 DRI_Challenge denotes The findings confirmed the presence of beneficial effects of BK+Ca and K+ATP openers on airway defence mechanisms.
T9 1145-1296 DRI_Outcome denotes Although both openers dampened pro-inflammatory cytokines and mast cells infiltration, an evident anti-inflammatory effect was provided only by NS1619.
T10 1297-1438 DRI_Challenge denotes Therefore, we conclude that particularly BK+Ca channels represent a promising new drug target in treatment of airway's allergic inflammation.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 101-103 CVCL_Z839|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes Ca
T2 155-156 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 318-320 CVCL_Z839|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes Ca
T4 380-382 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T5 380-382 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T6 538-542 CVCL_6309|Cancer_cell_line|Homo sapiens denotes a 14
T7 538-542 CVCL_L990|Spontaneously_immortalized_cell_line|Mus musculus denotes a 14
T8 538-539 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T9 540-542 CVCL_ZS48|Finite_cell_line|Homo sapiens denotes 14
T10 565-567 CVCL_Z839|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes Ca
T11 749-752 CVCL_N817|Cancer_cell_line|Homo sapiens denotes pro
T12 1094-1096 CVCL_Z839|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes Ca
T13 1176-1179 CVCL_N817|Cancer_cell_line|Homo sapiens denotes pro
T14 1207-1211 CVCL_M374|Cancer_cell_line|Homo sapiens denotes mast
T15 1232-1234 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T16 1232-1234 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T17 1308-1310 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T18 1341-1343 CVCL_Z839|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes Ca
T19 1363-1364 CVCL_6479|Finite_cell_line|Mus musculus denotes a

GoldHamster

Id Subject Object Predicate Lexical cue
T5 0-13 1318915 denotes Potassium ion
T7 0-22 D015221 denotes Potassium ion channels
T10 10-22 GO:0022831 denotes ion channels
T11 36-42 D001249 denotes asthma
T12 36-42 D001249 denotes asthma
T13 60-67 1895 denotes calcium
T14 60-67 CHEBI:29320 denotes calcium
T15 60-67 CHEBI:22984 denotes calcium
T19 78-87 8588 denotes potassium
T20 78-96 D015221 denotes potassium channels
T22 109-112 318 denotes ATP
T21 109-112 D000255 denotes ATP
T23 109-112 CHEBI:30616 denotes ATP
T24 109-112 D000255 denotes ATP
T25 109-112 CHEBI:15422 denotes ATP
T29 123-132 8588 denotes potassium
T26 123-132 D011188 denotes potassium
T27 123-132 D011188 denotes potassium
T28 123-132 CHEBI:26216 denotes potassium
T31 136-139 318 denotes ATP
T30 136-139 D000255 denotes ATP
T32 136-139 CHEBI:30616 denotes ATP
T33 136-139 D000255 denotes ATP
T34 136-139 CHEBI:15422 denotes ATP
T38 181-206 UBERON:0004225 denotes airway smooth muscle cell
T41 188-206 CL:0000192 denotes smooth muscle cell
T45 211-222 CL:0000160 denotes goblet cell
T46 237-256 GO:0001816 denotes cytokine production
T48 327-330 318 denotes ATP
T47 327-330 D000255 denotes ATP
T49 327-330 CHEBI:30616 denotes ATP
T50 327-330 D000255 denotes ATP
T51 327-330 CHEBI:15422 denotes ATP
T52 340-347 CHEBI:34879 denotes NS 1619
T53 340-347 C086491 denotes NS 1619
T54 340-347 C086491 denotes NS 1619
T55 352-361 D020110 denotes pinacidil
T56 352-361 CHEBI:34923 denotes pinacidil
T57 352-361 CHEBI:91706 denotes pinacidil
T58 352-361 D020110 denotes pinacidil
T59 414-426 GO:0006954 denotes inflammation
T60 414-426 D007249 denotes inflammation
T61 414-426 D007249 denotes inflammation
T62 428-434 UBERON:0000117 denotes Airway
T63 428-434 UBERON:0001005 denotes Airway
T64 444-456 GO:0006954 denotes inflammation
T65 444-456 D007249 denotes inflammation
T66 444-456 D007249 denotes inflammation
T67 488-499 D006168 denotes guinea pigs
T68 495-499 PR:Q9W3Y4 denotes pigs
T71 495-499 PR:Q6PD26 denotes pigs
T72 495-499 PR:Q5XI31 denotes pigs
T73 495-499 PR:Q96S52 denotes pigs
T74 495-499 PR:000012706 denotes pigs
T79 574-577 318 denotes ATP
T78 574-577 D000255 denotes ATP
T80 574-577 CHEBI:30616 denotes ATP
T81 574-577 D000255 denotes ATP
T82 574-577 CHEBI:15422 denotes ATP
T85 613-633 UBERON:0004225 denotes airway smooth muscle
T90 673-678 UBERON:0001702 denotes cilia
T91 673-678 UBERON:0010168 denotes cilia
T92 726-729 PR:P0A6P9 denotes ENO
T93 726-729 PR:P15007 denotes ENO
T94 726-729 PR:Q2G028 denotes ENO
T95 726-729 PR:000022518 denotes ENO
T96 749-752 CVCL_N817 denotes pro
T100 749-752 SO:0001439 denotes pro
T97 749-752 CHEBI:32871 denotes pro
T98 749-752 CHEBI:32865 denotes pro
T99 749-752 CHEBI:50342 denotes pro
T101 749-752 CHEBI:32866 denotes pro
T102 766-775 D016207 denotes cytokines
T103 766-775 D016207 denotes cytokines
T104 783-789 UBERON:0001969 denotes plasma
T105 817-822 UBERON:0006314 denotes fluid
T108 863-883 UBERON:0004225 denotes airway smooth muscle
T113 902-907 UBERON:0001702 denotes cilia
T114 902-907 UBERON:0010168 denotes cilia
T115 954-959 UBERON:0001977 denotes serum
T116 974-980 CHEBI:34879 denotes NS1619
T117 974-980 C086491 denotes NS1619
T118 974-980 C086491 denotes NS1619
T119 989-992 PR:P0A6P9 denotes ENO
T120 989-992 PR:P15007 denotes ENO
T121 989-992 PR:Q2G028 denotes ENO
T122 989-992 PR:000022518 denotes ENO
T124 1103-1106 318 denotes ATP
T123 1103-1106 D000255 denotes ATP
T125 1103-1106 CHEBI:30616 denotes ATP
T126 1103-1106 D000255 denotes ATP
T127 1103-1106 CHEBI:15422 denotes ATP
T128 1118-1124 UBERON:0000117 denotes airway
T129 1118-1124 UBERON:0001005 denotes airway
T130 1176-1179 CVCL_N817 denotes pro
T134 1176-1179 SO:0001439 denotes pro
T131 1176-1179 CHEBI:32871 denotes pro
T132 1176-1179 CHEBI:32865 denotes pro
T133 1176-1179 CHEBI:50342 denotes pro
T135 1176-1179 CHEBI:32866 denotes pro
T136 1193-1202 D016207 denotes cytokines
T137 1193-1202 D016207 denotes cytokines
T138 1207-1211 PR:Q9NBD7 denotes mast
T139 1207-1211 PR:000008154 denotes mast
T141 1207-1211 Q9NBD7 denotes mast
T142 1207-1211 Q7TPM5 denotes mast
T140 1207-1211 CVCL_M374 denotes mast
T143 1289-1295 CHEBI:34879 denotes NS1619
T144 1289-1295 C086491 denotes NS1619
T145 1289-1295 C086491 denotes NS1619
T146 1379-1383 CHEBI:23888 denotes drug
T147 1407-1413 UBERON:0000117 denotes airway
T148 1407-1413 UBERON:0001005 denotes airway
T149 1425-1437 GO:0006954 denotes inflammation
T150 1425-1437 D007249 denotes inflammation
T151 1425-1437 D007249 denotes inflammation

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-43 Sentence denotes Potassium ion channels and allergic asthma.
T2 44-257 Sentence denotes High-conductive calcium-sensitive potassium channels (BK+Ca) and ATP-sensitive potassium (K+ATP) channels play a significant role in the airway smooth muscle cell and goblet cell function, and cytokine production.
T3 258-427 Sentence denotes The present study evaluated the therapeutic potential of BK+Ca and K+ATP openers, NS 1619 and pinacidil, respectively, in an experimental model of allergic inflammation.
T4 428-586 Sentence denotes Airway allergic inflammation was induced with ovalbumine in guinea pigs during 21 days, which was followed by a 14-day treatment with BK+Ca and K+ATP openers.
T5 587-823 Sentence denotes The outcome measures were airway smooth muscle cells reactivity in vivo and in vitro, cilia beating frequency and the level of exhaled NO (ENO), and the level of pro-inflammatory cytokines in the plasma and bronchoalveolar lavage fluid.
T6 824-960 Sentence denotes The openers of both channels decreased airway smooth muscle cells reactivity, cilia beating frequency, and cytokine levels in the serum.
T7 961-1029 Sentence denotes Furthermore, NS1619 reduced ENO and inflammatory cells infiltration.
T8 1030-1144 Sentence denotes The findings confirmed the presence of beneficial effects of BK+Ca and K+ATP openers on airway defence mechanisms.
T9 1145-1296 Sentence denotes Although both openers dampened pro-inflammatory cytokines and mast cells infiltration, an evident anti-inflammatory effect was provided only by NS1619.
T10 1297-1438 Sentence denotes Therefore, we conclude that particularly BK+Ca channels represent a promising new drug target in treatment of airway's allergic inflammation.
T1 0-43 Sentence denotes Potassium ion channels and allergic asthma.
T2 44-257 Sentence denotes High-conductive calcium-sensitive potassium channels (BK+Ca) and ATP-sensitive potassium (K+ATP) channels play a significant role in the airway smooth muscle cell and goblet cell function, and cytokine production.
T3 258-427 Sentence denotes The present study evaluated the therapeutic potential of BK+Ca and K+ATP openers, NS 1619 and pinacidil, respectively, in an experimental model of allergic inflammation.
T4 428-586 Sentence denotes Airway allergic inflammation was induced with ovalbumine in guinea pigs during 21 days, which was followed by a 14-day treatment with BK+Ca and K+ATP openers.
T5 587-823 Sentence denotes The outcome measures were airway smooth muscle cells reactivity in vivo and in vitro, cilia beating frequency and the level of exhaled NO (ENO), and the level of pro-inflammatory cytokines in the plasma and bronchoalveolar lavage fluid.
T6 824-960 Sentence denotes The openers of both channels decreased airway smooth muscle cells reactivity, cilia beating frequency, and cytokine levels in the serum.
T7 961-1029 Sentence denotes Furthermore, NS1619 reduced ENO and inflammatory cells infiltration.
T8 1030-1144 Sentence denotes The findings confirmed the presence of beneficial effects of BK+Ca and K+ATP openers on airway defence mechanisms.
T9 1145-1296 Sentence denotes Although both openers dampened pro-inflammatory cytokines and mast cells infiltration, an evident anti-inflammatory effect was provided only by NS1619.
T10 1297-1438 Sentence denotes Therefore, we conclude that particularly BK+Ca channels represent a promising new drug target in treatment of airway's allergic inflammation.