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PubMed:25315622 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 139-265 DRI_Outcome denotes Our previous studies show that provinol, a polyphenolic compound, has anti-inflammatory activity during allergic inflammation.
T2 266-477 DRI_Challenge denotes In the present study we investigated the effects of provinol and its combinations with clinically used antiasthmatics: budesonide or theophylline on airway defense mechanisms during experimental allergic asthma.
T3 478-607 DRI_Background denotes Separate groups of guinea pigs were treated during the course of 21-day ovalbumin sensitization with provinol (20 mg/kg/day, p.o.
T4 607-681 DRI_Background denotes ), or budesonide (1 mM by inhalation), or theophylline (10 mg/kg/day, i.p.
T5 681-765 DRI_Background denotes ), and with a half-dose combination of provinol+budesonide or provinol+theophylline.
T6 766-868 DRI_Background denotes Airways defense mechanisms: cough reflex and specific airway resistance (sRaw) were evaluated in vivo.
T7 869-952 DRI_Background denotes Tracheal smooth muscle reactivity and mucociliary clearance were examined in vitro.
T8 953-1146 DRI_Outcome denotes The findings were that provinol caused significant decreases in sRaw and in tracheal smooth muscle contractility, a suppression of cough reflex, and positively modulated ciliary beat frequency.
T9 1147-1261 DRI_Background denotes The bronchodilatory and antitussive effects of provinol were comparable with those of budesonide and theophylline.
T10 1262-1405 DRI_Background denotes Provinol given as add-on treatment significantly potentiated the effects of budesonide or theophylline, although the doses of each were halved.
T11 1406-1562 DRI_Outcome denotes We conclude that provinol not only has bronchodilatory and antitussive effects, but also potentiates similar effects exerted by budesonide and theophylline.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 180-181 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T2 205-208 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T3 205-208 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T4 227-235 CVCL_C410|Hybridoma|Mus musculus denotes activity
T5 287-289 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T6 589-591 CVCL_J923|Hybridoma|Mus musculus denotes 20
T7 693-694 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T8 1067-1068 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T9 1406-1408 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T10 1441-1444 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T11 1441-1444 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has

GoldHamster

Id Subject Object Predicate Lexical cue
T1 62-76 D018927 denotes antiasthmatics
T2 62-76 D018927 denotes antiasthmatics
T3 80-86 UBERON:0000117 denotes airway
T4 80-86 UBERON:0001005 denotes airway
T5 131-137 D001249 denotes asthma
T6 131-137 D001249 denotes asthma
T7 252-264 GO:0006954 denotes inflammation
T8 252-264 D007249 denotes inflammation
T9 252-264 D007249 denotes inflammation
T10 369-383 D018927 denotes antiasthmatics
T11 369-383 D018927 denotes antiasthmatics
T15 385-395 19831 denotes budesonide
T12 385-395 CHEBI:3207 denotes budesonide
T13 385-395 D019819 denotes budesonide
T14 385-395 D019819 denotes budesonide
T19 399-411 10438 denotes theophylline
T16 399-411 D013806 denotes theophylline
T17 399-411 D013806 denotes theophylline
T18 399-411 CHEBI:28177 denotes theophylline
T20 415-421 UBERON:0000117 denotes airway
T21 415-421 UBERON:0001005 denotes airway
T22 470-476 D001249 denotes asthma
T23 470-476 D001249 denotes asthma
T24 497-508 D006168 denotes guinea pigs
T25 504-508 PR:Q9W3Y4 denotes pigs
T28 504-508 PR:Q6PD26 denotes pigs
T29 504-508 PR:Q5XI31 denotes pigs
T30 504-508 PR:Q96S52 denotes pigs
T31 504-508 PR:000012706 denotes pigs
T32 550-559 PR:000025876 denotes ovalbumin
T33 550-559 E2RVI8 denotes ovalbumin
T34 550-559 P19104 denotes ovalbumin
T35 550-559 P01012 denotes ovalbumin
T38 550-559 O73860 denotes ovalbumin
T39 550-559 Q6V115 denotes ovalbumin
T36 550-559 D010047 denotes ovalbumin
T37 550-559 D010047 denotes ovalbumin
T40 560-573 GO:0046960 denotes sensitization
T44 613-623 19831 denotes budesonide
T41 613-623 CHEBI:3207 denotes budesonide
T42 613-623 D019819 denotes budesonide
T43 613-623 D019819 denotes budesonide
T48 649-661 10438 denotes theophylline
T45 649-661 D013806 denotes theophylline
T46 649-661 D013806 denotes theophylline
T47 649-661 CHEBI:28177 denotes theophylline
T52 729-739 19831 denotes budesonide
T49 729-739 CHEBI:3207 denotes budesonide
T50 729-739 D019819 denotes budesonide
T51 729-739 D019819 denotes budesonide
T56 752-764 10438 denotes theophylline
T53 752-764 D013806 denotes theophylline
T54 752-764 D013806 denotes theophylline
T55 752-764 CHEBI:28177 denotes theophylline
T57 766-773 UBERON:0001005 denotes Airways
T58 794-799 D003371 denotes cough
T59 794-799 D003371 denotes cough
T61 800-806 CHEBI:138164 denotes reflex
T60 800-806 GO:0060004 denotes reflex
T62 820-826 UBERON:0000117 denotes airway
T63 820-826 UBERON:0001005 denotes airway
T64 869-891 UBERON:0003387 denotes Tracheal smooth muscle
T69 907-928 GO:0120197 denotes mucociliary clearance
T70 1029-1051 UBERON:0003387 denotes tracheal smooth muscle
T75 1084-1089 D003371 denotes cough
T76 1084-1089 D003371 denotes cough
T78 1090-1096 CHEBI:138164 denotes reflex
T77 1090-1096 GO:0060004 denotes reflex
T79 1171-1182 CHEBI:51177 denotes antitussive
T83 1233-1243 19831 denotes budesonide
T80 1233-1243 CHEBI:3207 denotes budesonide
T81 1233-1243 D019819 denotes budesonide
T82 1233-1243 D019819 denotes budesonide
T87 1248-1260 10438 denotes theophylline
T84 1248-1260 D013806 denotes theophylline
T85 1248-1260 D013806 denotes theophylline
T86 1248-1260 CHEBI:28177 denotes theophylline
T88 1280-1283 PR:A5I0I2 denotes add
T89 1280-1283 PR:P22333 denotes add
T90 1280-1283 PR:Q54KF3 denotes add
T94 1338-1348 19831 denotes budesonide
T91 1338-1348 CHEBI:3207 denotes budesonide
T92 1338-1348 D019819 denotes budesonide
T93 1338-1348 D019819 denotes budesonide
T98 1352-1364 10438 denotes theophylline
T95 1352-1364 D013806 denotes theophylline
T96 1352-1364 D013806 denotes theophylline
T97 1352-1364 CHEBI:28177 denotes theophylline
T99 1465-1476 CHEBI:51177 denotes antitussive
T103 1534-1544 19831 denotes budesonide
T100 1534-1544 CHEBI:3207 denotes budesonide
T101 1534-1544 D019819 denotes budesonide
T102 1534-1544 D019819 denotes budesonide
T107 1549-1561 10438 denotes theophylline
T104 1549-1561 D013806 denotes theophylline
T105 1549-1561 D013806 denotes theophylline
T106 1549-1561 CHEBI:28177 denotes theophylline

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-138 Sentence denotes Effects of provinol and its combinations with clinically used antiasthmatics on airway defense mechanisms in experimental allergic asthma.
T2 139-265 Sentence denotes Our previous studies show that provinol, a polyphenolic compound, has anti-inflammatory activity during allergic inflammation.
T3 266-477 Sentence denotes In the present study we investigated the effects of provinol and its combinations with clinically used antiasthmatics: budesonide or theophylline on airway defense mechanisms during experimental allergic asthma.
T4 478-765 Sentence denotes Separate groups of guinea pigs were treated during the course of 21-day ovalbumin sensitization with provinol (20 mg/kg/day, p.o.), or budesonide (1 mM by inhalation), or theophylline (10 mg/kg/day, i.p.), and with a half-dose combination of provinol+budesonide or provinol+theophylline.
T5 766-868 Sentence denotes Airways defense mechanisms: cough reflex and specific airway resistance (sRaw) were evaluated in vivo.
T6 869-952 Sentence denotes Tracheal smooth muscle reactivity and mucociliary clearance were examined in vitro.
T7 953-1146 Sentence denotes The findings were that provinol caused significant decreases in sRaw and in tracheal smooth muscle contractility, a suppression of cough reflex, and positively modulated ciliary beat frequency.
T8 1147-1261 Sentence denotes The bronchodilatory and antitussive effects of provinol were comparable with those of budesonide and theophylline.
T9 1262-1405 Sentence denotes Provinol given as add-on treatment significantly potentiated the effects of budesonide or theophylline, although the doses of each were halved.
T10 1406-1562 Sentence denotes We conclude that provinol not only has bronchodilatory and antitussive effects, but also potentiates similar effects exerted by budesonide and theophylline.
T1 0-138 Sentence denotes Effects of provinol and its combinations with clinically used antiasthmatics on airway defense mechanisms in experimental allergic asthma.
T2 139-265 Sentence denotes Our previous studies show that provinol, a polyphenolic compound, has anti-inflammatory activity during allergic inflammation.
T3 266-477 Sentence denotes In the present study we investigated the effects of provinol and its combinations with clinically used antiasthmatics: budesonide or theophylline on airway defense mechanisms during experimental allergic asthma.
T4 478-765 Sentence denotes Separate groups of guinea pigs were treated during the course of 21-day ovalbumin sensitization with provinol (20 mg/kg/day, p.o.), or budesonide (1 mM by inhalation), or theophylline (10 mg/kg/day, i.p.), and with a half-dose combination of provinol+budesonide or provinol+theophylline.
T5 766-868 Sentence denotes Airways defense mechanisms: cough reflex and specific airway resistance (sRaw) were evaluated in vivo.
T6 869-952 Sentence denotes Tracheal smooth muscle reactivity and mucociliary clearance were examined in vitro.
T7 953-1146 Sentence denotes The findings were that provinol caused significant decreases in sRaw and in tracheal smooth muscle contractility, a suppression of cough reflex, and positively modulated ciliary beat frequency.
T8 1147-1261 Sentence denotes The bronchodilatory and antitussive effects of provinol were comparable with those of budesonide and theophylline.
T9 1262-1405 Sentence denotes Provinol given as add-on treatment significantly potentiated the effects of budesonide or theophylline, although the doses of each were halved.
T10 1406-1562 Sentence denotes We conclude that provinol not only has bronchodilatory and antitussive effects, but also potentiates similar effects exerted by budesonide and theophylline.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 470-476 HP_0002099 denotes asthma
T2 794-799 HP_0012735 denotes cough
T3 1052-1065 HP_0001371 denotes contractility
T4 1084-1089 HP_0012735 denotes cough