PubMed:25305591 / 904-1319
Annnotations
Inflammaging
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T5 | 0-415 | Sentence | denotes | In this study, we found that mice with a genetic deletion of VIPR2, encoding the VPAC2 receptor, exhibited exacerbated (MOG35-55)-induced EAE compared to wild type mice, characterized by enhanced clinical and histopathological features, increased proinflammatory cytokines (TNF-α, IL-6, IFN-γ (Th1), and IL-17 (Th17)) and reduced anti-inflammatory cytokines (IL-10, TGFβ, and IL-4 (Th2)) in the CNS and lymph nodes. |
| T5 | 0-415 | Sentence | denotes | In this study, we found that mice with a genetic deletion of VIPR2, encoding the VPAC2 receptor, exhibited exacerbated (MOG35-55)-induced EAE compared to wild type mice, characterized by enhanced clinical and histopathological features, increased proinflammatory cytokines (TNF-α, IL-6, IFN-γ (Th1), and IL-17 (Th17)) and reduced anti-inflammatory cytokines (IL-10, TGFβ, and IL-4 (Th2)) in the CNS and lymph nodes. |
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4 | 0-415 | DRI_Outcome | denotes | In this study, we found that mice with a genetic deletion of VIPR2, encoding the VPAC2 receptor, exhibited exacerbated (MOG35-55)-induced EAE compared to wild type mice, characterized by enhanced clinical and histopathological features, increased proinflammatory cytokines (TNF-α, IL-6, IFN-γ (Th1), and IL-17 (Th17)) and reduced anti-inflammatory cytokines (IL-10, TGFβ, and IL-4 (Th2)) in the CNS and lymph nodes. |
TEST-DiseaseOrPhenotypicFeature
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T4 | 138-141 | DiseaseOrPhenotypicFeature | denotes | EAE | D004681 |
| T5 | 247-262 | DiseaseOrPhenotypicFeature | denotes | proinflammatory | DISEASE |
TEST-OrganismTaxon
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 29-33 | OrganismTaxon | denotes | mice |
| T4 | 164-168 | OrganismTaxon | denotes | mice |
Test-SequenceVariant
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 49-65 | SequenceVariant | denotes | deletion of VIPR |
Test-GeneOrGeneProduct
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T13 | 61-66 | GeneOrGeneProduct | denotes | VIPR2 |
| T14 | 81-95 | GeneOrGeneProduct | denotes | VPAC2 receptor |
| T15 | 274-279 | GeneOrGeneProduct | denotes | TNF-α |
| T16 | 281-285 | GeneOrGeneProduct | denotes | IL-6 |
| T17 | 287-292 | GeneOrGeneProduct | denotes | IFN-γ |
| T18 | 304-309 | GeneOrGeneProduct | denotes | IL-17 |
| T19 | 330-357 | GeneOrGeneProduct | denotes | anti-inflammatory cytokines |
| T20 | 359-364 | GeneOrGeneProduct | denotes | IL-10 |
| T21 | 366-370 | GeneOrGeneProduct | denotes | TGFβ |
| T22 | 376-380 | GeneOrGeneProduct | denotes | IL-4 |
Test-merged-2
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T6647 | 49-65 | SequenceVariant | denotes | deletion of VIPR | |
| T13 | 61-66 | GeneOrGeneProduct | denotes | VIPR2 | |
| T14 | 81-95 | GeneOrGeneProduct | denotes | VPAC2 receptor | |
| T15 | 274-279 | GeneOrGeneProduct | denotes | TNF-α | |
| T16 | 281-285 | GeneOrGeneProduct | denotes | IL-6 | |
| T17 | 287-292 | GeneOrGeneProduct | denotes | IFN-γ | |
| T18 | 304-309 | GeneOrGeneProduct | denotes | IL-17 | |
| T19 | 330-357 | GeneOrGeneProduct | denotes | anti-inflammatory cytokines | |
| T20 | 359-364 | GeneOrGeneProduct | denotes | IL-10 | |
| T21 | 366-370 | GeneOrGeneProduct | denotes | TGFβ | |
| T22 | 376-380 | GeneOrGeneProduct | denotes | IL-4 | |
| T3340 | 29-33 | OrganismTaxon | denotes | mice | |
| T98021 | 164-168 | OrganismTaxon | denotes | mice | |
| T4 | 138-141 | DiseaseOrPhenotypicFeature | denotes | EAE | D004681 |
| T5 | 247-262 | DiseaseOrPhenotypicFeature | denotes | proinflammatory | DISEASE |
Test-merged
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T5 | 247-262 | DiseaseOrPhenotypicFeature | denotes | proinflammatory | DISEASE |
| T4 | 138-141 | DiseaseOrPhenotypicFeature | denotes | EAE | D004681 |
| T98021 | 164-168 | OrganismTaxon | denotes | mice | |
| T3340 | 29-33 | OrganismTaxon | denotes | mice | |
| T22 | 376-380 | GeneOrGeneProduct | denotes | IL-4 | |
| T21 | 366-370 | GeneOrGeneProduct | denotes | TGFβ | |
| T20 | 359-364 | GeneOrGeneProduct | denotes | IL-10 | |
| T19 | 330-357 | GeneOrGeneProduct | denotes | anti-inflammatory cytokines | |
| T18 | 304-309 | GeneOrGeneProduct | denotes | IL-17 | |
| T17 | 287-292 | GeneOrGeneProduct | denotes | IFN-γ | |
| T16 | 281-285 | GeneOrGeneProduct | denotes | IL-6 | |
| T15 | 274-279 | GeneOrGeneProduct | denotes | TNF-α | |
| T14 | 81-95 | GeneOrGeneProduct | denotes | VPAC2 receptor | |
| T13 | 61-66 | GeneOrGeneProduct | denotes | VIPR2 | |
| T6647 | 49-65 | SequenceVariant | denotes | deletion of VIPR |