PubMed:25286407 / 154-594 JSONTXT

{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T1","span":{"begin":0,"end":440},"obj":"BACKGROUND"}],"text":"Analgesic discography (discoblock) can be used to diagnose or treat discogenic low back pain by injecting a small amount of local anesthetics. However, recent in vitro studies have revealed cytotoxic effects of local anesthetics on intervertebral disc (IVD) cells. Here we aimed to investigate the deteriorative effects of lidocaine and bupivacaine on rabbit IVDs using an organotypic culture model and an in vivo long-term follow-up model."}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T1","span":{"begin":106,"end":107},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T2","span":{"begin":270,"end":272},"obj":"CVCL_5M23|Cancer_cell_line|Mesocricetus auratus"},{"id":"T3","span":{"begin":370,"end":372},"obj":"CVCL_8754|Cancer_cell_line|Homo sapiens"},{"id":"T4","span":{"begin":370,"end":372},"obj":"CVCL_H241|Cancer_cell_line|Homo sapiens"},{"id":"T5","span":{"begin":403,"end":405},"obj":"CVCL_8754|Cancer_cell_line|Homo sapiens"},{"id":"T6","span":{"begin":403,"end":405},"obj":"CVCL_H241|Cancer_cell_line|Homo sapiens"}],"text":"Analgesic discography (discoblock) can be used to diagnose or treat discogenic low back pain by injecting a small amount of local anesthetics. However, recent in vitro studies have revealed cytotoxic effects of local anesthetics on intervertebral disc (IVD) cells. Here we aimed to investigate the deteriorative effects of lidocaine and bupivacaine on rabbit IVDs using an organotypic culture model and an in vivo long-term follow-up model."}

{"project":"GoldHamster","denotations":[{"id":"T11","span":{"begin":0,"end":9},"obj":"CHEBI:35480"},{"id":"T12","span":{"begin":79,"end":92},"obj":"D017116"},{"id":"T13","span":{"begin":79,"end":92},"obj":"D017116"},{"id":"T16","span":{"begin":88,"end":92},"obj":"PR:Q9W0Y6"},{"id":"T17","span":{"begin":124,"end":141},"obj":"CHEBI:36333"},{"id":"T18","span":{"begin":124,"end":141},"obj":"D000779"},{"id":"T19","span":{"begin":124,"end":141},"obj":"D000779"},{"id":"T23","span":{"begin":211,"end":228},"obj":"CHEBI:36333"},{"id":"T24","span":{"begin":211,"end":228},"obj":"D000779"},{"id":"T25","span":{"begin":211,"end":228},"obj":"D000779"},{"id":"T31","span":{"begin":232,"end":251},"obj":"UBERON:0001066"},{"id":"T29","span":{"begin":232,"end":251},"obj":"C535531"},{"id":"T30","span":{"begin":232,"end":251},"obj":"C535531"},{"id":"T32","span":{"begin":253,"end":256},"obj":"Q9FS87"},{"id":"T33","span":{"begin":253,"end":256},"obj":"Q9SWG0"},{"id":"T34","span":{"begin":253,"end":256},"obj":"P12007"},{"id":"T35","span":{"begin":253,"end":256},"obj":"P26440"},{"id":"T36","span":{"begin":253,"end":256},"obj":"Q3SZI8"},{"id":"T37","span":{"begin":253,"end":256},"obj":"PR:P12007"},{"id":"T38","span":{"begin":253,"end":256},"obj":"P34275"},{"id":"T39","span":{"begin":253,"end":256},"obj":"Q9JHI5"},{"id":"T40","span":{"begin":253,"end":256},"obj":"PR:Q9SWG0"},{"id":"T41","span":{"begin":253,"end":256},"obj":"Q75IM9"},{"id":"T42","span":{"begin":253,"end":256},"obj":"PR:P26440"},{"id":"T43","span":{"begin":253,"end":256},"obj":"Q5RBD5"},{"id":"T44","span":{"begin":253,"end":256},"obj":"PR:000009166"},{"id":"T45","span":{"begin":253,"end":256},"obj":"PR:Q9JHI5"},{"id":"T46","span":{"begin":323,"end":332},"obj":"6387"},{"id":"T47","span":{"begin":323,"end":332},"obj":"D008012"},{"id":"T48","span":{"begin":323,"end":332},"obj":"CHEBI:6456"},{"id":"T49","span":{"begin":323,"end":332},"obj":"D008012"},{"id":"T51","span":{"begin":337,"end":348},"obj":"1815"},{"id":"T50","span":{"begin":337,"end":348},"obj":"D002045"},{"id":"T52","span":{"begin":337,"end":348},"obj":"CHEBI:3215"},{"id":"T53","span":{"begin":337,"end":348},"obj":"CHEBI:60790"},{"id":"T54","span":{"begin":337,"end":348},"obj":"CHEBI:6149"},{"id":"T55","span":{"begin":337,"end":348},"obj":"D002045"},{"id":"T57","span":{"begin":352,"end":358},"obj":"813859"},{"id":"T56","span":{"begin":352,"end":358},"obj":"D011817"},{"id":"T58","span":{"begin":352,"end":358},"obj":"9986"},{"id":"T59","span":{"begin":419,"end":423},"obj":"original_id"}],"text":"Analgesic discography (discoblock) can be used to diagnose or treat discogenic low back pain by injecting a small amount of local anesthetics. However, recent in vitro studies have revealed cytotoxic effects of local anesthetics on intervertebral disc (IVD) cells. Here we aimed to investigate the deteriorative effects of lidocaine and bupivacaine on rabbit IVDs using an organotypic culture model and an in vivo long-term follow-up model."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":79,"end":92},"obj":"HP_0003419"},{"id":"T2","span":{"begin":83,"end":92},"obj":"HP_0003418"},{"id":"T3","span":{"begin":88,"end":92},"obj":"HP_0012531"}],"text":"Analgesic discography (discoblock) can be used to diagnose or treat discogenic low back pain by injecting a small amount of local anesthetics. However, recent in vitro studies have revealed cytotoxic effects of local anesthetics on intervertebral disc (IVD) cells. Here we aimed to investigate the deteriorative effects of lidocaine and bupivacaine on rabbit IVDs using an organotypic culture model and an in vivo long-term follow-up model."}