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PubMed:25305591 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-195 Sentence denotes VPAC2 (vasoactive intestinal peptide receptor type 2) receptor deficient mice develop exacerbated experimental autoimmune encephalomyelitis with increased Th1/Th17 and reduced Th2/Treg responses.
T2 196-410 Sentence denotes Vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase-activating polypeptide (PACAP) are two structurally-related neuropeptides with widespread expression in the central and peripheral nervous systems.
T3 411-755 Sentence denotes Although these peptides have been repeatedly shown to exert potent anti-inflammatory actions when administered in animal models of inflammatory disease, mice deficient in VIP and PACAP were recently shown to exhibit different phenotypes (ameliorated and exacerbated, respectively) in response to experimental autoimmune encephalomyelitis (EAE).
T4 756-903 Sentence denotes Therefore, elucidating what are the specific immunoregulatory roles played by each of their receptor subtypes (VPAC1, VPAC2, and PAC1) is critical.
T5 904-1319 Sentence denotes In this study, we found that mice with a genetic deletion of VIPR2, encoding the VPAC2 receptor, exhibited exacerbated (MOG35-55)-induced EAE compared to wild type mice, characterized by enhanced clinical and histopathological features, increased proinflammatory cytokines (TNF-α, IL-6, IFN-γ (Th1), and IL-17 (Th17)) and reduced anti-inflammatory cytokines (IL-10, TGFβ, and IL-4 (Th2)) in the CNS and lymph nodes.
T6 1320-1483 Sentence denotes Moreover, the abundance and proliferative index of lymph node, thymus and CNS CD4(+)CD25(+)FoxP3(+) Tregs were strikingly reduced in VPAC2-deficient mice with EAE.
T7 1484-1598 Sentence denotes Finally, the in vitro suppressive activity of lymph node and splenic Tregs from VPAC2-deficient mice was impaired.
T8 1599-1770 Sentence denotes Overall, our results demonstrate critical protective roles for PACAP and the VPAC2 receptor against autoimmunity, promoting the expansion and maintenance of the Treg pool.
T1 0-195 Sentence denotes VPAC2 (vasoactive intestinal peptide receptor type 2) receptor deficient mice develop exacerbated experimental autoimmune encephalomyelitis with increased Th1/Th17 and reduced Th2/Treg responses.
T2 196-410 Sentence denotes Vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase-activating polypeptide (PACAP) are two structurally-related neuropeptides with widespread expression in the central and peripheral nervous systems.
T3 411-755 Sentence denotes Although these peptides have been repeatedly shown to exert potent anti-inflammatory actions when administered in animal models of inflammatory disease, mice deficient in VIP and PACAP were recently shown to exhibit different phenotypes (ameliorated and exacerbated, respectively) in response to experimental autoimmune encephalomyelitis (EAE).
T4 756-903 Sentence denotes Therefore, elucidating what are the specific immunoregulatory roles played by each of their receptor subtypes (VPAC1, VPAC2, and PAC1) is critical.
T5 904-1319 Sentence denotes In this study, we found that mice with a genetic deletion of VIPR2, encoding the VPAC2 receptor, exhibited exacerbated (MOG35-55)-induced EAE compared to wild type mice, characterized by enhanced clinical and histopathological features, increased proinflammatory cytokines (TNF-α, IL-6, IFN-γ (Th1), and IL-17 (Th17)) and reduced anti-inflammatory cytokines (IL-10, TGFβ, and IL-4 (Th2)) in the CNS and lymph nodes.
T6 1320-1483 Sentence denotes Moreover, the abundance and proliferative index of lymph node, thymus and CNS CD4(+)CD25(+)FoxP3(+) Tregs were strikingly reduced in VPAC2-deficient mice with EAE.
T7 1484-1598 Sentence denotes Finally, the in vitro suppressive activity of lymph node and splenic Tregs from VPAC2-deficient mice was impaired.
T8 1599-1770 Sentence denotes Overall, our results demonstrate critical protective roles for PACAP and the VPAC2 receptor against autoimmunity, promoting the expansion and maintenance of the Treg pool.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 196-410 DRI_Background denotes Vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase-activating polypeptide (PACAP) are two structurally-related neuropeptides with widespread expression in the central and peripheral nervous systems.
T2 411-755 DRI_Background denotes Although these peptides have been repeatedly shown to exert potent anti-inflammatory actions when administered in animal models of inflammatory disease, mice deficient in VIP and PACAP were recently shown to exhibit different phenotypes (ameliorated and exacerbated, respectively) in response to experimental autoimmune encephalomyelitis (EAE).
T3 756-903 DRI_Background denotes Therefore, elucidating what are the specific immunoregulatory roles played by each of their receptor subtypes (VPAC1, VPAC2, and PAC1) is critical.
T4 904-1319 DRI_Outcome denotes In this study, we found that mice with a genetic deletion of VIPR2, encoding the VPAC2 receptor, exhibited exacerbated (MOG35-55)-induced EAE compared to wild type mice, characterized by enhanced clinical and histopathological features, increased proinflammatory cytokines (TNF-α, IL-6, IFN-γ (Th1), and IL-17 (Th17)) and reduced anti-inflammatory cytokines (IL-10, TGFβ, and IL-4 (Th2)) in the CNS and lymph nodes.
T5 1320-1483 DRI_Outcome denotes Moreover, the abundance and proliferative index of lymph node, thymus and CNS CD4(+)CD25(+)FoxP3(+) Tregs were strikingly reduced in VPAC2-deficient mice with EAE.
T6 1484-1598 DRI_Outcome denotes Finally, the in vitro suppressive activity of lymph node and splenic Tregs from VPAC2-deficient mice was impaired.
T7 1599-1770 DRI_Outcome denotes Overall, our results demonstrate critical protective roles for PACAP and the VPAC2 receptor against autoimmunity, promoting the expansion and maintenance of the Treg pool.

TEST-CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 885-889 CellLine denotes PAC1 CVCL_U511

TEST-DiseaseOrPhenotypicFeature

Id Subject Object Predicate Lexical cue #label
T1 98-139 DiseaseOrPhenotypicFeature denotes experimental autoimmune encephalomyelitis D004681
T2 707-748 DiseaseOrPhenotypicFeature denotes experimental autoimmune encephalomyelitis D004681
T3 750-753 DiseaseOrPhenotypicFeature denotes EAE D004681
T4 1042-1045 DiseaseOrPhenotypicFeature denotes EAE D004681
T5 1151-1166 DiseaseOrPhenotypicFeature denotes proinflammatory DISEASE
T6 1479-1482 DiseaseOrPhenotypicFeature denotes EAE D004681

TEST-ChemicalEntity

Id Subject Object Predicate Lexical cue ID:
T1 7-36 ChemicalEntity denotes vasoactive intestinal peptide http://purl.obolibrary.org/obo/CHEBI_80331
T2 196-225 ChemicalEntity denotes Vasoactive intestinal peptide http://purl.obolibrary.org/obo/CHEBI_80331
T3 227-230 ChemicalEntity denotes VIP http://purl.obolibrary.org/obo/CHEBI_80331
T4 274-285 ChemicalEntity denotes polypeptide http://purl.obolibrary.org/obo/CHEBI_15841
T5 582-585 ChemicalEntity denotes VIP http://purl.obolibrary.org/obo/CHEBI_80331

TEST-OrganismTaxon

Id Subject Object Predicate Lexical cue
T1 73-77 OrganismTaxon denotes mice
T2 564-568 OrganismTaxon denotes mice
T3 933-937 OrganismTaxon denotes mice
T4 1068-1072 OrganismTaxon denotes mice
T5 1383-1389 OrganismTaxon denotes thymus
T6 1469-1473 OrganismTaxon denotes mice
T7 1580-1584 OrganismTaxon denotes mice

Test-SequenceVariant

Id Subject Object Predicate Lexical cue
T1 953-969 SequenceVariant denotes deletion of VIPR

Test-GeneOrGeneProduct

Id Subject Object Predicate Lexical cue
T1 0-5 GeneOrGeneProduct denotes VPAC2
T2 7-45 GeneOrGeneProduct denotes vasoactive intestinal peptide receptor
T3 196-225 GeneOrGeneProduct denotes Vasoactive intestinal peptide
T4 227-230 GeneOrGeneProduct denotes VIP
T5 236-285 GeneOrGeneProduct denotes pituitary adenylyl cyclase-activating polypeptide
T6 287-292 GeneOrGeneProduct denotes PACAP
T7 323-336 GeneOrGeneProduct denotes neuropeptides
T8 582-585 GeneOrGeneProduct denotes VIP
T9 590-595 GeneOrGeneProduct denotes PACAP
T10 867-872 GeneOrGeneProduct denotes VPAC1
T11 874-879 GeneOrGeneProduct denotes VPAC2
T12 885-889 GeneOrGeneProduct denotes PAC1
T13 965-970 GeneOrGeneProduct denotes VIPR2
T14 985-999 GeneOrGeneProduct denotes VPAC2 receptor
T15 1178-1183 GeneOrGeneProduct denotes TNF-α
T16 1185-1189 GeneOrGeneProduct denotes IL-6
T17 1191-1196 GeneOrGeneProduct denotes IFN-γ
T18 1208-1213 GeneOrGeneProduct denotes IL-17
T19 1234-1261 GeneOrGeneProduct denotes anti-inflammatory cytokines
T20 1263-1268 GeneOrGeneProduct denotes IL-10
T21 1270-1274 GeneOrGeneProduct denotes TGFβ
T22 1280-1284 GeneOrGeneProduct denotes IL-4
T23 1404-1408 GeneOrGeneProduct denotes CD25
T24 1411-1416 GeneOrGeneProduct denotes FoxP3
T25 1453-1458 GeneOrGeneProduct denotes VPAC2
T26 1564-1569 GeneOrGeneProduct denotes VPAC2
T27 1662-1667 GeneOrGeneProduct denotes PACAP
T28 1676-1690 GeneOrGeneProduct denotes VPAC2 receptor

Test-merged-2

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T52891 885-889 CellLine denotes PAC1 CVCL_U511
T6647 953-969 SequenceVariant denotes deletion of VIPR
T57044 7-36 ChemicalEntity denotes vasoactive intestinal peptide http://purl.obolibrary.org/obo/CHEBI_80331
T5537 196-225 ChemicalEntity denotes Vasoactive intestinal peptide http://purl.obolibrary.org/obo/CHEBI_80331
T90519 227-230 ChemicalEntity denotes VIP http://purl.obolibrary.org/obo/CHEBI_80331
T81919 274-285 ChemicalEntity denotes polypeptide http://purl.obolibrary.org/obo/CHEBI_15841
T20448 582-585 ChemicalEntity denotes VIP http://purl.obolibrary.org/obo/CHEBI_80331
T79599 0-5 GeneOrGeneProduct denotes VPAC2
T37040 7-45 GeneOrGeneProduct denotes vasoactive intestinal peptide receptor
T60511 196-225 GeneOrGeneProduct denotes Vasoactive intestinal peptide
T25011 227-230 GeneOrGeneProduct denotes VIP
T10130 236-285 GeneOrGeneProduct denotes pituitary adenylyl cyclase-activating polypeptide
T44134 287-292 GeneOrGeneProduct denotes PACAP
T9681 323-336 GeneOrGeneProduct denotes neuropeptides
T8 582-585 GeneOrGeneProduct denotes VIP
T9 590-595 GeneOrGeneProduct denotes PACAP
T10 867-872 GeneOrGeneProduct denotes VPAC1
T11 874-879 GeneOrGeneProduct denotes VPAC2
T12 885-889 GeneOrGeneProduct denotes PAC1
T13 965-970 GeneOrGeneProduct denotes VIPR2
T14 985-999 GeneOrGeneProduct denotes VPAC2 receptor
T15 1178-1183 GeneOrGeneProduct denotes TNF-α
T16 1185-1189 GeneOrGeneProduct denotes IL-6
T17 1191-1196 GeneOrGeneProduct denotes IFN-γ
T18 1208-1213 GeneOrGeneProduct denotes IL-17
T19 1234-1261 GeneOrGeneProduct denotes anti-inflammatory cytokines
T20 1263-1268 GeneOrGeneProduct denotes IL-10
T21 1270-1274 GeneOrGeneProduct denotes TGFβ
T22 1280-1284 GeneOrGeneProduct denotes IL-4
T23 1404-1408 GeneOrGeneProduct denotes CD25
T24 1411-1416 GeneOrGeneProduct denotes FoxP3
T25 1453-1458 GeneOrGeneProduct denotes VPAC2
T26 1564-1569 GeneOrGeneProduct denotes VPAC2
T27 1662-1667 GeneOrGeneProduct denotes PACAP
T28 1676-1690 GeneOrGeneProduct denotes VPAC2 receptor
T83856 73-77 OrganismTaxon denotes mice
T45131 564-568 OrganismTaxon denotes mice
T3340 933-937 OrganismTaxon denotes mice
T98021 1068-1072 OrganismTaxon denotes mice
T34700 1383-1389 OrganismTaxon denotes thymus
T82242 1469-1473 OrganismTaxon denotes mice
T7 1580-1584 OrganismTaxon denotes mice
T1 98-139 DiseaseOrPhenotypicFeature denotes experimental autoimmune encephalomyelitis D004681
T2 707-748 DiseaseOrPhenotypicFeature denotes experimental autoimmune encephalomyelitis D004681
T3 750-753 DiseaseOrPhenotypicFeature denotes EAE D004681
T4 1042-1045 DiseaseOrPhenotypicFeature denotes EAE D004681
T5 1151-1166 DiseaseOrPhenotypicFeature denotes proinflammatory DISEASE
T6 1479-1482 DiseaseOrPhenotypicFeature denotes EAE D004681

Test-merged

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T6 1479-1482 DiseaseOrPhenotypicFeature denotes EAE D004681
T5 1151-1166 DiseaseOrPhenotypicFeature denotes proinflammatory DISEASE
T4 1042-1045 DiseaseOrPhenotypicFeature denotes EAE D004681
T3 750-753 DiseaseOrPhenotypicFeature denotes EAE D004681
T2 707-748 DiseaseOrPhenotypicFeature denotes experimental autoimmune encephalomyelitis D004681
T1 98-139 DiseaseOrPhenotypicFeature denotes experimental autoimmune encephalomyelitis D004681
T7 1580-1584 OrganismTaxon denotes mice
T82242 1469-1473 OrganismTaxon denotes mice
T34700 1383-1389 OrganismTaxon denotes thymus
T98021 1068-1072 OrganismTaxon denotes mice
T3340 933-937 OrganismTaxon denotes mice
T45131 564-568 OrganismTaxon denotes mice
T83856 73-77 OrganismTaxon denotes mice
T28 1676-1690 GeneOrGeneProduct denotes VPAC2 receptor
T27 1662-1667 GeneOrGeneProduct denotes PACAP
T26 1564-1569 GeneOrGeneProduct denotes VPAC2
T25 1453-1458 GeneOrGeneProduct denotes VPAC2
T24 1411-1416 GeneOrGeneProduct denotes FoxP3
T23 1404-1408 GeneOrGeneProduct denotes CD25
T22 1280-1284 GeneOrGeneProduct denotes IL-4
T21 1270-1274 GeneOrGeneProduct denotes TGFβ
T20 1263-1268 GeneOrGeneProduct denotes IL-10
T19 1234-1261 GeneOrGeneProduct denotes anti-inflammatory cytokines
T18 1208-1213 GeneOrGeneProduct denotes IL-17
T17 1191-1196 GeneOrGeneProduct denotes IFN-γ
T16 1185-1189 GeneOrGeneProduct denotes IL-6
T15 1178-1183 GeneOrGeneProduct denotes TNF-α
T14 985-999 GeneOrGeneProduct denotes VPAC2 receptor
T13 965-970 GeneOrGeneProduct denotes VIPR2
T11 874-879 GeneOrGeneProduct denotes VPAC2
T10 867-872 GeneOrGeneProduct denotes VPAC1
T9 590-595 GeneOrGeneProduct denotes PACAP
T9681 323-336 GeneOrGeneProduct denotes neuropeptides
T44134 287-292 GeneOrGeneProduct denotes PACAP
T10130 236-285 GeneOrGeneProduct denotes pituitary adenylyl cyclase-activating polypeptide
T37040 7-45 GeneOrGeneProduct denotes vasoactive intestinal peptide receptor
T79599 0-5 GeneOrGeneProduct denotes VPAC2
T20448 582-585 ChemicalEntity denotes VIP http://purl.obolibrary.org/obo/CHEBI_80331
T90519 227-230 ChemicalEntity denotes VIP http://purl.obolibrary.org/obo/CHEBI_80331
T5537 196-225 ChemicalEntity denotes Vasoactive intestinal peptide http://purl.obolibrary.org/obo/CHEBI_80331
T6647 953-969 SequenceVariant denotes deletion of VIPR
T52891 885-889 CellLine denotes PAC1 CVCL_U511

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 720-730 HP_0002960 denotes autoimmune
T2 1699-1711 HP_0002960 denotes autoimmunity